An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl4-induced rat cirrhosis

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 2, 2010, Pages 287-296

  Pérez Carreón, Julio Isael ^a,b   Martínez Pérez, Lidia ^a   Loredo, María Lilia ^a   Yañez Maldonado, Lucia ^a   Velasco Loyden, Gabriela ^a   Vidrio Gómez, Susana ^a   Ramírez Salcedo, Jorge ^a   Hernández Luis, Francisco ^c   Velázquez Martínez, Israel ^c   Suárez Cuenca, Juan Antonio ^a   Hernández Muñoz, Rolando ^a   de Sánchez, Victoria Chagoya ^a  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

^b Instituto Nacional de Medicina Genómica INMEGEN   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

CCl4 hepatotoxicity; Fibrogenesis; Hepatoprotective effect; Liver transcriptome; Urea cycle

Indexed keywords

2 (6 AMINO 9H PURIN 9 YL) 5 (HYDROXYMETHYL)TETRAHYDROFURAN 3,4 DIOL ASPARTIC ACID; ADENOSINE DERIVATIVE; ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; APOLIPOPROTEIN A1; ARGININOSUCCINATE SYNTHASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBAMOYL PHOSPHATE SYNTHASE; CARBON TETRACHLORIDE; COLLAGEN; COLLAGEN TYPE 1; COLLAGENASE; DESMIN; FIBRONECTIN; IFC 305; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DISEASE MODEL; DNA MICROARRAY; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIPID STORAGE; LIVER CELL; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER FUNCTION; MALE; NONHUMAN; PHENOTYPE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; STELLATE CELL; TREATMENT DURATION;

ADENOSINE; ANIMALS; ASPARTIC ACID; CARBON TETRACHLORIDE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; KINETICS; LIPID METABOLISM; LIVER; LIVER CIRRHOSIS; MALE; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UREA;

RATTUS;

EID: 73749087013     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.11.005     Document Type: Article

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