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Volumn 39, Issue 1, 2011, Pages 394-401

TAT is not capable of transcellular delivery across an intact endothelial monolayer in vitro

Author keywords

Cell penetrating peptide; Endothelial barrier; TAT peptide; Transcellular delivery

Indexed keywords

BLOOD-BRAIN BARRIER; BRAIN PARENCHYMA; CELL INTEGRITY; CELL-PENETRATING PEPTIDE; DELIVERY VEHICLE; ELECTRICAL RESISTANCES; ENDOTHELIAL BARRIERS; FUSION PROTEINS; GREEN FLUORESCENT PROTEIN; IN-VITRO; POTENTIAL SOLUTIONS; TAT PEPTIDE; TIGHT JUNCTIONS; TRANSCELLULAR DELIVERY; ZONA OCCLUDENS;

EID: 78650915189     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-010-0144-x     Document Type: Article
Times cited : (29)

References (43)
  • 1
    • 0032519737 scopus 로고    scopus 로고
    • Central nervous system endothelium in neuroinflammatory, neuroinfectious, and neurodegenerative disease
    • DOI 10.1002/(SICI)1097-4547(19980215)51:4<423::AID-JNR2>3.0.CO;2-E
    • AV Andjelkovic JS Pachter 1998 Central nervous system endothelium in neuroinflammatory, neuroinfectious, and neurodegenerative disease J. Neurosci. Res. 51 423 430 1:CAS:528:DyaK1cXhtlWltr4%3D 10.1002/(SICI)1097-4547(19980215) 51:4<423::AID-JNR2>3.0.CO;2-E 9514196 (Pubitemid 28106703)
    • (1998) Journal of Neuroscience Research , vol.51 , Issue.4 , pp. 423-430
    • Andjelkovic, A.V.1    Pachter, J.S.2
  • 2
    • 0141816588 scopus 로고    scopus 로고
    • HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells
    • DOI 10.1002/jnr.10762
    • IE Andras H Pu MA Deli A Nath B Hennig M Toborek 2003 Hiv-1 tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells J. Neurosci. Res. 74 255 265 1:CAS:528:DC%2BD3sXotVWgt7Y%3D 10.1002/jnr.10762 14515355 (Pubitemid 37193712)
    • (2003) Journal of Neuroscience Research , vol.74 , Issue.2 , pp. 255-265
    • Andras, I.E.1    Pu, H.2    Deli, M.A.3    Nath, A.4    Hennig, B.5    Toborek, M.6
  • 3
    • 0035863869 scopus 로고    scopus 로고
    • Hiv-1 tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment
    • 1:CAS:528:DC%2BD3MXlvVWlug%3D%3D 11145723
    • M Arese C Ferrandi L Primo G Camussi F Bussolino 2001 Hiv-1 tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment J. Immunol. 166 1380 1388 1:CAS:528:DC%2BD3MXlvVWlug%3D%3D 11145723
    • (2001) J. Immunol. , vol.166 , pp. 1380-1388
    • Arese, M.1    Ferrandi, C.2    Primo, L.3    Camussi, G.4    Bussolino, F.5
  • 4
    • 0343247794 scopus 로고    scopus 로고
    • The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats
    • DOI 10.1016/S0304-3940(97)00239-5, PII S0304394097002395
    • MK Baskaya AM Rao A Dogan D Donaldson RJ Dempsey 1997 The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats Neurosci. Lett. 226 33 36 1:CAS:528:DyaK2sXjtFGqsb0%3D 10.1016/S0304-3940(97)00239-5 9153635 (Pubitemid 27190398)
    • (1997) Neuroscience Letters , vol.226 , Issue.1 , pp. 33-36
    • Baskaya, M.K.1    Rao, A.M.2    Dogan, A.3    Donaldson, D.4    Dempsey, R.J.5
  • 5
    • 33845966079 scopus 로고    scopus 로고
    • Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells
    • DOI 10.1016/j.brainres.2006.10.083, PII S0006899306031660
    • RC Brown AP Morris RG O'Neil 2007 Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells Brain Res. 1130 17 30 1:CAS:528:DC%2BD2sXls1WqtA%3D%3D 10.1016/j.brainres.2006. 10.083 17169347 (Pubitemid 46053886)
    • (2007) Brain Research , vol.1130 , Issue.1 , pp. 17-30
    • Brown, R.C.1    Morris, A.P.2    O'Neil, R.G.3
  • 6
    • 31344439465 scopus 로고    scopus 로고
    • The kinetics and tissue distribution of protein transduction in mice
    • DOI 10.1016/j.ejps.2005.10.011, PII S092809870500309X
    • SR Cai G Xu M Becker-Hapak M Ma SF Dowdy HL McLeod 2006 The kinetics and tissue distribution of protein transduction in mice Eur. J. Pharm. Sci. 27 311 319 1:CAS:528:DC%2BD28XotVemsA%3D%3D 10.1016/j.ejps.2005.10.011 16376528 (Pubitemid 43143256)
    • (2006) European Journal of Pharmaceutical Sciences , vol.27 , Issue.4 , pp. 311-319
    • Cai, S.-R.1    Xu, G.2    Becker-Hapak, M.3    Ma, M.4    Dowdy, S.F.5    McLeod, H.L.6
  • 7
    • 0036663014 scopus 로고    scopus 로고
    • In vivo delivery of a bcl-xl fusion protein containing the tat protein transduction domain protects against ischemic brain injury and neuronal apoptosis
    • 1:CAS:528:DC%2BD38XltF2msbo%3D 12097494
    • G Cao W Pei H Ge Q Liang Y Luo FR Sharp A Lu R Ran SH Graham J Chen 2002 In vivo delivery of a bcl-xl fusion protein containing the tat protein transduction domain protects against ischemic brain injury and neuronal apoptosis J. Neurosci. 22 5423 5431 1:CAS:528:DC%2BD38XltF2msbo%3D 12097494
    • (2002) J. Neurosci. , vol.22 , pp. 5423-5431
    • Cao, G.1    Pei, W.2    Ge, H.3    Liang, Q.4    Luo, Y.5    Sharp, F.R.6    Lu, A.7    Ran, R.8    Graham, S.H.9    Chen, J.10
  • 9
    • 17444406065 scopus 로고    scopus 로고
    • Permeability studies on in vitro blood-brain barrier models: Physiology, pathology, and pharmacology
    • DOI 10.1007/s10571-004-1377-8
    • MA Deli CS Abraham Y Kataoka M Niwa 2005 Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology Cell. Mol. Neurobiol. 25 59 127 10.1007/s10571-004-1377-8 15962509 (Pubitemid 40558585)
    • (2005) Cellular and Molecular Neurobiology , vol.25 , Issue.1 , pp. 59-127
    • Deli, M.A.1    Abraham, C.S.2    Kataoka, Y.3    Niwa, M.4
  • 10
    • 5644276383 scopus 로고    scopus 로고
    • Delivery of bioactive molecules into the cell: The Trojan horse approach
    • DOI 10.1016/j.mcn.2004.03.005, PII S1044743104000715
    • GP Dietz M Bahr 2004 Delivery of bioactive molecules into the cell: the Trojan horse approach Mol. Cell. Neurosci. 27 85 131 1:CAS:528: DC%2BD2cXos1Kksb4%3D 10.1016/j.mcn.2004.03.005 15485768 (Pubitemid 39370094)
    • (2004) Molecular and Cellular Neuroscience , vol.27 , Issue.2 , pp. 85-131
    • Dietz, G.P.H.1    Bahr, M.2
  • 11
    • 0026053833 scopus 로고
    • Epilepsy and the blood-brain barrier
    • 1:STN:280:DyaK3M7otleitw%3D%3D 2009437
    • R Duncan N Todd 1991 Epilepsy and the blood-brain barrier Br. J. Hosp. Med. 45 32 34 1:STN:280:DyaK3M7otleitw%3D%3D 2009437
    • (1991) Br. J. Hosp. Med. , vol.45 , pp. 32-34
    • Duncan, R.1    Todd, N.2
  • 12
    • 0028054797 scopus 로고
    • Tat-mediated delivery of heterologous proteins into cells
    • 1:CAS:528:DyaK2cXhslegsbs%3D 10.1073/pnas.91.2.664 8290579
    • S Fawell J Seery Y Daikh C Moore LL Chen B Pepinsky J Barsoum 1994 Tat-mediated delivery of heterologous proteins into cells Proc. Natl Acad. Sci. USA 91 664 668 1:CAS:528:DyaK2cXhslegsbs%3D 10.1073/pnas.91.2.664 8290579
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 664-668
    • Fawell, S.1    Seery, J.2    Daikh, Y.3    Moore, C.4    Chen, L.L.5    Pepinsky, B.6    Barsoum, J.7
  • 13
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • DOI 10.1016/0092-8674(88)90263-2
    • AD Frankel CO Pabo 1988 Cellular uptake of the tat protein from human immunodeficiency virus Cell 55 1189 1193 1:CAS:528:DyaL1MXlsFOnsA%3D%3D 10.1016/0092-8674(88)90263-2 2849510 (Pubitemid 19020071)
    • (1988) Cell , vol.55 , Issue.6 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 14
    • 60249085704 scopus 로고    scopus 로고
    • Bifunctional chimeric fusion proteins engineered for DNA delivery: Optimization of the protein to DNA ratio
    • 1:CAS:528:DC%2BD1MXit1Oit70%3D 19402206
    • S Gao MJ Simon B Morrison III S Banta 2009 Bifunctional chimeric fusion proteins engineered for DNA delivery: optimization of the protein to DNA ratio Biochim. Biophys. Acta 1790 198 207 1:CAS:528:DC%2BD1MXit1Oit70%3D 19402206
    • (2009) Biochim. Biophys. Acta , vol.1790 , pp. 198-207
    • Gao, S.1    Simon, M.J.2    Morrison Iii, B.3    Banta, S.4
  • 15
    • 0024448151 scopus 로고
    • Calculation of protein extinction coefficients from amino acid sequence data
    • 1:CAS:528:DyaL1MXmt1ygt7Y%3D 10.1016/0003-2697(89)90602-7 2610349
    • SC Gill PH von Hippel 1989 Calculation of protein extinction coefficients from amino acid sequence data Anal. Biochem. 182 319 326 1:CAS:528: DyaL1MXmt1ygt7Y%3D 10.1016/0003-2697(89)90602-7 2610349
    • (1989) Anal. Biochem. , vol.182 , pp. 319-326
    • Gill, S.C.1    Von Hippel, P.H.2
  • 16
    • 0024209811 scopus 로고
    • Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein
    • DOI 10.1016/0092-8674(88)90262-0
    • M Green PM Loewenstein 1988 Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein Cell 55 1179 1188 1:CAS:528:DyaL1MXhtlSksr0%3D 10.1016/0092-8674(88)90262-0 2849509 (Pubitemid 19020070)
    • (1988) Cell , vol.55 , Issue.6 , pp. 1179-1188
    • Green, M.1    Loewenstein, P.M.2
  • 17
    • 44349096287 scopus 로고    scopus 로고
    • Hypertension and Cerebrovascular Dysfunction
    • DOI 10.1016/j.cmet.2008.03.010, PII S1550413108000818
    • C Iadecola RL Davisson 2008 Hypertension and cerebrovascular dysfunction Cell Metab. 7 476 484 1:CAS:528:DC%2BD1cXnsVCktbY%3D 10.1016/j.cmet.2008.03.010 18522829 (Pubitemid 351729202)
    • (2008) Cell Metabolism , vol.7 , Issue.6 , pp. 476-484
    • Iadecola, C.1    Davisson, R.L.2
  • 18
    • 39749120467 scopus 로고    scopus 로고
    • Blood brain barrier in hypoxic-ischemic conditions
    • DOI 10.2174/156720208783565645
    • C Kaur EA Ling 2008 Blood brain barrier in hypoxic-ischemic conditions Curr. Neurovasc. Res. 5 71 81 1:CAS:528:DC%2BD1cXlslelurY%3D 10.2174/156720208783565645 18289024 (Pubitemid 351302657)
    • (2008) Current Neurovascular Research , vol.5 , Issue.1 , pp. 71-81
    • Kaur, C.1    Ling, E.A.2
  • 19
    • 0036829818 scopus 로고    scopus 로고
    • L is protective after middle cerebral artery occlusion in mice
    • DOI 10.1002/ana.10356
    • E Kilic GP Dietz DM Hermann M Bahr 2002 Intravenous tat-bcl-xl is protective after middle cerebral artery occlusion in mice Ann. Neurol. 52 617 622 1:CAS:528:DC%2BD38XovFKkt7w%3D 10.1002/ana.10356 12402259 (Pubitemid 35246865)
    • (2002) Annals of Neurology , vol.52 , Issue.5 , pp. 617-622
    • Kilic, E.1    Dietz, G.P.H.2    Hermann, D.M.3    Bahr, M.4
  • 20
    • 0038304351 scopus 로고    scopus 로고
    • Intravenous TAT-GDNF is protective after focal cerebral ischemia in mice
    • DOI 10.1161/01.STR.0000066869.45310.50
    • U Kilic E Kilic GP Dietz M Bahr 2003 Intravenous tat-gdnf is protective after focal cerebral ischemia in mice Stroke 34 1304 1310 10.1161/01.STR. 0000066869.45310.50 12677018 (Pubitemid 36547533)
    • (2003) Stroke , vol.34 , Issue.5 , pp. 1304-1310
    • Kilic, U.1    Kilic, E.2    Dietz, G.P.H.3    Bahr, M.4
  • 21
    • 0037371137 scopus 로고    scopus 로고
    • Hiv-1 tat-mediated apoptosis in human brain microvascular endothelial cells
    • 1:CAS:528:DC%2BD3sXht12htLg%3D 12594291
    • TA Kim HK Avraham YH Koh S Jiang IW Park S Avraham 2003 Hiv-1 tat-mediated apoptosis in human brain microvascular endothelial cells J. Immunol. 170 2629 2637 1:CAS:528:DC%2BD3sXht12htLg%3D 12594291
    • (2003) J. Immunol. , vol.170 , pp. 2629-2637
    • Kim, T.A.1    Avraham, H.K.2    Koh, Y.H.3    Jiang, S.4    Park, I.W.5    Avraham, S.6
  • 22
    • 21144447321 scopus 로고    scopus 로고
    • Transport of surface-modified nanoparticles through cell monolayers
    • DOI 10.1002/cbic.200400174
    • AM Koch F Reynolds HP Merkle R Weissleder L Josephson 2005 Transport of surface-modified nanoparticles through cell monolayers Chembiochem 6 337 345 1:CAS:528:DC%2BD2MXhsVKhurc%3D 10.1002/cbic.200400174 15651046 (Pubitemid 40879747)
    • (2005) ChemBioChem , vol.6 , Issue.2 , pp. 337-345
    • Koch, A.M.1    Reynolds, F.2    Merkle, H.P.3    Weissleder, R.4    Josephson, L.5
  • 23
    • 77955171730 scopus 로고    scopus 로고
    • Permeability of endothelial and astrocyte cocultures: In vitro blood-brain barrier models for drug delivery studies
    • 10.1007/s10439-010-0023-5 20361260
    • G Li MJ Simon LM Cancel ZD Shi X Ji JM Tarbell B Morrison III BM Fu 2010 Permeability of endothelial and astrocyte cocultures: in vitro blood-brain barrier models for drug delivery studies Ann. Biomed. Eng. 38 2499 2511 10.1007/s10439-010-0023-5 20361260
    • (2010) Ann. Biomed. Eng. , vol.38 , pp. 2499-2511
    • Li, G.1    Simon, M.J.2    Cancel, L.M.3    Shi, Z.D.4    Ji, X.5    Tarbell, J.M.6    Morrison Iii, B.7    Fu, B.M.8
  • 24
    • 1642575965 scopus 로고    scopus 로고
    • Passage of cell-penetrating peptides across a human epithelial cell layer in vitro
    • DOI 10.1042/BJ20030760
    • ME Lindgren MM Hallbrink AM Elmquist U Langel 2004 Passage of cell-penetrating peptides across a human epithelial cell layer in vitro Biochem. J. 377 69 76 1:CAS:528:DC%2BD2cXis1Wisg%3D%3D 10.1042/BJ20030760 12968950 (Pubitemid 38114433)
    • (2004) Biochemical Journal , vol.377 , Issue.1 , pp. 69-76
    • Lindgren, M.E.1    Hallbrink, M.M.2    Elmquist, A.M.3    Langel, U.4
  • 25
    • 33745224981 scopus 로고    scopus 로고
    • Neuroprotection of tat-glur6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways
    • 1:CAS:528:DC%2BD28XlvVGktLo%3D 10.1074/jbc.M513490200 16624817
    • XM Liu DS Pei QH Guan YF Sun XT Wang QX Zhang GY Zhang 2006 Neuroprotection of tat-glur6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways J. Biol. Chem. 281 17432 17445 1:CAS:528:DC%2BD28XlvVGktLo%3D 10.1074/jbc.M513490200 16624817
    • (2006) J. Biol. Chem. , vol.281 , pp. 17432-17445
    • Liu, X.M.1    Pei, D.S.2    Guan, Q.H.3    Sun, Y.F.4    Wang, X.T.5    Zhang, Q.X.6    Zhang, G.Y.7
  • 26
    • 33947137771 scopus 로고    scopus 로고
    • Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium
    • DOI 10.1016/j.exer.2006.12.018, PII S0014483507000061
    • L Ma K Kuang RW Smith D Rittenband P Iserovich FP Diecke J Fischbarg 2007 Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium Exp. Eye Res. 84 790 798 1:CAS:528: DC%2BD2sXjtFGrs7g%3D 10.1016/j.exer.2006.12.018 17320078 (Pubitemid 46400643)
    • (2007) Experimental Eye Research , vol.84 , Issue.4 , pp. 790-798
    • Ma, L.1    Kuang, K.2    Smith, R.W.3    Rittenband, D.4    Iserovich, P.5    Diecke, F.P.J.6    Fischbarg, J.7
  • 28
    • 0141894132 scopus 로고    scopus 로고
    • Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies
    • DOI 10.1016/S0006-8993(03)03443-7
    • Y Omidi L Campbell J Barar D Connell S Akhtar M Gumbleton 2003 Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies Brain Res. 990 95 112 1:CAS:528:DC%2BD3sXotVymurk%3D 10.1016/S0006-8993(03)03443-7 14568334 (Pubitemid 37247600)
    • (2003) Brain Research , vol.990 , Issue.1-2 , pp. 95-112
    • Omidi, Y.1    Campbell, L.2    Barar, J.3    Connell, D.4    Akhtar, S.5    Gumbleton, M.6
  • 29
    • 33748452503 scopus 로고    scopus 로고
    • Molecular Trojan horses for blood-brain barrier drug delivery
    • DOI 10.1016/j.coph.2006.06.001, PII S1471489206001172, Anti-infectives/New Technologies
    • WM Pardridge 2006 Molecular Trojan horses for blood-brain barrier drug delivery Curr. Opin. Pharmacol. 6 494 500 1:CAS:528:DC%2BD28XpsVWrsL8%3D 10.1016/j.coph.2006.06.001 16839816 (Pubitemid 44348531)
    • (2006) Current Opinion in Pharmacology , vol.6 , Issue.5 , pp. 494-500
    • Pardridge, W.M.1
  • 30
    • 0036246659 scopus 로고    scopus 로고
    • Mutational analysis of a human immunodeficiency virus type 1 tat protein transduction domain which is required for delivery of an exogenous protein into mammalian cells
    • 1:CAS:528:DC%2BD38XjsFWmsb0%3D 11961273
    • J Park J Ryu KA Kim HJ Lee JH Bahn K Han EY Choi KS Lee HY Kwon SY Choi 2002 Mutational analysis of a human immunodeficiency virus type 1 tat protein transduction domain which is required for delivery of an exogenous protein into mammalian cells J. Gen. Virol. 83 1173 1181 1:CAS:528:DC%2BD38XjsFWmsb0%3D 11961273
    • (2002) J. Gen. Virol. , vol.83 , pp. 1173-1181
    • Park, J.1    Ryu, J.2    Kim, K.A.3    Lee, H.J.4    Bahn, J.H.5    Han, K.6    Choi, E.Y.7    Lee, K.S.8    Kwon, H.Y.9    Choi, S.Y.10
  • 31
    • 25144504434 scopus 로고    scopus 로고
    • HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK1/2 activation
    • DOI 10.1038/sj.jcbfm.9600125, PII 9600125
    • H Pu J Tian IE Andras K Hayashi G Flora B Hennig M Toborek 2005 Hiv-1 tat protein-induced alterations of zo-1 expression are mediated by redox-regulated erk 1/2 activation J. Cereb. Blood Flow. Metab. 25 1325 1335 1:CAS:528:DC%2BD2MXhtFGlt77E 10.1038/sj.jcbfm.9600125 15829913 (Pubitemid 41348734)
    • (2005) Journal of Cerebral Blood Flow and Metabolism , vol.25 , Issue.10 , pp. 1325-1335
    • Pu, H.1    Tian, J.2    Andras, I.E.3    Hayashi, K.4    Flora, G.5    Hennig, B.6    Toborek, M.7
  • 32
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • DOI 10.1126/science.285.5433.1569
    • SR Schwarze A Ho A Vocero-Akbani SF Dowdy 1999 In vivo protein transduction: delivery of a biologically active protein into the mouse Science 285 1569 1572 1:CAS:528:DyaK1MXlslOru78%3D 10.1126/science.285.5433.1569 10477521 (Pubitemid 29420581)
    • (1999) Science , vol.285 , Issue.5433 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 33
    • 0028955870 scopus 로고
    • Shear stress increases hydraulic conductivity of cultured endothelial monolayers
    • 1:CAS:528:DyaK2MXktFantLo%3D 7532373
    • HW Sill YS Chang JR Artman JA Frangos TM Hollis JM Tarbell 1995 Shear stress increases hydraulic conductivity of cultured endothelial monolayers Am. J. Physiol. 268 H535 H543 1:CAS:528:DyaK2MXktFantLo%3D 7532373
    • (1995) Am. J. Physiol. , vol.268
    • Sill, H.W.1    Chang, Y.S.2    Artman, J.R.3    Frangos, J.A.4    Hollis, T.M.5    Tarbell, J.M.6
  • 34
    • 69249146180 scopus 로고    scopus 로고
    • Tat-mediated intracellular protein delivery to primary brain cells is dependent on glycosaminoglycan expression
    • 1:CAS:528:DC%2BD1MXptVGksr8%3D 10.1002/bit.22377 19449355
    • MJ Simon S Gao WH Kang S Banta B Morrison III 2009 Tat-mediated intracellular protein delivery to primary brain cells is dependent on glycosaminoglycan expression Biotechnol. Bioeng. 104 10 19 1:CAS:528: DC%2BD1MXptVGksr8%3D 10.1002/bit.22377 19449355
    • (2009) Biotechnol. Bioeng. , vol.104 , pp. 10-19
    • Simon, M.J.1    Gao, S.2    Kang, W.H.3    Banta, S.4    Morrison Iii, B.5
  • 36
    • 3242674408 scopus 로고    scopus 로고
    • Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models
    • DOI 10.1023/B:PHAM.0000033013.45204.c3
    • R Trehin U Krauss AG Beck-Sickinger HP Merkle HM Nielsen 2004 Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and tat(47-57) through well-differentiated epithelial models Pharm. Res. 21 1248 1256 1:CAS:528:DC%2BD2cXltF2gsbo%3D 10.1023/B:PHAM.0000033013.45204.c3 15290867 (Pubitemid 38954211)
    • (2004) Pharmaceutical Research , vol.21 , Issue.7 , pp. 1248-1256
    • Trehin, R.1    Krauss, U.2    Beck-Sickinger, A.G.3    Merkle, H.P.4    Nielsen, H.M.5
  • 37
    • 0037159193 scopus 로고    scopus 로고
    • Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: Lack of correlation with heparan sulfate
    • DOI 10.1021/bi026097e
    • S Violini V Sharma JL Prior M Dyszlewski D Piwnica-Worms 2002 Evidence for a plasma membrane-mediated permeability barrier to tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate Biochemistry 41 12652 12661 1:CAS:528:DC%2BD38Xntlaisbc%3D 10.1021/bi026097e 12379107 (Pubitemid 35192494)
    • (2002) Biochemistry , vol.41 , Issue.42 , pp. 12652-12661
    • Violini, S.1    Sharma, V.2    Prior, J.L.3    Dyszlewski, M.4    Piwnica-Worms, D.5
  • 38
    • 0030904245 scopus 로고    scopus 로고
    • A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • DOI 10.1074/jbc.272.25.16010
    • E Vives P Brodin B Lebleu 1997 A truncated hiv-1 tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus J. Biol. Chem. 272 16010 16017 1:CAS:528:DyaK2sXktFGnsb4%3D 10.1074/jbc.272.25.16010 9188504 (Pubitemid 27265584)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.25 , pp. 16010-16017
    • Vives, E.1    Brodin, P.2    Lebleu, B.3
  • 39
    • 63249115678 scopus 로고    scopus 로고
    • The blood-brain barrier in brain homeostasis and neurological diseases
    • 1:CAS:528:DC%2BD1MXktFahur0%3D 10.1016/j.bbamem.2008.10.022 19061857
    • N Weiss F Miller S Cazaubon PO Couraud 2009 The blood-brain barrier in brain homeostasis and neurological diseases Biochim. Biophys. Acta 1788 842 857 1:CAS:528:DC%2BD1MXktFahur0%3D 10.1016/j.bbamem.2008.10.022 19061857
    • (2009) Biochim. Biophys. Acta , vol.1788 , pp. 842-857
    • Weiss, N.1    Miller, F.2    Cazaubon, S.3    Couraud, P.O.4
  • 40
    • 0029909407 scopus 로고    scopus 로고
    • Optimized codon usage and chromophore mutations provide enhanced sensitivity with the green fluorescent protein
    • DOI 10.1093/nar/24.22.4592
    • TT Yang L Cheng SR Kain 1996 Optimized codon usage and chromophore mutations provide enhanced sensitivity with the green fluorescent protein Nucleic Acids Res. 24 4592 4593 1:CAS:528:DyaK28XntlSitbw%3D 10.1093/nar/24.22.4592 8948654 (Pubitemid 26388650)
    • (1996) Nucleic Acids Research , vol.24 , Issue.22 , pp. 4592-4593
    • Yang, T.-T.1    Cheng, L.2    Kain, S.R.3
  • 41
    • 30744434357 scopus 로고    scopus 로고
    • TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic-ischemic brain injury via inhibition of caspases and AIF
    • DOI 10.1016/j.nbd.2005.07.015, PII S0969996105002147
    • W Yin G Cao MJ Johnnides AP Signore Y Luo RW Hickey J Chen 2006 Tat-mediated delivery of bcl-xl protein is neuroprotective against neonatal hypoxic-ischemic brain injury via inhibition of caspases and AIF Neurobiol. Dis. 21 358 371 1:CAS:528:DC%2BD28XmsVGntA%3D%3D 10.1016/j.nbd.2005.07.015 16140540 (Pubitemid 43099859)
    • (2006) Neurobiology of Disease , vol.21 , Issue.2 , pp. 358-371
    • Yin, W.1    Cao, G.2    Johnnides, M.J.3    Signore, A.P.4    Luo, Y.5    Hickey, R.W.6    Chen, J.7
  • 42
    • 77950560732 scopus 로고    scopus 로고
    • Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease
    • 1:CAS:528:DC%2BC3cXltlemurY%3D 10.2353/ajpath.2010.090406 20150433
    • X Yin J Wright T Wall P Grammas 2010 Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease Am. J. Pathol. 176 1600 1606 1:CAS:528:DC%2BC3cXltlemurY%3D 10.2353/ajpath.2010.090406 20150433
    • (2010) Am. J. Pathol. , vol.176 , pp. 1600-1606
    • Yin, X.1    Wright, J.2    Wall, T.3    Grammas, P.4
  • 43
    • 60449088253 scopus 로고    scopus 로고
    • Non-invasive measurement of solute permeability in cerebral microvessels of the rat
    • 1:CAS:528:DC%2BD1MXisFWnsr4%3D 10.1016/j.mvr.2008.08.004 18838082
    • W Yuan Y Lv M Zeng BM Fu 2009 Non-invasive measurement of solute permeability in cerebral microvessels of the rat Microvasc. Res. 77 166 173 1:CAS:528:DC%2BD1MXisFWnsr4%3D 10.1016/j.mvr.2008.08.004 18838082
    • (2009) Microvasc. Res. , vol.77 , pp. 166-173
    • Yuan, W.1    Lv, Y.2    Zeng, M.3    Fu, B.M.4


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