Validation of an in vitro model for assessment of androstenedione hepatotoxicity using the rat liver cell line clone-9

Journal of Applied Toxicology

Volumn 28, Issue 5, 2008, Pages 703-709

  Sahu, Saura C ^a   Wiesenfeld, Paddy L ^a   Kim, Chung S ^a   Ross, Ivan A ^a   Sapienza, Philip P ^a   Newell, Richard ^a   O'Donnell, Michael W ^a   Flynn, Thomas J ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Androstenedione; Clone 9 cells; Hepatotoxicity; Liver; Rat

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANDROSTENEDIONE; CARBON MONOXIDE; CASPASE 3; CYTOCHROME P450; DOUBLE STRANDED DNA; LIPID; LIVER ENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL ISOLATION; CELL LINE; CELL VIABILITY; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; ENZYME ACTIVITY; ENZYME RELEASE; EPITHELIUM CELL; FATTY LIVER; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; LIVER; LIVER CELL; LIVER TOXICITY; MALE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; SPRAGUE DAWLEY RAT; SUPERNATANT; VALIDATION STUDY;

ADENOSINE TRIPHOSPHATE; ANDROSTENEDIONE; ANIMALS; BIOLOGICAL MARKERS; CASPASE 3; CELL LINE; CLONE CELLS; DNA; ENZYMES; FEMALE; HEPATITIS, TOXIC; HEPATOCYTES; LIVER; MODELS, BIOLOGICAL; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

RATTUS;

EID: 47549113865     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1325     Document Type: Article

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