-
1
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh, K. et al. (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun., 236, 313-322.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.236
, pp. 313-322
-
-
Itoh, K.1
-
2
-
-
2342511435
-
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway
-
Motohashi, H. et al. (2004) Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc. Natl Acad. Sci. USA, 101, 6379-6384.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 6379-6384
-
-
Motohashi, H.1
-
3
-
-
12444257799
-
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
-
Itoh, K. et al. (2003) Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells, 8, 379-391.
-
(2003)
Genes Cells
, vol.8
, pp. 379-391
-
-
Itoh, K.1
-
4
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
Kobayashi, A. et al. (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol. Cell. Biol., 24, 7130-7139.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
-
5
-
-
36148977625
-
Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis
-
Iida, K. et al. (2007) Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis. Carcinogenesis, 28, 2398-2403.
-
(2007)
Carcinogenesis
, vol.28
, pp. 2398-2403
-
-
Iida, K.1
-
6
-
-
33745848469
-
Oxidative DNA damage: mechanisms and significance in health and disease
-
Kasai, H. et al. (2006) Oxidative DNA damage: mechanisms and significance in health and disease. Antioxid. Redox Signal., 8, 981-983.
-
(2006)
Antioxid. Redox Signal.
, vol.8
, pp. 981-983
-
-
Kasai, H.1
-
7
-
-
65249138393
-
Myeloid-derived suppressor cells: linking inflammation and cancer
-
Ostrand-Rosenberg, S. et al. (2009) Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol., 182, 4499-4506.
-
(2009)
J. Immunol.
, vol.182
, pp. 4499-4506
-
-
Ostrand-Rosenberg, S.1
-
8
-
-
34447118098
-
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
-
Nagaraj, S. et al. (2007) Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat. Med., 13, 828-835.
-
(2007)
Nat. Med.
, vol.13
, pp. 828-835
-
-
Nagaraj, S.1
-
9
-
-
0024582560
-
Conversion of Lewis lung carcinoma into ascitic form
-
Sato, T. et al. (1989) Conversion of Lewis lung carcinoma into ascitic form. Oncology, 46, 188-192.
-
(1989)
Oncology
, vol.46
, pp. 188-192
-
-
Sato, T.1
-
10
-
-
0018828414
-
In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties
-
Poste, G. et al. (1980) In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties. Cancer Res., 40, 1636-1644.
-
(1980)
Cancer Res.
, vol.40
, pp. 1636-1644
-
-
Poste, G.1
-
11
-
-
33749844245
-
Noninvasive optical tracking of red fluorescent protein-expressing cancer cells in a model of metastatic breast cancer
-
Winnard, P.T. Jr. et al. (2006) Noninvasive optical tracking of red fluorescent protein-expressing cancer cells in a model of metastatic breast cancer. Neoplasia, 8, 796-806.
-
(2006)
Neoplasia
, vol.8
, pp. 796-806
-
-
Winnard P.T., Jr.1
-
12
-
-
0015717433
-
Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice
-
Stoner, G.D. et al. (1973) Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice. Cancer Res., 33, 3069-3085.
-
(1973)
Cancer Res.
, vol.33
, pp. 3069-3085
-
-
Stoner, G.D.1
-
13
-
-
57349108021
-
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice
-
Okada, K. et al. (2008) Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am. J. Physiol. Gastrointest. Liver Physiol., 295, G735-G47.
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.295
-
-
Okada, K.1
-
14
-
-
53349125963
-
Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells
-
Sinha, P. et al. (2008) Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J. Immunol., 181, 4666-4675.
-
(2008)
J. Immunol.
, vol.181
, pp. 4666-4675
-
-
Sinha, P.1
-
15
-
-
36348989162
-
Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells
-
Nefedova, Y. et al. (2007) Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells. Cancer Res., 67, 11021-11028.
-
(2007)
Cancer Res.
, vol.67
, pp. 11021-11028
-
-
Nefedova, Y.1
-
16
-
-
42749088621
-
Nrf2 activation by sulforaphane restores the agerelated decrease of T(H)1 immunity: role of dendritic cells
-
Kim, H.J. et al. (2008) Nrf2 activation by sulforaphane restores the agerelated decrease of T(H)1 immunity: role of dendritic cells. J. Allergy Clin. Immunol., 121, 1255-1261e7.
-
(2008)
J. Allergy Clin. Immunol.
, vol.121
-
-
Kim, H.J.1
-
17
-
-
0021100690
-
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
-
Dignam, J.D. et al. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res., 11, 1475-1489.
-
(1983)
Nucleic Acids Res.
, vol.11
, pp. 1475-1489
-
-
Dignam, J.D.1
-
18
-
-
34848827480
-
Subcellular localization and cytoplasmic complex status of endogenous Keap1
-
Watai, Y. et al. (2007) Subcellular localization and cytoplasmic complex status of endogenous Keap1. Genes Cells, 12, 1163-1178.
-
(2007)
Genes Cells
, vol.12
, pp. 1163-1178
-
-
Watai, Y.1
-
19
-
-
0021678736
-
Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose
-
Kyhse-Andersen, J. (1984) Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J. Biochem. Biophys. Methods, 10, 203-209.
-
(1984)
J. Biochem. Biophys. Methods
, vol.10
, pp. 203-209
-
-
Kyhse-Andersen, J.1
-
20
-
-
0035875447
-
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
-
Aoki, Y. et al. (2001) Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol. Appl. Pharmacol., 173, 154-160.
-
(2001)
Toxicol. Appl. Pharmacol.
, vol.173
, pp. 154-160
-
-
Aoki, Y.1
-
21
-
-
0037763721
-
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
-
Nguyen, T. et al. (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol., 43, 233-260.
-
(2003)
Annu. Rev. Pharmacol. Toxicol.
, vol.43
, pp. 233-260
-
-
Nguyen, T.1
-
22
-
-
27744450995
-
Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema
-
Ishii, Y. et al. (2005) Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. J. Immunol., 175, 6968-6975.
-
(2005)
J. Immunol.
, vol.175
, pp. 6968-6975
-
-
Ishii, Y.1
-
23
-
-
33645530745
-
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
-
Thimmulappa, R.K. et al. (2006) Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J. Clin. Invest., 116, 984-995.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 984-995
-
-
Thimmulappa, R.K.1
-
24
-
-
42349094504
-
Tumor escape mechanism governed by myeloid-derived suppressor cells
-
Nagaraj, S. et al. (2008) Tumor escape mechanism governed by myeloid-derived suppressor cells. Cancer Res., 68, 2561-2563.
-
(2008)
Cancer Res.
, vol.68
, pp. 2561-2563
-
-
Nagaraj, S.1
-
25
-
-
48649107126
-
Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells
-
Shojaei, F. et al. (2008) Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells. Cancer Res., 68, 5501-5504.
-
(2008)
Cancer Res.
, vol.68
, pp. 5501-5504
-
-
Shojaei, F.1
-
26
-
-
56249086316
-
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer
-
Khor, T.O. et al. (2008) Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer. Cancer Prev. Res. (Phila. Pa), 1, 187-191.
-
(2008)
Cancer Prev. Res. (Phila. Pa)
, vol.1
, pp. 187-191
-
-
Khor, T.O.1
-
27
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
-
Ramos-Gomez, M. et al. (2001) Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc. Natl Acad. Sci. USA, 98, 3410-3415.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
-
28
-
-
33748089664
-
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
-
Xu, C. et al. (2006) Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2. Cancer Res., 66, 8293-8296.
-
(2006)
Cancer Res.
, vol.66
, pp. 8293-8296
-
-
Xu, C.1
-
29
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
Ohta, T. et al. (2008) Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res., 68, 1303-1309.
-
(2008)
Cancer Res.
, vol.68
, pp. 1303-1309
-
-
Ohta, T.1
-
30
-
-
33344456501
-
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
-
Padmanabhan, B. et al. (2006) Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol. Cell, 21, 689-700.
-
(2006)
Mol. Cell
, vol.21
, pp. 689-700
-
-
Padmanabhan, B.1
-
31
-
-
53049105119
-
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
-
Shibata, T. et al. (2008) Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology, 135, 1358-13681368 e1-4.
-
(2008)
Gastroenterology
, vol.135
-
-
Shibata, T.1
-
32
-
-
51649130168
-
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
-
Shibata, T. et al. (2008) Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc. Natl Acad. Sci. USA, 105, 13568-13573.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 13568-13573
-
-
Shibata, T.1
-
33
-
-
33750885385
-
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
-
Singh, A. et al. (2006) Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med., 3, e420.
-
(2006)
PLoS Med.
, vol.3
-
-
Singh, A.1
|