Progressive ratio responding in an obese mouse model: Effects of fenfluramine

Neuropharmacology

Volumn 59, Issue 7-8, 2010, Pages 619-626

  Finger, Beate C ^a   Dinan, Timothy G ^a,b   Cryan, John F ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Food intake; Learning; Leptin; Ob ob; Operant; Reward

Indexed keywords

FENFLURAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FOOD INTAKE; INSTRUMENTAL CONDITIONING; LEAN BODY WEIGHT; MALE; MOTIVATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REINFORCEMENT;

ANIMALS; APPETITE DEPRESSANTS; APPETITIVE BEHAVIOR; CONDITIONING, OPERANT; EXTINCTION, PSYCHOLOGICAL; FENFLURAMINE; LEARNING; LEPTIN; MALE; MICE; MICE, OBESE; MOTIVATION; OBESITY; REWARD;

EID: 77958093580     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.08.010     Document Type: Article

References (72)

1. Arnold J.M., Roberts D.C. A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement. Pharmacol. Biochem. Behav. 1997, 57:441-447.
2. Asakawa A., Inui A., Inui T., Katsuura G., Fujino M.A., Kasuga M. Leptin treatment ameliorates anxiety in ob/ob obese mice. J. Diab. Compl. 2003, 17:105-107.
3. Bailey C.J., Flatt P.R. Anorectic effect of fenfluramine, cholecystokinin and neurotensin in genetically obese (ob/ob) mice. Comp. Biochem. Physiol. A Comp. Physiol. 1986, 84:451-454.
4. Belin D., Jonkman S., Dickinson A., Robbins T.W., Everitt B.J. Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction. Behav. Brain Res. 2009, 199:89-102.
5. Berman D.E., Dudai Y. Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex. Science 2001, 291:2417-2419.
6. Berthoud H.R. Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance. Obesity (Silver Spring) 2006, (Suppl. 5):197S-200S.
7. Bloom S.R., Kuhajda F.P., Laher I., Pi-Sunyer X., Ronnett G.V., Tan T.M., Weigle D.S. The obesity epidemic: pharmacological challenges. Mol. Interv. 2008, 8:82-98.
8. Blundell J.E. Is there a role for serotonin (5-hydroxytryptamine) in feeding?. Int. J. Obesity 1977, 1:15-42.
9. Blundell J.E. Serotonin and the biology of feeding. Am. J. Clin. Nutr. 1992, 55:155S-159S.
10. Blundell J.E., Levin F., King N.A., Barkeling B., Gustafsson T., Hellstrom P.M., Holst J.J., Naslund E. Overconsumption and obesity: peptides and susceptibility to weight gain. Regul. Pept. 2008, 149:32-38.
11. Bouton M.E. Context and behavioral processes in extinction. Learn. Mem. 2004, 11:485-494.
12. Bouton M.E., Westbrook R.F., Corcoran K.A., Maren S. Contextual and temporal modulation of extinction: behavioral and biological mechanisms. Biol. Psychiatr. 2006, 60:352-360.
13. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995, 269:546-549.
14. Cason A.M., Smith R.J., Tahsili-Fahadan P., Moorman D.E., Sartor G.C., Aston-Jones G. Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiol. Behav. 2010, 100:419-428.
15. Davis C., Patte K., Levitan R., Reid C., Tweed S., Curtis C. From motivation to behaviour: a model of reward sensitivity, overeating, and food preferences in the risk profile for obesity. Appetite 2007, 48:12-19.
16. El-Ghundi M., O'Dowd B.F., Erclik M., George S.R. Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice. Eur. J. Neurosci. 2003, 17:851-862.
17. Findley J.D. Preference and switching under concurrent scheduling. J. Exp. Anal. Behav. 1958, 1:123-144.
18. Finger B.C., Dinan T.G., Cryan J.F. Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours. Psychopharmacology (Berl.) 2010, 4:559-568.
19. Frazier C.R., Mason P., Zhuang X., Beeler J.A. Sucrose exposure in early life alters adult motivation and weight gain. PLoS One 2008, 3:e3221.
20. Friedman J.M. Obesity in the new millennium. Nature 2000, 404:632-634.
21. Fulton S., Pissios P., Manchon R.P., Stiles L., Frank L., Pothos E.N., Maratos-Flier E., Flier J.S. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 2006, 51:811-822.
22. Garfield A.S., Heisler L.K. Pharmacological targeting of the serotonergic system for the treatment of obesity. J. Physiol. 2009, 587:49-60.
23. Glass M.J., O'Hare E., Cleary J.P., Billington C.J., Levine A.S. The effect of naloxone on food-motivated behavior in the obese Zucker rat. Psychopharmacology (Berl.) 1999, 141:378-384.
24. Greenwood M.R.C., Quartermaln D., Johnson P.R., Cruce J.A.F., Hirsch J. Food motivated behavior in genetically obese and hypothalamic-hyperphagic rats and mice. Physiol. Behav. 1974, 13:687-692.
25. Griffiths R.R., Brady J.V., Snell J.D. Progressive-ratio performance maintained by drug infusions: comparison of cocaine, diethylpropion, chlorphentermine, and fenfluramine. Psychopharmacology (Berl.) 1978, 56:5-13.
26. Hajnal A., Acharya N.K., Grigson P.S., Covasa M., Twining R.C. Obese OLETF rats exhibit increased operant performance for palatable sucrose solutions and differential sensitivity to D2 receptor antagonism. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 293:R1846-R1854.
27. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995, 269:543-546.
28. Hart C.L., Haney M., Vosburg S.K., Rubin E., Foltin R.W. Gabapentin does not reduce smoked cocaine self-administration: employment of a novel self-administration procedure. Behav. Pharmacol. 2007, 18:71-75.
29. Hayward M.D., Low M.J. The contribution of endogenous opioids to food reward is dependent on sex and background strain. Neuroscience 2007, 144:17-25.
30. Hodos W. Progressive ratio as a measure of reward strength. Science 1961, 134:943-944.
31. Hodos W., Valenstein E.S. An evaluation of response rate as a measure of rewarding intracranial stimulation. J. Comp. Physiol. Psychol. 1962, 55:80-84.
32. Ingalls A.M., Dickie M.M., Snell G.D. Obese, a new mutation in the house mouse. J. Hered. 1950, 41:317-318.
33. Katz J.L. Models of relative reinforcing efficacy of drugs and their predictive utility. Behav. Pharmacol 1990, 1:283-301.
34. la Fleur S.E., Vanderschuren L.J., Luijendijk M.C., Kloeze B.M., Tiesjema B., Adan R.A. A reciprocal interaction between food-motivated behavior and diet-induced obesity. Int. J. Obes. (Lond.) 2007, 31:1286-1294.
35. Laposky A.D., Shelton J., Bass J., Dugovic C., Perrino N., Turek F.W. Altered sleep regulation in leptin-deficient mice. Am. J. Physiol. Regul. Integr.Comp. Physiol. 2006, 290:R894-R903.
36. Leibowitz S.F., Alexander J.T. Hypothalamic serotonin in control of eating behavior, meal size, and body weight. Biol. Psychiatr. 1998, 44:851-864.
37. Li X.L., Aou S., Oomura Y., Hori N., Fukunaga K., Hori T. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 2002, 113:607-615.
38. Lindström P. The physiology of obese-hyperglycemic mice [ob/ob mice]. Scientific World J. 2007, 7:666-685.
39. Lucas J.J., Yamamoto A., Scearce-Levie K., Saudou F., Hen R. Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice. J. Neurosci. 1998, 18:5537-5544.
40. Lutter M., Nestler E.J. Homeostatic and hedonic signals interact in the regulation of food intake. J. Nutr. 2009, 139:629-632.
41. Miller K.J. Serotonin 5-ht2c receptor agonists: potential for the treatment of obesity. Mol. Interv. 2005, 5:282-291.
42. Mobini S., Chiang T.J., Ho M.Y., Bradshaw C.M., Szabadi E. Comparison of the effects of clozapine, haloperidol, chlorpromazine and d-amphetamine on performance on a time-constrained progressive ratio schedule and on locomotor behaviour in the rat. Psychopharmacology (Berl.) 2000, 152:47-54.
43. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., Schwartz M.W. Central nervous system control of food intake and body weight. Nature 2006, 443:289-295.
44. Nasser J.A., Evans S.M., Geliebter A., Pi-Sunyer F.X., Foltin R.W. Use of an operant task to estimate food reinforcement in adult humans with and without BED. Obesity (Silver Spring) 2008, 16:1816-1820.
45. Nasser J.A., Gluck M.E., Geliebter A. Impulsivity and test meal intake in obese binge eaters. Appetite 2004, 43:303-307.
46. Neill J.C., Cooper S.J. Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors. Psychopharmacology (Berl.) 1989, 97:213-218.
47. Ohta R., Shigemura N., Sasamoto K., Koyano K., Ninomiya Y. Conditioned taste aversion learning in leptin-receptor-deficient db/db mice. Neurobiol. Learn. Mem. 2003, 80:105-112.
48. Oomura Y., Hori N., Shiraishi T., Fukunaga K., Takeda H., Tsuji M., Matsumiya T., Ishibashi M., Aou S., Li X.L., Kohno D., Uramura K., Sougawa H., Yada T., Wayner M.J., Sasaki K. Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides 2006, 27:2738-2749.
49. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995, 269.
50. Pickering C., Alsiö J., Hulting A.L., Schiöth H.B. Withdrawal from free-choice high-fat high-sugar diet induces craving only in obesity-prone animals. Psychopharmacology (Berl.) 2009, 204:431-443.
51. Plaza-Zabala A., Viñals X., Maldonado R., Robledo P. Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice. Psychopharmacology (Berl.) 2010, 208:563-573.
52. Reynolds M.A., Goodrick C.L., Ingram D.K. Decreased resistance to extinction in ob/ob mice following operant training. Physiol. Behav. 1982, 29:643-647.
53. Richardson N.R., Roberts D.C. Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy. J. Neurosci. Methods 1996, 66:1-11.
54. Rickard J.F., Body S., Zhang Z., Bradshaw C.M., Szabadi E. Effect of reinforcer magnitude on performance maintained by progressive-ratio schedules. J. Exp. Anal. Behav. 2009, 91:75-87.
55. Roberts D.C., Morgan D., Liu Y. How to make a rat addicted to cocaine. Prog. Neuropsychopharmacol. Biol. Psychiatr. 2007, 31:1614-1624.
56. Rothman R.B., Baumann M.H. Serotonin releasing agents. Neurochemical, therapeutic and adverse effects. Pharmacol. Biochem. Behav. 2002, 71:825-836.
57. Sclafani A. Appetite and hunger in experimental obesity syndromes. Hunger: Basic Mechanisms and Clinical Implications 1976, 281-295. Raven Press, New York. D. Novin, W. Wyricka, G. Bray (Eds.).
58. Simansky K.J. Serotonergic control of the organization of feeding and satiety. Behav. Brain. Res. 1996, 73:37-42.
59. Simansky K.J., Nicklous D.M. Parabrachial infusion of d-fenfluramine reduces food intake. Blockade by the 5-HT(1B) antagonist SB-216641. Pharmacol. Biochem. Behav. 2002, 71:681-690.
60. Singh D., Lakey J.R., Sanders M.K. Hunger motivation in gold-thioglucose-treated and genetically obese female mice. J. Comp. Physiol. Psychol. 1974, 86:890-897.
61. Sprott R.L. Long-term studies of feeding behavior of obese, diabetic, and viable yellow mutant mice under ad lib. and operant conditions. Psychol. Rep 1972, 30:991-1003.
62. Stafford D., LeSage M.G., Glowa J.R. Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review. Psychopharmacology (Berl.) 1998, 139:169-184.
63. Stoops W.W. Reinforcing effects of stimulants in humans: sensitivity of progressive-ratio schedules. Exp. Clin. Psychopharmacol. 2008, 16:503-512.
64. Strohmayer A.J., Smith G.P. Abnormal feeding and postprandial behavioral responses to food deprivation in genetically obese mice (C57BI/6J-ob/ob). Physiol. Behav. 1979, 22:1157-1162.
65. Temple J.L., Legierski C.M., Giacomelli A.M., Salvy S.J., Epstein L.H. Overweight children find food more reinforcing and consume more energy than do nonoverweight children. Am. J. Clin. Nutr. 2008, 87:1121-1127.
66. van Baak M.A., Astrup A. Consumption of sugars and body weight. Obes Rev. 2009, 10(Suppl. 1):9-23.
67. Vickers S.P., Clifton P.G., Dourish C.T. Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT1A receptor subtype. Psychopharmacology (Berl.) 1996, 125:168-175.
68. Vickers S.P., Clifton P.G., Dourish C.T., Tecott L.H. Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice. Psychopharmacology (Berl.) 1999, 143:309-314.
69. Vickers S.P., Dourish C.T. Serotonin receptor ligands and the treatment of obesity. Curr. Opin. Investig. Drugs 2004, 5:377-388.
70. Vickers S.P., Dourish C.T., Kennett G.A. Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology 2001, 41:200-209.
71. Winocur G., Greenwood C.E., Piroli G.G., Grillo C.A., Reznikov L.R., Reagan L.P., McEwen B.S. Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity. Behav Neurosci. 2005, 119.
72. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.