CSF-1 and PI 3-kinase regulate podosome distribution and assembly in macrophages

Cell Motility and the Cytoskeleton

Volumn 63, Issue 3, 2006, Pages 132-140

  Wheeler, Ann R ^a,b   Smith, Stephen D ^a,b   Ridley, Anne J ^a,b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Actin cytoskeleton; Colony stimulating factor 1; Macrophages; Podosomes

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACTIN; ACTIN BINDING PROTEIN; COLONY STIMULATING FACTOR 1; INTEGRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL POLARITY; CELL SPREADING; CELL TYPE; CONTROLLED STUDY; ENZYME REGULATION; MACROPHAGE; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, INBRED C57BL;

ANIMALIA;

EID: 33644856778     PISSN: 08861544     EISSN: 10970169     Source Type: Journal    
DOI: 10.1002/cm.20111     Document Type: Article

References (50)

1. Abram CL, Seals DF, Pass I, Salinsky D, Maurer L, Roth TM, Courtneidge SA. 2003. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. J Biol Chem 278:16844-16851.
2. Adi S, Wu NY, Rosenthal SM. 2001. Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and Wortmannin. Endocrinology 142:498-501.
3. Allen WE, Jones GE, Pollard JW, Ridley AJ. 1997. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. J Cell Sci 110:707-720.
4. Allen WE, Zicha D, Ridley AJ, Jones GE. 1998. A role for Cdc42 in macrophage chemotaxis. J Cell Biol 141:1147-1157.
5. Babb SG, Matsudaira P, Sato M, Correia I, Lim SS. 1997. Fimbrin in podosomes of monocyte-derived osteoclasts. Cell Motil Cytoskeleton 37:308-325.
6. Berdeaux RL, Diaz B, Kim L, Martin GS. 2004. Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function. J Cell Biol 166:317-323.
7. Bruzzaniti A, Neff L, Sanjay A, Home WC, De Camilli P, Baron R. 2005. Dynamin forms a Src kinase-sensitive complex with CbI and regulates podosomes and osteoclast activity. Mol Biol Cell 16:3301-3313.
8. Burns S, Thrasher AJ, Blundell MP, Machesky L, Jones GE. 2001. Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation. Blood 98:1142-1149.
9. Burns S, Hardy SJ, Buddle J, Yong KL, Jones GE, Thrasher AJ. 2004. Maturation of DC is associated with changes in motile characteristics and adherence. Cell Motil Cytoskeleton 57:118-132.
10. Calle Y, Chou HC, Thrasher AJ, Jones GE. 2004. Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells. J Pathol 204:460-469.
11. Chellaiah M, Kizer N, Silva M, Alvarez U, Kwiatkowski D, Hruska KA. 2000. Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J Cell Biol 148: 665-678.
12. Chellaiah MA, Biswas RS, Yuen D, Alvarez UM, Hruska KA. 2001. Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. J Biol Chem 276:47434-47444.
13. Correia I, Chu D, Chou YH, Goldman RD, Matsudaira P. 1999. Integrating the actin and vimentin cytoskeletons. adhesion-dependent formation of fimbrin-vimentin complexes in macrophages. J Cell Biol 146:831-842.
14. Correll PH, Morrison AC, Lutz MA. 2004. Receptor tyrosine kinases and the regulation of macrophage activation. J Leukoc Biol 75:731-737.
15. Destaing O, Saltel F, Geminard JC, Jurdic P, Bard F. 2003. Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein. Mol Biol Cell 14:407-416.
16. Duong LT, Rodan GA. 2000. PYK2 is an adhesion kinase in macrophages, localized in podosomes and activated by β2-integrin ligation. Cell Motil Cytoskeleton 47:174-188.
17. Evans JG, Correia I, Krasavina O, Watson N, Matsudaira P. 2003. Macrophage podosomes assemble at the leading lamella by growth and fragmentation. J Cell Biol 161:697-705.
18. Gavazzi I, Nermut MV, Marchisio PC. 1989. Ultrastructure and gold-immunolabelling of cell-substratum adhesions (podosomes) in RSV-transformed BHK cells. J Cell Sci 94:85-99.
19. Goto T, Maeda H, Tanaka T. 2002. A selective inhibitor of matrix metalloproteinases inhibits the migration of isolated osteoclasts by increasing the life span of podosomes. J Bone Miner Metab 20:98-105.
20. Johansson MW, Lye MH, Barthel SR, Duffy AK, Annis DS, Mosher DF. 2004. Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes. Am J Respir Cell Mol Biol 31:413-422.
21. Jones GE, Zicha D, Dunn GA, Blundell M, Thrasher A. 2002. Restoration of podosomes and chemotaxis in Wiskott-Aldrich syndrome macrophages following induced expression of WASp. Int J Biochem Cell Biol 34:806-815.
22. Jones GE, Prigmore E, Calvez R, Hogan C, Dunn GA, Hirsch E, Wymann MP, Ridley AJ. 2003. Requirement for PI 3-kinase γ in macrophage migration to MCP-1 and CSF-1. Exp Cell Res 290:120-131.
23. Kelley TW, Graham MM, Doseff AI, Pomerantz RW, Lau SM, Ostrowski MC, Franke TF, Marsh CB. 1999. Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. J Biol Chem 274:26393-26398.
24. Kwiatkowski DJ. 1999. Functions of gelsolin: motility, signaling, apoptosis, cancer. Curr Opin Cell Biol 11:103-108.
25. Leverrier Y, Ridley AJ. 2001. Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages. Curr Biol 11:195-199.
26. Leverrier Y, Okkenhaug K, Sawyer C, Bilancio A, Vanhaesebroeck B, Ridley AJ. 2003. Class I phosphoinositide 3-kinase p110β is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. J Biol Chem 278:38437-38442.
27. Linder S, Aepfelbacher M. 2003. Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol 13:376-385.
28. Linder S, Hufner K, Wintergerst U, Aepfelbacher M. 2000. Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages. J Cell Sci 113:4165-4176.
29. Linder S, Nelson D, Weiss M, Aepfelbacher M. 1999. Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages. Proc Natl Acad Sci USA 96:9648-9653.
30. Marchisio PC, Bergui L, Corbascio GC, Cremona O, D'Urso N, Schena M, Tesio L, Caligaris-Cappio F. 1988. Vinculin, talin, and integrins are localized at specific adhesion sites of-malignant B lymphocytes. Blood 72:830-833.
31. McNiven MA, Baldassarre M, Buccione R. 2004. The role of dynamin in the assembly and function of podosomes and invadopodia. Front Biosci 9:1944-1953.
32. Meili R, Firtel RA. 2003. Two poles and a compass. Cell 114:153-156.
33. Mizutani K, Miki H, He H, Maruta H, Takenawa T. 2002. Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. Cancer Res 62:669-674.
34. Moreau V, Tatin F, Varon C, Genot E. 2003. Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA. Mol Cell Biol 23:6809-6822.
35. Nermut MV, Eason P, Hirst EM, Kellie S. 1991. Cell/substratum adhesions in RSV-transformed rat fibroblasts. Exp Cell Res 193:382-397.
36. Ochoa GC, Slepnev VI, Neff L, Ringstad N, Takei K, Daniell L, Kim W, Cao H, McNiven M, Baron R and others. 2000. A functional link between dynamin and the actin cytoskeleton at podosomes. J Cell Biol 150:377-389.
37. Okkenhaug K, Vanhaesebroeck B. 2003. PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol 3: 317-330.
38. Orth JD, McNiven MA. 2003. Dynamin at the actin-membrane interface. Curr Opin Cell Biol 15:31-39.
39. Paulnock DM. 2000. Macrophages: A Practical Approach. Oxford: Oxford University Press, xvi, 211 p.
40. Pfaff M, Jurdic P. 2001. Podosomes in osteoclast-like cells: structural analysis and cooperative roles of paxillin, proline-rich tyrosine kinase 2 (Pyk2) and integrin αVβ3. J Cell Sci 114:2775-2786.
41. Pilkington MF, Sims SM, Dixon SJ. 1998. Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in vitro. J Bone Miner Res 13:688-694.
42. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. 2003. Cell migration: integrating signals from front to back. Science 302:1704-1709.
43. Seals DF, Azucena EF, Jr., Pass I, Tesfay L, Gordon R, Woodrow M, Resau JH, Courtneidge SA. 2005. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell 7: 155-165.
44. Teti A, Taranta A, Migliaccio S, Degiorgi A, Santandrea E, Villanova I, Faraggiana T, Chellaiah M, Hruska KA. 1998. Colony stimulating factor-1-induced osteoclast spreading depends on substrate and requires the vitronectin receptor and the c-src protooncogene. J Bone Miner Res 13:50-58.
45. Vanhaesebroeck B, Jones GE, Allen WE, Zicha D, Hooshmand-Rad R, Sawyer C, Wells C, Waterfield MD, Ridley AJ. 1999. Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages. Nat Cell Biol 1:69-71.
46. Ware MF, Wells A, Lauffenburger DA. 1998. Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner. J Cell Sci 111:2423-2432.
47. Webb SE, Pollard JW, Jones GE. 1996. Direct observation and quantification of macrophage chemoattraction to the growth factor CSF-1. J Cell Sci 109:793-803.
48. Wells CM, Walmsley M, Ooi S, Tybulewicz V, Ridley AJ. 2004. Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration. J Cell Sci 117:1259-1268.
49. Williams LM, Ridley AJ. 2000. Lipopolysaccharide induces actin reorganization and tyrosine phosphorylation of Pyk2 and paxillin in monocytes and macrophages. J Immunol 164:2028-2036.
50. Yeung YG, Wang Y, Einstein DB, Lee PS, Stanley ER. 1998. Colony-stimulating factor-1 stimulates the formation of multimeric cytosolic complexes of signaling proteins and cytoskeletal components in macrophages. J Biol Chem 273:17128-17137.