Matrine inhibits vascular smooth muscle cell proliferation by modulating the expression of cell cycle regulatory genes

Acta Pharmacologica Sinica

Volumn 31, Issue 10, 2010, Pages 1329-1335

  Zhu, Ping ^a   Chen, Ji Mei ^a   Chen, Shu Zhen ^b   Zhang, Cheng ^a   Zheng, Shao Yi ^a   Long, Guang ^a   Chan, Ji ^c   Zhou, Zhi Ling ^b   Fan, Rui Xin ^a   Fan, Xiao Ping ^a   Chen, Yan Fang ^b   Zhuang, Jian ^a  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b WRIGHT STATE UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

cdk 2; cdk 4; cell cycle; cyclin D1; cyclin E; matrine; p21; p27; proliferation; vascular smooth muscle cells

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; MATRINE; METHYLENE BLUE; PROTEIN P21; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE SILENCING; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ALKALOIDS; ANIMALS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; CYCLINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; QUINOLIZINES; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 77957736347     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.145     Document Type: Article

References (37)

1. Welt FG, Rogers C. Inflammation and restenosis in the stent era. Arterioscler Thromb Vasc Biol 2002;22:1769-76.
2. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993;362:801-9.
3. Zhou Y, Shan H, Qiao G, Sui X, Lu Y, Yang B. Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens AIT. Biol Pharm Bull 2008;31:2057-62.
4. Li Y, Wang B, Zhou C, Bi Y. Matrine induces apoptosis in angiotensin II-stimulated hyperplasia of cardiac fibroblasts: effects on Bcl-2/Bax expression and caspase-3 activation. Basic Clin Pharmacol Toxicol 2007;101:1-8.
5. Li Y, Yang Y, Fang L, Zhang Z, Jin J, Zhang K. Anti-hepatitis activities in the broth of Ganoderma lucidum supplemented with a Chinese herbal medicine. Am J Chin Med 2006;34:341-9.
6. Ma L, Wen S, Zhan Y, He Y, Liu X, Jiang J. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med 2008;74:245-51.
7. Liu XS, Jiang J. Molecular mechanism of matrine-induced apoptosis in leukemia K562 cells. Am J Chin Med 2006;34:1095-103.
8. Zhang L, Wang T, Wen X, Wei Y, Peng X, Li H, et al. Effect of matrine on HeLa cell adhesion and migration. Eur J Pharmacol 2007;563:69-76.
9. Dai ZJ, Gao J, Ji ZZ, Wang XJ, Ren HT, Liu XX, et al. Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3. J Ethnopharmacol 2009;123:91-6.
10. Zhu MY, Jiang ZH, Lu YW, Guo Y, Gan JJ. Matrine and anti-tumor drugs in inhibiting the growth of human lung cancer cell line. Zhong Xi Yi Jie He Xue Bao 2008;6:163-5.
11. Zhang LP, Jiang JK, Tam JW, Zhang Y, Liu XS, Xu XR, et al. Effects of matrine on proliferation and differentiation in K-562 cells. Leuk Res 2001;25:793-800.
12. Jiang H, Hou C, Zhang S, Xie H, Zhou W, Jin Q, et al. Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur J Pharmacol 2007;559:98-108.
13. Sinauridze EI, Kireev DA, Popenko NY, Pichugin AV, Panteleev MA, Krymskaya OV, et al. Platelet microparticle membranes have 50-to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost 2007;97:425-34.
14. Wei JW, Liao JF, Chuang CY, Chen CF, Han PW. Cardiovascular effects of matrine isolated from the Chinese herb Shan-dou-gen. Proc Natl Sci Counc Repub China B 1985;9:215-9.
15. 1 arrest and induce apoptosis in pulmonary artery smooth muscle cells through a p27Kip1-independent pathway. Circ Res 2003;92:501-9.
16. 1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci USA 1999;96:7797-802.
17. Braun-Dullaeus RC, Mann MJ, Seay U, Zhang L, von der Leyen HE, Morris RE, et al. Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phos phatidylinositol 3-kinase and mammalian target of rapamycin. Arterioscler Thromb Vasc Biol 2001;21:1152-8.
18. Adams PD. Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim Biophys Acta 2001;1471: M123-M133.
19. Ekholm SV, Reed SI. Regulation of G (1) cyclin-dependent kinases in the mammalian cell cycle. Curr Opin Cell Biol 2000;12:676-84.
20. 1/S phase transition. Nat Cell Biol 2005;7:831-6.
21. Stacey DW. Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells. Curr Opin Cell Biol 2003;15:158-63.
22. Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S, et al. Cyclin E ablation in the mouse. Cell 2003;114:431-43.
23. Corsini A, Verri D, Raiteri M, Quarato P, Paoletti R, Fumagalli R. Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes. Arterioscler Thromb Vasc Biol 1995;15:420-8.
24. Thyberg J, Palmberg L, Nilsson J, Ksiazek T, Sjolund M. Phenotype modulation in primary cultures of arterial smooth muscle cells. On the role of platelet-derived growth factor. Differentiation 1983;25:156-67.
25. Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O'Shaughnessy C, et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med 2003;349:1315-23.
26. Schofer J, Schluter M, Gershlick AH, Wijns W, Garcia E, Schampaert E, et al. Sirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomised controlled trial (E-SIRIUS). Lancet 2003;362:1093-9.
27. Oliver MH, Harrison NK, Bishop JE, Cole PJ, Laurent GJ. A rapid and convenient assay for counting cells cultured in microwell plates: application for assessment of growth factors. J Cell Sci 1989;92(Pt 3):513-8.
28. Ferri N, Granata A, Pirola C, Torti F, Pfister PJ, Dorent R, et al. Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression. Mol Pharmacol 2008;74:144-53.
29. Endesfelder S, Kliche A, Lochmuller H, von MA, Speer A. Antisense oligonucleotides and short interfering RNAs silencing the cyclindependent kinase inhibitor p21 improve proliferation of Duchenne muscular dystrophy patients' primary skeletal myoblasts. J Mol Med 2005;83:64-71.
30. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, et al. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 1995;9:935-44.
31. Takahashi A, Taniguchi T, Ishikawa Y, Yokoyama M. Tranilast inhibits vascular smooth muscle cell growth and intimal hyperplasia by induction of p21 (waf1/cip1/sdi1) and p53. Circ Res 1999;84:543-50.
32. 1 arrest. Cell 1994;76:1013-23.
33. Sherr CJ. Cancer cell cycles. Science 1996;274:1672-7.
34. Morgan DO. Principles of CDK regulation. Nature 1995;374:131-4.
35. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 1993;366:701-4.
36. Toyoshima H, Hunter T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 1994;78:67-74.
37. Jiang H, Hou C, Zhang S, Xie H, Zhou W, Jin Q, et al. Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur J Pharmacol 2007;559:98-108.