Skewing of cytokine profiles towards T helper cell type 2 response in visceral leishmaniasis patients unresponsive to sodium antimony gluconate

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 97, Issue 4, 2003, Pages 409-412

  Thakur, C P ^a   Mitra, D K ^b   Narayan, S ^a  

^a Balaji Utthan Sansthan   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

India; Interferon ; Interleukin 4; Leishmania donovani; Sodium antimony gluconate; Visceral leishmaniasis

Indexed keywords

AMPHOTERICIN B DEOXYCHOLATE; ANTIMONY GLUCONATE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4;

ADULT; ARTICLE; CALCULATION; CELL STIMULATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE DURATION; DISEASE SEVERITY; DOSE TIME EFFECT RELATION; DRUG DOSE REGIMEN; DRUG RESPONSE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; FREQUENCY ANALYSIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; MALE; PARASITOLOGY; POLARIZATION; SPLEEN SIZE; STATISTICAL SIGNIFICANCE; TH2 CELL; VISCERAL LEISHMANIASIS;

ADOLESCENT; ADULT; ANTIMONY SODIUM GLUCONATE; ANTIPROTOZOAL AGENTS; CELLS, CULTURED; CYTOKINES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; LEISHMANIASIS, VISCERAL; LYMPHOCYTE ACTIVATION; MALE; TH2 CELLS; TREATMENT FAILURE;

LEISHMANIA DONOVANI; PROTOZOA;

EID: 19244365963     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(03)90071-X     Document Type: Article

References (12)

1. Agarwal S.K. Anuradha S. Bayeja U.K. Singh A. Singh N.P. & Sokhi J. Cytokine profile in human immunodeficiency virus positive patients with and without tuberculosis Journal of the Association of Physicians of India, 49 2001 799-802
2. Afrin F. & Ali N. Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes Infection and Immunity 65 1997 2371-2377
3. Hondowicz B. & Scott P. Influence of parasite load on the ability of type 1 T cells to control Leishmania major infection Infection and Immunity 70 2002 498-503
4. Kemp K. Cytokine-producing T cell subsets in human leishmaniasis Archivum Immunologiae et Therapiae Experimentalis 48 2000 173-176
5. Kole L. Das L. & Das P.K. Synergistic effect of interferon-gamma and mannosylated liposome-mcorporated doxorubicin in the therapy of experimental visceral leishmaniasis Journal of Infectious Diseases 180 1999 811-820
6. Mitra D.K. De Rosa S.C. Luke A. Balamurugan A. Khaitan B.K. Tung J. Mehra N.K. Terr A.I. O'Garra A. Herzenberg L.A. & Roederer M. Differential representations of memory T cell subsets are characteristic of polarized immunity in leprosy and atopic diseases International Immunology 11 1999 1801-1810
7. Moll H. & Berberich C. Dendritic cell-based vaccination strategies: induction of protective immunity against leishmaniasis Immunobiology 204 2001 659-666
8. Thakur C.P. Pandey A.K. & Sinha G.P. Comparison of regimens of amphotericin B deoxycholate in kalaazar Indian Journal of Medical Research 103 1996 259-263
9. Thakur C.P. Hassan S.M. Kumar N. Kumar P. Narayan S. Pandey A.K. Roy A.K. Sinha G.P. & Sinha S.P. Do the diminishing efficacy and increasing toxicity of sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar, India justify its continued use as a first line drug? An observational study of 40 cases Annals of Tropical Medicine and Parasitology 92 1998 561-569
10. Uzonna J.E. Brestscher P. Wei G. & Yurkowski D. Immune elimination of Leishmania major in mice: implications for immune memory, vaccination and reactivation disease Journal of Immunology 167 2001 6967-6974
11. Wendel K.A. & Sterlin T.R. Tuberculosis and HIV/AIDS Clinical Care 14 2002 9-15
12. WHO Control of the Leishmaniases. Report of a WHO Expert Committee Technical Report series, No. 793 1990 World Health OrganizationGeneva