-
2
-
-
0032840464
-
Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein
-
Slupska MM, Luther WM, Chiang JH, Yang H, Miller JH (1999) Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein. J Bacteriol 181: 6210-6213.
-
(1999)
J Bacteriol
, vol.181
, pp. 6210-6213
-
-
Slupska, M.M.1
Luther, W.M.2
Chiang, J.H.3
Yang, H.4
Miller, J.H.5
-
3
-
-
34250900982
-
Base-excision repair of oxidative DNA damage
-
David SS, O'Shea VL, Kundu S (2007) Base-excision repair of oxidative DNA damage. Nature 447: 941-950.
-
(2007)
Nature
, vol.447
, pp. 941-950
-
-
David, S.S.1
O'Shea, V.L.2
Kundu, S.3
-
4
-
-
47849100494
-
Mechanism of oxidative DNA damage repair and relevance to human pathology
-
D'Errico M, Parlanti E, Dogliotti E (2008) Mechanism of oxidative DNA damage repair and relevance to human pathology. Mutat Res 659: 4-14.
-
(2008)
Mutat Res
, vol.659
, pp. 4-14
-
-
D'errico, M.1
Parlanti, E.2
Dogliotti, E.3
-
5
-
-
0034654256
-
Identification of human MutY homolog (hMYH) as a repair enzyme for 2- hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria
-
Ohtsubo T, Nishioka K, Imaiso Y, Iwai S, Shimokawa H, et al. (2000) Identification of human MutY homolog (hMYH) as a repair enzyme for 2- hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res 28: 1355-1364.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 1355-1364
-
-
Ohtsubo, T.1
Nishioka, K.2
Imaiso, Y.3
Iwai, S.4
Shimokawa, H.5
-
6
-
-
0141532257
-
Mutator phenotyper of MUTYH-null Mouse embryonic stem cells
-
Hirano S, Tominaga Y, Ichinoe A, Ushijima Y, Tsuchimoto D, et al. (2003) Mutator phenotyper of MUTYH-null Mouse embryonic stem cells. J Biol Chem 278: 38121-38124.
-
(2003)
J Biol Chem
, vol.278
, pp. 38121-38124
-
-
Hirano, S.1
Tominaga, Y.2
Ichinoe, A.3
Ushijima, Y.4
Tsuchimoto, D.5
-
7
-
-
66249146924
-
Role of MUTYH and MSH2 in the control of oxidative DNA damage, genetic instability, and tumorigenesis
-
Russo MT, De Luca G, Casorelli I, Degan P, Molatore S, et al. (2009) Role of MUTYH and MSH2 in the control of oxidative DNA damage, genetic instability, and tumorigenesis. Cancer Res 69: 4372-4379.
-
(2009)
Cancer Res
, vol.69
, pp. 4372-4379
-
-
Russo, M.T.1
de Luca, G.2
Casorelli, I.3
Degan, P.4
Molatore, S.5
-
8
-
-
34547105083
-
MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis
-
Sakamoto K, Tominaga Y, Yamauchi K, Nakatsu Y, Sakumi K, et al. (2007) MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis. Cancer Res 67: 6599-6604.
-
(2007)
Cancer Res
, vol.67
, pp. 6599-6604
-
-
Sakamoto, K.1
Tominaga, Y.2
Yamauchi, K.3
Nakatsu, Y.4
Sakumi, K.5
-
9
-
-
10844274799
-
Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice
-
Sieber OM, Howarth KM, Thirlwell C, Rowan A, Mandir N, et al. (2004) Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice. Cancer Res 64: 8876-8881.
-
(2004)
Cancer Res
, vol.64
, pp. 8876-8881
-
-
Sieber, O.M.1
Howarth, K.M.2
Thirlwell, C.3
Rowan, A.4
Mandir, N.5
-
10
-
-
0036478899
-
Inherited variants of MYH associated with somatic G:C>T:A mutations in colorectal tumors
-
Al-Tassan N, Chmiel NH, Maynard J, Fleming N, Livingston AL, et al. (2002) Inherited variants of MYH associated with somatic G:C>T:A mutations in colorectal tumors. Nat Genet 30: 227-232.
-
(2002)
Nat Genet
, vol.30
, pp. 227-232
-
-
Al-Tassan, N.1
Chmiel, N.H.2
Maynard, J.3
Fleming, N.4
Livingston, A.L.5
-
11
-
-
0036848267
-
Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C>T:A mutations
-
Jones S, Emmerson P, Maynard J, Best JM, Jordan S, et al. (2002) Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C>T:A mutations. Hum Mol Genet 11: 2961-2967.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2961-2967
-
-
Jones, S.1
Emmerson, P.2
Maynard, J.3
Best, J.M.4
Jordan, S.5
-
12
-
-
10744220394
-
Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway
-
Lipton L, Halford SE, Johnson V, Novelli MR, Jones A, et al. (2003) Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. Cancer Res 63: 7595-7599.
-
(2003)
Cancer Res
, vol.63
, pp. 7595-7599
-
-
Lipton, L.1
Halford, S.E.2
Johnson, V.3
Novelli, M.R.4
Jones, A.5
-
13
-
-
68849121037
-
Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis
-
Gushima M, Hirahashi M, Matsumoto T, Fujita K, Fujisawa R, et al. (2009) Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis. J Pathol 219: 77-86.
-
(2009)
J Pathol
, vol.219
, pp. 77-86
-
-
Gushima, M.1
Hirahashi, M.2
Matsumoto, T.3
Fujita, K.4
Fujisawa, R.5
-
14
-
-
9144271661
-
The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation
-
Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, et al. (2003) The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Invest 112: 1887-1894.
-
(2003)
J Clin Invest
, vol.112
, pp. 1887-1894
-
-
Hofseth, L.J.1
Khan, M.A.2
Ambrose, M.3
Nikolayeva, O.4
Xu-Welliver, M.5
-
15
-
-
34347262689
-
Chemically induced mouse models of intestinal inflammation
-
Wirtz S, Neufert C, Weigmann B, Neurath MF (2007) Chemically induced mouse models of intestinal inflammation. Nat Protoc 2: 541-546.
-
(2007)
Nat Protoc
, vol.2
, pp. 541-546
-
-
Wirtz, S.1
Neufert, C.2
Weigmann, B.3
Neurath, M.F.4
-
16
-
-
0032446105
-
Dextran sulfate enhances the level of an oxidative DNA damage biomarker, 8-oxo-7,8- dihydro-29-deoxyguanosine, in rat colonic mucosa
-
Tardieu D, Jaeg JP, Cadet J, Embvani E, Corpet DE, et al. (1998) Dextran sulfate enhances the level of an oxidative DNA damage biomarker, 8-oxo-7,8- dihydro-29-deoxyguanosine, in rat colonic mucosa. Cancer Lett 134: 1-5.
-
(1998)
Cancer Lett
, vol.134
, pp. 1-5
-
-
Tardieu, D.1
Jaeg, J.P.2
Cadet, J.3
Embvani, E.4
Corpet, D.E.5
-
17
-
-
46749127004
-
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
-
Meira LB, Bugni JM, Green SL, Lee CW, Pang B, et al. (2008) DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest 118: 2516-2525.
-
(2008)
J Clin Invest
, vol.118
, pp. 2516-2525
-
-
Meira, L.B.1
Bugni, J.M.2
Green, S.L.3
Lee, C.W.4
Pang, B.5
-
18
-
-
3042739635
-
Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumorprone mice defective in both the Myh and Ogg1 DNA glycosylases
-
Russo MT, De Luca G, Degan P, Parlanti E, Dogliotti E, et al. (2004) Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumorprone mice defective in both the Myh and Ogg1 DNA glycosylases. Cancer Res 64: 4411-4414.
-
(2004)
Cancer Res
, vol.64
, pp. 4411-4414
-
-
Russo, M.T.1
de Luca, G.2
Degan, P.3
Parlanti, E.4
Dogliotti, E.5
-
19
-
-
0346656706
-
Oxidative DNA damage in the mucosa of ulcerative colitis increases with disease duration and dysplasia
-
D'Incà R, Cardin R, Benazzato L, Angriman I, Martines D, et al. (2004) Oxidative DNA damage in the mucosa of ulcerative colitis increases with disease duration and dysplasia. Inflamm Bowel Dis 10: 23-27.
-
(2004)
Inflamm Bowel Dis
, vol.10
, pp. 23-27
-
-
D'incà, R.1
Cardin, R.2
Benazzato, L.3
Angriman, I.4
Martines, D.5
-
20
-
-
0033768784
-
Characterisation of acute murine dextran sodium sulphate colitis: Cytokine profile and dose dependency
-
Egger B, Bajaj-Elliott M, MacDonald TT, Inglin R, Eysselein VE, et al. (2000) Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency. Digestion 62: 240-248.
-
(2000)
Digestion
, vol.62
, pp. 240-248
-
-
Egger, B.1
Bajaj-Elliott, M.2
Macdonald, T.T.3
Inglin, R.4
Eysselein, V.E.5
-
21
-
-
34247631655
-
Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation
-
Beck PL, Li Y, Wong J, Chen CW, Keenan CM, et al. (2007) Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation. Gastroenterology 132: 1778-1790.
-
(2007)
Gastroenterology
, vol.132
, pp. 1778-1790
-
-
Beck, P.L.1
Li, Y.2
Wong, J.3
Chen, C.W.4
Keenan, C.M.5
-
22
-
-
54449102022
-
Involvement of IL- 17A in the pathogenesis of DSS-induced colitis in mice
-
Ito R, Kita M, Shin-Ya M, Kishida T, Urano A, et al. (2008) Involvement of IL- 17A in the pathogenesis of DSS-induced colitis in mice. Biochemical and Biophysical Research Communications 377: 12-16.
-
(2008)
Biochemical and Biophysical Research Communications
, vol.377
, pp. 12-16
-
-
Ito, R.1
Kita, M.2
Shin-Ya, M.3
Kishida, T.4
Urano, A.5
-
23
-
-
34249801765
-
G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice
-
Eijkelkamp N, Heijnen CJ, Lucas A, Premont RT, Elsenbruch S, et al. (2007) G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. Gut 56: 847-854.
-
(2007)
Gut
, vol.56
, pp. 847-854
-
-
Eijkelkamp, N.1
Heijnen, C.J.2
Lucas, A.3
Premont, R.T.4
Elsenbruch, S.5
-
24
-
-
44649176479
-
Strategies to cure experimental autoimmune colitis using antigen-specific Foxp3+ regulatory T cells
-
de Zoeten EF, Hancock WW (2008) Strategies to cure experimental autoimmune colitis using antigen-specific Foxp3+ regulatory T cells. Gastroenterology 134: 2171-2174.
-
(2008)
Gastroenterology
, vol.134
, pp. 2171-2174
-
-
de Zoeten, E.F.1
Hancock, W.W.2
-
25
-
-
0035180067
-
Control of intestinal inflammation by regulatory T cells
-
Singh B, Read S, Asseman C, Malmström V, Mottet C, et al. (2001) Control of intestinal inflammation by regulatory T cells. Immunol Rev 182: 190-200.
-
(2001)
Immunol Rev
, vol.182
, pp. 190-200
-
-
Singh, B.1
Read, S.2
Asseman, C.3
Malmström, V.4
Mottet, C.5
-
26
-
-
66149137296
-
Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBSinduced colitis
-
Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, et al. (2009) Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBSinduced colitis. Inflamm Bowel Dis 15: 341-352.
-
(2009)
Inflamm Bowel Dis
, vol.15
, pp. 341-352
-
-
Alex, P.1
Zachos, N.C.2
Nguyen, T.3
Gonzales, L.4
Chen, T.E.5
-
27
-
-
62449202866
-
Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
-
Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, et al. (2009) Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 323: 1488-1492.
-
(2009)
Science
, vol.323
, pp. 1488-1492
-
-
Tsuji, M.1
Komatsu, N.2
Kawamoto, S.3
Suzuki, K.4
Kanagawa, O.5
-
28
-
-
0033539610
-
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
-
Klungland A, Rosewell I, Hollenbach S, Larsen E, Daly G, et al. (1999) Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A 96: 13300-13305.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 13300-13305
-
-
Klungland, A.1
Rosewell, I.2
Hollenbach, S.3
Larsen, E.4
Daly, G.5
-
29
-
-
13244277795
-
Potential role for 8- oxoguanine DNA glycosylase in regulating inflammation
-
Mabley J, Pacher P, Deb A, Wallace R, Elder R, et al. (2005) Potential role for 8- oxoguanine DNA glycosylase in regulating inflammation. FASEB J 19: 290-292.
-
(2005)
FASEB J
, vol.19
, pp. 290-292
-
-
Mabley, J.1
Pacher, P.2
Deb, A.3
Wallace, R.4
Elder, R.5
-
30
-
-
33748465954
-
Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse
-
Touati E, Michel V, Thiberge JM, Avé P, Huerre M, et al. (2006) Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse. Helicobacter 11: 494-505.
-
(2006)
Helicobacter
, vol.11
, pp. 494-505
-
-
Touati, E.1
Michel, V.2
Thiberge, J.M.3
Avé, P.4
Huerre, M.5
-
31
-
-
48149086418
-
Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice
-
Liao J, Seril DN, Lu GG, Zhang M, Toyokuni S, et al. (2008) Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice. Mol Carcinog 47: 638-46.
-
(2008)
Mol Carcinog
, vol.47
, pp. 638-646
-
-
Liao, J.1
Seril, D.N.2
Lu, G.G.3
Zhang, M.4
Toyokuni, S.5
-
32
-
-
0036531943
-
Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors
-
Kohonen-Corish MR, Daniel JJ, te Riele H, Buffinton GD, Dahlstrom JE (2002) Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors. Cancer Res 62: 2092-2097.
-
(2002)
Cancer Res
, vol.62
, pp. 2092-2097
-
-
Kohonen-Corish, M.R.1
Daniel, J.J.2
te Riele, H.3
Buffinton, G.D.4
Dahlstrom, J.E.5
-
33
-
-
34247110393
-
Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice
-
Taniguchi K, Kakinuma S, Tokairin Y, Arai M, Kohno H, et al. (2006) Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice. Oncology 71: 124-130.
-
(2006)
Oncology
, vol.71
, pp. 124-130
-
-
Taniguchi, K.1
Kakinuma, S.2
Tokairin, Y.3
Arai, M.4
Kohno, H.5
-
34
-
-
36248929864
-
Anti-inflammatory effects of 8-hydroxy-29-deoxyguanosine on lipopolysaccharide-induced inflammation via Rac suppression in Balb/c mice
-
Choi S, Choi HH, Lee SH, Ko SH, You HJ, et al. (2007) Anti-inflammatory effects of 8-hydroxy-29-deoxyguanosine on lipopolysaccharide-induced inflammation via Rac suppression in Balb/c mice. Free Radic Biol Med 43: 1594-603.
-
(2007)
Free Radic Biol Med
, vol.43
, pp. 1594-1603
-
-
Choi, S.1
Choi, H.H.2
Lee, S.H.3
Ko, S.H.4
You, H.J.5
-
35
-
-
34249819364
-
8-oxo-7,8- dihydroguanosine triphosphate(8-oxoGTP) down-regulates respiratory burst of neutrophils by antagonizing GTP toward Rac, a small GTP binding protein
-
Kim HJ, Yoon SH, Ryu HO, Yoon BH, Choi S, et al. (2007) 8-oxo-7,8- dihydroguanosine triphosphate(8-oxoGTP) down-regulates respiratory burst of neutrophils by antagonizing GTP toward Rac, a small GTP binding protein. Free Radic Res 41: 655-62.
-
(2007)
Free Radic Res
, vol.41
, pp. 655-662
-
-
Kim, H.J.1
Yoon, S.H.2
Ryu, H.O.3
Yoon, B.H.4
Choi, S.5
-
36
-
-
13244299159
-
A Vital Role for Ape1/Ref1 Protein Short Article in Repairing Spontaneous DNA Damage in Human Cells
-
Fung H, Demple B (2005) A Vital Role for Ape1/Ref1 Protein Short Article in Repairing Spontaneous DNA Damage in Human Cells. Mol Cell 17: 463-470.
-
(2005)
Mol Cell
, vol.17
, pp. 463-470
-
-
Fung, H.1
Demple, B.2
-
37
-
-
0029829265
-
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
-
Xanthoudakis S, Smeyne RJ, Wallace JD, Curran T (1996) The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A 93: 8919-8923.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 8919-8923
-
-
Xanthoudakis, S.1
Smeyne, R.J.2
Wallace, J.D.3
Curran, T.4
-
38
-
-
77957823924
-
Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development
-
[Epub ahead of print]
-
Luo M, He H, Kelley MR, Georgiadis M (2009) Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development. Antioxid Redox Signal. [Epub ahead of print].
-
(2009)
Antioxid Redox Signal
-
-
Luo, M.1
He, H.2
Kelley, M.R.3
Georgiadis, M.4
-
39
-
-
48349107170
-
A new APE1/Ref-1- dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity
-
Ando K, Hirao S, Kabe Y, Ogura Y, Sato I, et al. (2008) A new APE1/Ref-1- dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res 36: 4327-4336.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 4327-4336
-
-
Ando, K.1
Hirao, S.2
Kabe, Y.3
Ogura, Y.4
Sato, I.5
-
40
-
-
2342520175
-
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors
-
Xie Y, Yang H, Cunanan C, Okamoto K, Shibata D, et al. (2004) Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res 64: 3096-3102.
-
(2004)
Cancer Res
, vol.64
, pp. 3096-3102
-
-
Xie, Y.1
Yang, H.2
Cunanan, C.3
Okamoto, K.4
Shibata, D.5
-
41
-
-
0016335085
-
Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy
-
McLean IW, Nakane PK (1974) Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. J Histochem Cytochem 12: 1077-1083.
-
(1974)
J Histochem Cytochem
, vol.12
, pp. 1077-1083
-
-
McLean, I.W.1
Nakane, P.K.2
-
42
-
-
38149054921
-
Overexpression of human NOX1 complex induces genome instability in mammalian cells
-
Chiera F, Meccia E, Degan P, Aquilina G, Pietraforte D, et al. (2008) Overexpression of human NOX1 complex induces genome instability in mammalian cells. Free Radic Biol Med 44: 332-342.
-
(2008)
Free Radic Biol Med
, vol.44
, pp. 332-342
-
-
Chiera, F.1
Meccia, E.2
Degan, P.3
Aquilina, G.4
Pietraforte, D.5
-
43
-
-
20144376089
-
Two modes of microsatellite instability in human cancer: Differential connection of defective DNA mismatch repair to dinucleotide repeat instability
-
Oda S, Maehara Y, Ikeda Y, Oki E, Egashira A, et al. (2005) Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability. Nucleic Acids Research 33: 1628-1636.
-
(2005)
Nucleic Acids Research
, vol.33
, pp. 1628-1636
-
-
Oda, S.1
Maehara, Y.2
Ikeda, Y.3
Oki, E.4
Egashira, A.5
-
44
-
-
0033535944
-
Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
-
Yao X, Buermeyer AB, Narayanan L, Tran D, Baker SM, et al. (1999) Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Pro. Natl. Acad. Sci. USA 96: 6850-6855.
-
(1999)
Pro. Natl. Acad. Sci. USA
, vol.96
, pp. 6850-6855
-
-
Yao, X.1
Buermeyer, A.B.2
Narayanan, L.3
Tran, D.4
Baker, S.M.5
-
45
-
-
0038079411
-
-
StataCorp, College StationTX: Stata Corporation, Cary, Illinois, USA
-
StataCorp (2003) Stata Statistical Software: release 8.1. College StationTX: Stata Corporation, Cary, Illinois, USA.
-
(2003)
Stata Statistical Software: Release 8.1
-
-
|