Guanosine protects human neuroblastoma cells from oxidative stress and toxicity induced by amyloid-β peptide oligomers

Journal of Biological Regulators and Homeostatic Agents

Volumn 24, Issue 3, 2010, Pages 297-306

  Tarozzi, Andrea ^a   Merlicco, A ^a   Morroni, F ^a   Bolondi, C ^a   Di Iorio, P ^b   Ciccarelli, R ^b   Romano, S ^b   Giuliani, P ^b   Hrelia, P ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

A oligomers; Guanosine; Neuroprotection; Reactive oxygen species; SH SY5Y cells

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; GUANINE; GUANOSINE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; OLIGOMER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PURINE; REACTIVE OXYGEN METABOLITE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); ANTIOXIDANT; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROPROTECTION; OXIDATIVE STRESS; DRUG EFFECTS; METABOLISM; NEUROBLASTOMA; PATHOLOGY; SIGNAL TRANSDUCTION; TOXICITY; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; ANTIOXIDANTS; CELL LINE, TUMOR; GUANOSINE; HUMANS; MAP KINASE SIGNALING SYSTEM; NEUROBLASTOMA; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 77957922522     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Mattson MP. Pathways towards and away from Alzheimer's disease. Nature 2004; 430:631-9.
2. LaFerla FM, Green KN, Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 2007; 8:499-509.
3. Liu Y, Dargusch R, Banh C, Miller CA, Schubert D. Detecting bioactive amyloid beta peptide species in Alzheimer's disease. J Neurochem 2004; 91:648-56. (Pubitemid 39431159)
4. Lue LF, Kuo YM, Roher AE, et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 1999; 155:853-62.
5. Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006; 440:352-7.
6. Crouch PJ, Harding SM, White AR, Camakaris J, Bush AI, Masters CL. Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease. Int J Biochem Cell Biol 2008; 40:181-98.
7. Smith DG, Cappai R, Barnham KJ. The redox chemistry of the Alzheimer's disease amyloid beta peptide. Biochim Biophys Acta 2007; 1768:1976-90.
8. Tamagno E, Guglielmotto M, Aragno M, et al. Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem 2008; 104:683-95.
9. Rathbone M, Pilutti L, Caciagli F, Jiang S. Neurotrophic effects of extracellular guanosine. Nucleosides Nucleotides Nucleic Acids 2008; 27:666-72.
10. Christjanson LJ, Middlemiss PJ, Rathbone MP. Stimulation of astrocyte proliferation by purine and pyrimidine nucleotides and nucleosides. Glia 1993; 7:176-82.
11. Gysbers JW, Rathbone MP. Neurite outgrowth in PC12 cells is enhanced by guanosine through both cAMP-dependent and -independent mechanisms. Neurosci Lett 1996; 220:175-8.
12. Middlemiss PJ, Gysbers J, Rathbone MP. Extracellular guanosine and guanosine-5-triphosphate increase NGF synthesis and release from cultured mouse neopallidal astrocytes. Brain Res 1995; 677:152-6.
13. Schmidt AP, Lara DR, Souza DO. Proposal of a guanine-based purinergic system in the mammalian central nervous system. Pharmacol Ther 2007; 116:401-16.
14. Gudkov SV, Shtarkman IN, Smirnova VS, Chernikov AV, Bruskov VI. Guanosine and inosine display antioxidant activity, protect DNA in vitro from oxidative damage induced by reactive oxygen species, and serve as radioprotectors in mice. Radiat Res 2006; 165:538-45.
15. Roos DH, Puntel RL, Santos MM, et al. Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: involvement of oxidative stress and glutamatergic system. Toxicol In Vitro 2009; 23:302-7.
16. Tarozzi A, Merlicco A, Morroni F, Franco F, Cantelli-Forti G, Teti G, Falconi M, Hrelia P. Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity. Neuroreport 2008; 19:1483-6.
17. Tarozzi A, Morroni F, Merlicco A, Hrelia S, Angeloni C, Cantelli-Forti G, Hrelia P. Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line. J Neurochem 2009; 111:1161-71.
18. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
19. Di Iorio P, Ballerini P, Traversa U, et al. The antiapoptotic effect of guanosine is mediated by the activation of the PI3-kinase/AKT/PKB pathway in cultured rat astrocytes. Glia 2004; 46:356-68. (Pubitemid 38679194)
20. Pettifer KM, Kleywegt S, Bau CJ, Ramsbottom JD, Vertes E, Ciccarelli R, Caciagli F, Werstiuk ES, Rathbone MP. Guanosine protects SH-SY5Y cells against beta-amyloid-induced apoptosis. Neuroreport 2004; 15:833-6.
21. Baldwin SA, Mackey JR, Cass CE, Young JD. Nucleoside transporters: molecular biology and implications for therapeutic development. Mol Med Today 1999; 5:216-24.
22. Traversa U, Bombi G, Di Iorio P, Ciccarelli R, Werstiuk ES, Rathbone MP. Specific [H3]-guanosine binding sites in rat brain membranes. Br J Pharmacol 2002; 135:969-76.
23. Traversa U, Bombi G, Camaioni E, Macchiarulo A, Costantino G, Palmieri C, Caciagli F, Pellicciari R. Rat brain guanosine binding site. Biological studies and pseudo-receptor construction. Bioorg Med Chem 2003; 11:5417-25.
24. Sayre LM, Perry G, Smith MA. Oxidative stress and neurotoxicity. Chem Res Toxicol 2008; 21:172-88.
25. Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N. Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. J Biol Chem 2008; 283:17721-30.
26. Tamagno E, Guglielmotto M, Giliberto L, Vitali A, Borghi R, Autelli R, Danni O, Tabaton M. JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1. Neurobiol Aging 2009; 30:1563-73.
27. Kim SK, Park HJ, Hong HS, Baik EJ, Jung MW, Mook-Jung I. ERK1/2 is an endogenous negative regulator of the gamma-secretase activity. FASEB J 2006; 20:157-9. (Pubitemid 43100499)