Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells

European Journal of Pharmacology

Volumn 559, Issue 2-3, 2007, Pages 98-108

  Jiang, Hua ^a,b   Hou, ChunHui ^a   Zhang, ShuBing ^a   Xie, HengYue ^a   Zhou, WeiYing ^a   Jin, QiHuang ^a   Cheng, XiaoDong ^a   Qian, RuoLan ^a   Zhang, XueJun ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Apoptosis; E2F 1; K562; Matrine; Mitochondria

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CELL CYCLE PROTEIN; MATRINE; MITOCHONDRIAL PROTEIN; PROTEIN BAX; PROTEIN P53; RETINOBLASTOMA PROTEIN; SOPHORA FLAVESCENS EXTRACT; TRANSCRIPTION FACTOR E2F1;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN K 562; CELL TYPE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL;

ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG SYNERGISM; E2F1 TRANSCRIPTION FACTOR; ENZYME ACTIVATION; ETOPOSIDE; HELA CELLS; HUMANS; K562 CELLS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MITOCHONDRIA; PROTEIN TRANSPORT; QUINOLIZINES; RETINOBLASTOMA PROTEIN; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; U937 CELLS; UP-REGULATION;

EID: 33847136330     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.12.017     Document Type: Article

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