c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors

Blood

Volumn 114, Issue 10, 2009, Pages 2097-2106

  Guo, Yinshi ^a   Niu, Chao ^b   Breslin, Peter ^a,c   Tang, Minghui ^a   Zhang, Shubin ^a   Wei, Wei ^a   Kini, Ameet R ^a   Paner, Gladell P ^a   Alkan, Serhan ^a   Morris, Stephan W ^b   Diaz, Manuel ^a   Stiff, Patrick J ^a   Zhang, Jiwang ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; ERYTHROCYTE; ERYTHROID CELL; GRANULOCYTE; HEMATOPOIETIC STEM CELL; LEUKOPENIA; MACROPHAGE; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; ONCOGENE C MYC; POLYPLOIDY; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTOSIS; ANIMAL; CELL SIZE; CYTOLOGY; ERYTHROID PRECURSOR CELL; GENETICS; MEGAKARYOBLAST; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; PLOIDY; THROMBOCYTOPOIESIS;

MYC PROTEIN; MYC PROTEIN, MOUSE;

ANEMIA; ANIMALS; B-LYMPHOCYTES; BLOOD PLATELETS; BONE MARROW; CELL DIFFERENTIATION; CELL SIZE; ERYTHROCYTES; ERYTHROID PRECURSOR CELLS; GRANULOCYTES; LEUKOPENIA; MACROPHAGES; MEGAKARYOCYTE PROGENITOR CELLS; MEGAKARYOCYTES; MICE; MICE, KNOCKOUT; PLOIDIES; PROTO-ONCOGENE PROTEINS C-MYC; T-LYMPHOCYTES; THROMBOCYTOSIS; THROMBOPOIESIS;

EID: 70349246859     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-01-197947     Document Type: Article

References (50)

1. Shizuru JA, Negrin RS, Weissman IL. Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med. 2005;56:509-538.
2. Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132:631-644. (Pubitemid 351260057)
3. Adhikary S, Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol. 2005;6:635-645. (Pubitemid 41081267)
4. de Alboran IM, O'Hagan RC, Gärtner F, et al. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 2001;14:45-55. (Pubitemid 32144686)
5. Hoffman B, Amanullah A, Shafarenko M, Liebermann DA. The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene. 2002;21:3414-3421. (Pubitemid 34587713)
6. Dubois NC, Adolphe C, Ehninger A, Wang RA, Robertson EJ, Trumpp A. Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function. Development. 2008;135:2455-2465.
7. Murphy MJ, Wilson A, Trumpp A. More than just proliferation: Myc function in stem cells. Trends Cell Biol. 2005;15:128-137. (Pubitemid 40332535)
8. Wilson A, Murphy MJ, Oskarsson T, et al. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev. 2004;18:2747-2763. (Pubitemid 39507768)
9. Laurenti E, Varnum-Finney B, Wilson A, et al. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell. 2008;3:611-624.
10. Baena E, Ortiz M, Martinez AC, Moreno de Alboran I. c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin(-)Sca-1(+)c-Kit(-) cell generation through p21. Exp Hematol. 2007;35:1333-1343. (Pubitemid 47302585)
11. Kuhn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995;269:1427-1429.
12. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425:836-841. (Pubitemid 37351467)
13. Zhang J, Grindley JC, Yin T, et al. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature. 2006;441:518-522. (Pubitemid 44050154)
14. Mercher T, Cornejo MG, Sears C, et al. Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell. 2008;3:314-326.
15. Cairo S, De Falco F, Pizzo M, Salomoni P, Pandolfi PP, Meroni G. PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Oncogene. 2005;24:2195-2203. (Pubitemid 40516586)
16. Schreiner S, Birke M, García-Cuéllar MP, Zilles O, Greil J, Slany RK. MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation. Cancer Res. 2001;61:6480-6486. (Pubitemid 32783255)
17. Sawyers CL, Callahan W, Witte ON. Dominant negative MYC blocks transformation by ABL oncogenes. Cell. 1992;70:901-910.
18. Luo H, Li Q, O'Neal J, Kreisel F, Le Beau MM, Tomasson MH. c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations. Blood. 2005;106:2452-2461. (Pubitemid 41510820)
19. Smith DP, Bath ML, Harris AW, Cory S. T-cell lymphomas mask slower developing B-lymphoid and myeloid tumours in transgenic mice with broad haemopoietic expression of MYC. Oncogene. 2005;24:3544-3553. (Pubitemid 40756224)
20. Langebrake C, Creutzig U, Reinhardt D. Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts. Klin Padiatr. 2005;217:126-134. (Pubitemid 40705232)
21. Wanzel M, Herold S, Eilers M. Transcriptional repression by Myc. Trends Cell Biol. 2003;13:146-150.
22. Amati B, Alevizopoulos K, Vlach J. Myc and the cell cycle. Front Biosci. 1998;3:250-268.
23. Mateyak MK, Obaya AJ, Adachi S, Sedivy JM. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ. 1997;8:1039-1048. (Pubitemid 27433292)
24. He C, Hu H, Braren R, et al. c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo. Development. 2008;135:2467-2477.
25. Douglas NC, Jacobs H, Bothwell AL, Hayday AC. Defining the specific physiological requirements for c-Myc in T cell development. Nat Immunol. 2001;2:307-315. (Pubitemid 33706341)
26. Bettess MD, Dubois N, Murphy MJ, et al. c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium. Mol Cell Biol. 2005;25:7868-7878. (Pubitemid 41170145)
27. Baena E, Gandarilla A, Vallesphino M, et al. c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver. Proc Natl Acad Sci U S A. 2005;102:7286-7291. (Pubitemid 40696371)
28. Oskarsson T, Essers MA, Dubois N, et al. Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes Dev. 2006;20:2024-2029. (Pubitemid 44157454)
29. Habib T, Park H, Tsang M, et al. Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol. 2007;179:717-731. (Pubitemid 350146257)
30. Koster MI, Huntzinger KA, Roop DR. Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation. J Investig Dermatol Symp Proc. 2002;7:41-45.
31. Janz S. Uncovering MYC's full oncogenic potential in the hematopoietic system. Oncogene. 2005;24:3541-3543. (Pubitemid 40756223)
32. Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 1999;13:2658-2669.
33. Vousden KH. Switching from life to death: the Miz-ing link between Myc and p53. Cancer Cell. 2002;2:351-352.
34. Kirsch IR, Bertness V, Silver J, Hollis GF. Regulated expression of the c-myb and c-myc oncogenes during erythroid differentiation. J Cell Biochem. 1986;32:11-21.
35. Brewer G. Regulation of c-myc mRNA decay in vitro by a phorbol ester-inducible, ribosome-associated component in differentiating megakaryoblasts. J Biol Chem. 2000;275:33336-33345. (Pubitemid 30808542)
36. Skoda RC, Tsai SF, Orkin SH, Leder P. Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. J Exp Med. 1995;181:1603-1613
37. Thompson A, Zhang Y, Kamen D, Jackson CW, Cardiff RD, Ravid K. Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization. J Biol Chem. 1996;271:22976-22982. (Pubitemid 26314727)
38. Kuhl C, Atzberger A, Iborra F, Nieswandt B, Porcher C, Vyas P. GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1. Mol Cell Biol. 2005;25:8592-8606. (Pubitemid 41369179)
39. Huang Z, Richmond TD, Muntean AG, Barber DL, Weiss MJ, Crispino JD. STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice. J Clin Invest. 2007;117:3890-3899. (Pubitemid 350224098)
40. Iwasaki H, Mizuno S, Wells RA, Cantor AB, Watanabe S, Akashi K. GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/ erythrocyte lineages. Immunity. 2003;19:451-462. (Pubitemid 37153420)
41. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997;16:3965-3973. (Pubitemid 27281012)
42. Chang AN, Cantor AS, Fujiwara Y, et al. GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A. 2002;99:9237-9242. (Pubitemid 34764597)
43. Bouilloux F, Juban G, Cohet N, et al. EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation. Blood. 2008;112:576-584.
44. Kostyak JC, Naik UP. Megakaryopoiesis: transcriptional insights into megakaryocyte maturation. Front Biosci. 2007;12:2050-2062.
45. Carpinelli MR, Hilton DJ, Metcalf P, et al. Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A. 2004;101:6553-6558.
46. Sandberg ML, Sutton SE, Pletcher MT, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8:153-166. (Pubitemid 40197733)
47. Cogswell JP, Cogswell PC, Kuehl WM, et al. Mechanism of c-myc regulation by c-Myb in different cell lineages. Mol Cell Biol. 1993;13:2858-2869. (Pubitemid 23133957)
48. Kaushansky K, Broudy VC, Lin N, et al. Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci U S A. 1995;92:3234-3238.
49. Yoshihara H, Arai F, Hosokawa K, et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell. 2007;1:685-697. (Pubitemid 350215333)
50. Qian H, Buza-Vidas N, Hyland CD, et al. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell. 2007;1:671-684. (Pubitemid 350215331)