Experience-dependent changes in temperature and behavioral activity induced by MDMA

Physiology and Behavior

Volumn 89, Issue 3, 2006, Pages 358-363

  Reveron, Maria E ^a   Maier, Esther Y ^a   Duvauchelle, Christine L ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Ecstasy; Locomotion; MDMA self administration; Operant conditioning; Thermoregulation

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BASAL BODY TEMPERATURE; BEHAVIOR CHANGE; CONTROLLED STUDY; CORE TEMPERATURE; DRUG SELF ADMINISTRATION; EXPERIENCE; HYPOTHERMIA; INFORMATION PROCESSING; INSTRUMENTAL CONDITIONING; LOCOMOTION; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT COURSE THERAPY; STATISTICAL SIGNIFICANCE; THERMOREGULATION;

EID: 33748922593     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2006.06.021     Document Type: Article

References (44)

1. Piper B.J., Fraiman J.B., and Meyer J.S. Repeated MDMA ("ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding. Dev Psychobiol 47 2 (2005) 145-157
2. Nash Jr. J.F., Meltzer H.Y., and Gudelsky G.A. Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine. J Pharmacol Exp Ther 245 3 (1988) 873-879
3. Malberg J.E., and Seiden L.S. Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. J Neurosci 18 13 (1998) 5086-5094
4. Fantegrossi W.E., Godlewski T., Karabenick R.L., Stephens J.M., Ullrich T., Rice K.C., et al. Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice. Psychopharmacology (Berl) 166 3 (2003) 202-211
5. O'Shea E., Granados R., Esteban B., Colado M.I., and Green A.R. The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy'). Neuropharmacology 37 7 (1998) 919-926
6. Carvalho M., Carvalho F., Remiao F., de Lourdes Pereira M., Pires-das-Neves R., and de Lourdes Bastos M. Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: influence of ambient temperature. Arch Toxicol 76 3 (2002) 166-172
7. Mills E.M., Banks M.L., Sprague J.E., and Finkel T. Pharmacology: uncoupling the agony from ecstasy. Nature 426 6965 (2003) 403-404
8. Freedman R.R., Johanson C.E., and Tancer M.E. Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans. Psychopharmacology (Berl) 183 2 (2005) 248-256
9. Dafters R.I., and Lynch E. Persistent loss of thermoregulation in the rat induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") but not by fenfluramine. Psychopharmacology (Berl) 138 2 (1998) 207-212
10. Dafters R.I. Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption, and chronic dosing. Physiol Behav 58 5 (1995) 877-882
11. Gordon C.J., and Fogelson L. Metabolic and thermoregulatory responses of the rat maintained in acrylic or wire-screen cages: implications for pharmacological studies. Physiol Behav 56 1 (1994) 73-79
12. Reveron M.E., Monks T.J., and Duvauchelle C.L. Age-dependent (+)MDMA-mediated neurotoxicity in mice. Neurotoxicology (2005)
13. Malberg J.E., Sabol K.E., and Seiden L.S. Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat. J Pharmacol Exp Ther 278 1 (1996) 258-267
14. Broening H.W., Bowyer J.F., and Slikker Jr. W. Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. J Pharmacol Exp Ther 275 1 (1995) 325-333
15. Liechti M.E., Saur M.R., Gamma A., Hell D., and Vollenweider F.X. Psychological and physiological effects of MDMA ("ecstasy") after pretreatment with the 5-HT(2) antagonist ketanserin in healthy humans. Neuropsychopharmacology 23 4 (2000) 396-404
16. Marston H.M., Reid M.E., Lawrence J.A., Olverman H.J., and Butcher S.P. Behavioural analysis of the acute and chronic effects of MDMA treatment in the rat. Psychopharmacology (Berl) 144 1 (1999) 67-76
17. O'Shea E., Escobedo I., Orio L., Sanchez V., Navarro M., Green A.R., et al. Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats. Neuropsychopharmacology 30 7 (2005) 1312-1323
18. Spanos L.J., and Yamamoto B.K. Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat. Pharmacol Biochem Behav 32 4 (1989) 835-840
19. Hiramatsu M., Nabeshima T., Kameyama T., Maeda Y., and Cho A.K. The effect of optical isomers of 3,4-methylenedioxymethamphetamine (MDMA) on stereotyped behavior in rats. Pharmacol Biochem Behav 33 2 (1989) 343-347
20. Green A.R., Cross A.J., and Goodwin G.M. Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"). Psychopharmacology (Berl) 119 3 (1995) 247-260
21. Gold L.H., Koob G..F., and Geyer M.A. Stimulant and hallucinogenic behavioral profiles of 3,4-methylenedioxymethamphetamine and N-ethyl-3,4-methylenedioxyamphetamine in rats. J Pharmacol Exp Ther 247 2 (1988) 547-555
22. Callaway C.W., Wing L.L., and Geyer M.A. Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats. J Pharmacol Exp Ther 254 2 (1990) 456-464
23. Kalivas P.W., Duffy P., and White S.R. MDMA elicits behavioral and neurochemical sensitization in rats. Neuropsychopharmacology 18 6 (1998) 469-479
24. Ramos M., Goni-Allo B., and Aguirre N. Studies on the role of dopamine D1 receptors in the development and expression of MDMA-induced behavioral sensitization in rats. Psychopharmacology (Berl) 177 1-2 (2004) 100-110
25. Crespi D., Mennini T., and Gobbi M. Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine. Br J Pharmacol 121 8 (1997) 1735-1743
26. Gudelsky G.A., and Nash J.F. Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions. J Neurochem 66 1 (1996) 243-249
27. Wichems C.H., Hollingsworth C.K., and Bennett B.A. Release of serotonin induced by 3,4-methylenedioxymethamphetamine (MDMA) and other substituted amphetamines in cultured fetal raphe neurons: further evidence for calcium-independent mechanisms of release. Brain Res 695 1 (1995) 10-18
28. Mechan A.O., Esteban B., O'Shea E., Elliott J.M., Colado M.I., and Green A.R. The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats. Br J Pharmacol 135 1 (2002) 170-180
29. Shankaran M., and Gudelsky G.A. A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration. Psychopharmacology (Berl) 147 1 (1999) 66-72
30. Gold L.H., Hubner C.B., and Koob G.F. A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA. Psychopharmacology (Berl) 99 1 (1989) 40-47
31. Bankson M.G., and Cunningham K.A. Pharmacological studies of the acute effects of (+)-3,4-methylenedioxymethamphetamine on locomotor activity: role of 5-HT(1B/1D) and 5-HT(2) receptors. Neuropsychopharmacology 26 1 (2002) 40-52
32. Bankson M.G., and Cunningham K.A. 3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions. J Pharmacol Exp Ther 297 3 (2001) 846-852
33. Sanchez V., O'Shea E., Saadat K.S., Elliott J.M., Colado M.I., and Green A.R. Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurones. J Psychopharmacol 18 3 (2004) 412-416
34. Green A.R., Sanchez V., O'Shea E., Saadat K.S., Elliott J.M., and Colado M.I. Effect of ambient temperature and a prior neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA. Psychopharmacology (Berl) 173 3-4 (2004) 264-269
35. Ikegami A., and Duvauchelle C.L. Nucleus accumbens and medial prefrontal cortex dopaminergic response to self-administered cocaine in naive rats. Neurosci Lett 354 3 (2004) 205-208
36. Schenk S., Gittings D., Johnstone M., and Daniela E. Development, maintenance and temporal pattern of self-administration maintained by ecstasy (MDMA) in rats. Psychopharmacology (Berl) 169 1 (2003) 21-27
37. Bligh J. The central neurology of mammalian thermoregulation. Neuroscience 4 9 (1979) 1213-1216
38. Fozard J.R. Neuronal 5-HT receptors in the periphery. Neuropharmacology 23 12B (1984) 1473-1486
39. Modi G.M., Yang P.B., Swann A.C., and Dafny N. Chronic exposure to MDMA (ecstasy) elicits behavioral sensitization in rats but fails to induce cross-sensitization to other psychostimulants. Behav Brain Funct 2 1 (2006) 1
40. Pettit H.O., Pan H.T., Parsons L.H., and Justice Jr. J.B. Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration. J Neurochem 55 3 (1990) 798-804
41. McMahon L.R., Filip M., and Cunningham K.A. Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. J Neurosci 21 19 (2001) 7781-7787
42. Dafters R.I. Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats. Psychopharmacology (Berl) 114 3 (1994) 505-508
43. Daniela E., Brennan K., Gittings D., Hely L., and Schenk S. Effect of SCH 23390 on (+/-)-3,4-methylenedioxymethamphetamine hyperactivity and self-administration in rats. Pharmacol Biochem Behav 77 4 (2004) 745-750
44. Koteja P. The evolution of concepts on the evolution of endothermy in birds and mammals. Physiol Biochem Zool 77 6 (2004) 1043-1050