Adult hematopoietic stem cells require NKAP for maintenance and survival

Blood

Volumn 116, Issue 15, 2010, Pages 2684-2693

  Pajerowski, Anthony G ^a,b   Shapiro, Michael J ^b   Gwin, Kimberly ^b   Sundsbak, Rhianna ^b   Nelson Holte, Molly ^b   Medina, Kay ^b   Shapiro, Virginia Smith ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; P19INK4D; P21CIP1; UNCLASSIFIED DRUG; WAF1; CDKN1A PROTEIN, MOUSE; COREPRESSOR PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL SURVIVAL; CHIMERA; ERYTHROCYTE; GENE; GENE DELETION; GRANULOCYTE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LYMPHOCYTE; MALE; MEGAKARYOCYTE; MOUSE; NKAP GENE; NONHUMAN; PRIORITY JOURNAL; ADULT STEM CELL; ANIMAL; CELL PROLIFERATION; CYTOLOGY; FEMALE; GENETICS; KNOCKOUT MOUSE; METABOLISM; NEWBORN; PHYSIOLOGY; PREGNANCY; PROMOTER REGION; RADIATION CHIMERA; TRANSGENIC MOUSE;

ADULT STEM CELLS; ANIMALS; ANIMALS, NEWBORN; CELL PROLIFERATION; CELL SURVIVAL; CO-REPRESSOR PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NF-KAPPA B; PREGNANCY; PROMOTER REGIONS, GENETIC; RADIATION CHIMERA; RNA, MESSENGER;

EID: 77957943998     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-02-268391     Document Type: Article

References (44)

1. Teitell MA, Mikkola HK. Transcriptional activators, repressors and epigenetic modifiers controlling hematopoietic stem cell development. Pediatr Res. 2006;59(4 Pt 2):33R-39R.
2. Hock H, Hamblen MJ, Rooke HM, et al. Gfi-1 restricts proliferation and preserves functional integrity of haemopoietic stem cells. Nature. 2004;431(7011):1002-1007. (Pubitemid 39434423)
3. Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 2003;423(6937):255-260.
4. Park I, Qian D, Kiel M, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423(6937):302-305. (Pubitemid 40852701)
5. Shimizu R, Yamamoto M. Gene expression regulation and domain function of hematopoietic GATA factors. Semin Cell Dev Biol. 2005;16(1):129-136. (Pubitemid 40126883)
6. Loose M, Swiers G, Patient R. Transcriptional networks regulating hematopoietic cell fate decisions. Curr Opin Hematol. 2007;14(4):307-314.
7. Myatt SS, Lam EW. Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis. Cell Div. 2007;12(2):6-14.
8. Ezoe S, Matsumura I, Satoh Y, Tanaka H, Kanakura Y. Cell cycle regulation in hematopoietic stem/progenitor cells. Cell Cycle. 2004;3(3):314-318. (Pubitemid 41359082)
9. Qian Z, Chen L, Fernald AA, Williams BO, Le Beau MM. A critical role for APC in hematopoietic stem and progenitor cell survival. J Exp Med. 2008;205(9):2163-2175.
10. Cheng T, Rodrigues N, Shen H, et al. Hematopoietic stem cell quiescence maintained by p21 Cip1/Waf1. Science. 2000;287(5459):1804-1808. (Pubitemid 30143963)
11. Oguro H, Iwama A, Morita Y, Kamijo T, van Lohuisen M, Nakauchi H. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med. 2006;203(10):2247- 2253.
12. Pajerowski AG, Nguyen C, Aghajanian H, Shapiro MJ, Shapiro VS. NKAP is a transcriptional represor of Notch signaling and is required for T cell development. Immunity. 2009;30(5):696-707.
13. Stadtfeld M, Graf T. Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development. 2005;132(1):203-213.
14. Kuhn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995;269(5229):1427-1429.
15. Zaugg K, Su Y-W, Reilly PT, et al. Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. Proc Natl Acad Sci U S A. 2007;104(10):3805-3810. (Pubitemid 47181535)
16. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real time quantitative PCR and the 2(-DeltaDelta C(T)) method. Methods. 2001;25(4):402-408.
17. Nguyen J, Yamada D, Schultz DC, Defossez P-A. Assessment of sera for chromatin-immunoprecipitation. Biotechniques. 2008;44(1):66-68.
18. Tremblay CS, Huard CC, Huang FF, et al. The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling. J Biol Chem. 2009;284(20):13384-13395.
19. Wilson A, Murphy MJ, Oskarsson T, et al. c-Myc controls the balance between hematopoiesis stem cell self-renewal and differentiation. Genes Dev. 2004;18(22):2747-2763.
20. Liu Y, Pop R, Sadegh C, Brugnara C, Haase VH, Socolovsky M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood. 2006;108(1):123-133.
21. Cumano A, Godin I. Ontogeny of the hematopoietic system. Annu Rev Immunol. 2007;25:745-785.
22. Kim I, He S, Yilmaz OH, Kiel MJ, Morrison SJ. Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood. 2006;108(2):737-744. (Pubitemid 44061378)
23. Kiel MJ, Morrison SJ. Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol. 2008;8(4):290-301.
24. Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C. E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors. Proc Natl Acad Sci U S A. 2009;106(6):1930-1935.
25. Tsai FY, Keller G, Kuo FC, et al. An early hematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994;371(6494):221-226.
26. Sandberg ML, Sutton SE, Pletcher MT, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8(2):153-166.
27. Tschan MP, Peters UR, Cajot JF, Betticher DC, Fey MF, Tobler A. The cyclin-dependent kinase inhibitors p18Ink4c and p19Ink4d are highly expressed in CD34+ progenitor and acute myeloid leukemia cells but not in normal differentiated myeloid cells. Br J Haemotol. 1999;106(3):644-651. (Pubitemid 29434201)
28. Cheng T, Rodrigues N, Dombkowski D, Stier S, Scadden DT. Stem cell repopulation efficiency but not pool size is governed by p27 Kip1. Nat Med. 2000;6(11):1235-1240.
29. Opferman JT, Iwasaki H, Ong CC, et al. Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science. 2005;307(5712):1101- 1104.
30. Liu Y, Elf SE, Miyata Y, et al. p53 regulates hematopoietic stem cell quiescence. Cell Stem Cell. 2009;4(1):37-48.
31. Guo Y, Niu C, Breslin P, et al. c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Blood. 2009;114(10):2097-2106.
32. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13(12):1501-1512.
33. Rangarajan A, Talora C, Okuyama R, et al. Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 2001;20(13):3427-3436.
34. Kozar K, Ciemerych MA, Rebel VI, et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell. 2004;118(4):477-491.
35. Malumbres M, Sotillo R, Santamaria D, et al. Mammalian cells cycle without the D-type cyclin-dependent kinases cdk4 and cdk6. Cell. 2004;118(4):493-504. (Pubitemid 39485668)
36. Kim I, Saunders TL, Morrison SJ. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell. 2007;130(3):470-483.
37. Kumano K, Chiba S, Kunisato A, et al. Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. Immunity. 2003;18(5):699-711.
38. Maillard I, Koch U, Dumortier A, et al. Canonical notch signaling is dispensible for the maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2008;2(4):356-366.
39. De Smedt M, Reynvoet K, Kerre T, et al. Active form of Notch imposes T cell fate in human progenitor cells. J Immunol. 2002;169(6):3021-3029. (Pubitemid 35013145)
40. Pui JC, Allman D, Xu L, et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity. 1999;11(3):299-308.
41. Han H, Tanigaki K, Yamamoto N, et al. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol. 2002;14(6):637-645.
42. Rao SS, O'Neil J, Liberator CD, et al. Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia. Cancer Res. 2009;69(7):3060-3068.
43. Yokota T, Matsuzaki Y, Miyazawa K, Zindy F, Roussel MF, Sakai T. Histone deacetylase inhibitors activate Ink4d gene through Sp1 site in its promoter. Oncogene. 2004;23(31):5340-5349. (Pubitemid 39005809)
44. Ocker M, Schneider-Stock R. Histone deacetylase inhbitors: signaling towards p21Cip1/Waf1. Int J Biochem Cell Biol. 2007;39(7-8):1367-1374.