Neurite outgrowth in PC12 cells is enhanced by guanosine through both cAMP-dependent and -independent mechanisms

Neuroscience Letters

Volumn 220, Issue 3, 1996, Pages 175-178

  Gysbers, John W ^a   Rathbone, Michel P ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

5' N' Ethylcarboxamidoadenosine; cAMP; Neurite outgrowth; Pheochromocytoma; Purines

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENYLATE CYCLASE; GUANOSINE; GUANOSINE TRIPHOSPHATE; NERVE GROWTH FACTOR;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; NEURITE; NONHUMAN; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; RAT;

ADENINE; ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ADENYLATE CYCLASE; ANIMALS; ANTINEOPLASTIC AGENTS; CYCLIC AMP; ENZYME INHIBITORS; FORSKOLIN; GUANOSINE; GUANOSINE TRIPHOSPHATE; NERVE GROWTH FACTORS; NEURITES; PC12 CELLS; RATS;

EID: 0030595985     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13253-5     Document Type: Article

References (20)

1. [1] Chern, Y., Chiou, J.-Y., Lai, H.-L. and Tsai, M.-H., Regulation of adenylyl cyclase type VI activity during desensitization of the A2a adenosine receptor-mediated cyclic AMP response: role for protein phosphatase 2A, Mol. Pharmacol., 48 (1995) 1-8.
2. [2] Frodin, M., Peraldi, P. and Van Obberghen, E., Cyclic AMP activates the mitogen-activated protein kinase cascade in PC 12 cells, J. Biol. Chem., 269 (1994) 6207-6214.
3. [3] Greene, L.A. and Tischler, A.S., Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to NGF, Proc. Natl. Acad. Sci. USA, 73 (1976) 2424-2428.
4. [4] Gunning, P.W., Letourneau, P.C., Landreth, G.E. and Shooter, E.M., The action of nerve growth factor and dibutyryl adenosine cyclic 3′:5′-monophosphate on rat pheochromocytoma reveals distinct stages in the mechanisms underlying neurite outgrowth, J. Neurosci., 1 (1981) 1085-1095.
5. [5] Guroff, G., Dickens, G., End, D. and Londos, C., The action of adenosine analogs on PC12 cells, J. Neurochem., 37 (1981) 1431-1439.
6. [6] Gysbers, J.W. and Rathbone, M.P., Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells, Neuro Report, 3 (1992) 997-1000.
7. [7] Gysbers, J.W. and Rathbone, M.P., GTP and guanosine synergistically enhance NGF-induced neurite outgrowth from PC12 cells, Int. J. Dev. Neurosci., 14 (1996) 19-34.
8. [8] Gysbers, J.W., Mariggir, M.A., Pietrangelo, T., Fano, G. and Rathbone, M.P., Extracellular GTP increases intracellular calcium in PC12 cells, Soc. Neurosci. Abstr. (26th Annual Meeting), 22 (1996) 737.
9. [9] Harris, D.M., Asaad, M.M., Phillips, M.B., Goldenberg, H.J. and Antonaccio, M.J., Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives, J. Cyclic Nucleotide Res., 5 (1979) 125-134.
10. [10] Hindley, S., Middlemiss, P.J. and Rathbone, M.P., Guanosine stimulates accumulation of intracellular cGMP in PC12 cells, Soc. Neurosci. Abstr. (23rd Annual Meeting), 19 (1993) 1310.
11. [11] Huffaker, T., Corcoran, T. and Wagner, J.A., Adenosine inhibits cell division and promotes neurite extension in PC12 cells, J. Cell. Physiol., 120 (1984) 188-196.
12. [12] Marshall, C.J., Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated activation, Cell, 80 (1995) 179-185.
13. [13] Maurice, D.H. and Haslam, R.J., Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP, Mol. Pharmacol., 37 (1990) 671-681.
14. [14] Race, H.M. and Wagner, J.A., Nerve growth factor affects cyclic AMP metabolism, but not by directly stimulating adenylate cyclase activity, J. Neurochem., 44 (1985) 1588-1592.
15. [15] Rathbone, M.P., Middlemiss, P.J., DeLuca, B. and Jovetich, M., Extracellular guanosine increases astrocyte cAMP: inhibition by A2 antagonists, NeuroReport, 2 (1991) 661-664.
16. [16] Roskoski, J.R. and Roskoski, L.M., Activation of tyrosine hydroxylase in PC12 cells by the cyclic GMP and cyclic AMP second messenger systems, J. Neurochem., 48 (1987) 236-241.
17. [17] Rusanescu, G., Haiging, Q., Thaomas, S.M., Brugge, J.S. and Haleguoa, S., Calcium influx induces neurite outgrowth through a src-ras signaling cassette. Neuron, 15 (1995) 1415-1425.
18. [18] Weishaar, R.E., Cain, M.H. and Bristol, J.A., A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity, J. Med. Chem., 28 (1985) 537-545.
19. [19] Whalin, M.E., Scammel, J.G., Strada, S.J. and Thompson, W.J., Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells, Mol. Pharmacol., 39 (1991) 711-717.
20. [20] Williams, M., Abreu, M., Jarvis, M.F. and Noronha-Blob, L., Characterization of adenosine receptors in the PC12 pheochromocytoma cell line using radioligand binding: evidence for A-2 selectivity, J. Neurochem., 48 (1987) 498-502.