BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21CIP1/WAF1

Journal of Biological Chemistry

Volumn 285, Issue 41, 2010, Pages 31774-31782

  Tokunaga, Masahiro ^a   Ezoe, Sachiko ^a,b   Tanaka, Hirokazu ^a   Satoh, Yusuke ^a   Fukushima, Kentaro ^a   Matsui, Keiko ^a   Shibata, Masaru ^a   Tanimura, Akira ^a   Oritani, Kenji ^a   Matsumura, Itaru ^a,c   Kanakura, Yuzuru ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY HOSPITAL   (Japan)

^c KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GROWTH KINETICS; MEDICAL PROBLEMS; SIGNALING; STEM CELLS; TRANSCRIPTION FACTORS; TROPOSPHERE;

CHRONIC MYELOGENOUS LEUKEMIA; COLONY FORMATION; CYCLIN-DEPENDENT KINASE INHIBITORS; DIRECT INTERACTIONS; ERYTHROID CELLS; FARNESYLTRANSFERASE; HEMATOPOIETIC STEM CELLS; MITOGENIC; MYELOID CELLS; PHOSPHATIDYLINOSITOL 3-KINASE; POLYCYTHEMIA VERA; SIGNALING MOLECULES; TYROSINE KINASE;

ATMOSPHERIC BOUNDARY LAYER;

BCR ABL PROTEIN; CELL PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; JANUS KINASE 2; MANUMYCIN; MANUMYCIN A; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN N RAS; PROTEIN P15; RAS PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG; AMIDE; CDKN1A PROTEIN, MOUSE; CDKN2A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ENZYME INHIBITOR; JAK2 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; POLYENE; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE KINASE;

ANEMIA; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL GROWTH; CELL LINEAGE; CELL MATURATION; CELL STRAIN 3T3; CHRONIC MYELOID LEUKEMIA; COLONY FORMATION; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROPOIESIS; GROWTH INHIBITION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; MITOGENESIS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; STROMA CELL; WILD TYPE; 3T3 CELL LINE; AMINO ACID SUBSTITUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; METABOLISM; MISSENSE MUTATION; MUTANT MOUSE STRAIN;

MURINAE; MUS;

AMINO ACID SUBSTITUTION; ANIMALS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME INHIBITORS; ERYTHROPOIESIS; FUSION PROTEINS, BCR-ABL; HUMANS; JANUS KINASE 2; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MAP KINASE KINASE KINASES; MICE; MICE, MUTANT STRAINS; MUTATION, MISSENSE; MYELOID CELLS; NIH 3T3 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; POLYENES; POLYUNSATURATED ALKAMIDES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77957794047     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.118653     Document Type: Article

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