A comparison of the reinforcing efficacy of 3,4- methylenedioxymethamphetamine (MDMA, "ecstasy") with cocaine in rhesus monkeys

Drug and Alcohol Dependence

Volumn 78, Issue 2, 2005, Pages 135-140

  Lile, Joshua A ^a,b   Ross, Jason T ^a   Nader, Michael A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Cocaine; Drug abuse; MDMA; Reinforcing efficacy; Rhesus monkey

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; COCAINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG SELF ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY;

EID: 17444362685     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2004.10.006     Document Type: Article

References (43)

1. R.L. Balster Drug abuse potential evaluation in animals Br. J. Addict. 86 1991 1549 1558
2. G. Battaglia, B.P. Brooks, C. Kulsakdinum, and E.B. DeSouza Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites Eur. J. Pharmacol. 149 1988 159 163
3. G. Battaglia, and E.B. DeSouza Pharmacologic profile of amphetamine derivatives at various brain recognition sites: selective effects on serotonin systems NIDA Res. Monogr. 94 1989 240 258
4. P.M. Beardsley, R.L. Balster, and L.S. Harris Self-administration of methylenedioxymethamphetamine (MDMA) by rhesus monkeys Drug Alcohol Depend. 18 1986 149 157
5. P.M. Callahan, and J.B. Appel Differences in the stimulus properties of 3,4-methylenedioxymethamphetamine in animals trained to discriminate hallucinogens from saline J. Pharmacol. Exp. Ther. 246 1988 866 870
6. H.V. Curran Is MDMA ('Ecstasy') neurotoxic in humans? An overview of evidence and of methodological problems in research Neuropsychobiology 42 2000 34 41
7. E. Daniela, K. Brennan, D. Gittings, L. Hely, and S. Schenk Effect of SCH 23390 on (±)-3,4-methylenedioxymethamphetamine hyperactivity and self-administration in rats Pharmacol. Biochem. Behav. 77 2004 745 750
8. R.Y. Depoortere, D.H. Li, J.D. Lane, and M.W. Emmett-Oglesby Parameters of self-administration of cocaine in rats under progressive-ratio schedule Pharmacol. Biochem. Behav. 45 1993 539 548
9. S.M. Evans, and C.E. Johanson Discriminative stimulus properties of (±)-3,4-methylenedioxymethamphetamine and (±)-3,4- methylenedioxyamphetamine in pigeons Drug Alcohol Depend. 18 1986 159 164
10. W.E. Fantegrossi, T. Ullrich, K.C. Rice, J.H. Woods, and G. Winger 3,4-Methylenedioxymethamphetamine (MDMA "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement Psychopharmacology 161 2002 356 364
11. W.E. Fantegrossi, J.H. Woods, and G. Winger Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys Behav. Pharmacol. 15 2004 149 157
12. W.E. Fantegrossi, W.L. Woolverton, M. Kilbourn, P. Sherman, J. Yuan, G. Hatzidimitriou, J.H. Woods, and G. Winger Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys Neuropsychopharmacology 29 2004 1270 1281
13. L.H. Gold, and R.L. Balster Evaluation of nefazodone self-administration in rhesus monkeys Drug Alcohol Depend. 28 1991 241 247
14. L.H. Gold, G.F. Koob, and M.A. Geyer Stimulant and hallucinogenic behavioral profiles of 3,4-methylenedioxymethamphetamine and N-ethyl-3,4-methylenedioxyamphetamine in rats J. Pharmacol. Exp. Ther. 247 1988 547 555
15. A.K. Goodwin, and L.E. Baker A three-choice discrimination procedure dissociates the discriminative stimulus effects of d-amphetamine and (±)-MDMA in rats Exp. Clin. Psychopharmacol. 8 2000 415 423
16. Gowing, L.R., Henry-Hedwards, S.M., Irvine, R.J., Ali, R.L., 2001. Ecstasy and other ring-substituted amphetamines. World Health Organization, Mental Health and Substance Dependence Department. Available at www.who.int.
17. W. Hodos Progressive ratio as a measure of reward strength Science 134 1961 943 944
18. W. Hodos, and G. Kalman Effects of increment size and reinforcer volume on progressive ratio performance J. Exp. Anal. Behav. 6 1963 387 392
19. L.L. Howell, and L.D. Byrd Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey J. Pharmacol. Exp. Ther. 275 1995 1551 1559
20. J.B. Kamien, C.E. Johanson, C.R. Schuster, and W.L. Woolverton The effects of (±)-methylenedioxymethamphetamine and (±)- methylenedioxyamphetamine in monkeys trained to discriminate (+)-amphetamine from saline Drug Alcohol Depend. 18 1986 139 147
21. R.J. Lamb, and R.R. Griffiths Self-injection of d-1-3,4- methylenedioxymethamphetamine (MDMA) in the baboon Psychopharmacology 91 1987 268 272
22. M.E. Liechti, A. Gamma, and F.X. Vollenweider Gender differences in the subjective effects of MDMA Psychopharmacology 154 2001 161 168
23. J.A. Lile, D. Morgan, A.M. Birmingham, H.M.L. Davies, and M.A. Nader The reinforcing efficacy of the dopamine reuptake inhibitor PTT as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeys J. Pharmacol. Exp. Ther. 303 2002 640 648
24. J.A. Lile, Z. Wang, W.L. Woolverton, J.E. France, T.C. Gregg, H.M.L. Davies, and M.A. Nader The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics J. Pharmacol. Exp. Ther. 307 2003 356 366
25. A.C. Parrott Human psychopharmacology of ecstasy (MDMA): a review of 15 years of empirical research Hum. Psychopharmacol. Clin. Exp. 16 2001 557 577
26. E. Ratzenboeck, A. Saria, N. Kriechbaum, and G. Zernig Reinforcing effects of MDMA ("ecstacy") in drug-naive and cocaine-trained rats Pharmacology 62 2001 138 144
27. N.R. Richardson, and D.C.S. Roberts Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy J. Neurosci. Methods 66 1996 1 11
28. M.C. Ritz, R.J. Lamb, S.R. Goldberg, and M.J. Kuhar Cocaine receptors on dopamine transporters are related to self-administration of cocaine Science 237 1987 1219 1223
29. R.B. Rothman, M.H. Baumann, C.M. Dersch, D.V. Romero, K.C. Rice, F.I. Carroll, and J.S. Partilla Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin Synapse 39 2001 32 41
30. S. Schenk, D. Gittings, M. Johnstone, and E. Daniela Development, maintenance and temporal pattern of self-administration maintained by ecstasy (MDMA) in rats Psychopharmacology 169 2003 21 27
31. D. Stafford, M.G. LeSage, and J.R. Glowa Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review Psychopharmacology 139 1998 169 184
32. Substance Abuse and Mental Health Services Administration, 2002. Results from the 2001 National Household Survey on Drug Abuse: national findings. DHHS, Rockville, MD.
33. Substance Abuse and Mental Health Services Administration, 2003. Results from the 2002 National Household Survey on Drug Abuse: national findings. DHHS, Rockville, MD.
34. M. Tancer, and C.E. Johanson Reinforcing, subjective and physiological effects of MDMA in humans: a comparison with d-amphetamine and mCPP Drug Alcohol Depend. 72 2003 33 44
35. M. Teitler, S. Leonhardt, N.M. Appel, E.B. De Souza, and R.A. Glennon Receptor pharmacology of MDMA and related hallucinogens Ann. N.Y. Acad. Sci. 600 1990 6626 6638
36. T. Thompson Behavioral mechanisms of drug dependence J.E. Barrett Advances in Behavioral Pharmacology 1984 Academic Press, Inc. New York, NY pp. 1-45
37. United Nations Office on Drugs and Crime, 2003. Ecstasy and Amphetamines Global Survey 2003. UN, New York, NY.
38. K.E. Vanover, M.A. Nader, and W.L. Woolverton Evaluation of the discriminative stimulus and reinforcing effects of sertraline in rhesus monkeys Pharmacol. Biochem. Behav. 41 1992 789 793
39. K. Wolff, A.W. Hay, K. Sherlock, and M. Conner Contents of ecstasy Lancet 346 1995 1100 1101
40. J.H. Woods, and R.E. Tessel Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey Science 185 1974 1067 1069
41. W.L. Woolverton, and C.E. Johanson Preference in rhesus monkeys given a choice between cocaine and d l-cathinone J. Exp. Anal. Behav. 41 1984 35 43
42. T. Yanagita An experimental framework for evaluation of dependence liability of various types of drug in monkeys Pharmacology and the Future of Man. Proceedings of the Fifth International Congress on Pharmacology, vol. 1 1972 Karger Basel, Switzerland 7 17
43. T. Yanagita Intravenous self-administration of R(-)-cathinone and 2-amino-1-(2,5-dimethoxy-4-methyl) phenylpropane in rhesus monkeys Drug Alcohol Depend. 17 1986 135 141