Increased delivery of TAT across an endothelial monolayer following ischemic injury

Neuroscience Letters

Volumn 486, Issue 1, 2010, Pages 1-4

  Simon, Melissa J ^a   Kang, Woo Hyeun ^a   Gao, Shan ^a   Banta, Scott ^a   Morrison, Barclay ^a  

^a Columbia University ^*  (United States)

Author keywords

Cell penetrating peptide; Endothelial barrier; Ischemia; TAT peptide

Indexed keywords

GLUCOSE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; OXYGEN; TRANSACTIVATOR PROTEIN;

ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN HYPOXIA; BRAIN ISCHEMIA; CELL CULTURE; ELECTRIC RESISTANCE; ENDOTHELIUM; ENDOTHELIUM CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; CELL LINE; CELLS, CULTURED; ELECTRIC IMPEDANCE; ENDOTHELIUM, VASCULAR; MICE; PHARMACEUTICAL VEHICLES; RATS; RATS, SPRAGUE-DAWLEY; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 77957928403     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.09.029     Document Type: Article

References (31)

1. Albayrak S., Zhao Q., Siesjo B.K., Smith M.L. Effect of transient focal ischemia on blood-brain barrier permeability in the rat: correlation to cell injury. Acta Neuropathol. 1997, 94:158-163.
2. Baskaya M.K., Rao A.M., Dogan A., Donaldson D., Dempsey R.J. The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neurosci. Lett. 1997, 226:33-36.
3. Belayev L., Busto R., Zhao W., Ginsberg M.D. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res. 1996, 739:88-96.
4. Brown R.C., Morris A.P., O'Neil R.G. Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells. Brain Res. 2007, 1130:17-30.
5. Cai S.R., Xu G., Becker-Hapak M., Ma M., Dowdy S.F., McLeod H.L. The kinetics and tissue distribution of protein transduction in mice. Eur. J. Pharm. Sci. 2006, 27:311-319.
6. Cao G., Pei W., Ge H., Liang Q., Luo Y., Sharp F.R., Lu A., Ran R., Graham S.H., Chen J. In vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis. J. Neurosci. 2002, 22:5423-5431.
7. Chang Y.S., Munn L.L., Hillsley M.V., Dull R.O., Yuan J., Lakshminarayanan S., Gardner T.W., Jain R.K., Tarbell J.M. Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties. Microvasc. Res. 2000, 59:265-277.
8. Choi J.J., Wang S., Tung Y.S., Morrison B., Konofagou E.E. Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. Ultrasound Med. Biol. 2009, 36:58-67.
9. de Vries H.E., Blom-Roosemalen M.C., van Oosten M., de Boer A.G., van Berkel T.J., Breimer D.D., Kuiper J. The influence of cytokines on the integrity of the blood-brain barrier in vitro. J. Neuroimmunol. 1996, 64:37-43.
10. Deli M.A., Abraham C.S., Kataoka Y., Niwa M. Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology. Cell Mol. Neurobiol. 2005, 25:59-127.
11. Dobbin J, Crockard H.A., Ross-Russell R. Transient blood-brain barrier permeability following profound temporary global ischaemia: an experimental study using 14C-AIB. J. Cereb. Blood Flow Metab. 1989, 9:71-78.
12. Duncan R., Todd N. Epilepsy and the blood-brain barrier. Br. J. Hosp. Med. 1991, 45:32-34.
13. Fawell S., Seery J., Daikh Y., Moore C., Chen L.L., Pepinsky B., Barsoum J. Tat-mediated delivery of heterologous proteins into cells. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:664-668.
14. Gao S., Simon M.J., Morrison B., Banta S. Bifunctional chimeric fusion proteins engineered for DNA delivery: optimization of the protein to DNA ratio. Biochim. Biophys. Acta 2009, 1790:198-207.
15. Kaur C., Ling E.A. Blood brain barrier in hypoxic-ischemic conditions. Curr. Neurovasc. Res. 2008, 5:71-81.
16. Kilic E., Dietz G.P., Hermann D.M., Bahr M. Intravenous TAT-Bcl-Xl is protective after middle cerebral artery occlusion in mice. Ann. Neurol. 2002, 52:617-622.
17. Kilic U., Kilic E., Dietz G.P., Bahr M. Intravenous TAT-GDNF is protective after focal cerebral ischemia in mice. Stroke 2003, 34:1304-1310.
18. Koto T., Takubo K., Ishida S., Shinoda H., Inoue M., Tsubota K., Okada Y., Ikeda E. Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells. Am. J. Pathol. 2007, 170:1389-1397.
19. Li G., Simon M.J., Cancel L.M., Shi Z.D., Ji X., Tarbell J.M., Morrison B., Fu B.M. Permeability of endothelial and astrocyte cocultures: in vitro blood-brain barrier models for drug delivery studies. Ann. Biomed. Eng. 2010, 38:2499-2511.
20. Liu X.M., Pei D.S., Guan Q.H., Sun Y.F., Wang X.T., Zhang Q.X., Zhang G.Y. Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways. J. Biol. Chem. 2006, 281:17432-17445.
21. Mark K.S., Davis T.P. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Am. J. Physiol. Heart Circ. Physiol. 2002, 282:H1485-1494.
22. Omidi Y., Campbell L., Barar J., Connell D., Akhtar S., Gumbleton M. Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies. Brain Res. 2003, 990:95-112.
23. Patel M.M, Goyal B.R., Bhadada S.V., Bhatt J.S., Amin A.F. Getting into the brain: approaches to enhance brain drug delivery. CNS Drugs 2009, 23:35-58.
24. Persidsky Y., Ramirez S.H., Haorah J., Kanmogne G.D. Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J. Neuroimmune Pharmacol. 2006, 1:223-236.
25. Preston E., Sutherland G., Finsten A. Three openings of the blood-brain barrier produced by forebrain ischemia in the rat. Neurosci. Lett. 1993, 149:75-78.
26. Simon M.J., Gao S., Kang W.H., Banta S., Morrison B. TAT-mediated intracellular protein delivery to primary brain cells is dependent on glycosaminoglycan expression. Biotechnol. Bioeng. 2009, 104:10-19.
27. M.J. Simon, W.H. Kang, S. Gao, S. Banta, B. Morrison 3rd., TAT is not capable of transcellular delivery across an intact endothelial monolayer in vitro, Ann. Biomed. Eng., in press, doi:10.1007/s10439-010-0144-x.
28. Yang T.T., Cheng L., Kain S.R. Optimized codon usage and chromophore mutations provide enhanced sensitivity with the green fluorescent protein. Nucleic acids Res. 1996, 24:4592-4593.
29. Yeh W.L., Lu D.Y., Lin C.J., Liou H.C., Fu W.M. Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression. Mol. Pharmacol. 2007, 72:440-449.
30. Yin W., Cao G., Johnnides M.J., Signore A.P., Luo Y., Hickey R.W., Chen J. TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic-ischemic brain injury via inhibition of caspases and AIF. Neurobiol. Dis. 2006, 21:358-371.
31. Zhu D., Wang Y., Singh I., Bell R.D., Deane R., Zhong Z., Sagare A., Winkler E.A., Zlokovic B.V. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood 2010, 115:4963-4972.