Studies on the synthesis of N′-acetyl AZA-analogues of Ganciclovir - Unexpected liability of N′-(2-hydroxyethyl)-azanucleosides under basic conditions

Nucleosides, Nucleotides and Nucleic Acids

Volumn 29, Issue 10, 2010, Pages 768-785

  Koszytkowska Stawinska, Mariola ^a  

^a WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

aza nucleosides; N (2 hydroxyethyl)amides; N O acyl migration; Nucleoside analogues; O N acyl migration

Indexed keywords

1 [N (1,3 DIPIVALOYLOXYPROP 2 YL)ACETYLAMINOMETHYL] 5 METHYL 1H,3H PYRIMIDIN 2,4 DIONE; 1 [N (1,3 DIPIVALOYLOXYPROP 2 YL)ACETYLAMINOMETHYL] 5 METHYL 1H,3H PYRIMIDIN 4 ON 2 THIONE; 2 (ACETYLAMINO) 6 (DIPHEYNLCARBAMOYL) 9 [N (1,3 DIPIVALOYLOXYPROP 2 YL)ACETYLAMINOMETHYL] 9H PURINE; 4 (BENZOYLAMINO) 1 [N )1,3 DIPIVALOYLOXYPROP 2 YL)ACETYLAMINOMETHYL] 1H PYRIMIDIN 2 ONE; GANCICLOVIR DERIVATIVE; NUCLEIC ACID BASE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLATION; AMMONOLYSIS; ARTICLE; DEACETYLATION; DRUG SYNTHESIS; FRAGMENTATION REACTION; MOLECULAR INTERACTION; MOLECULAR MECHANICS; SILYLATION;

ACETAMIDES; AZA COMPOUNDS; GANCICLOVIR; HYDROGEN-ION CONCENTRATION; NUCLEOSIDES; THERMODYNAMICS;

EID: 77957978467     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770.2010.519367     Document Type: Article

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