Adaptor protein Lnk inhibits c-Fms-mediated macrophage function

Journal of Leukocyte Biology

Volumn 88, Issue 4, 2010, Pages 699-706

  Gueller, Saskia ^a,b   Goodridge, Helen S ^b   Niebuhr, Birte ^c   Xing, Hongtao ^b   Koren Michowitz, Maya ^b   Serve, Hubert ^a   Underhill, David M ^b   Brandts, Christian H ^a   Koeffler, H Phillip ^b,d  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^d Singapore Cancer Institute   (Singapore)

Author keywords

Cytokine; Migration; Receptor tyrosine kinase; ROS; Signaling

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN LNK; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FMS; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZYMOSAN; LNK PROTEIN, MOUSE; PROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BONE MARROW; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; CLONOGENIC ASSAY; COLONY FORMING UNIT M; CONTROLLED STUDY; GROWTH INHIBITION; IMMUNOMODULATION; MACROPHAGE; MACROPHAGE FUNCTION; MACROPHAGE MIGRATION; MEDIATOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; WILD TYPE; ANIMAL; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; METABOLISM; NEUTROPHIL CHEMOTAXIS; PHAGOCYTOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

MUS;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CHEMOTAXIS, LEUKOCYTE; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MICE; MICE, KNOCKOUT; PHAGOCYTOSIS; PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 77957864524     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0309185     Document Type: Article

References (42)

1. Ema, H., Sudo, K., Seita, J., Matsubara, A., Morita, Y., Osawa, M., Takatsu, S., Takaki, S., Nakauchi, H. (2005) Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev. Cell 8, 907-914.
2. Nobuhisa, I., Takizawa, M., Takaki, S., Inoue, H., Okita, K., Ueno, M., Takatsu, K., Taga, T. (2003) Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein. Mol. Cell. Biol. 23, 8486-8494.
3. Takaki, S., Morita, H., Tezuka, Y., Takatsu, K. (2002) Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein. J. Exp. Med. 195, 151-160.
4. Velazquez, L., Cheng, A. M., Fleming, H. E., Furlonger, C., Vesely, S., Bernstein, A., Paige, C. J., Pawson, T. (2002) Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J. Exp. Med. 195, 1599-1611.
5. Takaki, S., Sauer, K., Iritani, B. M., Chien, S., Ebihara, Y., Tsuji, K., Takatsu, K., Perlmutter, R. M. (2000) Control of B cell production by the adaptor protein Lnk. Definition of a conserved family of signal-modulating proteins. Immunity 13, 599-609.
6. Takaki, S., Tezuka, Y., Sauer, K., Kubo, C., Kwon, S. M., Armstead, E., Nakao, K., Katsuki, M., Perlmutter, R. M., Takatsu, K. (2003) Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein. J. Immunol. 170, 703-710.
7. Tong, W., Lodish, H. F. (2004) Lnk inhibits Tpo-Mpl signaling and Tpo-mediated megakaryocytopoiesis. J. Exp. Med. 200, 569-580.
8. Tong, W., Zhang, J., Lodish, H. F. (2005) Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood 105, 4604-4612.
9. Li, Y., He, X., Schembri-King, J., Jakes, S., Hayashi, J. (2000) Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation. J. Immunol. 164, 5199-5206.
10. Takaki, S. (2002) Lnk, an adaptor protein regulate production of B cells and hematopoietic stem cells. Tanpakushitsu Kakusan Koso 47, 2188-2193.
11. Boulday, G., Coulon, F., Fraser, C. C., Soulillou, J. P., Charreau, B. (2002) Transcriptional up-regulation of the signaling regulatory protein LNK in activated endothelial cells. Transplantation 74, 1352-1354.
12. Gueller, S., Gery, S., Nowak, V., Liu, L., Serve, H., Koeffler, H. P. (2008) Adaptor protein Lnk associates with Tyr(568) in c-Kit. Biochem. J. 415, 241-245.
13. Guilbert, L. J., Stanley, E. R. (1980) Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells. J. Cell Biol. 85, 153-159.
14. Stoy, N. (2001) Macrophage biology and pathobiology in the evolution of immune responses: a functional analysis. Pathobiology 69, 179-211.
15. Adams, D. O., Hamilton, T. A. (1984) The cell biology of macrophage activation. Annu. Rev. Immunol. 2, 283-318.
16. Bourette, R. P., Rohrschneider, L. R. (2000) Early events in M-CSF receptor signaling. Growth Factors 17, 155-166.
17. Cecchini, M. G., Dominguez, M. G., Mocci, S., Wetterwald, A., Felix, R., Fleisch, H., Chisholm, O., Hofstetter, W., Pollard, J. W., Stanley, E. R. (1994) Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development 120, 1357-1372.
18. Stanley, E. R., Chen, D. M., Lin, H. S. (1978) Induction of macrophage production and proliferation by a purified colony stimulating factor. Nature 274, 168-170.
19. Roth, P., Stanley, E. R. (1992) The biology of CSF-1 and its receptor. Curr. Top. Microbiol. Immunol. 181, 141-167.
20. Sherr, C. J., Rettenmier, C. W., Sacca, R., Roussel, M. F., Look, A. T., Stanley, E. R. (1985) The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell 41, 665-676.
21. Cheng, M., Wang, D., Roussel, M. F. (1999) Expression of c-Myc in response to colony-stimulating factor-1 requires mitogen-activated protein kinase kinase-1. J. Biol. Chem. 274, 6553-6558.
22. Valledor, A. F., Comalada, M., Xaus, J., Celada, A. (2000) The differential time-course of extracellular-regulated kinase activity correlates with the macrophage response toward proliferation or activation. J. Biol. Chem. 275, 7403-7409.
23. Jones, G. E., Prigmore, E., Calvez, R., Hogan, C., Dunn, G. A., Hirsch, E., Wymann, M. P., Ridley, A. J. (2003) Requirement for PI 3-kinase γ in macrophage migration to MCP-1 and CSF-1. Exp. Cell Res. 290, 120-131.
24. Kelley, T. W., Graham, M. M., Doseff, A. I., Pomerantz, R. W., Lau, S. M., Ostrowski, M. C., Franke, T. F., Marsh, C. B. (1999) Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. J. Biol. Chem. 274, 26393-26398.
25. Wheeler, A. P., Smith, S. D., Ridley, A. J. (2006) CSF-1 and PI 3-kinase regulate podosome distribution and assembly in macrophages. Cell Motil. Cytoskeleton 63, 132-140.
26. Yu, W., Chen, J., Xiong, Y., Pixley, F. J., Dai, X. M., Yeung, Y. G., Stanley, E. R. (2008) CSF-1 receptor structure/function in MacCsf1r-/- macrophages: regulation of proliferation, differentiation, and morphology. J. Leukoc. Biol. 84, 852-863.
27. Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L., Aderem, A. (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc. Natl. Acad. Sci. USA 97, 13766-13771.
28. Brown, G. D., Taylor, P. R., Reid, D. M., Willment, J. A., Williams, D. L., Martinez-Pomares, L., Wong, S. Y., Gordon, S. (2002) Dectin-1 is a major β-glucan receptor on macrophages. J. Exp. Med. 196, 407-412.
29. Takeda, K., Kaisho, T., Akira, S. (2003) Toll-like receptors. Annu. Rev. Immunol. 21, 335-376.
30. Sester, D. P., Beasley, S. J., Sweet, M. J., Fowles, L. F., Cronau, S. L., Stacey, K. J., Hume, D. A. (1999) Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival. J. Immunol. 163, 6541-6550.
31. Goyal, A., Wang, Y., Graham, M. M., Doseff, A. I., Bhatt, N. Y., Marsh, C. B. (2002) Monocyte survival factors induce Akt activation and suppress caspase-3. Am. J. Respir. Cell Mol. Biol. 26, 224-230.
32. Sweet, M. J., Campbell, C. C., Sester, D. P., Xu, D., McDonald, R. C., Stacey, K. J., Hume, D. A., Liew, F. Y. (2002) Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of Toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. J. Immunol. 168, 392-399.
33. Alatery, A., Basta, S. (2008) An efficient culture method for generating large quantities of mature mouse splenic macrophages. J. Immunol. Methods 338, 47-57.
34. Moon, K. A., Kim, S. Y., Kim, T. B., Yun, E. S., Park, C. S., Cho, Y. S., Moon, H. B., Lee, K. Y. (2007) Allergen-induced CD11b+ CD11c(int) CCR3+ macrophages in the lung promote eosinophilic airway inflammation in a mouse asthma model. Int. Immunol. 19, 1371-1381.
35. Underhill, D. M., Rossnagle, E., Lowell, C. A., Simmons, R. M. (2005) Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 106, 2543-2550.
36. Webb, S. E., Pollard, J. W., Jones, G. E. (1996) Direct observation and quantification of macrophage chemoattraction to the growth factor CSF-1. J. Cell Sci. 109, 793-803.
37. Bersenev, A., Wu, C., Balcerek, J., Tong, W. (2008) Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. J. Clin. Invest. 118, 2832-2844.
38. Gery, S., Gueller, S., Chumakova, K., Kawamata, N., Liu, L., Koeffler, H. P. (2007) Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L, associated with myeloproliferative disorders. Blood 110, 3360-3364.
39. Yamato, K., el-Hajjaoui, Z., Simon, K., Koeffler, H. P. (1990) Modulation of interleukin-1 β RNA in monocytic cells infected with human immunodeficiency virus-1. J. Clin. Invest. 86, 1109-1114.
40. Schlick, E., Hartung, K., Chirigos, M. A. (1984) Role of prostaglandin E and interferon in secretion of colony-stimulating factor by murine macrophages after in vitro treatment with biological response modifiers. Int. J. Immunopharmacol. 6, 407-418.
41. Yalcin, S., Mungamuri, S. K., Marinkovic, D., Zhang, X., Tong, W., Cullen, D., Ghaffari, S. (2008) Oxidative stress-mediated activation of AKT/mTOR signaling pathway leads to myeloproliferative syndrome in FoxO3 null mice: a role for Lnk adaptor protein. Blood 112, 509 (ASH Annual Meeting Abstracts).
42. Wang, Y., Zeigler, M. M., Lam, G. K., Hunter, M. G., Eubank, T. D., Khramtsov, V. V., Tridandapani, S., Sen, C. K., Marsh, C. B. (2007) The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival. Am. J. Respir. Cell Mol. Biol. 36, 68-77.