Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling

Stem Cells

Volumn 28, Issue 9, 2010, Pages 1476-1486

  Cha, Young ^a   Moon, Bo Hyun ^b   Lee, Mi Ok ^a   Ahn, Hee Jin ^a   Lee, Hye Jin ^b   Lee, Kyung Ah ^a,b   Fornace Jr , Albert J ^c   Kim, Kwang Soo ^b,d   Cha, Hyuk Jin ^a,b   Park, Kyung Soon ^a,b  

^a CHA University   (South Korea)

^b CHA University   (South Korea)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

c Myc; Jak Stat3; LIFR; Mouse embryonic stem cells; Pluripotency; Self renewal; SHP 1; Stemness; Zap70

Indexed keywords

JANUS KINASE 1; LEUKEMIA INHIBITORY FACTOR RECEPTOR; LIPOCORTIN 5; MYC PROTEIN; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE PHOSPHATASE SHP 1; STAT3 PROTEIN; JAK1 PROTEIN, MOUSE; MYC PROTEIN, MOUSE; PTPN6 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; ZAP70 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL RENEWAL; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVITY; IMMUNOBLOTTING; MOUSE; NATURAL KILLER CELL; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; CELL LINE; CELL LINEAGE; CELL PROLIFERATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE; RNA INTERFERENCE; SCID MOUSE; TERATOMA; TIME;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CELL PROLIFERATION; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; JANUS KINASE 1; MICE; MICE, INBRED NOD; MICE, SCID; PLURIPOTENT STEM CELLS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, OSM-LIF; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TERATOMA; TIME FACTORS; TRANSFECTION; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 77958121543     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.470     Document Type: Article

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