Effects of synthetic androgens on liver function using the rabbit as a model

Journal of Andrology

Volumn 31, Issue 5, 2010, Pages 472-481

  Hild, Sheri Ann ^a   Attardi, Barbara J ^a   Koduri, Sailaja ^a,b   Till, Bruce A ^a   Reel, Jerry R ^a  

^a BIOQUAL INC   (United States)

^b BioReliance Corporation   (United States)

Author keywords

11 methyl 19 nortestosterone 17 dodecylcarbonate; Bromsulfonphthalein; Dimethandrolone 17 undecanoate; Hepatotoxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BROMSULFOPHTHALEIN; GAMMA GLUTAMYLTRANSFERASE; IDITOL DEHYDROGENASE; LIVER ENZYME; METHYLTESTOSTERONE; TESTOSTERONE; TRESTOLONE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EFFECT; DRUG RETENTION; ENZYME BLOOD LEVEL; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; LIVER FUNCTION; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; GAMMA-GLUTAMYLTRANSFERASE; L-IDITOL 2-DEHYDROGENASE; LIVER; MALE; METHYLTESTOSTERONE; NANDROLONE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RABBITS; SULFOBROMOPHTHALEIN; TESTOSTERONE; TESTOSTERONE CONGENERS;

EID: 77957844709     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.109.009365     Document Type: Article

References (38)

1. Asada M, Galambos JT. Sorbitol dehydrogenase and hepatocellular injury: an experimental and clinical study. Gastroenterology. 1963;44:578-587.
2. Attardi BJ, Hild SA, Reel JR. Dimethandrolone undecanoate: a new potent orally active androgen with progestational activity. Endocrinology. 2006;147:3016-3026.
3. Borhan-Manesh F, Farnum JB. Methyltestosterone-induced cholestasis: the importance of disproportionately low serum alkaline phosphatase level. Arch Intern Med. 1989;124:2127-2129. (Pubitemid 19232239)
4. Brandoni A, DiGiusto G, Franca R, Passamonti S, Torres AM. Expression of kidney and liver bilitranslocase in response to acute biliary obstruction. Nephron. 2010;114:35-40.
5. Brandoni A, Torres AM. Characterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of Oatp1. J Histochem Cytochem. 2009;57: 449-456.
6. Carmichael RH, Wilson C, Martz BL. Effect of anabolic steroids on liver function tests in rabbits. Proc Soc Exp Biol Med. 1963;113: 1006-1008.
7. Chuttani HK, Gupta PS, Gulati S, Gupta DH. Acute copper sulfate poisoning. Am J Med. 1965;39:849-854.
8. Coert A, Geelen J, de Visser J, van der Vies J. The pharmacology and metabolism of testosterone undecanoate (TU), a new orally active androgen. Acta Endocrinol. 1975;79:789-800.
9. Colon AR, Pardo V, Sandberg DH. Experimental Reye's Syndrome induced by viral potentiation of chemical toxin. In: Pollack JD, ed. Reye's Syndrome. New York, NY: Grune and Stratton; 1974:194-214.
10. deLorimier AA, Gordan GS, Lowe RC, Carbone JV. Methyl testosterone, related steroids, and liver function. Arch Intern Med. 1965;116:289-294.
11. Henry RJ, Chiamori N, Ware AG. Determination of bromsul-fonphthalein in serum by means of acetone precipitation of proteins. Tech Bull Registry Med Technol. 1959;29:117-119.
12. Heywood R, Chesterman H, Ball SA, Wadsworth PF. Toxicity of methyl testosterone in the beagle dog. Toxicology. 1977;7: 357-365. (Pubitemid 8137139)
13. Ishak HK, Zimmerman HJ. Hepatotoxic effects of the anabolic androgenic steroids. Semin Liver Dis. 1987;7:230-236. (Pubitemid 18041648)
14. Josse R, Aninat C, Glaise D, Dumont J, Fessard V, Morel F, Poul JM, Guguen-Guillouzo C, Guillouzo A. Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies. Drug Metab Dispos. 2008;36:1111-1118. (Pubitemid 351717469)
15. Karmen AJ, Wroblewski F, La Du JS. Transaminase activity in human blood. J Clin Invest. 1955;34:126-131.
16. Larner JM, Reel JR, Blye RP. Circulating concentrations of the antiprogestins CDB-2914 and mifepristone in the female rhesus monkey following various routes of administration. Hum Reprod. 2000;15:1100-1106.
17. Li AP. Screening for human ADME/Tox properties in drug discovery. Drug Discov Today. 2001;6:357-366. (Pubitemid 32208650)
18. Li AP, Lu C, Brent JA, Pham C, Fackett A, Ruegg CE, Silber PM. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and application in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chem Biol Interact. 1999;121: 17-35. (Pubitemid 29240667)
19. Miquel M, Soler A, Vaque A, Ojanguren I, Costa J, Planas R. Suspected cross-hepatotoxicity of flutamide and cyproterone acetate. Liver Int. 2007;27:1144-1147. (Pubitemid 47399450)
20. Molino G, Cavanna A, Biondi AM, Macri G, Urigu S, Ugazio G. Bromsulphalein (BSP) kinetics in the rat: a new approach in evaluating experimental hepatotoxicity. Int Arch Occup Environ Health. 1982;51:73-79. (Pubitemid 13198366)
21. Moslen MT. Toxic responses of the liver. In: Klaassen CD, ed. Casarett & O'Doull's Toxicology: The Basic Science of Poisons. 5th ed. New York, NY: McGraw-Hill; 1996:403-416.
22. National Research Council. Guide for the Care and Use of Animals. Washington, DC: National Academy Press; 1996.
23. Pagonis TA, Koukoulis GN, Hadjichristodoulou CS, Toli PN, Angelopoulos NV. Multivitamins and phospholipids complex protects the hepatic cells from androgenic-anabolic-steroids- induced toxicity. Clin Toxicol. 2008;46:57-66.
24. Sahu SC, Wiesenfeld PL, Kim CS, Ross IA, Sapienza PP, Newell R, O'Donnell MW, Flynn TJ. Validation of an in vitro model for assessment of androstenedione hepatotoxicity using the rat liver cell line clone-9. J Appl Toxicol. 2008;28:703-709. (Pubitemid 352009762)
25. Sanchez-Osorio M, Duarte-Rojo A, Martinez-Benitez B, Torre A, Uribe M. Anabolic-androgenic steroids and liver injury. Liver Int. 2008;28:278-282.
26. Snel CAW, Pang KS, Mulder GJ. Glutathione conjugation of bromosulfophthalein in relation to hepatic glutathione content in the rat in vivo and in the perfused rat liver. Hepatology. 1995;21:1387-1394.
27. Soto A, Foy BD, Frazier JM. Effect of cadmium on bromosul-fophthalein kinetics in the isolated perfused rat liver system. Toxicol Sci. 2002;69:460-469. (Pubitemid 35244220)
28. Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Pharmacol Ther. 2006;109:1-11. (Pubitemid 41740811)
29. Sundaram K, Kumar N. 7α-Methyl-19-nortestosterone (MENT): the optimal androgen for male contraception and replacement therapy. Int J Androl. 2000;23:13-15. (Pubitemid 30330225)
30. Szasz G, Bergmeyer HU. γ-Glutamyltranspeptidase. In: Methods of Enzymatic Analysis. Weinheim, Germany: Verlag Chemie; 1974:715-720.
31. Taylor W, Snowball S. The effects of long-term administration of methyl testosterone on the development of liver lesions in BALB/c mice. J Pathol. 1984;143:211-218. (Pubitemid 14094485)
32. Tennant BC, Balazs T, Baldwin BH, Hornbuckle WE, Castleman WL, Boelsterli U, Kallfelz FA. Assessment of hepatic function in rabbits with steroid-induced cholestatic liver injury. Fundam Appl Toxicol. 1981;1:329-333.
33. Vaitukaitis J, Robbins JB, Nieschlag E, Ross GT. A method for producing specific antisera with small doses of immunogen. J Clin Endocrinol. 1971;33:988-991.
34. Welder AA, Robertson JW, Melchert RB. Toxic effect of anabolic- androgenic steroids in primary rat hepatic cell cultures. J Pharmacol Toxicol Methods. 1995;33:187-195.
35. Wiesner IS, Rawnsley HM, Brooks FP, Senior JR. Sorbitol dehydrogenase in the diagnosis of liver disease. Am J Dig Dis. 1965;10:147-151.
36. Wroblewski F, La Du JS. Serum glutamic pyruvic transaminase in cardiac with hepatic disease. Proc Soc Exp Biol Med. 1956a;91:569-571.
37. Wroblewski F, La Du JS. Serum glutamic pyruvic transaminase SGP-T in hepatic disease: a preliminary report. Ann Intern Med. 1956b;45:801-811.
38. Yam J, Reeves M, Roberts RJ. Comparison of sulfobromophthalein (BSP) and sulfobromophthalein gluthathione (BSP-GSH) disposition under conditions of altered liver function and in the isolated perfused rat liver. J Lab Clin Med. 1976;87:373-383.