Pharmacological characterization of [125I]CHIBA-1006 binding, a new radioligand for α7 nicotinic acetylcholine receptors, to rat brain membranes

Brain Research

Volumn 1360, Issue , 2010, Pages 130-137

  Wu, Jin ^a   Toyohara, Jun ^a,d   Tanibuchi, Yuko ^a   Fujita, Yuko ^a   Zhang, Jichun ^a   Chen, Hongxian ^a   Matsuo, Masaaki ^b   Wang, Rong Fu ^c   Hashimoto, Kenji ^a  

^a CHIBA UNIVERSITY   (Japan)

^b NARD Institute Co Ltd   (Japan)

^c PEKING UNIVERSITY FIRST HOSPITAL   (China)

^d TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Brain; Nicotinic receptor; Rat; Receptor binding assay

Indexed keywords

1,4 DIAZABICYCLO[3.2.2]NONANE 4 CARBOXYLIC ACID 4 BROMOPHENYL ESTER; [IODINE 125]4 IODOPHENYL 1,4 DIAZAICYCLO[3.2.2]NONANE 4 CARBOXYLATE; A844606; ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR; ALPHA BUNGAROTOXIN; CHIBA 1001; DIAGNOSTIC AGENT; METHYLLYCACONITINE; MG624; NICOTINE; NICOTINIC RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG; UNLABELED 4 IODOPHENYL 1,4 DIAZAICYCLO[3.2.2]NONANE 4 CARBOXYLATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CHEMICAL STRUCTURE; EQUILIBRIUM CONSTANT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

ANIMALS; AZABICYCLO COMPOUNDS; BINDING SITES; BINDING, COMPETITIVE; BRAIN; BUNGAROTOXINS; CEREBRAL CORTEX; DATA INTERPRETATION, STATISTICAL; MALE; MEMBRANES; NICOTINIC ANTAGONISTS; RADIOPHARMACEUTICALS; RATS; RECEPTORS, NICOTINIC;

RATTUS;

EID: 77957951952     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.08.095     Document Type: Article

References (60)

1. 3H]A-585539 [(1S, 4S)-2, 2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1] heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain J. Pharmacol. Exp. Ther. 324 2008 179 187
2. S. Barak, M. Arad, A. De Levie, M.D. Black, G. Griebel, and I. Weiner Pro-cognitive and antipsychotic efficacy of the α7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia Neuropsychopharmacology 34 2009 1753 1763
3. N.L. Benowitz Pharmacology of nicotine: addiction and therapeutics Annu. Rev. Pharmacol. Toxicol. 36 1996 597 613
4. R.S. Bitner, W.H. Bunnelle, D.J. Anderson, C.A. Briggs, J. Buccafusco, P. Curzon, M.W. Decker, J.M. Frost, J.H. Gronlien, E. Gubbins, J. Li, J. Malysz, S. Markosyan, K. Marsh, M.D. Meyer, A.L. Nikkel, R.J. Radek, H.M. Robb, D. Timmermann, J.P. Sullivan, and M. Gopalakrishnan Broad-spectrum efficacy across cognitive domains by α7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways J. Neurosci. 27 2007 10578 10587
5. B. Biton, O.E. Bergis, F. Galli, A. Nedelec, A.W. Lochead, S. Jegham, D. Godet, C. Lanneau, R. Santamaria, F. Chesney, J. Léonardon, P. Granger, M.W. Debono, G.A. Bohme, F. Sgard, F. Besnard, D. Graham, A. Coste, A. Oblin, O. Curet, X. Vigé, C. Voltz, L. Rouquier, J. Souilhac, V. Santucci, C. Gueudet, D. Françon, R. Steinberg, G. Griebel, F. Oury-Donat, P. George, P. Avenet, and B. Scatton SSR180711, a novel selective α7 nicotinic receptor partial agonist: (1) binding and functional profile Neuropsychopharmacology 32 2007 1 16
6. A.L. Bodnar, L.A. Cortes-Burgos, K.K. Cook, D.M. Dinh, V.E. Groppi, M. Hajos, N.R. Higdon, W.E. Hoffmann, R.S. Hurst, J.K. Myers, B.N. Rogers, T.M. Wall, M.L. Wolfe, and E. Wong Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors J. Med. Chem. 48 2005 905 908
7. J.J. Buccafusco, and A.V. Terry Jr. Multiple CNS targets for eliciting beneficial effects on memory and cognition J. Pharmacol. Exp. Ther. 295 2000 438 446
8. 50) of an enzymatic reaction Biochem. Pharmacol. 22 1973 3099 3108
9. J.A. Court, C. Martin-Ruiz, A. Graham, and E. Perry Nicotinic receptors in human brain: topography and pathology J. Chem. Neuroanat. 20 2000 281 298
10. S. Couturier, D. Bertrand, J.M. Matter, M.C. Hernandez, S. Bertrand, N. Millar, S. Valera, T. Barkas, and M. Ballivet A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX Neuron 5 1990 847 856
11. 3H]methyllycaconitine: a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors Neuropharmacology 38 1999 679 690
12. E. Domínguez del Toro, J.M. Juíz, F.I. Smillie, J. Lindstrom, and M. Criado Expression of α7 neuronal nicotinic receptors during postnatal development of the rate cerebellum Brain Res. Dev. Brain Res. 98 1997 125 133
13. L.P. Dwoskin, and P.A. Crooks Competitive neuronal receptor antagonists a new direction for drug discovery J. Pharmacol. Exp. Ther. 298 2001 395 402
14. M. Frings, M. Maschke, and D. Timmann Cerebellum and cognition-viewed from philosophy of mind Cerebellum 12 2007 1 7
15. 3H]DOPA in various regions of the brain J. Neurochem. 13 1966 655 669
16. C. Gotti, D. Fornasari, and F. Clementi Human neuronal nicotinic receptors Prog. Neurobiol. 53 1997 199 237
17. C. Gotti, E. Carbonnelle, M. Moretti, R. Zwart, and F. Clementi Drugs selective for nicotinic receptor subtypes: a real possibility or a dream? Behav. Brain Res. 113 2000 183 192
18. A. Graham, J.A. Court, C.M. Martin-Ruiz, E. Jaros, R. Perry, S.G. Volsen, S. Bose, N. Evans, P. Ince, A. Kuryatov, J. Lindstrom, C. Gotti, and E.K. Perry Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum Neuroscience 113 2002 493 507
19. M. Hajós, R.S. Hurst, W.E. Hoffmann, M. Krause, T.M. Wall, N.R. Higdon, and V.E. Groppi The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats J. Pharmacol. Exp. Ther. 312 2005 1213 1222
20. 3H]6- nitroquipazine binding sites in rat brain Eur. J. Pharmacol. 180 1990 273 281
21. K. Hashimoto, K. Koike, E. Shimizu, and M. Iyo α7 Nicotinic receptor agonists as potential therapeutic drugs for schizophrenia Curr. Med. Chem.- CNS Agents 5 2005 171 184
22. K. Hashimoto, T. Ishima, Y. Fujita, M. Matsuo, T. Kobashi, M. Takahagi, H. Tsukada, and M. Iyo Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective α7 nicotinic receptor agonist SSR180711 Biol. Psychiatry 63 2008 92 97 (Pubitemid 350234890)
23. 11C]CHIBA-1001 as a novel PET ligand for α7 nicotinic receptors in the brain: a PET study in conscious monkeys PLoS One 3 2008 e3231
24. E. Hellström-Lindahl, O. Gorbounova, A. Seiger, M. Mousavi, and A. Nordberg Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord Brain Res. Dev. Brain Res. 108 1998 147 160
25. R.C. Hogg, and D. Bertrand Nicotinic acetylcholine receptors as drug targets Curr. Drug Targets CNS Neurol. Disord. 3 2004 123 130
26. M.W. Holladay, M.J. Dart, and J.K. Lynch Neuronal nicotinic acetylcholine receptors as targets for drug discovery J. Med. Chem. 40 1997 4169 4194
27. S.W. Kim, Y.S. Ding, D. Alexoff, V. Patel, J. Logan, K.S. Lin, C. Shea, L. Muench, Y. Xu, P. Carter, P. King, J.R. Constanzo, J.A. Ciaccio, and J.S. Fowler Synthesis and positron emission tomography studies of C-11-labeled isotopomers and metabolites of GTS-21, a partial α7 nicotinic cholinergic agonist drug Nucl. Med. Biol. 34 2007 541 551
28. 2+ ions in nicotinic facilitation of GABA release in mouse thalamus J. Neurosci. 17 1997 576 585
29. E.D. Levin, C. Bettegowda, J. Blosser, and J. Gordon AR-R17779, and α7 nicotinic agonist, improves learning and memory in rats Behav. Pharmacol. 10 1999 675 680
30. E.D. Levin Nicotinic receptor subtypes and cognitive function J. Neurobiol. 53 2002 633 640
31. G.K. Lloyd, and M. Williams Neuronal nicotinic receptors as novel drug targets J. Pharmacol. Exp. Ther. 292 2000 461 467
32. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
33. D.R.E. Macallan, G.G. Lunt, S. Wonnacott, K.L. Swanson, H. Rapoport, and E.X. Albuquerque Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems FEBS Lett. 226 1988 357 363
34. M.J. Marks, and A.C. Collins Characterization of nicotine binding in mouse brain and comparison with the binding of α-bungarotoxin and quinuclidinyl benzilate Mol. Pharmacaol. 22 1982 554 564
35. L.F. Martin, W.R. Kem, and R. Freedman Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia Psychopharmacology (Berl) 174 2004 54 64
36. D. Mebs, K. Narita, S. Iwanaga, Y. Samejima, and C.Y. Lee Amino acid sequence of α-bungarotoxin from the venom of Bungarus multicinctus Biochem. Biophys. Res. Commun. 44 1971 711 716
37. R. Nashmi, and H.A. Lester CNS localization of neuronal nicotinic receptors J. Mol. Neurosci. 30 2006 181 184
38. 125I]iodo-MLA). A new ligand for the α7 nicotinic acetylcholine receptor J. Med. Chem. 43 2000 142 145
39. 125I]iodomethyllycaconitine in the rat Synapse 44 2002 117 123
40. P.A. Newhouse, A. Potter, and A. Singh Effects of nicotinic stimulation on cognitive performance Curr. Opin. Pharmacol. 4 2004 36 46
41. 125I]I-TSA as a brain nicotinic acetylcholine receptor α7 subtype imaging agent Nucl. Med. Biol. 33 2006 311 316
42. M. Ogawa, H. Tsukada, K. Hatano, Y. Ouchi, H. Saji, and Y. Magata Central in vivo nicotinic acetylcholine receptor imaging agents for positron emission tomography (PET) and single photon emission computed tomography (SPECT) Biol. Pharm. Bull. 32 2009 337 340
43. D.C. Perry, Y. Xiao, H.N. Nguyen, J.L. Musachio, M.I. Dávila-García, and K.J. Kellar Measuring nicotinic receptors with characteristics of α4β2, α3β2 and α3β4 subtypes in rat tissues by autoradiography J. Neurochem. 82 2002 468 481
44. P. Pichat, O.E. Bergis, J.P. Terranova, A. Urani, C. Duarte, V. Santucci, C. Gueudet, C. Voltz, R. Steinberg, J. Stemmelin, F. Oury-Donat, P. Avenet, G. Griebel, and B. Scatton SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia Neuropsychopharmacology 32 2007 17 34
45. M. Quik, Y. Polonskaya, A. Gillespie, M. Jakowec, G.K. Lloyd, and J.W. Langston Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization J. Comp. Neurol. 425 2000 58 69
46. J.D. Schmitt Exploring the nature of molecular recognition in nicotinic acetylcholine receptors Curr. Med. Chem. 7 2000 749 800
47. M. Segal, Y. Dudai, and A. Amsterdam Distribution of an α-bungarotoxin-binding cholinergic nicotinic receptor in rat brain Brain Res. 148 1978 105 119 (Pubitemid 8344486)
48. P. Séguéla, J. Wadiche, K. Dineley-Miller, J.A. Dani, and J.W. Patrick Molecular cloning, functional properties, and distribution of rat brain α7: a nicotinic cation channel highly permeable to calcium J. Neurosci. 13 1993 596 604
49. 3H]CHIBA-1001 binding to α7 nicotinic acetylcholine receptors in the brain from rat, monkey, and human Brain Res. 1348 2010 200 209
50. M.S. Thomsen, D.Z. Christensen, H.H. Hansen, J.P. Redrobe, and J.D. Mikkelsen α7 Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment Neuropharmacology 56 2009 1001 1009
51. 11C]CHIBA-1001 for mapping α7 nicotinic receptors by positron emission tomography Ann. Nucl. Med. 23 2009 301 309
52. J. Toyohara, and K. Hashimoto α7 Nicotinic receptor agonists: potential therapeutic drugs for treatment of cognitive impairments in schizophrenia and Alzheimer's disease Open Med. Chem. J. 4 2010 37 56
53. 11C]A-844606 in mice and conscious monkeys PLoS One 5 2010 e8961
54. J. Toyohara, J. Wu, and K. Hashimoto Recent development of radioligands for imaging α7 nicotinic acetylcholine receptors in the brain Curr. Top. Med. Chem. 10 2010 1544 1557
55. M. Van Kampen, K. Selbach, R. Schneider, E. Schiegel, F. Boess, and R. Schreiber AR-R 17779 improves social recognition in rats by activation of nicotinic α7 receptors Psychopharmacology (Berl) 172 2004 375 383
56. J.M. Ward, V.B. Cockcroft, G.G. Lunt, F.S. Smillie, and S. Wonnacott Methyllycaconitine: a selective probe for neuronal alpha-bungarotoxin binding sites FEBS Lett. 270 1990 45 48
57. 125I]-epibatidine Br. J. Pharmacol. 131 2000 729 739
58. D.G. Wishka, D.P. Walker, K.M. Yates, S.C. Reitz, S. Jia, J.K. Myers, K.L. Olson, E.J. Jacobsen, M.L. Wolfe, V.E. Groppi, A.J. Hanchar, B.A. Thornburgh, L.A. Cortes-Burgos, E.H. Wong, B.A. Staton, T.J. Raub, N.R. Higdon, T.M. Wall, R.S. Hurst, R.R. Walters, W.E. Hoffmann, M. Hajos, S. Franklin, G. Carey, L.H. Gold, K.K. Cook, S.B. Sands, S.X. Zhao, J.R. Soglia, A.S. Kalgutkar, S.P. Arneric, and B.N. Rogers Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl] furo[2, 3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure-activity relationship J. Med. Chem. 49 2006 4425 4436
59. J.W. Young, K. Finlayson, C. Spratt, H.M. Marston, N. Crawford, J.S. Kelly, and J. Sharkey Nicotine improves sustained attention in mice: evidence for involvement of the α7 nicotinic acetylcholine receptor Neuropsychopharmacology 29 2004 891 900
60. J.W. Young, N. Crawford, J.S. Kelly, L.E. Kerr, H.M. Marston, C. Spratt, K. Finlayson, and J. Sharkey Impaired attention is central to the cognitive deficits observed in α7 deficient mice Eur. Neuropsychopharmacol. 17 2007 145 155