Computer based design, synthesis and biological evaluation of novel indole derivatives as HCV NS3-4A serine protease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 7877-7887

  Ismail, Nasser S M ^a   El Dine, Riham Salah ^b   Hattori, Masao ^b   Takahashi, Kazunori ^c   Ihara, Masataka ^c  

^a Ain Shams University   (Egypt)

^b UNIVERSITY OF TOYAMA   (Japan)

^c HOSHI UNIVERSITY   (Japan)

Author keywords

HCV; Indole derivatives; Molecular modeling; Protease synthesis

Indexed keywords

2 [6 (5 METHOXY 1H INDOL 3 YL) 4 OXO 6 (4 TRIFLUOROMETHYL)PHENYL]HEXANAMIDO] 3 PHENYLPROPANOIC ACID; 2 [6 (5 METHOXY 1H INDOL 3 YL) 6 (4 METHOXYPHENYL) 4 OXOHEXANAMIDO] PHENYLPROPANOIC ACID; ALUMINUM CHLORIDE; DOCKING PROTEIN; HCV NS3 PROTEASE INHIBITOR; INDOLE DERIVATIVE; NONSTRUCTURAL PROTEIN 3; QUININE; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER AIDED DESIGN; DIASTEREOISOMER; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HEPATITIS C VIRUS; MICHAEL ADDITION; MOLECULAR MODEL; PHARMACOPHORE; SIMULATION;

BINDING SITES; BINDING, COMPETITIVE; COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; DRUG DESIGN; INDOLES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SERINE PROTEINASE INHIBITORS; SOFTWARE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 50649097899     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.084     Document Type: Article

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