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Volumn 78, Issue 5, 2010, Pages 818-826

Constitutive activity of serotonin2C receptors at G protein-independent signaling: Modulation by RNA editing and antidepressants

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; BETA ARRESTIN; CALMODULIN; CLOMIPRAMINE; FLUOXETINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MESSENGER RNA; MIANSERIN; MIRTAZAPINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C; SEROTONIN 2C RECEPTOR; TRAZODONE;

EID: 77958130024     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.066035     Document Type: Article
Times cited : (35)

References (41)
  • 1
    • 59949102887 scopus 로고    scopus 로고
    • Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors
    • Aloyo VJ, Berg KA, Spampinato U, Clarke WP, and Harvey JA (2009) Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors. Pharmacol Ther 121:160-173.
    • (2009) Pharmacol Ther , vol.121 , pp. 160-173
    • Aloyo, V.J.1    Berg, K.A.2    Spampinato, U.3    Clarke, W.P.4    Harvey, J.A.5
  • 3
    • 14844338481 scopus 로고    scopus 로고
    • alphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation
    • DOI 10.1074/jbc.M412924200
    • Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G, and Lefkowitz RJ (2005) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem 280:8041-8050. (Pubitemid 40349702)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.9 , pp. 8041-8050
    • Barnes, W.G.1    Reiter, E.2    Violin, J.D.3    Ren, X.-R.4    Milligan, G.5    Lefkowitz, R.J.6
  • 4
    • 0035823506 scopus 로고    scopus 로고
    • mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation
    • Belcheva MM, Szù csM, Wang D, Sadee W, and Coscia CJ (2001) mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation. J Biol Chem 276:33847-33853.
    • (2001) J Biol Chem , vol.276 , pp. 33847-33853
    • Belcheva, M.M.1    Szù, Cs.M.2    Wang, D.3    Sadee, W.4    Coscia, C.J.5
  • 5
    • 40849102720 scopus 로고    scopus 로고
    • 2C receptor alters both ligand-dependent and -independent receptor signaling
    • DOI 10.1124/jpet.107.131524
    • Berg KA, Dunlop J, Sanchez T, Silva M, and Clarke WP (2008a) A conservative, single-amino acid substitution in the second cytoplasmic domain of the human serotonin2C receptor alters both ligand-dependent and -independent receptor signaling. J Pharmacol Exp Ther 324:1084-1092. (Pubitemid 351397836)
    • (2008) Journal of Pharmacology and Experimental Therapeutics , vol.324 , Issue.3 , pp. 1084-1092
    • Berg, K.A.1    Dunlop, J.2    Sanchez, T.3    Silva, M.4    Clarke, W.P.5
  • 6
    • 50349100815 scopus 로고    scopus 로고
    • Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression
    • Berg KA, Harvey JA, Spampinato U, and Clarke WP (2008b) Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression. Prog Brain Res 172:287-305.
    • (2008) Prog Brain Res , vol.172 , pp. 287-305
    • Berg, K.A.1    Harvey, J.A.2    Spampinato, U.3    Clarke, W.P.4
  • 10
    • 40849137938 scopus 로고    scopus 로고
    • Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: Differential modulation of cell surface expression and signal transduction
    • Chanrion B, Mannoury la Cour C, Gavarini S, Seimandi M, Vincent L, Pujol JF, Bockaert J, Marin P, and Millan MJ (2008) Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction. Mol Pharmacol 73:748-757.
    • (2008) Mol Pharmacol , vol.73 , pp. 748-757
    • Chanrion, B.1    Mannoury La Cour, C.2    Gavarini, S.3    Seimandi, M.4    Vincent, L.5    Pujol, J.F.6    Bockaert, J.7    Marin, P.8    Millan, M.J.9
  • 11
    • 1842610940 scopus 로고    scopus 로고
    • Constitutive Activity of the Serotonin2C Receptor Inhibits in Vivo Dopamine Release in the Rat Striatum and Nucleus Accumbens
    • DOI 10.1523/JNEUROSCI.0112-04.2004
    • De Deurwaerdère P, Navailles S, Berg KA, Clarke WP, and Spampinato U (2004) Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J Neurosci 24:3235-3241. (Pubitemid 38451889)
    • (2004) Journal of Neuroscience , vol.24 , Issue.13 , pp. 3235-3241
    • De Deurwaerdere, P.1    Navailles, S.2    Berg, K.A.3    Clarke, W.P.4    Spampinato, U.5
  • 14
    • 12744273085 scopus 로고    scopus 로고
    • How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing
    • Englander MT, Dulawa SC, Bhansali P, and Schmauss C (2005) How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing. J Neurosci 25:648-651.
    • (2005) J Neurosci , vol.25 , pp. 648-651
    • Englander, M.T.1    Dulawa, S.C.2    Bhansali, P.3    Schmauss, C.4
  • 15
    • 0026471994 scopus 로고
    • Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium
    • Esterle TM and Sanders-Bush E (1992) Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium. J Neurosci 12:4775-4782.
    • (1992) J Neurosci , vol.12 , pp. 4775-4782
    • Esterle, T.M.1    Sanders-Bush, E.2
  • 18
    • 1642285042 scopus 로고    scopus 로고
    • 2C receptors to multiple actions of central serotonin systems
    • DOI 10.1016/j.ejphar.2004.01.036, PII S0014299904000457
    • Giorgetti M and Tecott LH (2004) Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems. Eur J Pharmacol 488:1-9. (Pubitemid 38388517)
    • (2004) European Journal of Pharmacology , vol.488 , Issue.1-3 , pp. 1-9
    • Giorgetti, M.1    Tecott, L.H.2
  • 19
    • 0037171846 scopus 로고    scopus 로고
    • Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims
    • DOI 10.1016/S0896-6273(02)00660-8
    • Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, and Schmauss C (2002) Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 34:349-356. (Pubitemid 34465494)
    • (2002) Neuron , vol.34 , Issue.3 , pp. 349-356
    • Gurevich, I.1    Tamir, H.2    Arango, V.3    Dwork, A.J.4    Mann, J.J.5    Schmauss, C.6
  • 20
    • 0032589301 scopus 로고    scopus 로고
    • Serotonin 5-HT(2C) receptor RNA editing alters receptor basal activity: Implications for serotonergic signal transduction
    • DOI 10.1046/j.1471-4159.1999.731711.x
    • Herrick-Davis K, Grinde E, and Niswender CM (1999) Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. J Neurochem 73:1711-1717. (Pubitemid 29440175)
    • (1999) Journal of Neurochemistry , vol.73 , Issue.4 , pp. 1711-1717
    • Herrick-Davis, K.1    Grinde, E.2    Niswender, C.M.3
  • 22
    • 0038645126 scopus 로고    scopus 로고
    • RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders
    • DOI 10.1016/S0304-3940(03)00608-6
    • Iwamoto K and Kato T (2003) RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders. Neurosci Lett 346:169-172. (Pubitemid 36829288)
    • (2003) Neuroscience Letters , vol.346 , Issue.3 , pp. 169-172
    • Iwamoto, K.1    Kato, T.2
  • 23
    • 23044492613 scopus 로고    scopus 로고
    • Altered RNA editing of serotonin 2C receptor in a rat model of depression
    • DOI 10.1016/j.neures.2005.06.001, PII S0168010205001562
    • Iwamoto K, Nakatani N, Bundo M, Yoshikawa T, and Kato T (2005) Altered RNA editing of serotonin 2C receptor in a rat model of depression. Neurosci Res 53:69-76. (Pubitemid 41073729)
    • (2005) Neuroscience Research , vol.53 , Issue.1 , pp. 69-76
    • Iwamoto, K.1    Nakatani, N.2    Bundo, M.3    Yoshikawa, T.4    Kato, T.5
  • 24
    • 33751509646 scopus 로고    scopus 로고
    • A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation
    • DOI 10.1210/me.2006-0098
    • Kara E, Crépieux P, Gauthier C, Martinat N, Piketty V, Guillou F, and Reiter E (2006) A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation. Mol Endocrinol 20:3014-3026. (Pubitemid 44833552)
    • (2006) Molecular Endocrinology , vol.20 , Issue.11 , pp. 3014-3026
    • Kara, E.1    Crepieux, P.2    Gauthier, C.3    Martinat, N.4    Piketty, V.5    Guillou, F.6    Reiter, E.7
  • 25
    • 58149306364 scopus 로고    scopus 로고
    • Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling
    • Labasque M, Reiter E, Becamel C, Bockaert J, and Marin P (2008) Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. Mol Biol Cell 19:4640-4650.
    • (2008) Mol Biol Cell , vol.19 , pp. 4640-4650
    • Labasque, M.1    Reiter, E.2    Becamel, C.3    Bockaert, J.4    Marin, P.5
  • 26
    • 70349330851 scopus 로고    scopus 로고
    • In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: Differential effects of inverse agonist versus antagonist
    • Leggio GM, Cathala A, Neny M, Rouge-Pont F, Drago F, Piazza PV, and Spampinato U (2009) In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. J Neurochem 111:614-623.
    • (2009) J Neurochem , vol.111 , pp. 614-623
    • Leggio, G.M.1    Cathala, A.2    Neny, M.3    Rouge-Pont, F.4    Drago, F.5    Piazza, P.V.6    Spampinato, U.7
  • 28
    • 33646365380 scopus 로고    scopus 로고
    • A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors
    • DOI 10.1074/jbc.M508074200
    • Marion S, Oakley RH, Kim KM, Caron MG, and Barak LS (2006) A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. J Biol Chem 281:2932-2938. (Pubitemid 43845759)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.5 , pp. 2932-2938
    • Marion, S.1    Oakley, R.H.2    Kim, K.-M.3    Caron, M.G.4    Barak, L.S.5
  • 29
    • 1642453638 scopus 로고    scopus 로고
    • RNA Editing Induces Variation in Desensitization and Trafficking of 5-Hydroxytryptamine 2c Receptor Isoforms
    • DOI 10.1074/jbc.M308742200
    • Marion S, Weiner DM, and Caron MG (2004) RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms. J Biol Chem 279:2945-2954. (Pubitemid 38114287)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.4 , pp. 2945-2954
    • Marion, S.1    Weiner, D.M.2    Caron, M.G.3
  • 30
    • 0036892263 scopus 로고    scopus 로고
    • 13and pertussis toxin-insensitive Gbetagamma subunits
    • DOI 10.1124/mol.62.6.1339
    • McGrew L, Chang MS, and Sanders-Bush E (2002) Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits. Mol Pharmacol 62:1339-1343. (Pubitemid 35403828)
    • (2002) Molecular Pharmacology , vol.62 , Issue.6 , pp. 1339-1343
    • McGrew, L.1    Chang, M.S.S.2    Sanders-Bush, E.3
  • 31
    • 33645230435 scopus 로고    scopus 로고
    • Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: Focus on novel therapeutic strategies
    • Millan MJ (2005) Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie 60:441-460.
    • (2005) Therapie , vol.60 , pp. 441-460
    • Millan, M.J.1
  • 32
    • 33645452696 scopus 로고    scopus 로고
    • Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
    • Millan MJ (2006) Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110:135-370.
    • (2006) Pharmacol Ther , vol.110 , pp. 135-370
    • Millan, M.J.1
  • 33
    • 33750451628 scopus 로고    scopus 로고
    • Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors
    • DOI 10.1111/j.1471-4159.2006.04188.x
    • Navailles S, Moison D, Ryczko D, and Spampinato U (2006) Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors. J Neurochem 99:1311-1319. (Pubitemid 44655294)
    • (2006) Journal of Neurochemistry , vol.99 , Issue.4 , pp. 1311-1319
    • Navailles, S.1    Moison, D.2    Ryczko, D.3    Spampinato, U.4
  • 34
    • 0033515573 scopus 로고    scopus 로고
    • RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity
    • Niswender CM, Copeland SC, Herrick-Davis K, Emeson RB, and Sanders-Bush E (1999) RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J Biol Chem 274:9472-9478.
    • (1999) J Biol Chem , vol.274 , pp. 9472-9478
    • Niswender, C.M.1    Copeland, S.C.2    Herrick-Davis, K.3    Emeson, R.B.4    Sanders-Bush, E.5
  • 36
    • 37549070995 scopus 로고    scopus 로고
    • Neuroprotection by imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway
    • Peng CH, Chiou SH, Chen SJ, Chou YC, Ku HH, Cheng CK, Yen CJ, Tsai TH, Chang YL, and Kao CL (2008) Neuroprotection by imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway. Eur Neuropsychopharmacol 18:128-140.
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 128-140
    • Peng, C.H.1    Chiou, S.H.2    Chen, S.J.3    Chou, Y.C.4    Ku, H.H.5    Cheng, C.K.6    Yen, C.J.7    Tsai, T.H.8    Chang, Y.L.9    Kao, C.L.10
  • 39
    • 20744434986 scopus 로고    scopus 로고
    • 2C receptor signaling to extracellular signal-regulated kinases 1 and 2
    • DOI 10.1111/j.1471-4159.2005.03161.x
    • Werry TD, Gregory KJ, Sexton PM, and Christopoulos A (2005) Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2. J Neurochem 93:1603-1615. (Pubitemid 40853284)
    • (2005) Journal of Neurochemistry , vol.93 , Issue.6 , pp. 1603-1615
    • Werry, T.D.1    Gregory, K.J.2    Sexton, P.M.3    Christopoulos, A.4
  • 40
    • 46149088211 scopus 로고    scopus 로고
    • RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function
    • Werry TD, Loiacono R, Sexton PM, and Christopoulos A (2008a) RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacol Ther 119:7-23.
    • (2008) Pharmacol Ther , vol.119 , pp. 7-23
    • Werry, T.D.1    Loiacono, R.2    Sexton, P.M.3    Christopoulos, A.4
  • 41
    • 54049141206 scopus 로고    scopus 로고
    • Pharmacology of 5HT(2C) receptor-mediated ERK1/2 phosphorylation: Agonist-specific activation pathways and the impact of RNA editing
    • Werry TD, Stewart GD, Crouch MF, Watts A, Sexton PM, and Christopoulos A (2008b) Pharmacology of 5HT(2C) receptor-mediated ERK1/2 phosphorylation: agonist-specific activation pathways and the impact of RNA editing. Biochem Pharmacol 76:1276-1287.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1276-1287
    • Werry, T.D.1    Stewart, G.D.2    Crouch, M.F.3    Watts, A.4    Sexton, P.M.5    Christopoulos, A.6


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