Gabapentin does not reduce smoked cocaine self-administration: Employment of a novel self-administration procedure

Behavioural Pharmacology

Volumn 18, Issue 1, 2007, Pages 71-75

  Hart, Carl L ^a,b   Haney, Margaret ^a   Vosburg, Suzanne K ^a   Rubin, Eric ^a   Foltin, Richard W ^a  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

aminobutyric acid; Choice; Cocaine; Gabapentin; Humans; Mood; Neurontin

Indexed keywords

COCAINE; GABAPENTIN; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COCAINE DEPENDENCE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DECISION MAKING; DOSE RESPONSE; DRUG DEPENDENCE TREATMENT; DRUG EFFECT; DRUG SELF ADMINISTRATION; DRUG TREATMENT FAILURE; HOSPITAL PATIENT; HUMAN; MAINTENANCE THERAPY; MALE; OUTPATIENT; PATIENT COMPLIANCE; PURCHASING; SMOKING;

ADULT; AFFECT; AMBULATORY CARE; AMINES; AROUSAL; BLOOD PRESSURE; CHOICE BEHAVIOR; COCAINE; COCAINE-RELATED DISORDERS; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EUPHORIA; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HEART RATE; HUMANS; MALE; MOTIVATION; PATIENT ADMISSION; SELF ADMINISTRATION; TOKEN ECONOMY; TREATMENT FAILURE;

EID: 33846228020     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/FBP.0b013e328014139d     Document Type: Article

References (20)

1. Bisaga A, Aharonovich E, Garawi F, Levin FR, Rubin E, Raby WN, Nunes EV (2006). A randomized placebo-controlled trial of gabapentin for cocaine dependence. Drug Alcohol Depend 81:267-274.
2. Campbell UC, Lac ST, Carroll ME (1999). Effects of baclofen on maintenance and reinstatement of intravenous cocaine self-administration in rats. Psychopharmacology 143:209-214.
3. Dewey SL, Morgan AE, Ashby CR Jr, Horan B, Kushner SA, Logan J, et al. (1998). A novel strategy for the treatment of cocaine addiction. Synapse 30:119-129.
4. Foltin RW, Fischman MW, Nestadt G, Stromberger H, Cornell EE, Pearlson GD (1990). Demonstration of naturalistic methods for cocaine smoking by human volunteers. Drug Alcohol Depend 26:145-154.
5. Haney M, Hart C, Collins ED, Foltin RW (2005). Smoked cocaine discrimination in humans: effects of gabapentin. Drug Alcohol Depend 80:53-61.
6. Hart CL, Haney M, Collins ED, Rubin E, Foltin RW (2007). Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses. Drug and Alcohol Dependence 86:274-277.
7. Hart CL, Ward AS, Collins ED, Haney M, Foltin RW (2004). Gabapentin maintenance decreases smoked cocaine-related subjective effects, but not self-administration by humans. Drug Alcohol Depend 73:279-287.
8. Hart CL, Haney M, Collins ED, Rubin E, Foltin RW (2006). Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses. Drug Alcohol Depend [Epub ahead of print].
9. Jones HE, Garrett BE, Griffiths RR (2001). Reinforcing effects of oral cocaine: contextual determinants. Psychopharmacology 154:143-152.
10. Kampman KM, Pettinati H, Lynch KG, Dackis C, Sparkman T, Weigley C, O'Brien CP (2004). A pilot trial of topiramate for the treatment of cocaine dependence. Drug Alcohol Depend 75:233-240.
11. Kushner SA, Dewey SL, Kornetsky C (1999). The irreversible gamma-aminobutyric acid (GABA) transaminase inhibitor gamma-vinyl-GABA blocks cocaine self-administration in rats. J Pharmacol Exp Ther 290:797-802.
12. Lile JA, Stoops WW, Allen TS, Glaser PE, Hays LR, Rush CR (2004a). Baclofen does not alter the reinforcing, subject-rated or cardiovascular effects of intranasal cocaine in humans. Psychopharmacology 171:441-449.
13. Lile JA, Stoops WW, Glaser PE, Hays LR, Rush CR (2004b). Acute administration of the GABA reuptake inhibitor tiagabine does not alter the effects of oral cocaine in humans. Drug Alcohol Depend 76:81-91.
14. Myrick H, Henderson S, Brady KT, Malcolm R (2001). Gabapentin in the treatment of cocaine dependence: a case series. J Clin Psychiatry 62:19-23.
15. Schiffer WK, Marsteller D, Dewey SL (2003). Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine. Psychopharmacology 168:339-343.
16. Silverman K, Kirby KC, Griffiths RR (1994a). Modulation of drug reinforcement by behavioral requirements following drug ingestion. Psychopharmacology 114:243-247.
17. Silverman K, Mumford GK, Griffiths RR (1994b). Enhancing caffeine reinforcement by behavioral requirements following drug ingestion. Psychopharmacology 114:424-432.
18. Stoops WW, Lile JA, Fillmore MT, Glaser PEA, Rush CR (2005a). Reinforcing effects of methylphenidate: influence of dose and behavioral demands following drug administration. Psychopharmacology 177:349-355.
19. Stoops WW, Lile JA, Fillmore MT, Glaser PEA, Rush CR (2005b). Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration. Psychopharmacology 182:186-193.
20. Stromberg MF, Mackler SA, Volpicelli JR, O'Brien CP, Dewey SL (2001). The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat. Pharmacol Biochem Behav 68:291-299.