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Volumn 18, Issue 21, 2010, Pages 7475-7485

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections

(10) Tasdemir, Deniz a Sanabria, David b Lauinger, Ina L a Tarun, Alice c,d Herman, Rob c Perozzo, Remo e Zloh, Mire a Kappe, Stefan H c Brun, Reto f Carballeira, Néstor M b

a UNIVERSITY OF LONDON (United Kingdom)

b UNIVERSITY OF PUERTO RICO (Puerto Rico)

c SEATTLE BIOMEDICAL RESEARCH INSTITUTE (United States)

d UNIVERSITY OF PITTSBURGH (United States)

e UNIVERSITY OF GENEVA (Switzerland)

f SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE (Switzerland)

Author keywords

Blood stage; Hexadecynoic acid; Liver stage; Malaria; Protozoa; Type II fatty acid biosynthesis

Indexed keywords

ANTIPROTOZOAL AGENT; ATOVAQUONE; HEXADECYNOIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME KINETICS; ERYTHROCYTE; FATTY ACID SYNTHESIS; FLOW CYTOMETRY; HEPATITIS; HUMAN; HUMAN CELL; LEISHMANIA DONOVANI; LIPOPHILICITY; LIVER; MAMMAL CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PLASMODIUM YOELII INFECTION; RAT; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ALKYNES; ANTIMALARIALS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; ERYTHROCYTES; FATTY ACID SYNTHETASE COMPLEX, TYPE II; FATTY ACIDS, UNSATURATED; HUMANS; KINETICS; LIVER; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

LEISHMANIA DONOVANI; MAMMALIA; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PROTOZOA; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 77958021758 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.08.055 Document Type: Article

Times cited : (29)

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