Bone-marrow-derived CXCR4-positive tissue-committed stem cell recruitment in human right ventricular remodeling

Human Pathology

Volumn 41, Issue 11, 2010, Pages 1566-1576

  Castellani, Chiara ^a   Padalino, Massimo ^a   China, Paolo ^a   Fedrigo, Marny ^a   Frescura, Carla ^a   Milanesi, Ornella ^a   Stellin, Giovanni ^a   Thiene, Gaetano ^a   Angelini, Annalisa ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

Cardiac remodeling; Congenital heart disease; CXCR4 mobilization; CXCR4 SDF 1 axis; Stem cells

Indexed keywords

C KIT PROTEIN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; PROTEIN; STROMAL CELL DERIVED FACTOR 1 ALPHA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CXCR4 PROTEIN, HUMAN; PTPRC PROTEIN, HUMAN; STEM CELL FACTOR RECEPTOR; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; BONE MARROW; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOCARDIUM; EPICARDIUM; EXTRACARDIAC PROGENITOR CELL; HEART HYPERTROPHY; HEART MUSCLE; HEART RIGHT VENTRICLE; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOPLASTIC LEFT HEART SYNDROME; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; MUSCLE CELL; NORWOOD PROCEDURE; PRESCHOOL CHILD; PROTEIN EXPRESSION; STEM CELL; STEM CELL MOBILIZATION; STEM CELL RECRUITMENT; BONE MARROW CELL; HEART VENTRICLE; HEMATOPOIETIC STEM CELL; INFANT; METABOLISM; PATHOLOGY;

ANTIGENS, CD45; BIOLOGICAL MARKERS; BONE MARROW CELLS; CHEMOKINE CXCL12; CHILD, PRESCHOOL; HEART VENTRICLES; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HUMANS; HYPOPLASTIC LEFT HEART SYNDROME; INFANT; MYOCARDIUM; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, CXCR4; VENTRICULAR REMODELING;

EID: 77957958907     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.12.017     Document Type: Article

References (34)

1. Urbanek K., Torella D., and Shikh F. Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure Proc Natl Acad Sci USA 102 2005 8692 8697
2. Linke A., Muller P., and Nurzynska D. Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function Pro Natl Acad Sci USA 102 2005 8966 8971
3. Beltrami A.P., Cesselli D., and Bergamin N. Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow) Blood 110 2007 3438 3446
4. Urbanek K., Quaini F., and Tasca G. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy Pro Natl Acad Sci USA 100 2003 10440 10445
5. Minami E., Laflamme M.A., Saffitz J.E., and Murry C.E. Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart Circulation 122 2005 2951 2958
6. Angelini A., Castellani C., and Tona F. Continuous engraftment and differentiation of male recipient Y-chromosome-positive cardiomyocytes in donor female human heart transplants J Heart Lung Transplant 26 2007 1110 1118
7. Abdel-Latif A., Bolli R., and Tleyjeh I.M. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis Arch Intern Med 167 2007 989 997
8. Wessels A., and Perez-Pomares J.M. The epicardium and epicardially-derived cells (EPDCs) as cardiac stem cells Anat Rec a Discov mol Cell Evol Biol 276 2004 43 57
9. van Tuyn J., Atsma D.E., and Winter E.M. Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro Stem Cells 25 2007 271 278
10. Kucia M., Ratajczak J., and Ratajczak M.Z. Bone marrow as a source of circulating CXCR4+ tissue-committed stem cells Biol Cell 97 2005 133 146 (Pubitemid 40298268)
11. Wojakowski W., Tendera M., and Michalowska A. Mobilization of CD34+/CXCR4+, CD34-/CD117+, c-met+ stem cells, and mononuclear cells expressing early cardiac muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction Circulation. 110 2004 3213 3220
12. Li F., Wang X., Capasso J.M., and Gerdes A.M. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development J Mol Cell Cardiol 28 1996 1737 1746
13. Sedmera D., Thompson R.P., and Kolar F. Effect of increased pressure loading on heart growth in neonatal rats J Mol Cell Cardiol 35 2003 301 309
14. Vida V.L., Angelini A., and Ausoni S. Age is a risk factor for maladaptive changes in rats exposed to increased pressure loading of the right ventricular myocardium Cardiol Young 17 2007 202 211
15. Bogaard H.J., Abe K., Vonk-Noordegraaf A., and Voelkel N.F. The right ventricle under pressure. Cellular and molecular mechanisms of right-heart failure in pulmonary hypertension Chest 135 2009 794 804
16. Olivetti G., Melissari M., and Balbi T. Myocyte cellular hypertrophy is responsible for ventricular remodelling in the hypertrophied heart of middle-aged individuals in the absence of cardiac failure Cardiovasc Res 28 1994 1199 1208
17. Pikkarainen S., Tokola H., Kerkelä R., and Ruskoaho H. GATA transcription factors in the developing and adult heart Cardiovasc Res 63 2004 196 207
18. Pu W.T., Ishiwata T., Juraszek A.L., and Ma Q Izumo S. GATA 4 is a dosage-sensitive regulator of cardiac morphogenesis Dev Biol 275 2004 235 244
19. Zhang M., Mal N., and Kiedrowski M. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction FASEB 21 2007 3197 3207 (Pubitemid 47565538)
20. Nadal-Ginard B., Kajastura J., Leri A., and Anversa P. Myocyte death, growth, and regeneration in cardiac hypertrophy and failure Circ Res 92 2003 139 150
21. Urbanek K., Cesselli D., and Rota M. Stem cell niches in the adult mouse heart Proc Natl Acad Sci USA 103 2006 9226 9231
22. Manner J. Experimental study on the formation of epicardium in chick embryos Anat Embryol (Berlin) 187 1993 281 289
23. Perez-Pomarez J.M., Carmona R., Gonzales-Iriarte M., Atencia G., Wessels A., and Munoz-Chapuli R. Origin of coronary endothelial cells from epicardial mesothelium in avian embryo Int J Dev Biol 46 2002 1005 1013
24. Limana F., Zacheo A., and Mocini D. Identification of myocardial and vascular precursor cells in human and mouse epicardium Circ Res 101 2007 1255 1265
25. Sato H., Shiraishi I., Takamatsu T., and Hamaoka K. Detection of TUNEL-positive cardiomyocytes and c-Kit-positive progenitor cells in children with congenital heart disease J Mol Cell Cardiol 43 2007 254 261
26. Rafii S. Circulating endothelial precursors: mystery, reality, and promise J Clin Invest 105 2000 17 19
27. Kucia M., Reca R., Jala V.R., Dawn B., Ratajczk J., and Ratajczak M.Z. Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells Leukemia 19 2005 1118 1127 (Pubitemid 40945992)
28. Ceradini D.J., Kulkarni A.R., and Callaghan M.J. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 Nat Med 10 2004 858 864
29. Smart N., and Riley P.R. The stem cell movement Circ Res 102 2008 1155 1168
30. Askari A.T., Unzek S., and Popovic Z.B. Effects of stromal-cell-derived factor-1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy Lancet 362 2003 697 703
31. Ratajczak M.Z., Kucia M., Reca R., Majka M., Janowska-Wieczorek A., and Ratajczak J. Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells "hide out" in the bone marrow Leukemia 18 2004 29 40
32. Zhang D., Fan G.C., and Zhou X. Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium J Moll Cell Cardiol 44 2008 281 292
33. Stumm R.K., Rummel J., and Junker V. A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia J Neurosci 22 2002 5865 5878
34. 6 integrin expression Stem Cells 26 2008 1723 1731