Motilides accelerate regional gastrointestinal transit in the dog

Alimentary Pharmacology and Therapeutics

Volumn 14, Issue 7, 2000, Pages 955-960

  Chiba, T ^a   Thomforde, G M ^a   Kost, L J ^a   Allen, R G ^a   Phillips, S F ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN; INDIUM 111; MOTILIN; TECHNETIUM 99M;

ANIMAL EXPERIMENT; ARTICLE; ASCENDING COLON; COLON; CONTROLLED STUDY; DOG; DOSE RESPONSE; FEMALE; INTESTINE TRANSIT TIME; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; SCINTIGRAPHY; STOMACH EMPTYING;

ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROMYCIN; FEMALE; GASTROINTESTINAL AGENTS; GASTROINTESTINAL TRANSIT; MOTILIN; RADIONUCLIDE IMAGING;

EID: 0033921416     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2000.00793.x     Document Type: Article

References (38)

1. 1 Brown JC, Cook MA, Dryburgh JR. Motilin, a gastric motor activity stimulating polypeptide; the complete amino acid sequence. Can J Biochem 1973; 51: 533-7.
2. 2 Itoh Z, Honda R, Aizawa I, Takeuchi S, Hiwatashi K, Couch EF. Interdigestive motor activity of the lower esophageal sphincter in the conscious dog. Am J Dig Dis 1978; 23: 239-47.
3. 3 Itoh Z, Honda R, Hiwatashi K. Motilin-induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol 1976; 11(Suppl. 39): 93-110.
4. 4 Itoh Z, Aizawa I, Sekiguchi T. The interdigestive migrating complex and its significance in man. Clin Gastroenterol 1982; 11: 497-521.
5. 5 Itoh Z. Effect of GI motility in dogs. In: Itoh Z, eds. Motilin. San Diego: CA Academic, 1990: 133-53.
6. 6 Dent J, Dodds WJ, Sekiguchi T, Hogan WJ, Arndorfer RC. Interdigestive phasic contractions of the human lower esophageal sphincter. Gastroenterology 1983; 84: 453-60.
7. 7 Shibata C, Sasaki I, Naito H, et al. Effect of motilin on colonic motor activity in the interdigestive state in conscious dogs. Tohoku J Exp Med 1995; 176: 53-60.
8. 8 Christofides ND, Long RG, Fitzpatrick ML, McGregor GP, Bloom SR. Effect of motilin on the gastric emptying of glucose and fat in humans. Gastroenterology 1981; 80: 456-60.
9. 9 Christofides ND, Modlin IM, Fitzpatrick MD, Bloom SR. Effect of motilin on the rate of gastric emptying and gut hormone release during breakfast. Gastroenterology 1979; 76: 903-7.
10. 10 Ruppin H, Domschke S, Domschke W, Wünch E, Jaeger E, Demling L. Effects of 13-Nle-Motilin in man-inhibition of gastric evacuation and stimulation in peptic secretion. Scand J Gastroenterol 1975; 10: 199-202.
11. 11 Debas HT, Yamagishi T, Dryburgh JR. Motilin enhances gastric emptying of liquids in dogs. Gastroenterology 1977; 73: 777-80.
12. 12 Itoh Z, Nakaya M, Suzuki T, Arai H, Wakabayashi K. Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog. Am J Physiol 1984; 247: G688-94.
13. 13 Omura S, Tsuzuki K, Sunazuka T, et al. Macrorides with gastrointestinal motor stimulating activity. J Med Chem 1987; 30: 1941-3.
14. 14 Tomomasa T, Kuroume T, Arai H, Wakabayashi K, Itoh Z. Erythromycin induces migrating motor complex in human gastrointestinal tract. Dig Dis Sci 1986; 31: 157-61.
15. 15 Zara GP, Thompson HH, Pilot MA, Ritchie HD. Effects of erythromycin on gastrointestinal tract motility. J Antimicrob Chemother 1985; 16: 175-9.
16. 16 Annese V, Janssens J, Vantrappen G, et al. Erythromycin accelerates gastric emptying by inducing antral contractions and improved gastroduodenal coordination. Gastroenterology 1992; 102: 823-8.
17. 17 Lin HC, Sanders SL, Gu YG, Doty JE. Erythromycin accelerates solid emptying at the expense of gastric sieving. Dig Dis Sci 1994; 39: 124-8.
18. 18 Samsom M, Jebbink RJ, Akkermans LM, Bravenboer B, Van Berge Henegouwen GP, Smout AJ. Effects of oral erythromycin on fasting and postprandial antroduodenal motility in patients with type I diabetes, measured with an ambulatory manometric technique. Diabetes Care 1997; 20: 129-34.
19. 19 Tack J, Janssens J, Vantrappen G, et al. Effect of erythromycin on gastric motility in controls and in diabetic gastroparesis. Gastroenterology 1992; 103: 72-9.
20. 20 Hasler W, Heldsinger A, Soudah H, Owyang C. Erythromycin promotes colonic transit in humans: Mediation via motilin receptors. Gastroenterology 1990; 98: A358(Abstract).
21. 21 Sharma SS, Bhargava N, Mathur SC. Effect of oral erythromycin on colonic transit in patients with idiopathic constipation: a pilot study. Dig Dis Sci 1995; 40: 2446-9.
22. 22 Vassallo MJ, Camilleri M, Sullivan SN, Thomforde GM. Effects of erythromycin on gut transit in pseudo-obstruction due to hereditary coproporphyria. J Clin Gastroenterol 1992; 14: 255-9.
23. 23 Jameson JS, Rogers J, Misiewicz JJ, Raimundo AH, Henry MM. Oral or intravenous erythromycin has no effect on human distal colonic motility. Aliment Pharmacol Ther 1992; 6: 589-95.
24. 24 Iwanaga Y, Wen J, Thollander MS, et al. Scintigraphic measurement of regional gastrointestinal transit in the dog. Am J Physiol 1998; 275: G904-9.
25. 25 Wen J, Phillips SF, Kost LJ. Scintigraphic measurement of regional gut transit in the dog. Gastroenterology 1995; 108: A709(Abstract).
26. 26 Charles F, Camilleri M, Phillips SF, Thomforde GM, Forstrom LA. Scintigraphy of the whole gut: clinical evaluation of transit disorders. Mayo Clin Proc 1995; 70: 113-8.
27. 27 Charles F, Phillips SF, Camilleri M, Thomforde GM. Rapid gastric emptying in patients with functional diarrhoea. Mayo Clin Proc 1997; 72: 323-8.
28. 28 Adachi H, Toda N, Hayashi S, et al. Mechanism of the excitatory action of motilin on isolated rabbit intestine. Gastroenterology 1981; 80: 783-8.
29. 29 Poitras P, Lahaie RG, St-Pierre S, Trudel L. Comparative stimulation of motilin duodenal receptor by porcine or canine motilin. Gastroenterology 1987; 92: 658-62.
30. 30 Bormans V, Peeters TL, Vantrappen G. Motilin receptors in rabbit stomach and small intestine. Regul Pept 1986; 15: 143-53.
31. 31 Peeters TL, Bormans V, Depoortere I, Vantrappen G. Comparison of motilin binding to crude homogenates of human and canine gastrointestinal smooth muscle tissue. Regul Pept 1988; 23: 171-82.
32. 32 Parkman HP, Pagano AP, Vozzelli MA, Ryan JP. Gastrokinetic effects of erythromycin: myogenic and neurogenic mechanisms of action in rabbit stomach. Am J Physiol 1995; 269: G418-26.
33. 33 Otterson MF, Sarna SK. Gastrointestinal motor effects of erythromycin. Am J Physiol 1990; 259: G355-63.
34. 34 Van Assche G, Depoortere I, Thijs T, Janssens JJ, Peeters TL. Concentration-dependent stimulation of cholinergic motor nerves or smooth muscle by [Nle 13] motilin in the isolated rabbit gastric antrum. Eur J Pharmacol 1997; 337: 267-74.
35. 35 Fox JET, Daniel EE, Jury J, Robotham R. The mechanism of motilin excitation of the canine small intestine. Life Sci 1984; 34: 1001-6.
36. 36 Van Assche G, Thijs T, Depoortere I, Peeters TL. Excitatory effect of motilin on the isolated human colon. Gastroenterology 1995; 108: A703(Abstract).
37. 37 Depporate I, Peeters TL, Vantrappen G. Motilin receptors of the rabbit colon. Peptides 1991; 12: 89-94.
38. 38 Hasler WL, Heldsinger A, Owyang C. Erythromycin contracts rabbit colon myocytes via occupation of motilin receptors. Am J Physiol 1992; 262: G50-5.