9-Dihydroerythromycin ethers as motilin agonists - Developing structure-activity relationships for potency and safety

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 21, 2010, Pages 7651-7658

  Liu, Yaoquan ^a   Li, Yong ^a   Myles, David C ^a   Claypool, Mark ^a   Carreras, Christopher W ^a,b   Shaw, Simon J ^a,c  

^a KOSAN BIOSCIENCES INC   (United States)

^b Ardelyx Inc   (United States)

^c RIGEL PHARMACEUTICALS INC   (United States)

Author keywords

Erythromycin; hERG; Macrolides; Motilin agonists

Indexed keywords

AMIDE; AMINE; CARBAMIC ACID DERIVATIVE; ERYTHROMYCIN DERIVATIVE; FORMAMIDE DERIVATIVE; POTASSIUM CHANNEL HERG; THIOUREA DERIVATIVE; TRIAZOLE DERIVATIVE; UREA DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ERYTHROMYCIN; ETHER-A-GO-GO POTASSIUM CHANNELS; ETHERS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOTILIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77958015414     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.035     Document Type: Article

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