Sodium stibogluconate resistance in Leishmania donovani correlates with greater tolerance to macrophage antileishmanial responses and trivalent antimony therapy

Parasitology

Volumn 131, Issue 6, 2005, Pages 747-757

  Carter, K C ^a   Hutchison, S ^a   Boitelle, A ^a   Murray, H W ^a,b   Sundar, S ^c   Mullen, A B ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c BANARAS HINDU UNIVERSITY   (India)

Author keywords

Drug resistance; Glutathione; Leishmania donovani; Sodium stibogluconate

Indexed keywords

ANTIMONY TARTRATE; BUTHIONINE SULFOXIMINE; HYDROGEN PEROXIDE; INTERLEUKIN 6; NITRITE; STIBOGLUCONATE SODIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG RESPONSE; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; LEISHMANIA DONOVANI; LEISHMANIASIS; LONGITUDINAL STUDY; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; RESPIRATORY BURST; SPLEEN CELL; TH1 CELL; TH2 CELL; TREATMENT OUTCOME; UPREGULATION; VIRULENCE;

ANIMALS; ANTIMONY POTASSIUM TARTRATE; ANTIMONY SODIUM GLUCONATE; ANTIPROTOZOAL AGENTS; BUTHIONINE SULFOXIMINE; CRICETINAE; DRUG RESISTANCE; FEMALE; HUMANS; HYDROGEN PEROXIDE; INTERLEUKIN-6; LEISHMANIA DONOVANI; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MESOCRICETUS; MICE; MICE, INBRED BALB C; NITRITES; SPLEEN; VIRULENCE;

ANIMALIA; LEISHMANIA DONOVANI;

EID: 28844456074     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182005008486     Document Type: Article

References (24)

1. Bailey, H. H. (1998). L-S, R-buthionine sulfoximine: historical development and clinical issues. Chemico-Biological Interactions 111-112, 239-254.
2. Banduwardene, R, Mullen, A. B. and Carter, K. C. (1997). Immune responses of Leishmania donovani infected BALB/c mice following treatment with free and vesicular sodium stibogluconate formulations. International Journal of Immunopharmacology 19, 195-203.
3. Barr, S. D. and Gedamu, L. (2003). Role of peroxidoxins in Leishmania chagasi survival. Evidence of an enzymatic defense against nitrosative stress. Journal of Biological Chemistry 278, 10816-10823.
4. Carter, K. C., Baillie, A. J., Alexander, J. and Dolan, T. F. (1988). The therapeutic effect of sodium stibogluconate in the BALB/c mice infected with L. donovani is organ dependent. 1988. Journal of Pharmacy and Pharmacology 40, 370-373.
5. Carter, K. C., Mullen, A. B., Sundar, S. and Kenney, R. T. (2001). The efficacy of vesicular and free sodium stibogluconate formulations against clinical isolates of Leishmania donovani. Antimicrobrobial Agents and Chemotherapy 45, 355-359.
6. Carter, K. C., Sundar, S., Spickett, C., Pereira, O. C. and Mullen, A. B. (2003). The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis. Antimicrobrobial Agents and Chemotherapy 47, 1529-1535.
7. Croft, S. L. and Coombs, G. H. (2003). Leishmaniasis - current chemotherapy and recent advances in the search for novel drugs. Trends in Parasitology 19, 502-508.
8. Engwerda, C. R. and Kaye, P. M. (1999). Organ-specific immune responses associated with infectious disease. Immunology Today 2000 21, 73-78.
9. Gebel, T. (1997). Arsenic and antimony: comparative approach on mechanistic toxicology. Chemico-biological Interactions 107, 131-144.
10. Goodwin, L. C. and Page, J. E. (1943). A study of the excretion of inorganic antimonials using a polarographic procedure. Biochemistry 22, 236-240.
11. Goyal, N., Roy, U. and Rastogi, A. K. (1996). Relative resistance of promastigotes of a virulent and an avirulent strain of Leishmania donovani to hydrogen peroxide. Free Radical Biology and Medicine 21, 683-689.
12. Grondin, K., Haimeur, A., Mukhopadhyay, R., Rosen, B. P. and Ouellette, M. (1997). Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae. EMBO Journal 16, 3057-3065.
13. Haddad, J. J. (2002). Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology. Respiratory Research 3, 26-53.
14. Haddad, J. J., Saade, N. E. and Safieh-Garabedian, B. (2002). Redox regulation of TNF-alpha biosynthesis: augmentation by irreversible inhibition of gamma-glutamylcysteine synthetase and the involvement of an I kappaB-alpha/NF-kappaB-independent pathway in alveolar epithelial cells. Cell Signal 14, 211-218.
15. Haimeur, A. and Ouellette, M. (1998). Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate. Antimicrobial Agents and Chemotherapy 42, 1689-1694.
16. Kapoor, P., Sachdev, M. and Madhubala, R. (2000). Inhibition of glutathione synthesis as a chemotherapeutic strategy for leishmaniasis. Tropical Medicine and International Health 5, 438-442.
17. Legare, D., Papadoulou, B., Roy, G., Mukhopadhyay, R., Haimeur, A., Dey, S., Grondin, K., Brochu, C., Rosen, B. P. and Ouellette, M. (1997). Efflux systems and increased trypanothionine levels in arsenite-resistant Leishmania. Experimental Parasitology 87, 275-282.
18. Murata, Y., Shimamura, T. and Hamuro, J. (2002). The polarization of T(h)1/T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production. International Immunology 14, 201-212.
19. Murray, H. W. and Delph-Etienne, S. (2000). Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis. Infection and Immunity 68, 288-293.
20. Murray, H. W. and Nathan, C. F. (1999). Macrophage microbial mechanism in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral leishmaniasis. Journal of Experimental Medicine 189, 741-746.
21. Sereno, D., Cavaleyra, M., Zemzoumi, K., Maquaire, S., Ouaissi, A. and Lemesre, J. L. (1998). Axenically grown amastigotes of Leishmania infantum used as an in vitro model to investigate the pentavalent antimony mode of action. Antimicrobial Agents and Chemotherapy 42, 3097-3102.
22. Sudhandiran, G. and Shaha, C. (2003). Antimonial induced increase in intracellular Ca2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani amastigotes. Journal of Biological Chemistry 278, 25120-25132.
23. The Registry of Toxic Effects of Chemical Substances (2003). RTECS #: CC6825000, CAS #: 28300-74-5.
24. Wyllie, S., Cunningham, M. L. and Fairlamb, A. H. (2004). Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani. Journal of Biological Chemistry 279, 39925-39932.