-
1
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri G.D., von Mehren M., Blanke C.D., Van den Abbeele A.D., Eisenberg B., Roberts P.J., Heinrich M.C., Tuveson D.A., Singer S., Janicek M., Fletcher J.A., Silverman S.G., Silberman S.L., Capdeville R., Kiese B., Peng B., Dimitrijevic S., Druker B.J., Corless C., Fletcher C.D., Joensuu H. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N. Engl. J. Med. 2002, 347:472-480.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
von Mehren, M.2
Blanke, C.D.3
Van den Abbeele, A.D.4
Eisenberg, B.5
Roberts, P.J.6
Heinrich, M.C.7
Tuveson, D.A.8
Singer, S.9
Janicek, M.10
Fletcher, J.A.11
Silverman, S.G.12
Silberman, S.L.13
Capdeville, R.14
Kiese, B.15
Peng, B.16
Dimitrijevic, S.17
Druker, B.J.18
Corless, C.19
Fletcher, C.D.20
Joensuu, H.21
more..
-
2
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon D.J., Leyland-Jones B., Shak S., Fuchs H., Paton V., Bajamonde A., Fleming T., Eiermann W., Wolter J., Pegram M., Baselga J., Norton L. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 2001, 344:783-792.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
3
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
Bonner J.A., Harari P.M., Giralt J., Azarnia N., Shin D.M., Cohen R.B., Jones C.U., Sur R., Raben D., Jassem J., Ove R., Kies M.S., Baselga J., Youssoufian H., Amellal N., Rowinsky E.K., Ang K.K. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 2006, 354:567-578.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
Azarnia, N.4
Shin, D.M.5
Cohen, R.B.6
Jones, C.U.7
Sur, R.8
Raben, D.9
Jassem, J.10
Ove, R.11
Kies, M.S.12
Baselga, J.13
Youssoufian, H.14
Amellal, N.15
Rowinsky, E.K.16
Ang, K.K.17
-
4
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D., Humblet Y., Siena S., Khayat D., Bleiberg H., Santoro A., Bets D., Mueser M., Harstrick A., Verslype C., Chau I., Van C.E. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 2004, 351:337-345.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
Bets, D.7
Mueser, M.8
Harstrick, A.9
Verslype, C.10
Chau, I.11
Van, C.E.12
-
5
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd F.A., Rodrigues P.J., Ciuleanu T., Tan E.H., Hirsh V., Thongprasert S., Campos D., Maoleekoonpiroj S., Smylie M., Martins R., Van K.M., Dediu M., Findlay B., Tu D., Johnston D., Bezjak A., Clark G., Santabarbara P., Seymour L. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. 2005, 353:123-132.
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues, P.J.2
Ciuleanu, T.3
Tan, E.H.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
Van, K.M.11
Dediu, M.12
Findlay, B.13
Tu, D.14
Johnston, D.15
Bezjak, A.16
Clark, G.17
Santabarbara, P.18
Seymour, L.19
-
6
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore M.J., Goldstein D., Hamm J., Figer A., Hecht J.R., Gallinger S., HJ Au., Murawa P., Walde D., Wolff R.A., Campos D., Lim R., Ding K., Clark G., Voskoglou-Nomikos T., Ptasynski M., Parulekar W. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 2007, 25:1960-1966.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
Figer, A.4
Hecht, J.R.5
Gallinger, S.6
HJ, A.7
Murawa, P.8
Walde, D.9
Wolff, R.A.10
Campos, D.11
Lim, R.12
Ding, K.13
Clark, G.14
Voskoglou-Nomikos, T.15
Ptasynski, M.16
Parulekar, W.17
-
7
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van C.E., Peeters M., Siena S., Humblet Y., Hendlisz A., Neyns B., Canon J.L., Van Laethem J.L., Maurel J., Richardson G., Wolf M., Amado R.G. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 2007, 25:1658-1664.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1658-1664
-
-
Van, C.E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
Canon, J.L.7
Van Laethem, J.L.8
Maurel, J.9
Richardson, G.10
Wolf, M.11
Amado, R.G.12
-
8
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G., Carducci M., Tomczak P., Dutcher J., Figlin R., Kapoor A., Staroslawska E., Sosman J., McDermott D., Bodrogi I., Kovacevic Z., Lesovoy V., Schmidt-Wolf I.G., Barbarash O., Gokmen E., O'Toole T., Lustgarten S., Moore L., Motzer R.J. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N. Engl. J. Med. 2007, 356:2271-2281.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
Kovacevic, Z.11
Lesovoy, V.12
Schmidt-Wolf, I.G.13
Barbarash, O.14
Gokmen, E.15
O'Toole, T.16
Lustgarten, S.17
Moore, L.18
Motzer, R.J.19
-
9
-
-
85013312416
-
Tumor angiogenesis: therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 1971, 285:1182-1186.
-
(1971)
N. Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
10
-
-
0025141337
-
What is the evidence that tumors are angiogenesis dependent?
-
Folkman J. What is the evidence that tumors are angiogenesis dependent?. J. Natl. Cancer Inst. 1990, 82:4-6.
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 4-6
-
-
Folkman, J.1
-
11
-
-
0033580889
-
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
-
Holash J., Maisonpierre P.C., Compton D., Boland P., Alexander C.R., Zagzag D., Yancopoulos G.D., Wiegand S.J. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999, 284:1994-1998.
-
(1999)
Science
, vol.284
, pp. 1994-1998
-
-
Holash, J.1
Maisonpierre, P.C.2
Compton, D.3
Boland, P.4
Alexander, C.R.5
Zagzag, D.6
Yancopoulos, G.D.7
Wiegand, S.J.8
-
12
-
-
0033067863
-
Matrix-degrading proteases and angiogenesis during development and tumor formation
-
Werb Z., TH Vu., Rinkenberger J.L., Coussens L.M. Matrix-degrading proteases and angiogenesis during development and tumor formation. APMIS 1999, 107:11-18.
-
(1999)
APMIS
, vol.107
, pp. 11-18
-
-
Werb, Z.1
TH, V.2
Rinkenberger, J.L.3
Coussens, L.M.4
-
13
-
-
35349012675
-
Regulation of vascular morphogenesis by Notch signaling
-
Roca C., Adams R.H. Regulation of vascular morphogenesis by Notch signaling. Genes Dev. 2007, 21:2511-2524.
-
(2007)
Genes Dev.
, vol.21
, pp. 2511-2524
-
-
Roca, C.1
Adams, R.H.2
-
14
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
15
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
Bergers G., Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer 2003, 3:401-410.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
16
-
-
0032516078
-
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment
-
Hobbs S.K., Monsky W.L., Yuan F., Roberts W.G., Griffith L., Torchilin V.P., Jain R.K. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. USA 1998, 95:4607-4612.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 4607-4612
-
-
Hobbs, S.K.1
Monsky, W.L.2
Yuan, F.3
Roberts, W.G.4
Griffith, L.5
Torchilin, V.P.6
Jain, R.K.7
-
17
-
-
0032889698
-
Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis
-
Dvorak H.F., Nagy J.A., Feng D., Brown L.F., Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr. Top. Microbiol. Immunol. 1999, 237:97-132.
-
(1999)
Curr. Top. Microbiol. Immunol.
, vol.237
, pp. 97-132
-
-
Dvorak, H.F.1
Nagy, J.A.2
Feng, D.3
Brown, L.F.4
Dvorak, A.M.5
-
18
-
-
0034796595
-
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
-
Jain R.K. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat. Med. 2001, 7:987-989.
-
(2001)
Nat. Med.
, vol.7
, pp. 987-989
-
-
Jain, R.K.1
-
19
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N., Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr. Rev. 1997, 18:4-25.
-
(1997)
Endocr. Rev.
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
20
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol. 2002, 20:4368-4380.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
22
-
-
0035062394
-
The splice variants of vascular endothelial growth factor (VEGF) and their receptors
-
Robinson C.J., Stringer S.E. The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J. Cell Sci. 2001, 114:853-865.
-
(2001)
J. Cell Sci.
, vol.114
, pp. 853-865
-
-
Robinson, C.J.1
Stringer, S.E.2
-
23
-
-
0030614869
-
VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix
-
Poltorak Z., Cohen T., Sivan R., Kandelis Y., Spira G., Vlodavsky I., Keshet E., Neufeld G. VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J. Biol. Chem. 1997, 272:7151-7158.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7151-7158
-
-
Poltorak, Z.1
Cohen, T.2
Sivan, R.3
Kandelis, Y.4
Spira, G.5
Vlodavsky, I.6
Keshet, E.7
Neufeld, G.8
-
24
-
-
0032907687
-
Vascular endothelial growth factor (VEGF) and its receptors
-
Neufeld G., Cohen T., Gengrinovitch S., Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999, 13:9-22.
-
(1999)
FASEB J.
, vol.13
, pp. 9-22
-
-
Neufeld, G.1
Cohen, T.2
Gengrinovitch, S.3
Poltorak, Z.4
-
25
-
-
0029004025
-
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
-
Dvorak H.F., Brown L.F., Detmar M., Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 1995, 146:1029-1039.
-
(1995)
Am. J. Pathol.
, vol.146
, pp. 1029-1039
-
-
Dvorak, H.F.1
Brown, L.F.2
Detmar, M.3
Dvorak, A.M.4
-
26
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood J.M., Bold G., Buchdunger E., Cozens R., Ferrari S., Frei J., Hofmann F., Mestan J., Mett H., O'Reilly T., Persohn E., Rosel J., Schnell C., Stover D., Theuer A., Towbin H., Wenger F., Woods-Cook K., Menrad A., Siemeister G., Schirner M., Thierauch K.H., Schneider M.R., Drevs J., Martiny-Baron G., Totzke F. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000, 60:2178-2189.
-
(2000)
Cancer Res.
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
Cozens, R.4
Ferrari, S.5
Frei, J.6
Hofmann, F.7
Mestan, J.8
Mett, H.9
O'Reilly, T.10
Persohn, E.11
Rosel, J.12
Schnell, C.13
Stover, D.14
Theuer, A.15
Towbin, H.16
Wenger, F.17
Woods-Cook, K.18
Menrad, A.19
Siemeister, G.20
Schirner, M.21
Thierauch, K.H.22
Schneider, M.R.23
Drevs, J.24
Martiny-Baron, G.25
Totzke, F.26
more..
-
27
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel D.B., Laird A.D., Xin X., Louie S.G., Christensen J.G., Li G., Schreck R.E., Abrams T.J., Ngai T.J., Lee L.B., Murray L.J., Carver J., Chan E., Moss K.G., Haznedar J.O., Sukbuntherng J., Blake R.A., Sun L., Tang C., Miller T., Shirazian S., McMahon G., Cherrington J.M. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. 2003, 9:327-337.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
Li, G.6
Schreck, R.E.7
Abrams, T.J.8
Ngai, T.J.9
Lee, L.B.10
Murray, L.J.11
Carver, J.12
Chan, E.13
Moss, K.G.14
Haznedar, J.O.15
Sukbuntherng, J.16
Blake, R.A.17
Sun, L.18
Tang, C.19
Miller, T.20
Shirazian, S.21
McMahon, G.22
Cherrington, J.M.23
more..
-
28
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm S.M., Carter C., Tang L., Wilkie D., McNabola A., Rong H., Chen C., Zhang X., Vincent P., McHugh M., Cao Y., Shujath J., Gawlak S., Eveleigh D., Rowley B., Liu L., Adnane L., Lynch M., Auclair D., Taylor I., Gedrich R., Voznesensky A., Riedl B., Post L.E., Bollag G., Trail P.A. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004, 64:7099-7109.
-
(2004)
Cancer Res.
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
29
-
-
0030856731
-
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
-
Presta L.G., Chen H., O'Connor S.J., Chisholm V., Meng Y.G., Krummen L., Winkler M., Ferrara N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 1997, 57:4593-4599.
-
(1997)
Cancer Res.
, vol.57
, pp. 4593-4599
-
-
Presta, L.G.1
Chen, H.2
O'Connor, S.J.3
Chisholm, V.4
Meng, Y.G.5
Krummen, L.6
Winkler, M.7
Ferrara, N.8
-
30
-
-
0037102369
-
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
-
Wedge S.R., Ogilvie D.J., Dukes M., Kendrew J., Chester R., Jackson J.A., Boffey S.J., Valentine P.J., Curwen J.O., Musgrove H.L., Graham G.A., Hughes G.D., Thomas A.P., Stokes E.S., Curry B., Richmond G.H., Wadsworth P.F., Bigley A.L., Hennequin L.F. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002, 62:4645-4655.
-
(2002)
Cancer Res.
, vol.62
, pp. 4645-4655
-
-
Wedge, S.R.1
Ogilvie, D.J.2
Dukes, M.3
Kendrew, J.4
Chester, R.5
Jackson, J.A.6
Boffey, S.J.7
Valentine, P.J.8
Curwen, J.O.9
Musgrove, H.L.10
Graham, G.A.11
Hughes, G.D.12
Thomas, A.P.13
Stokes, E.S.14
Curry, B.15
Richmond, G.H.16
Wadsworth, P.F.17
Bigley, A.L.18
Hennequin, L.F.19
-
31
-
-
0034648793
-
Vascular-specific growth factors and blood vessel formation
-
Yancopoulos G.D., Davis S., Gale N.W., Rudge J.S., Wiegand S.J., Holash J. Vascular-specific growth factors and blood vessel formation. Nature 2000, 407:242-248.
-
(2000)
Nature
, vol.407
, pp. 242-248
-
-
Yancopoulos, G.D.1
Davis, S.2
Gale, N.W.3
Rudge, J.S.4
Wiegand, S.J.5
Holash, J.6
-
32
-
-
0033588842
-
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
-
Holash J., Wiegand S.J., Yancopoulos G.D. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999, 18:5356-5362.
-
(1999)
Oncogene
, vol.18
, pp. 5356-5362
-
-
Holash, J.1
Wiegand, S.J.2
Yancopoulos, G.D.3
-
33
-
-
0030851764
-
Signaling vascular morphogenesis and maintenance
-
Hanahan D. Signaling vascular morphogenesis and maintenance. Science 1997, 277:48-50.
-
(1997)
Science
, vol.277
, pp. 48-50
-
-
Hanahan, D.1
-
34
-
-
13144254247
-
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2
-
Lin P., Buxton J.A., Acheson A., Radziejewski C., Maisonpierre P.C., Yancopoulos G.D., Channon K.M., Hale L.P., Dewhirst M.W., George S.E., Peters K.G. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. Proc. Natl. Acad. Sci. USA 1998, 95:8829-8834.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8829-8834
-
-
Lin, P.1
Buxton, J.A.2
Acheson, A.3
Radziejewski, C.4
Maisonpierre, P.C.5
Yancopoulos, G.D.6
Channon, K.M.7
Hale, L.P.8
Dewhirst, M.W.9
George, S.E.10
Peters, K.G.11
-
35
-
-
0033168916
-
Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway
-
Siemeister G., Schirner M., Weindel K., Reusch P., Menrad A., Marme D., Martiny-Baron G. Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway. Cancer Res. 1999, 59:3185-3191.
-
(1999)
Cancer Res.
, vol.59
, pp. 3185-3191
-
-
Siemeister, G.1
Schirner, M.2
Weindel, K.3
Reusch, P.4
Menrad, A.5
Marme, D.6
Martiny-Baron, G.7
-
36
-
-
0035255001
-
Differential inhibition of tumor angiogenesis by tie2 and vascular endothelial growth factor receptor-2 dominant-negative receptor mutants
-
Stratmann A., Acker T., Burger A.M., Amann K., Risau W., Plate K.H. Differential inhibition of tumor angiogenesis by tie2 and vascular endothelial growth factor receptor-2 dominant-negative receptor mutants. Int. J. Cancer 2001, 91:273-282.
-
(2001)
Int. J. Cancer
, vol.91
, pp. 273-282
-
-
Stratmann, A.1
Acker, T.2
Burger, A.M.3
Amann, K.4
Risau, W.5
Plate, K.H.6
-
37
-
-
13444249481
-
Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody
-
Popkov M., Jendreyko N., McGavern D.B., Rader C., Barbas C.F. Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody. Cancer Res. 2005, 65:972-981.
-
(2005)
Cancer Res.
, vol.65
, pp. 972-981
-
-
Popkov, M.1
Jendreyko, N.2
McGavern, D.B.3
Rader, C.4
Barbas, C.F.5
-
38
-
-
7944220649
-
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
-
Oliner J., Min H., Leal J., Yu D., Rao S., You E., Tang X., Kim H., Meyer S., Han S.J., Hawkins N., Rosenfeld R., Davy E., Graham K., Jacobsen F., Stevenson S., Ho J., Chen Q., Hartmann T., Michaels M., Kelley M., Li L., Sitney K., Martin F., Sun J.R., Zhang N., Lu J., Estrada J., Kumar R., Coxon A., Kaufman S., Pretorius J., Scully S., Cattley R., Payton M., Coats S., Nguyen L., Desilva B., Ndifor A., Hayward I., Radinsky R., Boone T., Kendall R. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 2004, 6:507-516.
-
(2004)
Cancer Cell
, vol.6
, pp. 507-516
-
-
Oliner, J.1
Min, H.2
Leal, J.3
Yu, D.4
Rao, S.5
You, E.6
Tang, X.7
Kim, H.8
Meyer, S.9
Han, S.J.10
Hawkins, N.11
Rosenfeld, R.12
Davy, E.13
Graham, K.14
Jacobsen, F.15
Stevenson, S.16
Ho, J.17
Chen, Q.18
Hartmann, T.19
Michaels, M.20
Kelley, M.21
Li, L.22
Sitney, K.23
Martin, F.24
Sun, J.R.25
Zhang, N.26
Lu, J.27
Estrada, J.28
Kumar, R.29
Coxon, A.30
Kaufman, S.31
Pretorius, J.32
Scully, S.33
Cattley, R.34
Payton, M.35
Coats, S.36
Nguyen, L.37
Desilva, B.38
Ndifor, A.39
Hayward, I.40
Radinsky, R.41
Boone, T.42
Kendall, R.43
more..
-
39
-
-
33847046849
-
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
-
Hellstrom M., Phng L.K., Hofmann J.J., Wallgard E., Coultas L., Lindblom P., Alva J., Nilsson A.K., Karlsson L., Gaiano N., Yoon K., Rossant J., Iruela-Arispe M.L., Kalen M., Gerhardt H., Betsholtz C. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007, 445:776-780.
-
(2007)
Nature
, vol.445
, pp. 776-780
-
-
Hellstrom, M.1
Phng, L.K.2
Hofmann, J.J.3
Wallgard, E.4
Coultas, L.5
Lindblom, P.6
Alva, J.7
Nilsson, A.K.8
Karlsson, L.9
Gaiano, N.10
Yoon, K.11
Rossant, J.12
Iruela-Arispe, M.L.13
Kalen, M.14
Gerhardt, H.15
Betsholtz, C.16
-
40
-
-
33847635620
-
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
-
Lobov I.B., Renard R.A., Papadopoulos N., Gale N.W., Thurston G., Yancopoulos G.D., Wiegand S.J. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc. Natl. Acad. Sci. USA 2007, 104:3219-3224.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 3219-3224
-
-
Lobov, I.B.1
Renard, R.A.2
Papadopoulos, N.3
Gale, N.W.4
Thurston, G.5
Yancopoulos, G.D.6
Wiegand, S.J.7
-
41
-
-
0036433637
-
Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression
-
Taylor K.L., Henderson A.M., Hughes C.C. Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc. Res. 2002, 64:372-383.
-
(2002)
Microvasc. Res.
, vol.64
, pp. 372-383
-
-
Taylor, K.L.1
Henderson, A.M.2
Hughes, C.C.3
-
42
-
-
53849106782
-
VEGF and delta-notch: interacting signalling pathways in tumour angiogenesis
-
Thurston G., Kitajewski J. VEGF and delta-notch: interacting signalling pathways in tumour angiogenesis. Brit. J. Cancer 2008, 99:1204-1209.
-
(2008)
Brit. J. Cancer
, vol.99
, pp. 1204-1209
-
-
Thurston, G.1
Kitajewski, J.2
-
43
-
-
33845907380
-
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
-
Ridgway J., Zhang G., Wu Y., Stawicki S., Liang W.C., Chanthery Y., Kowalski J., Watts R.J., Callahan C., Kasman I., Singh M., Chien M., Tan C., Hongo J.A., de S.F., Plowman G., Yan M. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006, 444:1083-1087.
-
(2006)
Nature
, vol.444
, pp. 1083-1087
-
-
Ridgway, J.1
Zhang, G.2
Wu, Y.3
Stawicki, S.4
Liang, W.C.5
Chanthery, Y.6
Kowalski, J.7
Watts, R.J.8
Callahan, C.9
Kasman, I.10
Singh, M.11
Chien, M.12
Tan, C.13
Hongo, J.A.14
de, S.F.15
Plowman, G.16
Yan, M.17
-
44
-
-
34247479498
-
Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
-
Scehnet J.S., Jiang W., Kumar S.R., Krasnoperov V., Trindade A., Benedito R., Djokovic D., Borges C., Ley E.J., Duarte A., Gill P.S. Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood 2007, 109:4753-4760.
-
(2007)
Blood
, vol.109
, pp. 4753-4760
-
-
Scehnet, J.S.1
Jiang, W.2
Kumar, S.R.3
Krasnoperov, V.4
Trindade, A.5
Benedito, R.6
Djokovic, D.7
Borges, C.8
Ley, E.J.9
Duarte, A.10
Gill, P.S.11
-
45
-
-
33845877157
-
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
-
Noguera-Troise I., Daly C., Papadopoulos N.J., Coetzee S., Boland P., Gale N.W., Lin H.C., Yancopoulos G.D., Thurston G. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006, 444:1032-1037.
-
(2006)
Nature
, vol.444
, pp. 1032-1037
-
-
Noguera-Troise, I.1
Daly, C.2
Papadopoulos, N.J.3
Coetzee, S.4
Boland, P.5
Gale, N.W.6
Lin, H.C.7
Yancopoulos, G.D.8
Thurston, G.9
-
46
-
-
2942670180
-
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
-
Ostman A. PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev. 2004, 15:275-286.
-
(2004)
Cytokine Growth Factor Rev.
, vol.15
, pp. 275-286
-
-
Ostman, A.1
-
47
-
-
0345798150
-
Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
-
Abramsson A., Lindblom P., Betsholtz C. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J. Clin. Invest 2003, 112:1142-1151.
-
(2003)
J. Clin. Invest
, vol.112
, pp. 1142-1151
-
-
Abramsson, A.1
Lindblom, P.2
Betsholtz, C.3
-
48
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G., Song S., Meyer-Morse N., Bergsland E., Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest 2003, 111:1287-1295.
-
(2003)
J. Clin. Invest
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
-
49
-
-
0036033456
-
Vessel co-option: how tumors obtain blood supply in the absence of sprouting angiogenesis
-
Leenders W.P., Kusters B., de Waal R.M. Vessel co-option: how tumors obtain blood supply in the absence of sprouting angiogenesis. Endothelium 2002, 9:83-87.
-
(2002)
Endothelium
, vol.9
, pp. 83-87
-
-
Leenders, W.P.1
Kusters, B.2
de Waal, R.M.3
-
50
-
-
0037081299
-
Vascular endothelial growth factor-A(165) induces progression of melanoma brain metastases without induction of sprouting angiogenesis
-
Kusters B., Leenders W.P., Wesseling P., Smits D., Verrijp K., Ruiter D.J., Peters J.P., Der Kogel A.J., de Waal R.M. Vascular endothelial growth factor-A(165) induces progression of melanoma brain metastases without induction of sprouting angiogenesis. Cancer Res. 2002, 62:341-345.
-
(2002)
Cancer Res.
, vol.62
, pp. 341-345
-
-
Kusters, B.1
Leenders, W.P.2
Wesseling, P.3
Smits, D.4
Verrijp, K.5
Ruiter, D.J.6
Peters, J.P.7
Der Kogel, A.J.8
de Waal, R.M.9
-
51
-
-
0141816826
-
Differential effects of vascular endothelial growth factor A isoforms in a mouse brain metastasis model of human melanoma
-
Kusters B., de Waal R.M., Wesseling P., Verrijp K., Maass C., Heerschap A., Barentsz J.O., Sweep F., Ruiter D.J., Leenders W.P. Differential effects of vascular endothelial growth factor A isoforms in a mouse brain metastasis model of human melanoma. Cancer Res. 2003, 63:5408-5413.
-
(2003)
Cancer Res.
, vol.63
, pp. 5408-5413
-
-
Kusters, B.1
de Waal, R.M.2
Wesseling, P.3
Verrijp, K.4
Maass, C.5
Heerschap, A.6
Barentsz, J.O.7
Sweep, F.8
Ruiter, D.J.9
Leenders, W.P.10
-
52
-
-
0037648635
-
Vascular endothelial growth factor-A determines detectability of experimental melanoma brain metastasis in GD-DTPA-enhanced MRI
-
Leenders W., Kusters B., Pikkemaat J., Wesseling P., Ruiter D., Heerschap A., Barentsz J., de Waal R.M. Vascular endothelial growth factor-A determines detectability of experimental melanoma brain metastasis in GD-DTPA-enhanced MRI. Int. J. Cancer 2003, 105:437-443.
-
(2003)
Int. J. Cancer
, vol.105
, pp. 437-443
-
-
Leenders, W.1
Kusters, B.2
Pikkemaat, J.3
Wesseling, P.4
Ruiter, D.5
Heerschap, A.6
Barentsz, J.7
de Waal, R.M.8
-
53
-
-
0242637170
-
Targeting angiogenesis: a review of angiogenesis inhibitors in the treatment of lung cancer
-
Sridhar S.S., Shepherd F.A. Targeting angiogenesis: a review of angiogenesis inhibitors in the treatment of lung cancer. Lung Cancer 2003, 42(Suppl. 1):S81-S91.
-
(2003)
Lung Cancer
, vol.42
, Issue.SUPPL. 1
-
-
Sridhar, S.S.1
Shepherd, F.A.2
-
54
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang J.C., Haworth L., Sherry R.M., Hwu P., Schwartzentruber D.J., Topalian S.L., Steinberg S.M., Chen H.X., Rosenberg S.A. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N. Engl. J. Med. 2003, 349:427-434.
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
Hwu, P.4
Schwartzentruber, D.J.5
Topalian, S.L.6
Steinberg, S.M.7
Chen, H.X.8
Rosenberg, S.A.9
-
55
-
-
36849019301
-
Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study
-
Burger R.A., Sill M.W., Monk B.J., Greer B.E., Sorosky J.I. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study. J. Clin. Oncol. 2007, 25:5165-5171.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 5165-5171
-
-
Burger, R.A.1
Sill, M.W.2
Monk, B.J.3
Greer, B.E.4
Sorosky, J.I.5
-
56
-
-
36849056497
-
Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
-
Cannistra S.A., Matulonis U.A., Penson R.T., Hambleton J., Dupont J., Mackey H., Douglas J., Burger R.A., Armstrong D., Wenham R., McGuire W. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J. Clin. Oncol. 2007, 25:5180-5186.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 5180-5186
-
-
Cannistra, S.A.1
Matulonis, U.A.2
Penson, R.T.3
Hambleton, J.4
Dupont, J.5
Mackey, H.6
Douglas, J.7
Burger, R.A.8
Armstrong, D.9
Wenham, R.10
McGuire, W.11
-
57
-
-
20644432867
-
Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer
-
Hurwitz H.I., Fehrenbacher L., Hainsworth J.D., Heim W., Berlin J., Holmgren E., Hambleton J., Novotny W.F., Kabbinavar F. Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer. J. Clin. Oncol. 2005, 23:3502-3508.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 3502-3508
-
-
Hurwitz, H.I.1
Fehrenbacher, L.2
Hainsworth, J.D.3
Heim, W.4
Berlin, J.5
Holmgren, E.6
Hambleton, J.7
Novotny, W.F.8
Kabbinavar, F.9
-
58
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio B.J., Catalano P.J., Meropol N.J., O'Dwyer P.J., Mitchell E.P., Alberts S.R., Schwartz M.A., Benson A.B. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J. Clin. Oncol. 2007, 25:1539-1544.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
O'Dwyer, P.J.4
Mitchell, E.P.5
Alberts, S.R.6
Schwartz, M.A.7
Benson, A.B.8
-
59
-
-
33750344252
-
Bevacizumab in the treatment of metastatic colorectal cancer: safety profile and management of adverse events
-
Hurwitz H., Saini S. Bevacizumab in the treatment of metastatic colorectal cancer: safety profile and management of adverse events. Semin. Oncol. 2006, 33:S26-S34.
-
(2006)
Semin. Oncol.
, vol.33
-
-
Hurwitz, H.1
Saini, S.2
-
60
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A., Gray R., Perry M.C., Brahmer J., Schiller J.H., Dowlati A., Lilenbaum R., Johnson D.H. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N. Engl. J. Med. 2006, 355:2542-2550.
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
61
-
-
20044364346
-
Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
-
Miller K.D., Chap L.I., Holmes F.A., Cobleigh M.A., Marcom P.K., Fehrenbacher L., Dickler M., Overmoyer B.A., Reimann J.D., Sing A.P., Langmuir V., Rugo H.S. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J. Clin. Oncol. 2005, 23:792-799.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 792-799
-
-
Miller, K.D.1
Chap, L.I.2
Holmes, F.A.3
Cobleigh, M.A.4
Marcom, P.K.5
Fehrenbacher, L.6
Dickler, M.7
Overmoyer, B.A.8
Reimann, J.D.9
Sing, A.P.10
Langmuir, V.11
Rugo, H.S.12
-
62
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K., Wang M., Gralow J., Dickler M., Cobleigh M., Perez E.A., Shenkier T., Cella D., Davidson N.E. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med. 2007, 357:2666-2676.
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
Dickler, M.4
Cobleigh, M.5
Perez, E.A.6
Shenkier, T.7
Cella, D.8
Davidson, N.E.9
-
63
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
-
Escudier B., Pluzanska A., Koralewski P., Ravaud A., Bracarda S., Szczylik C., Chevreau C., Filipek M., Melichar B., Bajetta E., Gorbunova V., Bay J.O., Bodrogi I., Jagiello-Gruszfeld A., Moore N. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007, 370:2103-2111.
-
(2007)
Lancet
, vol.370
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
Ravaud, A.4
Bracarda, S.5
Szczylik, C.6
Chevreau, C.7
Filipek, M.8
Melichar, B.9
Bajetta, E.10
Gorbunova, V.11
Bay, J.O.12
Bodrogi, I.13
Jagiello-Gruszfeld, A.14
Moore, N.15
-
64
-
-
0031055388
-
Angiogenesis in brain tumors, pathobiological and clinical aspects
-
Wesseling P., Ruiter D.J., Burger P.C. Angiogenesis in brain tumors, pathobiological and clinical aspects. J. Neurooncol. 1997, 32:253-265.
-
(1997)
J. Neurooncol.
, vol.32
, pp. 253-265
-
-
Wesseling, P.1
Ruiter, D.J.2
Burger, P.C.3
-
65
-
-
0026446102
-
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
-
Plate K.H., Breier G., Weich H.A., Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992, 359:845-848.
-
(1992)
Nature
, vol.359
, pp. 845-848
-
-
Plate, K.H.1
Breier, G.2
Weich, H.A.3
Risau, W.4
-
66
-
-
45249097586
-
Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability
-
Lai A., Filka E., McGibbon B., Nghiemphu P.L., Graham C., Yong W.H., Mischel P., Liau L.M., Bergsneider M., Pope W., Selch M., Cloughesy T. Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int. J. Radiat. Oncol. Biol. Phys. 2008, 71:1372-1380.
-
(2008)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.71
, pp. 1372-1380
-
-
Lai, A.1
Filka, E.2
McGibbon, B.3
Nghiemphu, P.L.4
Graham, C.5
Yong, W.H.6
Mischel, P.7
Liau, L.M.8
Bergsneider, M.9
Pope, W.10
Selch, M.11
Cloughesy, T.12
-
67
-
-
51449122032
-
Bevacizumab and irinotecan therapy in glioblastoma multiforme: a series of 13 cases
-
Ali S.A., McHayleh W.M., Ahmad A., Sehgal R., Braffet M., Rahman M., Bejjani G., Friedland D.M. Bevacizumab and irinotecan therapy in glioblastoma multiforme: a series of 13 cases. J. Neurosurg. 2008, 109:268-272.
-
(2008)
J. Neurosurg.
, vol.109
, pp. 268-272
-
-
Ali, S.A.1
McHayleh, W.M.2
Ahmad, A.3
Sehgal, R.4
Braffet, M.5
Rahman, M.6
Bejjani, G.7
Friedland, D.M.8
-
68
-
-
40749127163
-
Magnetic resonance imaging-based detection of glial brain tumors in mice after antiangiogenic treatment
-
Claes A., Gambarota G., Hamans B., van Tellingen O., Wesseling P., Maass C., Heerschap A., Leenders W. Magnetic resonance imaging-based detection of glial brain tumors in mice after antiangiogenic treatment. Int. J. Cancer 2008, 122:1981-1986.
-
(2008)
Int. J. Cancer
, vol.122
, pp. 1981-1986
-
-
Claes, A.1
Gambarota, G.2
Hamans, B.3
van Tellingen, O.4
Wesseling, P.5
Maass, C.6
Heerschap, A.7
Leenders, W.8
-
69
-
-
74049090120
-
Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme
-
Verhoeff J.J., van T.O., Claes A., Stalpers L.J., van Linde M.E., Richel D.J., Leenders W.P., van Furth W.R. Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme. BMC Cancer 2009, 9:444.
-
(2009)
BMC Cancer
, vol.9
, pp. 444
-
-
Verhoeff, J.J.1
van, T.O.2
Claes, A.3
Stalpers, L.J.4
van Linde, M.E.5
Richel, D.J.6
Leenders, W.P.7
van Furth, W.R.8
-
70
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B., Eisen T., Stadler W.M., Szczylik C., Oudard S., Siebels M., Negrier S., Chevreau C., Solska E., Desai A.A., Rolland F., Demkow T., Hutson T.E., Gore M., Freeman S., Schwartz B., Shan M., Simantov R., Bukowski R.M. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 2007, 356:125-134.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
71
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
Ratain M.J., Eisen T., Stadler W.M., Flaherty K.T., Kaye S.B., Rosner G.L., Gore M., Desai A.A., Patnaik A., Xiong H.Q., Rowinsky E., Abbruzzese J.L., Xia C., Simantov R., Schwartz B., O'Dwyer P.J. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 2006, 24:2505-2512.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
Flaherty, K.T.4
Kaye, S.B.5
Rosner, G.L.6
Gore, M.7
Desai, A.A.8
Patnaik, A.9
Xiong, H.Q.10
Rowinsky, E.11
Abbruzzese, J.L.12
Xia, C.13
Simantov, R.14
Schwartz, B.15
O'Dwyer, P.J.16
-
72
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet J.M., Ricci S., Mazzaferro V., Hilgard P., Gane E., Blanc J.F., de Oliveira A.C., Santoro A., Raoul J.L., Forner A., Schwartz M., Porta C., Zeuzem S., Bolondi L., Greten T.F., Galle P.R., Seitz J.F., Borbath I., Haussinger D.., Giannaris T., Shan M., Moscovici M., Voliotis D., Bruix J. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 2008, 359:378-390.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
de Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Haussinger, D..19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
-
73
-
-
51049095131
-
A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel
-
Flaherty K.T., Schiller J., Schuchter L.M., Liu G., Tuveson D.A., Redlinger M., Lathia C., Xia C., Petrenciuc O., Hingorani S.R., Jacobetz M.A., Van Belle P.A., Elder D., Brose M.S., Weber B.L., Albertini M.R., O'Dwyer P.J. A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel. Clin. Cancer Res. 2008, 14:4836-4842.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 4836-4842
-
-
Flaherty, K.T.1
Schiller, J.2
Schuchter, L.M.3
Liu, G.4
Tuveson, D.A.5
Redlinger, M.6
Lathia, C.7
Xia, C.8
Petrenciuc, O.9
Hingorani, S.R.10
Jacobetz, M.A.11
Van Belle, P.A.12
Elder, D.13
Brose, M.S.14
Weber, B.L.15
Albertini, M.R.16
O'Dwyer, P.J.17
-
74
-
-
43749110700
-
Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group
-
McDermott D.F., Sosman J.A., Gonzalez R., Hodi F.S., Linette G.P., Richards J., Jakub J.W., Beeram M., Tarantolo S., Agarwala S., Frenette G., Puzanov I., Cranmer L., Lewis K., Kirkwood J., White J.M., Xia C., Patel K., Hersh E. Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group. J. Clin. Oncol. 2008, 26:2178-2185.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2178-2185
-
-
McDermott, D.F.1
Sosman, J.A.2
Gonzalez, R.3
Hodi, F.S.4
Linette, G.P.5
Richards, J.6
Jakub, J.W.7
Beeram, M.8
Tarantolo, S.9
Agarwala, S.10
Frenette, G.11
Puzanov, I.12
Cranmer, L.13
Lewis, K.14
Kirkwood, J.15
White, J.M.16
Xia, C.17
Patel, K.18
Hersh, E.19
-
75
-
-
50649095250
-
Phase II trial of sorafenib in advanced thyroid cancer
-
Gupta-Abramson V., Troxel A.B., Nellore A., Puttaswamy K., Redlinger M., Ransone K., Mandel S.J., Flaherty K.T., Loevner L.A., O'Dwyer P.J., Brose M.S. Phase II trial of sorafenib in advanced thyroid cancer. J. Clin. Oncol. 2008.
-
(2008)
J. Clin. Oncol.
-
-
Gupta-Abramson, V.1
Troxel, A.B.2
Nellore, A.3
Puttaswamy, K.4
Redlinger, M.5
Ransone, K.6
Mandel, S.J.7
Flaherty, K.T.8
Loevner, L.A.9
O'Dwyer, P.J.10
Brose, M.S.11
-
76
-
-
40749122148
-
A phase II clinical trial of sorafenib in androgen-independent prostate cancer
-
Dahut W.L., Scripture C., Posadas E., Jain L., Gulley J.L., Arlen P.M., Wright J.J., Yu Y., Cao L., Steinberg S.M., ragon-Ching J.B., Venitz J., Jones E., Chen C.C., Figg W.D. A phase II clinical trial of sorafenib in androgen-independent prostate cancer. Clin. Cancer Res. 2008, 14:209-214.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 209-214
-
-
Dahut, W.L.1
Scripture, C.2
Posadas, E.3
Jain, L.4
Gulley, J.L.5
Arlen, P.M.6
Wright, J.J.7
Yu, Y.8
Cao, L.9
Steinberg, S.M.10
ragon-Ching, J.B.11
Venitz, J.12
Jones, E.13
Chen, C.C.14
Figg, W.D.15
-
77
-
-
36448965291
-
A clinical phase II study with sorafenib in patients with progressive hormone-refractory prostate cancer: a study of the CESAR Central European Society for Anticancer Drug Research-EWIV
-
Steinbild S., Mross K., Frost A., Morant R., Gillessen S., Dittrich C., Strumberg D., Hochhaus A., Hanauske A.R., Edler L., Burkholder I., Scheulen M. A clinical phase II study with sorafenib in patients with progressive hormone-refractory prostate cancer: a study of the CESAR Central European Society for Anticancer Drug Research-EWIV. Brit. J. Cancer 2007, 97:1480-1485.
-
(2007)
Brit. J. Cancer
, vol.97
, pp. 1480-1485
-
-
Steinbild, S.1
Mross, K.2
Frost, A.3
Morant, R.4
Gillessen, S.5
Dittrich, C.6
Strumberg, D.7
Hochhaus, A.8
Hanauske, A.R.9
Edler, L.10
Burkholder, I.11
Scheulen, M.12
-
78
-
-
34548504810
-
Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma
-
Elser C., Siu L.L., Winquist E., Agulnik M., Pond G.R., Chin S.F., Francis P., Cheiken R., Elting J., McNabola A., Wilkie D., Petrenciuc O., Chen E.X. Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma. J. Clin. Oncol. 2007, 25:3766-3773.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3766-3773
-
-
Elser, C.1
Siu, L.L.2
Winquist, E.3
Agulnik, M.4
Pond, G.R.5
Chin, S.F.6
Francis, P.7
Cheiken, R.8
Elting, J.9
McNabola, A.10
Wilkie, D.11
Petrenciuc, O.12
Chen, E.X.13
-
79
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer R.J., Michaelson M.D., Redman B.G., Hudes G.R., Wilding G., Figlin R.A., Ginsberg M.S., Kim S.T., Baum C.M., DePrimo S.E., JZ Li., Bello C.L., Theuer C.P., George D.J., Rini B.I. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 2006, 24:16-24.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
Hudes, G.R.4
Wilding, G.5
Figlin, R.A.6
Ginsberg, M.S.7
Kim, S.T.8
Baum, C.M.9
DePrimo, S.E.10
JZ, L.11
Bello, C.L.12
Theuer, C.P.13
George, D.J.14
Rini, B.I.15
-
80
-
-
33744954585
-
Sunitinib in patients with metastatic renal cell carcinoma
-
Motzer R.J., Rini B.I., Bukowski R.M., Curti B.D., George D.J., Hudes G.R., Redman B.G., Margolin K.A., Merchan J.R., Wilding G., Ginsberg M.S., Bacik J., Kim S.T., Baum C.M., Michaelson M.D. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006, 295:2516-2524.
-
(2006)
JAMA
, vol.295
, pp. 2516-2524
-
-
Motzer, R.J.1
Rini, B.I.2
Bukowski, R.M.3
Curti, B.D.4
George, D.J.5
Hudes, G.R.6
Redman, B.G.7
Margolin, K.A.8
Merchan, J.R.9
Wilding, G.10
Ginsberg, M.S.11
Bacik, J.12
Kim, S.T.13
Baum, C.M.14
Michaelson, M.D.15
-
81
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer R.J., Hutson T.E., Tomczak P., Michaelson M.D., Bukowski R.M., Rixe O., Oudard S., Negrier S., Szczylik C., Kim S.T., Chen I., Bycott P.W., Baum C.M., Figlin R.A. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 2007, 356:115-124.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
82
-
-
49249087039
-
Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
-
Rini B.I., Michaelson M.D., Rosenberg J.E., Bukowski R.M., Sosman J.A., Stadler W.M., Hutson T.E., Margolin K., Harmon C.S., DePrimo S.E., Kim S.T., Chen I., George D.J. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J. Clin. Oncol. 2008, 26:3743-3748.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
Bukowski, R.M.4
Sosman, J.A.5
Stadler, W.M.6
Hutson, T.E.7
Margolin, K.8
Harmon, C.S.9
DePrimo, S.E.10
Kim, S.T.11
Chen, I.12
George, D.J.13
-
83
-
-
39149120621
-
Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer
-
Socinski M.A., Novello S., Brahmer J.R., Rosell R., Sanchez J.M., Belani C.P., Govindan R., Atkins J.N., Gillenwater H.H., Pallares C., Tye L., Selaru P., Chao R.C., Scagliotti G.V. Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer. J. Clin. Oncol. 2008, 26:650-656.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 650-656
-
-
Socinski, M.A.1
Novello, S.2
Brahmer, J.R.3
Rosell, R.4
Sanchez, J.M.5
Belani, C.P.6
Govindan, R.7
Atkins, J.N.8
Gillenwater, H.H.9
Pallares, C.10
Tye, L.11
Selaru, P.12
Chao, R.C.13
Scagliotti, G.V.14
-
84
-
-
42949148257
-
Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
-
Burstein H.J., Elias A.D., Rugo H.S., Cobleigh M.A., Wolff A.C., Eisenberg P.D., Lehman M., Adams B.J., Bello C.L., DePrimo S.E., Baum C.M., Miller K.D. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J. Clin. Oncol. 2008, 26:1810-1816.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 1810-1816
-
-
Burstein, H.J.1
Elias, A.D.2
Rugo, H.S.3
Cobleigh, M.A.4
Wolff, A.C.5
Eisenberg, P.D.6
Lehman, M.7
Adams, B.J.8
Bello, C.L.9
DePrimo, S.E.10
Baum, C.M.11
Miller, K.D.12
-
85
-
-
49149114782
-
Activity of sunitinib in patients with advanced neuroendocrine tumors
-
Kulke M.H., Lenz H.J., Meropol N.J., Posey J., Ryan D.P., Picus J., Bergsland E., Stuart K., Tye L., Huang X., JZ Li., Baum C.M., Fuchs C.S. Activity of sunitinib in patients with advanced neuroendocrine tumors. J. Clin. Oncol. 2008, 26:3403-3410.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 3403-3410
-
-
Kulke, M.H.1
Lenz, H.J.2
Meropol, N.J.3
Posey, J.4
Ryan, D.P.5
Picus, J.6
Bergsland, E.7
Stuart, K.8
Tye, L.9
Huang, X.10
JZ, L.11
Baum, C.M.12
Fuchs, C.S.13
-
86
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial
-
Demetri G.D., van Oosterom A.T., Garrett C.R., Blackstein M.E., Shah M.H., Verweij J., McArthur G., Judson I.R., Heinrich M.C., Morgan J.A., Desai J., Fletcher C.D., George S., Bello C.L., Huang X., Baum C.M., Casali P.G. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006, 368:1329-1338.
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.D.1
van Oosterom, A.T.2
Garrett, C.R.3
Blackstein, M.E.4
Shah, M.H.5
Verweij, J.6
McArthur, G.7
Judson, I.R.8
Heinrich, M.C.9
Morgan, J.A.10
Desai, J.11
Fletcher, C.D.12
George, S.13
Bello, C.L.14
Huang, X.15
Baum, C.M.16
Casali, P.G.17
-
87
-
-
72449141577
-
Redefining the role of interferon in the treatment of malignant diseases
-
Bracarda S., Eggermont A.M., Samuelsson J. Redefining the role of interferon in the treatment of malignant diseases. Eur. J. Cancer 2010, 46:284-297.
-
(2010)
Eur. J. Cancer
, vol.46
, pp. 284-297
-
-
Bracarda, S.1
Eggermont, A.M.2
Samuelsson, J.3
-
88
-
-
77649182103
-
Interferon alpha inhibits hepatocellular carcinoma growth through inducing apoptosis and interfering with adhesion of tumor endothelial cells
-
Zhang T., Sun H.C., Zhou H.Y., Luo J.T., Zhang B.L., Wang P., Wang L., Qin L.X., Ren N., Ye S.L., Li Q., Tang Z.Y. Interferon alpha inhibits hepatocellular carcinoma growth through inducing apoptosis and interfering with adhesion of tumor endothelial cells. Cancer Lett. 2010, 290:204-210.
-
(2010)
Cancer Lett.
, vol.290
, pp. 204-210
-
-
Zhang, T.1
Sun, H.C.2
Zhou, H.Y.3
Luo, J.T.4
Zhang, B.L.5
Wang, P.6
Wang, L.7
Qin, L.X.8
Ren, N.9
Ye, S.L.10
Li, Q.11
Tang, Z.Y.12
-
89
-
-
51349135746
-
VEGF secretion is inhibited by interferon-alpha in several melanoma cell lines
-
Raig E.T., Jones N.B., Varker K.A., Benniger K., MR Go., Biber J.L., Lesinski G.B., Carson W.E. VEGF secretion is inhibited by interferon-alpha in several melanoma cell lines. J. Interferon Cytokine Res. 2008, 28:553-561.
-
(2008)
J. Interferon Cytokine Res.
, vol.28
, pp. 553-561
-
-
Raig, E.T.1
Jones, N.B.2
Varker, K.A.3
Benniger, K.4
MR, G.5
Biber, J.L.6
Lesinski, G.B.7
Carson, W.E.8
-
90
-
-
0030030347
-
Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684
-
Kirkwood J.M., Strawderman M.H., Ernstoff M.S., Smith T.J., Borden E.C., Blum R.H. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J. Clin. Oncol. 1996, 14:7-17.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 7-17
-
-
Kirkwood, J.M.1
Strawderman, M.H.2
Ernstoff, M.S.3
Smith, T.J.4
Borden, E.C.5
Blum, R.H.6
-
91
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman J.G., Latif F., Weng Y., Lerman M.I., Zbar B., Liu S., Samid D., Duan D.S., Gnarra J.R., Linehan W.M. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. Natl. Acad. Sci. USA 1994, 91:9700-9704.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
Lerman, M.I.4
Zbar, B.5
Liu, S.6
Samid, D.7
Duan, D.S.8
Gnarra, J.R.9
Linehan, W.M.10
-
92
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra J.R., Tory K., Weng Y., Schmidt L., Wei M.H., Li H., Latif F., Liu S., Chen F., Duh F.M. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat. Genet. 1994, 7:85-90.
-
(1994)
Nat. Genet.
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
Schmidt, L.4
Wei, M.H.5
Li, H.6
Latif, F.7
Liu, S.8
Chen, F.9
Duh, F.M.10
-
93
-
-
0027984204
-
Three-dimensional modelling of tumor-induced ovarian angiogenesis
-
Schoenfeld A., Levavi H., Breslavski D., Amir R., Ovadia J. Three-dimensional modelling of tumor-induced ovarian angiogenesis. Cancer Lett. 1994, 87:79-84.
-
(1994)
Cancer Lett.
, vol.87
, pp. 79-84
-
-
Schoenfeld, A.1
Levavi, H.2
Breslavski, D.3
Amir, R.4
Ovadia, J.5
-
94
-
-
11844254414
-
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
-
Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
95
-
-
0031469819
-
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
-
Boehm T., Folkman J., Browder T., O'Reilly M.S. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 1997, 390:404-407.
-
(1997)
Nature
, vol.390
, pp. 404-407
-
-
Boehm, T.1
Folkman, J.2
Browder, T.3
O'Reilly, M.S.4
-
96
-
-
38349135709
-
Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization
-
Claes A., Wesseling P., Jeuken J., Maass C., Heerschap A., Leenders W.P. Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization. Mol. Cancer Ther. 2008, 7:71-78.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 71-78
-
-
Claes, A.1
Wesseling, P.2
Jeuken, J.3
Maass, C.4
Heerschap, A.5
Leenders, W.P.6
-
97
-
-
4644304024
-
Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option
-
Leenders W.P., Kusters B., Verrijp K., Maass C., Wesseling P., Heerschap A., Ruiter D., Ryan A., De Waal R. Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option. Clin. Cancer Res. 2004, 10:6222-6230.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 6222-6230
-
-
Leenders, W.P.1
Kusters, B.2
Verrijp, K.3
Maass, C.4
Wesseling, P.5
Heerschap, A.6
Ruiter, D.7
Ryan, A.8
De Waal, R.9
-
98
-
-
0035884609
-
Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
-
Kunkel P., Ulbricht U., Bohlen P., Brockmann M.A., Fillbrandt R., Stavrou D., Westphal M., Lamszus K. Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Res. 2001, 61:6624-6628.
-
(2001)
Cancer Res.
, vol.61
, pp. 6624-6628
-
-
Kunkel, P.1
Ulbricht, U.2
Bohlen, P.3
Brockmann, M.A.4
Fillbrandt, R.5
Stavrou, D.6
Westphal, M.7
Lamszus, K.8
-
99
-
-
0033822622
-
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
-
Rubenstein J.L., Kim J., Ozawa T., Zhang M., Westphal M., Deen D.F., Shuman M.A. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2000, 2:306-314.
-
(2000)
Neoplasia
, vol.2
, pp. 306-314
-
-
Rubenstein, J.L.1
Kim, J.2
Ozawa, T.3
Zhang, M.4
Westphal, M.5
Deen, D.F.6
Shuman, M.A.7
-
100
-
-
44649100122
-
Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy
-
Claes A., Schuuring J., Boots-Sprenger S., Hendriks-Cornelissen S., Dekkers M., van der Kogel A.J., Leenders W.P., Wesseling P., Jeuken J.W. Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy. Brain Pathol. 2008, 18:423-433.
-
(2008)
Brain Pathol.
, vol.18
, pp. 423-433
-
-
Claes, A.1
Schuuring, J.2
Boots-Sprenger, S.3
Hendriks-Cornelissen, S.4
Dekkers, M.5
van der Kogel, A.J.6
Leenders, W.P.7
Wesseling, P.8
Jeuken, J.W.9
-
101
-
-
47949121903
-
Vessel normalization by VEGF inhibition. A complex story
-
Claes A., Leenders W. Vessel normalization by VEGF inhibition. A complex story. Cancer Biol. Ther. 2008, 7:1014-1016.
-
(2008)
Cancer Biol. Ther.
, vol.7
, pp. 1014-1016
-
-
Claes, A.1
Leenders, W.2
-
102
-
-
60649116273
-
Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival
-
Narayana A., Kelly P., Golfinos J., Parker E., Johnson G., Knopp E., Zagzag D., Fischer I., Raza S., Medabalmi P., Eagan P., Gruber M.L. Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival. J. Neurosurg. 2009, 110:173-180.
-
(2009)
J. Neurosurg.
, vol.110
, pp. 173-180
-
-
Narayana, A.1
Kelly, P.2
Golfinos, J.3
Parker, E.4
Johnson, G.5
Knopp, E.6
Zagzag, D.7
Fischer, I.8
Raza, S.9
Medabalmi, P.10
Eagan, P.11
Gruber, M.L.12
-
103
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos J.M., Lee C.R., Cruz-Munoz W., Bjarnason G.A., Christensen J.G., Kerbel R.S. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009, 15:232-239.
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
104
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M., Allen E., Hudock J., Takeda T., Okuyama H., Vinals F., Inoue M., Bergers G., Hanahan D., Casanovas O. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009, 15:220-231.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
Vinals, F.6
Inoue, M.7
Bergers, G.8
Hanahan, D.9
Casanovas, O.10
-
105
-
-
0037314650
-
Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer
-
Santimaria M., Moscatelli G., Viale G.L., Giovannoni L., Neri G., Viti F., Leprini A., Borsi L., Castellani P., Zardi L., Neri D., Riva P. Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer. Clin. Cancer Res. 2003, 9:571-579.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 571-579
-
-
Santimaria, M.1
Moscatelli, G.2
Viale, G.L.3
Giovannoni, L.4
Neri, G.5
Viti, F.6
Leprini, A.7
Borsi, L.8
Castellani, P.9
Zardi, L.10
Neri, D.11
Riva, P.12
-
106
-
-
0036841992
-
Differentiation between high- and low-grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin
-
Castellani P., Borsi L., Carnemolla B., Biro A., Dorcaratto A., Viale G.L., Neri D., Zardi L. Differentiation between high- and low-grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin. Am. J. Pathol. 2002, 161:1695-1700.
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 1695-1700
-
-
Castellani, P.1
Borsi, L.2
Carnemolla, B.3
Biro, A.4
Dorcaratto, A.5
Viale, G.L.6
Neri, D.7
Zardi, L.8
-
107
-
-
0037058717
-
Targeting of RGD-modified proteins to tumor vasculature: a pharmacokinetic and cellular distribution study
-
Schraa A.J., Kok R.J., Moorlag H.E., Bos E.J., Proost J.H., Meijer D.K., de Leij L.F., Molema G. Targeting of RGD-modified proteins to tumor vasculature: a pharmacokinetic and cellular distribution study. Int. J. Cancer 2002, 102:469-475.
-
(2002)
Int. J. Cancer
, vol.102
, pp. 469-475
-
-
Schraa, A.J.1
Kok, R.J.2
Moorlag, H.E.3
Bos, E.J.4
Proost, J.H.5
Meijer, D.K.6
de Leij, L.F.7
Molema, G.8
-
108
-
-
0036829759
-
Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model
-
Janssen M.L., Oyen W.J., Dijkgraaf I., Massuger L.F., Frielink C., Edwards D.S., Rajopadhye M., Boonstra H., Corstens F.H., Boerman O.C. Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model. Cancer Res. 2002, 62:6146-6151.
-
(2002)
Cancer Res.
, vol.62
, pp. 6146-6151
-
-
Janssen, M.L.1
Oyen, W.J.2
Dijkgraaf, I.3
Massuger, L.F.4
Frielink, C.5
Edwards, D.S.6
Rajopadhye, M.7
Boonstra, H.8
Corstens, F.H.9
Boerman, O.C.10
-
109
-
-
33845697526
-
Alpha v beta 3 integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide
-
Dijkgraaf I., Kruijtzer J.A., Frielink C., Corstens F.H., Oyen W.J., Liskamp R.M., Boerman O.C. Alpha v beta 3 integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide. Int. J. Cancer 2007, 120:605-610.
-
(2007)
Int. J. Cancer
, vol.120
, pp. 605-610
-
-
Dijkgraaf, I.1
Kruijtzer, J.A.2
Frielink, C.3
Corstens, F.H.4
Oyen, W.J.5
Liskamp, R.M.6
Boerman, O.C.7
-
110
-
-
20544451841
-
Specific occlusion of murine and human tumor vasculature by VCAM-1-targeted recombinant fusion proteins
-
Dienst A., Grunow A., Unruh M., Rabausch B., Nor J.E., Fries J.W., Gottstein C. Specific occlusion of murine and human tumor vasculature by VCAM-1-targeted recombinant fusion proteins. J. Natl. Cancer Inst. 2005, 97:733-747.
-
(2005)
J. Natl. Cancer Inst.
, vol.97
, pp. 733-747
-
-
Dienst, A.1
Grunow, A.2
Unruh, M.3
Rabausch, B.4
Nor, J.E.5
Fries, J.W.6
Gottstein, C.7
-
111
-
-
0035889654
-
Lack of specificity of endoglin expression for tumor blood vessels
-
Balza E., Castellani P., Zijlstra A., Neri D., Zardi L., Siri A. Lack of specificity of endoglin expression for tumor blood vessels. Int. J. Cancer 2001, 94:579-585.
-
(2001)
Int. J. Cancer
, vol.94
, pp. 579-585
-
-
Balza, E.1
Castellani, P.2
Zijlstra, A.3
Neri, D.4
Zardi, L.5
Siri, A.6
-
112
-
-
24944581963
-
Plexin D1 expression is induced on tumor vasculature and tumor cells: a novel target for diagnosis and therapy?
-
Roodink I., Raats J., van der Zwaag B., Verrijp K., Kusters B., Van Bokhoven H., Linkels M., de Waal R.M., Leenders W.P. Plexin D1 expression is induced on tumor vasculature and tumor cells: a novel target for diagnosis and therapy?. Cancer Res. 2005, 65:8317-8323.
-
(2005)
Cancer Res.
, vol.65
, pp. 8317-8323
-
-
Roodink, I.1
Raats, J.2
van der Zwaag, B.3
Verrijp, K.4
Kusters, B.5
Van Bokhoven, H.6
Linkels, M.7
de Waal, R.M.8
Leenders, W.P.9
-
113
-
-
57149095435
-
Semaphorin 3E expression correlates inversely with plexin D1 during tumor progression
-
Roodink I., Kats G., van Kempen L., Grunberg M., Maass C., Verrijp K., Raats J., Leenders W. Semaphorin 3E expression correlates inversely with plexin D1 during tumor progression. Am. J. Pathol. 2008, 173:1873-1881.
-
(2008)
Am. J. Pathol.
, vol.173
, pp. 1873-1881
-
-
Roodink, I.1
Kats, G.2
van Kempen, L.3
Grunberg, M.4
Maass, C.5
Verrijp, K.6
Raats, J.7
Leenders, W.8
-
114
-
-
70349861793
-
Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies
-
Roodink I., Verrijp K., Raats J., Leenders W.P. Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies. BMC Cancer 2009, 9:297.
-
(2009)
BMC Cancer
, vol.9
, pp. 297
-
-
Roodink, I.1
Verrijp, K.2
Raats, J.3
Leenders, W.P.4
-
115
-
-
77957929044
-
The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents
-
Siemann D.W. The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents. Cancer Treat. Rev. 2010.
-
(2010)
Cancer Treat. Rev.
-
-
Siemann, D.W.1
-
116
-
-
0344185348
-
Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis
-
Joyce J.A., Laakkonen P., Bernasconi M., Bergers G., Ruoslahti E., Hanahan D. Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 2003, 4:393-403.
-
(2003)
Cancer Cell
, vol.4
, pp. 393-403
-
-
Joyce, J.A.1
Laakkonen, P.2
Bernasconi, M.3
Bergers, G.4
Ruoslahti, E.5
Hanahan, D.6
-
117
-
-
0034682892
-
Genes expressed in human tumor endothelium
-
Croix B.St., Rago C., Velculescu V., Traverso G., Romans K.E., Montgomery E., Lal A., Riggins G.J., Lengauer C., Vogelstein B., Kinzler K.W. Genes expressed in human tumor endothelium. Science 2000, 289:1197-1202.
-
(2000)
Science
, vol.289
, pp. 1197-1202
-
-
Croix, B.1
Rago, C.2
Velculescu, V.3
Traverso, G.4
Romans, K.E.5
Montgomery, E.6
Lal, A.7
Riggins, G.J.8
Lengauer, C.9
Vogelstein, B.10
Kinzler, K.W.11
-
118
-
-
0344494515
-
Tumor vasculature address book: identification of stage-specific tumor vessel zip codes by phage display
-
Rafii S., Avecilla S.T., Jin D.K. Tumor vasculature address book: identification of stage-specific tumor vessel zip codes by phage display. Cancer Cell 2003, 4:331-333.
-
(2003)
Cancer Cell
, vol.4
, pp. 331-333
-
-
Rafii, S.1
Avecilla, S.T.2
Jin, D.K.3
-
119
-
-
33748847707
-
Development of the tumor vascular bed in response to hypoxia-induced VEGF-A differs from that in tumors with constitutive VEGF-A expression
-
Roodink I., van der L.J., Kusters B., Wesseling P., Verrijp K., de W.R., Leenders W. Development of the tumor vascular bed in response to hypoxia-induced VEGF-A differs from that in tumors with constitutive VEGF-A expression. Int. J. Cancer 2006, 119:2054-2062.
-
(2006)
Int. J. Cancer
, vol.119
, pp. 2054-2062
-
-
Roodink, I.1
van der, L.J.2
Kusters, B.3
Wesseling, P.4
Verrijp, K.5
de, W.R.6
Leenders, W.7
-
120
-
-
0036603896
-
In vivo phage display and vascular heterogeneity: implications for targeted medicine
-
Trepel M., Arap W., Pasqualini R. In vivo phage display and vascular heterogeneity: implications for targeted medicine. Curr. Opin. Chem. Biol. 2002, 6:399-404.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 399-404
-
-
Trepel, M.1
Arap, W.2
Pasqualini, R.3
-
121
-
-
73349136598
-
Isolation of targeting nanobodies against co-opted tumor vasculature
-
Roodink I., Franssen M., Zuidscherwoude M., Verrijp K., van der D.T., Raats J., Leenders W.P. Isolation of targeting nanobodies against co-opted tumor vasculature. Lab Invest. 2010, 90:61-67.
-
(2010)
Lab Invest.
, vol.90
, pp. 61-67
-
-
Roodink, I.1
Franssen, M.2
Zuidscherwoude, M.3
Verrijp, K.4
van der, D.T.5
Raats, J.6
Leenders, W.P.7
-
122
-
-
43249091515
-
SPECT imaging with 99mTc-labeled EGFR-specific nanobody for in vivo monitoring of EGFR expression
-
Huang L., Gainkam L.O., Caveliers V., Vanhove C., Keyaerts M., De B.P., Bossuyt A., Revets H., Lahoutte T. SPECT imaging with 99mTc-labeled EGFR-specific nanobody for in vivo monitoring of EGFR expression. Mol. Imaging Biol. 2008, 10:167-175.
-
(2008)
Mol. Imaging Biol.
, vol.10
, pp. 167-175
-
-
Huang, L.1
Gainkam, L.O.2
Caveliers, V.3
Vanhove, C.4
Keyaerts, M.5
De, B.P.6
Bossuyt, A.7
Revets, H.8
Lahoutte, T.9
-
123
-
-
10644228142
-
Efficient cancer therapy with a nanobody-based conjugate
-
Cortez-Retamozo V., Backmann N., Senter P.D., Wernery U., De B.P., Muyldermans S., Revets H. Efficient cancer therapy with a nanobody-based conjugate. Cancer Res. 2004, 64:2853-2857.
-
(2004)
Cancer Res.
, vol.64
, pp. 2853-2857
-
-
Cortez-Retamozo, V.1
Backmann, N.2
Senter, P.D.3
Wernery, U.4
De, B.P.5
Muyldermans, S.6
Revets, H.7
-
124
-
-
0032528192
-
Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display
-
Rajotte D., Arap W., Hagedorn M., Koivunen E., Pasqualini R., Ruoslahti E. Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display. J. Clin. Invest 1998, 102:430-437.
-
(1998)
J. Clin. Invest
, vol.102
, pp. 430-437
-
-
Rajotte, D.1
Arap, W.2
Hagedorn, M.3
Koivunen, E.4
Pasqualini, R.5
Ruoslahti, E.6
|