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Volumn 6, Issue 5, 2010, Pages 679-694

Targeted agents in ovarian cancer

Author keywords

ovarian cancer; targeted agents

Indexed keywords

3 (4 BROMO 2,6 DIFLUOROBENZYLOXY) 5 [3 [4 (1 PYRROLIDINYL)BUTYL]UREIDO] 4 ISOTHIAZOLECARBOXAMIDE; AFLIBERCEPT; BEVACIZUMAB; BIBF 1120; CARBOPLATIN; CEDIRANIB; CETUXIMAB; CISPLATIN; COMBRETASTATIN A4 PHOSPHATE; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; ERLOTINIB; EVEROLIMUS; GEFITINIB; GEMCITABINE; LAPATINIB; OLAPARIB; PACLITAXEL; PAZOPANIB; PERTUZUMAB; PLACEBO; PLATINUM COMPLEX; SUNITINIB; TAMOXIFEN; TEMSIROLIMUS; TOPOTECAN; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VOTRIENT;

EID: 77957735000     PISSN: 17455057     EISSN: 17455065     Source Type: Journal    
DOI: 10.2217/whe.10.48     Document Type: Review
Times cited : (4)

References (123)
  • 2
    • 67650410937 scopus 로고    scopus 로고
    • American Cancer Society American Cancer Society Atlanta
    • American Cancer Society: Cancer Facts & Figures 2009. American Cancer Society, Atlanta (2009).
    • (2009) Cancer Facts & Figures 2009
  • 3
    • 0025253463 scopus 로고
    • Adjuvant therapy in grade i and grade II epithelial ovarian cancer. Results of two prospective randomized trials
    • Young RC, Walton LA, Ellenberg SS et al.: Adjuvant therapy in grade I and grade II epithelial ovarian cancer. Results of two prospective randomized trials. N. Engl. J. Med. 322(15), 1021-1027 (1990).
    • (1990) N. Engl. J. Med. , vol.322 , Issue.15 , pp. 1021-1027
    • Young, R.C.1    Walton, L.A.2    Ellenberg, S.S.3
  • 4
    • 0030054309 scopus 로고    scopus 로고
    • Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with grade III and grade IV ovarian cancer
    • McGuire WP, Hoskins WJ, Brady MF et al.: Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with grade III and grade IV ovarian cancer. N. Engl. J. Med. 334(1), 1-6 (1996).
    • (1996) N. Engl. J. Med. , vol.334 , Issue.1 , pp. 1-6
    • McGuire, W.P.1    Hoskins, W.J.2    Brady, M.F.3
  • 5
    • 0141688377 scopus 로고    scopus 로고
    • Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected grade III ovarian cancer: A Gynecologic Oncology Group study
    • Ozols RF, Bundy BN, Greer BE et al.: Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected grade III ovarian cancer: a Gynecologic Oncology Group study. J. Clin. Oncol. 21(17), 3194-3200 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.17 , pp. 3194-3200
    • Ozols, R.F.1    Bundy, B.N.2    Greer, B.E.3
  • 6
    • 9744223515 scopus 로고    scopus 로고
    • Phase III randomized trial of docetaxelcarboplatin versus paclitaxel-carboplatin as frst-line chemotherapy for ovarian carcinoma
    • Vasey PA, Jayson GC, Gordon A et al.: Phase III randomized trial of docetaxelcarboplatin versus paclitaxel-carboplatin as frst-line chemotherapy for ovarian carcinoma. J. Natl Cancer Inst. 96(22), 1682-1691 (2004).
    • (2004) J. Natl Cancer Inst. , vol.96 , Issue.22 , pp. 1682-1691
    • Vasey, P.A.1    Jayson, G.C.2    Gordon, A.3
  • 7
    • 63049115790 scopus 로고    scopus 로고
    • Evaluation of new platinum-based treatment regimens in advanced-grade ovarian cancer: A Phase III Trial of the Gynecologic Cancer Intergroup
    • Bookman MA, Brady MF, McGuire WP et al.: Evaluation of new platinum-based treatment regimens in advanced-grade ovarian cancer: a Phase III Trial of the Gynecologic Cancer Intergroup. J. Clin. Oncol. 27(9), 1419-1425 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.9 , pp. 1419-1425
    • Bookman, M.A.1    Brady, M.F.2    McGuire, W.P.3
  • 8
    • 0346423733 scopus 로고    scopus 로고
    • Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for grade III ovarian cancer
    • Alberts DS, Liu PY, Hannigan EV et al.: Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for grade III ovarian cancer. N. Engl. J. Med. 335(26), 1950-1955 (1996).
    • (1996) N. Engl. J. Med. , vol.335 , Issue.26 , pp. 1950-1955
    • Alberts, D.S.1    Liu, P.Y.2    Hannigan, E.V.3
  • 9
    • 30044438368 scopus 로고    scopus 로고
    • Intraperitoneal cisplatin and paclitaxel in ovarian cancer
    • Armstrong DK, Bundy B, Wenzel L et al.: Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N. Engl. J. Med. 354(1), 34-43 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.1 , pp. 34-43
    • Armstrong, D.K.1    Bundy, B.2    Wenzel, L.3
  • 10
    • 0035865144 scopus 로고    scopus 로고
    • Phase III trial of standard-dose intravenous cisplatin plus paclitaxel versus moderately high-dose carboplatin followed by intravenous paclitaxel and intraperitoneal cisplatin in small-volume grade III ovarian carcinoma: An intergroup study of the Gynecologic Oncology Group
    • Southwestern Oncology Group, and Eastern Cooperative Oncology Group
    • Markman M, Bundy BN, Alberts DS et al.: Phase III trial of standard-dose intravenous cisplatin plus paclitaxel versus moderately high-dose carboplatin followed by intravenous paclitaxel and intraperitoneal cisplatin in small-volume grade III ovarian carcinoma: an intergroup study of the Gynecologic Oncology Group, Southwestern Oncology Group, and Eastern Cooperative Oncology Group. J. Clin. Oncol. 19(4), 1001-1007 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , Issue.4 , pp. 1001-1007
    • Markman, M.1    Bundy, B.N.2    Alberts, D.S.3
  • 11
    • 34447560090 scopus 로고    scopus 로고
    • Intraperitoneal chemotherapy for ovarian cancer: Overview and perspective
    • Rao G, Crispens M, Rothenberg ML: Intraperitoneal chemotherapy for ovarian cancer: overview and perspective. J. Clin. Oncol. 25(20), 2867-2872 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.20 , pp. 2867-2872
    • Rao, G.1    Crispens, M.2    Rothenberg, M.L.3
  • 12
    • 0036388148 scopus 로고    scopus 로고
    • Relapsed ovarian cancer: Challenges and management strategies for a chronic disease
    • Armstrong DK: Relapsed ovarian cancer: challenges and management strategies for a chronic disease. Oncologist 7(Suppl. 5), 20-28 (2002).
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 5 , pp. 20-28
    • Armstrong, D.K.1
  • 13
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • Ferrara N: Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 9(Suppl. 1), 2-10 (2004).
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 1 , pp. 2-10
    • Ferrara, N.1
  • 14
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J: Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285(21), 1182-1186 (1971).
    • (1971) N. Engl. J. Med. , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 15
    • 0036793818 scopus 로고    scopus 로고
    • Preoperative serum vascular endothelial growth factor levels: Signifcance in ovarian cancer
    • Cooper BC, Ritchie JM, Broghammer CL et al.: Preoperative serum vascular endothelial growth factor levels: signifcance in ovarian cancer. Clin. Cancer Res. 8(10), 3193-3197 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , Issue.10 , pp. 3193-3197
    • Cooper, B.C.1    Ritchie, J.M.2    Broghammer, C.L.3
  • 16
    • 33846933952 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) pathway as a therapeutic target in gynecologic malignancies
    • Frumovitz M, Sood AK: Vascular endothelial growth factor (VEGF) pathway as a therapeutic target in gynecologic malignancies. Gynecol. Oncol. 104(3), 768-778 (2007).
    • (2007) Gynecol. Oncol. , vol.104 , Issue.3 , pp. 768-778
    • Frumovitz, M.1    Sood, A.K.2
  • 17
    • 33751006991 scopus 로고    scopus 로고
    • Preoperative serum vascular endothelial growth factor as a prognostic parameter in ovarian cancer
    • Hefer LA, Zeillinger R, Grimm C et al.: Preoperative serum vascular endothelial growth factor as a prognostic parameter in ovarian cancer. Gynecol. Oncol. 103(2), 512-517 (2006).
    • (2006) Gynecol. Oncol. , vol.103 , Issue.2 , pp. 512-517
    • Hefer, L.A.1    Zeillinger, R.2    Grimm, C.3
  • 18
    • 0030923795 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in early grade ovarian carcinoma
    • Paley PJ, Staskus KA, Gebhard K et al.: Vascular endothelial growth factor expression in early grade ovarian carcinoma. Cancer 80(1), 98-106 (1997).
    • (1997) Cancer , vol.80 , Issue.1 , pp. 98-106
    • Paley, P.J.1    Staskus, K.A.2    Gebhard, K.3
  • 19
    • 0034046917 scopus 로고    scopus 로고
    • Prognostic signifcance of vascular endothelial growth factor expression in human ovarian carcinoma
    • Shen GH, Ghazizadeh M, Kawanami O et al.: Prognostic signifcance of vascular endothelial growth factor expression in human ovarian carcinoma. Br. J. Cancer 83(2), 196-203 (2000).
    • (2000) Br. J. Cancer , vol.83 , Issue.2 , pp. 196-203
    • Shen, G.H.1    Ghazizadeh, M.2    Kawanami, O.3
  • 20
    • 36849056497 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
    • Cannistra SA, Matulonis UA, Penson RT et al.: Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J. Clin. Oncol. 25(33), 5180-5186 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.33 , pp. 5180-5186
    • Cannistra, S.A.1    Matulonis, U.A.2    Penson, R.T.3
  • 21
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fuorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W et al.: Bevacizumab plus irinotecan, fuorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350(23), 2335-2342 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 22
    • 36849019301 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group Study J
    • Burger RA, Sill MW, Monk BJ, Greer BE, Sorosky JI: Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study J. Clin. Oncol. 25(33), 5165-5171 (2007).
    • (2007) Clin. Oncol. , vol.25 , Issue.33 , pp. 5165-5171
    • Burger, R.A.1    Sill, M.W.2    Monk, B.J.3    Greer, B.E.4    Sorosky, J.I.5
  • 23
    • 66149121478 scopus 로고    scopus 로고
    • Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: A meta-analysis
    • Hapani S, Chu D, Wu S: Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis. Lancet Oncol. 10(6), 559-568 (2009).
    • (2009) Lancet Oncol. , vol.10 , Issue.6 , pp. 559-568
    • Hapani, S.1    Chu, D.2    Wu, S.3
  • 24
    • 34447502449 scopus 로고    scopus 로고
    • Experience with bevacizumab in the management of epithelial ovarian cancer
    • Burger RA: Experience with bevacizumab in the management of epithelial ovarian cancer. J. Clin. Oncol. 25(20), 2902-2908 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.20 , pp. 2902-2908
    • Burger, R.A.1
  • 25
    • 33845287895 scopus 로고    scopus 로고
    • Bevacizumab plus erlotinib for patients with recurrent ovarian and fallopian tube cancer: Preliminary results of a multi-center Phase II trial
    • Friberg G, Oza AM, Morgan RJ, Vokes EE, Gandara DR, Fleming GF: Bevacizumab plus erlotinib for patients with recurrent ovarian and fallopian tube cancer: preliminary results of a multi-center Phase II trial. J. Clin. Oncol. 24(Suppl. 18S), (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.SUPPL. 18S
    • Friberg, G.1    Oza, A.M.2    Morgan, R.J.3    Vokes, E.E.4    Gandara, D.R.5    Fleming, G.F.6
  • 26
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC et al.: Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N. Engl. J. Med. 355(24), 2542-2550 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 27
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital Phase II consortia
    • Garcia AA, Hirte H, Fleming G et al.: Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital Phase II consortia. J. Clin. Oncol. 26(1), 76-82 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.1 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3
  • 28
    • 67649364437 scopus 로고    scopus 로고
    • Phase II prospective study of weekly topotecan and bevacizumab in platinum refractory ovarian cancer or peritoneal cancer
    • McGonigle KF, Muntz HG, Vuky JL et al.: Phase II prospective study of weekly topotecan and bevacizumab in platinum refractory ovarian cancer or peritoneal cancer. J. Clin. Oncol. 26(Suppl. 15), 5551 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.SUPPL. 15 , pp. 5551
    • McGonigle, K.F.1    Muntz, H.G.2    Vuky, J.L.3
  • 29
    • 77957737979 scopus 로고    scopus 로고
    • Effects of weekly bevacizumab and pegylated liposomal doxorubicin in heavily pretreated patients with recurrent or progressed ovarian cancer
    • Kikuchi Y, Kouta H, Kikuchi R et al.: Effects of weekly bevacizumab and pegylated liposomal doxorubicin in heavily pretreated patients with recurrent or progressed ovarian cancer. J. Clin. Oncol. 27(Suppl. 15), 5547 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15 , pp. 5547
    • Kikuchi, Y.1    Kouta, H.2    Kikuchi, R.3
  • 30
    • 80053935580 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin with bevacizumab in second-line treatment of ovarian cancer: Pharmacokinetics, safety, and preliminary outcome results
    • Muggia FM, Boyd L, Liebes L et al.: Pegylated liposomal doxorubicin with bevacizumab in second-line treatment of ovarian cancer: pharmacokinetics, safety, and preliminary outcome results. J. Clin. Oncol. 27(Suppl. 15), 5548 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15 , pp. 5548
    • Muggia, F.M.1    Boyd, L.2    Liebes, L.3
  • 31
    • 34447298651 scopus 로고    scopus 로고
    • A Phase II study of outpatient frst-line paclitaxel, carboplatin, and bevacizumab for advanced-grade epithelial ovarian, peritoneal, and fallopian tube cancer
    • Micha JP, Goldstein BH, Rettenmaier MA et al.: A Phase II study of outpatient frst-line paclitaxel, carboplatin, and bevacizumab for advanced-grade epithelial ovarian, peritoneal, and fallopian tube cancer. Int. J. Gynecol. Cancer 17(4), 771-776 (2007).
    • (2007) Int. J. Gynecol. Cancer , vol.17 , Issue.4 , pp. 771-776
    • Micha, J.P.1    Goldstein, B.H.2    Rettenmaier, M.A.3
  • 32
    • 71749110151 scopus 로고    scopus 로고
    • Preliminary results of a Phase II study of oxaliplatin, docetaxel, and bevacizumab as frst-line therapy of advanced cancer of the ovary, peritoneum, and fallopian tube
    • Rose PG, Drake R, Braly PS et al.: Preliminary results of a Phase II study of oxaliplatin, docetaxel, and bevacizumab as frst-line therapy of advanced cancer of the ovary, peritoneum, and fallopian tube. J. Clin. Oncol. 27(Suppl. 15), 5546 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15 , pp. 5546
    • Rose, P.G.1    Drake, R.2    Braly, P.S.3
  • 33
    • 77957746020 scopus 로고    scopus 로고
    • A Phase II study of intravenous (IV) and intraperitoneal (ip) paclitaxel, ip cisplatin, and iv bevacizumab as frst-line chemotherapy for optimal grade II or III ovarian, primary peritoneal, and fallopian tube cancer
    • Konner JA, Grabon D, Pezzulli S et al.: A Phase II study of intravenous (IV) and intraperitoneal (ip) paclitaxel, ip cisplatin, and iv bevacizumab as frst-line chemotherapy for optimal grade II or III ovarian, primary peritoneal, and fallopian tube cancer. J. Clin. Oncol. 27(Suppl. 15), 5539 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15 , pp. 5539
    • Konner, J.A.1    Grabon, D.2    Pezzulli, S.3
  • 34
    • 74849109064 scopus 로고    scopus 로고
    • Phase II study of intravenous bevacizumab and paclitaxel, and intraperitoneal cisplatin, followed by bevacizumab consolidation for advanced ovarian or peritoneal cancers
    • McMeekin DD, Lanneau G, Curiel J, Moore K, Walker J, Mannel R: Phase II study of intravenous bevacizumab and paclitaxel, and intraperitoneal cisplatin, followed by bevacizumab consolidation for advanced ovarian or peritoneal cancers. J. Clin. Oncol. 27(Suppl. 15), (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15
    • McMeekin, D.D.1    Lanneau, G.2    Curiel, J.3    Moore, K.4    Walker, J.5    Mannel, R.6
  • 35
    • 0345060442 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
    • Byrne AT, Ross L, Holash J et al.: Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin. Cancer Res. 9(15), 5721-5728 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.15 , pp. 5721-5728
    • Byrne, A.T.1    Ross, L.2    Holash, J.3
  • 36
    • 36849005801 scopus 로고    scopus 로고
    • VEGF-Trap for patients with recurrent platinum-resistant epithelial ovarian cancer: Preliminary results of a randomized, multicenter Phase II study
    • Tew WP, Colombo N, Ray-Coquard I et al.: VEGF-Trap for patients with recurrent platinum-resistant epithelial ovarian cancer: Preliminary results of a randomized, multicenter Phase II study. J. Clin. Oncol. 25(Suppl. 18), 5508 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.SUPPL. 18 , pp. 5508
    • Tew, W.P.1    Colombo, N.2    Ray-Coquard, I.3
  • 37
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF et al.: AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 65(10), 4389-4400 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.10 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 38
    • 34547681379 scopus 로고    scopus 로고
    • Phase i clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors
    • Drevs J, Siegert P, Medinger M et al.: Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors. J. Clin. Oncol. 25(21), 3045-3054 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.21 , pp. 3045-3054
    • Drevs, J.1    Siegert, P.2    Medinger, M.3
  • 39
    • 42949105645 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: The National Cancer Institute of Canada clinical trials group
    • Laurie SA, Gauthier I, Arnold A et al.: Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group. J. Clin. Oncol. 26(11), 1871-1878 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.11 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3
  • 40
    • 34547654541 scopus 로고    scopus 로고
    • Phase i dose escalation and pharmacokinetic study of AZD2171, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinase, in patients with hormone refractory prostate cancer (HRPC)
    • Ryan CJ, Stadler WM, Roth B et al.: Phase I dose escalation and pharmacokinetic study of AZD2171, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinase, in patients with hormone refractory prostate cancer (HRPC). Invest. New Drugs 25(5), 445-451 (2007).
    • (2007) Invest. New Drugs , vol.25 , Issue.5 , pp. 445-451
    • Ryan, C.J.1    Stadler, W.M.2    Roth, B.3
  • 41
    • 73949123481 scopus 로고    scopus 로고
    • Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer
    • Matulonis UA, Berlin S, Ivy P et al.: Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer. J. Clin. Oncol. 27(33), 5601-5606 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.33 , pp. 5601-5606
    • Matulonis, U.A.1    Berlin, S.2    Ivy, P.3
  • 42
    • 58149219264 scopus 로고    scopus 로고
    • A Phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: Fnal results of a PMH, Chicago and California consortia trial
    • Hirte HW, Vidal L, Fleming GF et al.: A Phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: fnal results of a PMH, Chicago and California consortia trial. J. Clin. Oncol. 26(Suppl.), 5521 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.SUPPL. , pp. 5521
    • Hirte, H.W.1    Vidal, L.2    Fleming, G.F.3
  • 43
    • 36549038661 scopus 로고    scopus 로고
    • Pazopanib (GW786034) is active in women with advanced epithelial ovarian, fallopian tube and peritoneal cancers: Initial results of a Phase II study J
    • Friedlander M, Hancock KC, Benigno B et al.: Pazopanib (GW786034) is active in women with advanced epithelial ovarian, fallopian tube and peritoneal cancers: initial results of a Phase II study J. Clin. Oncol. 25(Suppl.18), 5561 (2007).
    • (2007) Clin. Oncol. , vol.25 , Issue.SUPPL.18 , pp. 5561
    • Friedlander, M.1    Hancock, K.C.2    Benigno, B.3
  • 44
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X et al.: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. 9(1), 327-337 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 45
    • 0038204144 scopus 로고    scopus 로고
    • Is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell AM, Abrams TJ, Yuen HA et al.: SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101(9), 3597-3605 (2003).
    • (2003) Blood , vol.101 , Issue.9 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 46
    • 58149248099 scopus 로고    scopus 로고
    • A Phase II study of sunitinib (SU11248) in patients with recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma-NCIC CTG IND 185
    • Biagi JJ, Oza AM, Grimshaw R et al.: A Phase II study of sunitinib (SU11248) in patients with recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma-NCIC CTG IND 185. J. Clin. Oncol. 26(Suppl. 15), 5522 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.SUPPL. 15 , pp. 5522
    • Biagi, J.J.1    Oza, A.M.2    Grimshaw, R.3
  • 48
    • 1842607060 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate
    • West CM, Price P. Combretastatin A4 phosphate. Anticancer Drugs 15(3), 179-187 (2004).
    • (2004) Anticancer Drugs , vol.15 , Issue.3 , pp. 179-187
    • West, C.M.1    Price, P.2
  • 49
    • 0037562506 scopus 로고    scopus 로고
    • Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model
    • Shnyder SD, Cooper PA, Pettit GR, Lippert JW 3rd, Bibby MC: Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model. Anticancer Res. 23(2B), 1619-1623 (2003).
    • (2003) Anticancer Res. , vol.23 , Issue.2 B , pp. 1619-1623
    • Shnyder, S.D.1    Cooper, P.A.2    Pettit, G.R.3    Lippert III, J.W.4    Bibby, M.C.5
  • 50
    • 76449086344 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate (CA4P) carboplatin and paclitaxel in patients with platinum-resistant ovarian cancer: Fnal Phase II trial results
    • Zweifel M, Jayson G, Reed N et al.: Combretastatin A-4 phosphate (CA4P) carboplatin and paclitaxel in patients with platinum-resistant ovarian cancer: fnal Phase II trial results. J. Clin. Oncol. 27(Suppl. 15), (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15
    • Zweifel, M.1    Jayson, G.2    Reed, N.3
  • 51
    • 68449095803 scopus 로고    scopus 로고
    • A randomized Phase II placebo-controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer
    • Ledermann JA, Rustin GJ, Hackshaw A et al.: A randomized Phase II placebo-controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer. J. Clin. Oncol. 27(Suppl. 15), 5501 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15 , pp. 5501
    • Ledermann, J.A.1    Rustin, G.J.2    Hackshaw, A.3
  • 52
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • Ciardiello F, Caputo R, Damiano V et al.: Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin. Cancer Res. 9(4), 1546-1556 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.4 , pp. 1546-1556
    • Ciardiello, F.1    Caputo, R.2    Damiano, V.3
  • 53
    • 10744222964 scopus 로고    scopus 로고
    • Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy
    • Beebe JS, Jani JP, Knauth E et al.: Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 63(21), 7301-7309 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.21 , pp. 7301-7309
    • Beebe, J.S.1    Jani, J.P.2    Knauth, E.3
  • 54
    • 10744230127 scopus 로고    scopus 로고
    • An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors
    • Burgess AW, Cho HS, Eigenbrot C et al.: An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol. Cell 12(3), 541-552 (2003).
    • (2003) Mol. Cell , vol.12 , Issue.3 , pp. 541-552
    • Burgess, A.W.1    Cho, H.S.2    Eigenbrot, C.3
  • 56
    • 0029832861 scopus 로고    scopus 로고
    • Overexpression and relationships of HER-2/neuepidermal growth factor receptor p53, Ki-67, and tumor necrosis factor α in epithelial ovarian cancer
    • Goff BA, Shy K, Greer BE, Muntz HG, Skelly M, Gown AM: Overexpression and relationships of HER-2/neu, epidermal growth factor receptor, p53, Ki-67, and tumor necrosis factor α in epithelial ovarian cancer. Eur. J. Gynaecol. Oncol. 17(6), 487-492 (1996).
    • (1996) Eur. J. Gynaecol. Oncol. , vol.17 , Issue.6 , pp. 487-492
    • Goff, B.A.1    Shy, K.2    Greer, B.E.3    Muntz, H.G.4    Skelly, M.5    Gown, A.M.6
  • 57
    • 0026689587 scopus 로고
    • Epidermal growth factor receptor and transforming growth factor α expression in human ovarian carcinomas
    • Kohler M, Bauknecht T, Grimm M, Birmelin G, Kommoss F, Wagner E: Epidermal growth factor receptor and transforming growth factor α expression in human ovarian carcinomas. Eur. J. Cancer 28A(8-9), 1432-1437 (1992).
    • (1992) Eur. J. Cancer , vol.28 A , Issue.8-9 , pp. 1432-1437
    • Kohler, M.1    Bauknecht, T.2    Grimm, M.3    Birmelin, G.4    Kommoss, F.5    Wagner, E.6
  • 58
    • 0035027576 scopus 로고    scopus 로고
    • The growth factor receptors HER-2/neu and EGFR, their relationship, and their effects on the prognosis in early grade (FIGO I-II) epithelial ovarian carcinoma
    • Skirnisdottir I, Sorbe B, Seidal T: The growth factor receptors HER-2/neu and EGFR, their relationship, and their effects on the prognosis in early grade (FIGO I-II) epithelial ovarian carcinoma. Int. J. Gynecol. Cancer 11(2), 119-129 (2001).
    • (2001) Int. J. Gynecol. Cancer , vol.11 , Issue.2 , pp. 119-129
    • Skirnisdottir, I.1    Sorbe, B.2    Seidal, T.3
  • 59
    • 0031056372 scopus 로고    scopus 로고
    • EGFR and steroid receptors in ovarian carcinoma: Comparison with prognostic parameters and outcome of patients
    • Fischer-Colbrie J, Witt A, Heinzl H et al.: EGFR and steroid receptors in ovarian carcinoma: comparison with prognostic parameters and outcome of patients. Anticancer Res. 17(1B), 613-619 (1997).
    • (1997) Anticancer Res. , vol.17 , Issue.1 B , pp. 613-619
    • Fischer-Colbrie, J.1    Witt, A.2    Heinzl, H.3
  • 61
    • 28944439741 scopus 로고    scopus 로고
    • Effcacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: Results from a Phase II multicenter study
    • Gordon AN, Finkler N, Edwards RP et al.: Effcacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a Phase II multicenter study. Int. J. Gynecol. Cancer 15(5), 785-792 (2005).
    • (2005) Int. J. Gynecol. Cancer , vol.15 , Issue.5 , pp. 785-792
    • Gordon, A.N.1    Finkler, N.2    Edwards, R.P.3
  • 62
    • 4344646459 scopus 로고    scopus 로고
    • Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer
    • Perez-Soler R, Chachoua A, Hammond LA et al.: Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer. J. Clin. Oncol. 22(16), 3238-3247 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.16 , pp. 3238-3247
    • Perez-Soler, R.1    Chachoua, A.2    Hammond, L.A.3
  • 63
    • 44349178606 scopus 로고    scopus 로고
    • A Phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers
    • Vasey PA, Gore M, Wilson R et al.: A Phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers. Br. J. Cancer 98(11), 1774-1780 (2008).
    • (2008) Br. J. Cancer , vol.98 , Issue.11 , pp. 1774-1780
    • Vasey, P.A.1    Gore, M.2    Wilson, R.3
  • 64
    • 33947523019 scopus 로고    scopus 로고
    • A Phase II and pharmacodynamic study of geftinib in patients with refractory or recurrent epithelial ovarian cancer
    • Posadas EM, Liel MS, Kwitkowski V et al.: A Phase II and pharmacodynamic study of geftinib in patients with refractory or recurrent epithelial ovarian cancer. Cancer 109(7), 1323-1330 (2007).
    • (2007) Cancer , vol.109 , Issue.7 , pp. 1323-1330
    • Posadas, E.M.1    Liel, M.S.2    Kwitkowski, V.3
  • 65
    • 23044511620 scopus 로고    scopus 로고
    • Phase II study of geftinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: A Gynecologic Oncology Group Study
    • Schilder RJ, Sill MW, Chen X et al.: Phase II study of geftinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study. Clin. Cancer Res. 11(15), 5539-5548 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , Issue.15 , pp. 5539-5548
    • Schilder, R.J.1    Sill, M.W.2    Chen, X.3
  • 66
    • 33947318253 scopus 로고    scopus 로고
    • Geftinib in combination with tamoxifen in patients with ovarian cancer refractory or resistant to platinum-taxane based therapy - A Phase II trial of the AGO Ovarian Cancer Study Group (AGO-OVAR 2.6)
    • Wagner U, du Bois A, Pfsterer J et al.: Geftinib in combination with tamoxifen in patients with ovarian cancer refractory or resistant to platinum-taxane based therapy-a Phase II trial of the AGO Ovarian Cancer Study Group (AGO-OVAR 2.6). Gynecol. Oncol. 105(1), 132-137 (2007).
    • (2007) Gynecol. Oncol. , vol.105 , Issue.1 , pp. 132-137
    • Wagner, U.1    Du Bois, A.2    Pfsterer, J.3
  • 67
    • 47249145102 scopus 로고    scopus 로고
    • A Phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-grade ovarian, primary peritoneal, or fallopian tube cancer
    • Konner J, Schilder RJ, DeRosa FA et al.: A Phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-grade ovarian, primary peritoneal, or fallopian tube cancer. Gynecol. Oncol. 110(2), 140-145 (2008).
    • (2008) Gynecol. Oncol. , vol.110 , Issue.2 , pp. 140-145
    • Konner, J.1    Schilder, R.J.2    Derosa, F.A.3
  • 68
    • 60749092998 scopus 로고    scopus 로고
    • Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash
    • Schilder RJ, Pathak HB, Lokshin AE et al.: Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash. Gynecol. Oncol. 113(1), 21-27 (2009).
    • (2009) Gynecol. Oncol. , vol.113 , Issue.1 , pp. 21-27
    • Schilder, R.J.1    Pathak, H.B.2    Lokshin, A.E.3
  • 69
    • 39249085402 scopus 로고    scopus 로고
    • Phase II trial of cetuximab and carboplatin in relapsed platinum-sensitive ovarian cancer and evaluation of epidermal growth factor receptor expression: A Gynecologic Oncology Group study
    • Secord AA, Blessing JA, Armstrong DK et al.: Phase II trial of cetuximab and carboplatin in relapsed platinum-sensitive ovarian cancer and evaluation of epidermal growth factor receptor expression: a Gynecologic Oncology Group study. Gynecol. Oncol. 108(3), 493-499 (2008).
    • (2008) Gynecol. Oncol. , vol.108 , Issue.3 , pp. 493-499
    • Secord, A.A.1    Blessing, J.A.2    Armstrong, D.K.3
  • 70
    • 13944269636 scopus 로고    scopus 로고
    • Rash correlates with tumour response after cetuximab
    • Susman E: Rash correlates with tumour response after cetuximab. Lancet Oncol. 5(11), 647 (2004).
    • (2004) Lancet Oncol. , vol.5 , Issue.11 , pp. 647
    • Susman, E.1
  • 71
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplifcation of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplifcation of the HER-2/neu oncogene. Science 235(4785), 177-182 (1987).
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 72
    • 41149155032 scopus 로고    scopus 로고
    • HER2 status in ovarian carcinomas: A multicenter GINECO study of 320 patients
    • Tuefferd M, Couturier J, Penault-Llorca F et al.: HER2 status in ovarian carcinomas: a multicenter GINECO study of 320 patients. PLoS one 2(11), e1138 (2007).
    • (2007) PLoS One , vol.2 , Issue.11
    • Tuefferd, M.1    Couturier, J.2    Penault-Llorca, F.3
  • 73
    • 0037440042 scopus 로고    scopus 로고
    • Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A Phase II trial of the Gynecologic Oncology Group
    • Bookman MA, Darcy KM, Clarke-Pearson D, Boothby RA, Horowitz IR: Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a Phase II trial of the Gynecologic Oncology Group. J. Clin. Oncol. 21(2), 283-290 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.2 , pp. 283-290
    • Bookman, M.A.1    Darcy, K.M.2    Clarke-Pearson, D.3    Boothby, R.A.4    Horowitz, I.R.5
  • 74
    • 77950795867 scopus 로고    scopus 로고
    • HER2 overexpression/amplifcation and trastuzumab treatment in advanced ovarian cancer: A GINECO Phase II study
    • Ray-Coquard I, Guastalla JP, Djelila A et al.: HER2 overexpression/ amplifcation and trastuzumab treatment in advanced ovarian cancer: A GINECO Phase II study. Clin. Ovarian Cancer Special Issue 17-22 (2009).
    • (2009) Clin. Ovarian Cancer , Issue.17-22
    • Ray-Coquard, I.1    Guastalla, J.P.2    Djelila, A.3
  • 75
    • 19044380618 scopus 로고    scopus 로고
    • Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
    • Agus DB, Akita RW, Fox WD et al.: Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer cell 2(2), 127-137 (2002).
    • (2002) Cancer Cell , vol.2 , Issue.2 , pp. 127-137
    • Agus, D.B.1    Akita, R.W.2    Fox, W.D.3
  • 77
    • 33749003463 scopus 로고    scopus 로고
    • Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: Potential predictive relationship with tumor HER2 activation status
    • Gordon MS, Matei D, Aghajanian C et al.: Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status. J. Clin. Oncol. 24(26), 4324-4332 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.26 , pp. 4324-4332
    • Gordon, M.S.1    Matei, D.2    Aghajanian, C.3
  • 78
    • 77949900758 scopus 로고    scopus 로고
    • Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
    • Makhija S, Amler LC, Glenn D et al.: Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer. J. Clin. Oncol. 28(7), 1215-1223 (2009).
    • (2009) J. Clin. Oncol. , vol.28 , Issue.7 , pp. 1215-1223
    • Makhija, S.1    Amler, L.C.2    Glenn, D.3
  • 79
    • 80053254746 scopus 로고    scopus 로고
    • Combined topotecan and lapatinib in patients with early recurrent ovarian or peritoneal cancer after frst line of platinum-based chemotherapy: A French FEDEGYN-FNCLCC Phase II trial
    • Joly F, Weber B, Pautier P et al.: Combined topotecan and lapatinib in patients with early recurrent ovarian or peritoneal cancer after frst line of platinum-based chemotherapy: a French FEDEGYN-FNCLCC Phase II trial. J. Clin. Oncol. 27(Suppl. 15S), 5555 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15S , pp. 5555
    • Joly, F.1    Weber, B.2    Pautier, P.3
  • 81
    • 0344875495 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
    • Schultz N, Lopez E, Saleh-Gohari N, Helleday T: Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res. 31(17), 4959-4964 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , Issue.17 , pp. 4959-4964
    • Schultz, N.1    Lopez, E.2    Saleh-Gohari, N.3    Helleday, T.4
  • 82
    • 67650476607 scopus 로고    scopus 로고
    • Synthetic lethality - A new direction in cancer-drug development
    • Iglehart JD, Silver DP: Synthetic lethality-a new direction in cancer-drug development. N. Engl. J. Med. 361(2), 189-191 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.2 , pp. 189-191
    • Iglehart, J.D.1    Silver, D.P.2
  • 83
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA et al.: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361(2), 123-134 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 84
    • 68149161777 scopus 로고    scopus 로고
    • Phase II trial of the oral PARP inhibitor olaparib (AZD2281) in BRCA-defcient advanced ovarian cancer
    • Audeh MW, Penson RT, Friedlander M et al.: Phase II trial of the oral PARP inhibitor olaparib (AZD2281) in BRCA-defcient advanced ovarian cancer. J. Clin. Oncol. 25(Suppl. 15S) (2009).
    • (2009) J. Clin. Oncol. , vol.25 , Issue.SUPPL. 15S
    • Audeh, M.W.1    Penson, R.T.2    Friedlander, M.3
  • 85
    • 33746154897 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatinresistant tumor cells
    • Nguewa PA, Fuertes MA, Cepeda V et al.: Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatinresistant tumor cells. Med. Chem. (Shariqah (United Arab Emirates)), 2(1), 47-53 (2006).
    • (2006) Med. Chem. (Shariqah (United Arab Emirates)) , vol.2 , Issue.1 , pp. 47-53
    • Nguewa, P.A.1    Fuertes, M.A.2    Cepeda, V.3
  • 86
    • 55949092708 scopus 로고    scopus 로고
    • High sensitivity of BRCA1-defcient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
    • Rottenberg S, Jaspers JE, Kersbergen A et al.: High sensitivity of BRCA1-defcient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc. Natl Acad. Sci. USA 105(44), 17079-17084 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.44 , pp. 17079-17084
    • Rottenberg, S.1    Jaspers, J.E.2    Kersbergen, A.3
  • 87
    • 39849106300 scopus 로고    scopus 로고
    • Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
    • Sakai W, Swisher EM, Karlan BY et al.: Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature 451(7182), 1116-1120 (2008).
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1116-1120
    • Sakai, W.1    Swisher, E.M.2    Karlan, B.Y.3
  • 88
    • 33947166337 scopus 로고    scopus 로고
    • Preclinical evaluation of MORAb-003, a humanized monoclonal antibody antagonizing folate receptor-α
    • Ebel W, Routhier EL, Foley B et al.: Preclinical evaluation of MORAb-003, a humanized monoclonal antibody antagonizing folate receptor-α. Cancer Immun. 7, 6 (2007).
    • (2007) Cancer Immun. , vol.7 , pp. 6
    • Ebel, W.1    Routhier, E.L.2    Foley, B.3
  • 89
    • 39249085399 scopus 로고    scopus 로고
    • Folate receptor α as a tumor target in epithelial ovarian cancer
    • Kalli KR, Oberg AL, Keeney GL et al.: Folate receptor α as a tumor target in epithelial ovarian cancer. Gynecol. Oncol. 108(3), 619-626 (2008).
    • (2008) Gynecol. Oncol. , vol.108 , Issue.3 , pp. 619-626
    • Kalli, K.R.1    Oberg, A.L.2    Keeney, G.L.3
  • 90
    • 59349119253 scopus 로고    scopus 로고
    • Exploratory Phase II effcacy study of MORAb-003, a monoclonal antibody against folate receptorα, in platinum-sensitive ovarian cancer in frst relapse
    • Armstrong DK, Bicher A, Coleman RL et al.: Exploratory Phase II effcacy study of MORAb-003, a monoclonal antibody against folate receptorα, in platinum-sensitive ovarian cancer in frst relapse. J. Clin. Oncol. 26(Suppl. 15), 5500 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.SUPPL. 15 , pp. 5500
    • Armstrong, D.K.1    Bicher, A.2    Coleman, R.L.3
  • 91
    • 33745242315 scopus 로고    scopus 로고
    • Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
    • Del Bufalo D, Ciuffreda L, Trisciuoglio D et al.: Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res. 66(11), 5549-5554 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.11 , pp. 5549-5554
    • Del Bufalo, D.1    Ciuffreda, L.2    Trisciuoglio, D.3
  • 92
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: Insights into a complex relationship
    • Sabatini DM: mTOR and cancer: insights into a complex relationship. Nat. Rev. Cancer 6(9), 729-734 (2006).
    • (2006) Nat. Rev. Cancer , vol.6 , Issue.9 , pp. 729-734
    • Sabatini, D.M.1
  • 93
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G, Raymond E: Current development of mTOR inhibitors as anticancer agents. Nat. Rev. Drug Discov. 5(8), 671-688 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.8 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 96
    • 33846821872 scopus 로고    scopus 로고
    • Targeted therapy for metastatic renal cell carcinoma
    • Motzer RJ, Bukowski RM: Targeted therapy for metastatic renal cell carcinoma. J. Clin. Oncol. 24(35), 5601-5608 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.35 , pp. 5601-5608
    • Motzer, R.J.1    Bukowski, R.M.2
  • 97
    • 59249101893 scopus 로고    scopus 로고
    • Activation of mTOR in a subgroup of ovarian carcinomas: Correlation with p-eIF-4E and prognosis
    • Noske A, Lindenberg JL, Darb-Esfahani S et al.: Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis. Oncol. Rep. 20(6), 1409-1417 (2008).
    • (2008) Oncol. Rep. , vol.20 , Issue.6 , pp. 1409-1417
    • Noske, A.1    Lindenberg, J.L.2    Darb-Esfahani, S.3
  • 98
    • 68349157672 scopus 로고    scopus 로고
    • Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy
    • Zhang HY, Zhang PN, Sun H: Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy. Eur. J. Obstet. Gynecol. Reprod. Biol. 146(1), 81-86 (2009).
    • (2009) Eur. J. Obstet. Gynecol. Reprod. Biol. , vol.146 , Issue.1 , pp. 81-86
    • Zhang, H.Y.1    Zhang, P.N.2    Sun, H.3
  • 99
    • 34547130295 scopus 로고    scopus 로고
    • RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model
    • Mabuchi S, Altomare DA, Cheung M et al.: RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model. Clin. Cancer Res. 13(14), 4261-4270 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.14 , pp. 4261-4270
    • Mabuchi, S.1    Altomare, D.A.2    Cheung, M.3
  • 100
    • 36749068988 scopus 로고    scopus 로고
    • Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
    • Huynh H, Teo CC, Soo KC: Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer. Mol. Cancer Ther. 6(11), 2959-2966 (2007).
    • (2007) Mol. Cancer Ther. , vol.6 , Issue.11 , pp. 2959-2966
    • Huynh, H.1    Teo, C.C.2    Soo, K.C.3
  • 101
    • 62549099008 scopus 로고    scopus 로고
    • The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
    • Trinh XB, Tjalma WA, Vermeulen PB et al.: The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer. Br. J. Cancer, 100(6), 971-978 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.6 , pp. 971-978
    • Trinh, X.B.1    Tjalma, W.A.2    Vermeulen, P.B.3
  • 102
    • 0025935370 scopus 로고
    • Responsiveness of patients with advanced ovarian carcinoma to tamoxifen. A Gynecologic Oncology Group study of second-line therapy in 105 patients
    • Hatch KD, Beecham JB, Blessing JA, Creasman WT: Responsiveness of patients with advanced ovarian carcinoma to tamoxifen. A Gynecologic Oncology Group study of second-line therapy in 105 patients. Cancer 68(2), 269-271 (1991).
    • (1991) Cancer , vol.68 , Issue.2 , pp. 269-271
    • Hatch, K.D.1    Beecham, J.B.2    Blessing, J.A.3    Creasman, W.T.4
  • 103
    • 84921440416 scopus 로고    scopus 로고
    • Tamoxifen for relapse of ovarian cancer
    • Williams CJ: Tamoxifen for relapse of ovarian cancer. Cochrane Database Syst. Rev. (2), CD001034 (2000).
    • (2000) Cochrane Database Syst. Rev. , Issue.2
    • Williams, C.J.1
  • 104
    • 0036166523 scopus 로고    scopus 로고
    • Tamoxifen therapy for ovarian cancer in the adjuvant and advanced settings: Systematic review of the literature and implications for future research
    • Perez-Gracia JL, Carrasco EM: Tamoxifen therapy for ovarian cancer in the adjuvant and advanced settings: systematic review of the literature and implications for future research. Gynecol. Oncol. 84(2), 201-209 (2002).
    • (2002) Gynecol. Oncol. , vol.84 , Issue.2 , pp. 201-209
    • Perez-Gracia, J.L.1    Carrasco, E.M.2
  • 105
    • 0025190452 scopus 로고
    • The effects of estrogen, progesterone, and tamoxifen alone and in combination with cytotoxic agents against human ovarian carcinoma in vitro
    • Geisinger KR, Berens ME, Duckett Y, Morgan TM, Kute TE, Welander CE: The effects of estrogen, progesterone, and tamoxifen alone and in combination with cytotoxic agents against human ovarian carcinoma in vitro. Cancer 65(5), 1055-1061 (1990).
    • (1990) Cancer , vol.65 , Issue.5 , pp. 1055-1061
    • Geisinger, K.R.1    Berens, M.E.2    Duckett, Y.3    Morgan, T.M.4    Kute, T.E.5    Welander, C.E.6
  • 107
    • 0030580037 scopus 로고    scopus 로고
    • Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate
    • Panasci L, Jean-Claude BJ, Vasilescu D et al.: Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate. Biochem. Pharmacol. 52(7), 1097-1102 (1996).
    • (1996) Biochem. Pharmacol. , vol.52 , Issue.7 , pp. 1097-1102
    • Panasci, L.1    Jean-Claude, B.J.2    Vasilescu, D.3
  • 108
    • 0035668051 scopus 로고    scopus 로고
    • A combination of platinum and tamoxifen in advanced ovarian cancer failing platinum-based chemotherapy: Results of a Phase II study
    • Benedetti Panici P, Greggi S, Amoroso M et al.: A combination of platinum and tamoxifen in advanced ovarian cancer failing platinum-based chemotherapy: results of a Phase II study. Int. J. Gynecol. Cancer 11(6), 438-444 (2001).
    • (2001) Int. J. Gynecol. Cancer , vol.11 , Issue.6 , pp. 438-444
    • Benedetti Panici, P.1    Greggi, S.2    Amoroso, M.3
  • 109
    • 3543081555 scopus 로고    scopus 로고
    • Phase 2 trial of carboplatin plus tamoxifen in platinum-resistant ovarian cancer and primary carcinoma of the peritoneum
    • DOI 10.1016/j.ygyno.2004.05.004, PII S0090825804003142
    • Markman M, Webster K, Zanotti K, Peterson G, Kulp B, Belinson J: Phase II trial of carboplatin plus tamoxifen in platinumresistant ovarian cancer and primary carcinoma of the peritoneum. Gynecol. Oncol. 94(2), 404-408 (2004). (Pubitemid 39024545)
    • (2004) Gynecologic Oncology , vol.94 , Issue.2 , pp. 404-408
    • Markman, M.1    Webster, K.2    Zanotti, K.3    Peterson, G.4    Kulp, B.5    Belinson, J.6
  • 110
    • 12144290117 scopus 로고    scopus 로고
    • Phase II trial of anastrozole in women with asymptomatic mullerian cancer
    • del Carmen MG, Fuller AF, Matulonis U et al.: Phase II trial of anastrozole in women with asymptomatic mullerian cancer. Gynecol. Oncol. 91(3), 596-602 (2003).
    • (2003) Gynecol. Oncol. , vol.91 , Issue.3 , pp. 596-602
    • Del Carmen, M.G.1    Fuller, A.F.2    Matulonis, U.3
  • 111
    • 2342545914 scopus 로고    scopus 로고
    • Hormonal therapy with letrozole for relapsed epithelial ovarian cancer. Long-term results of a Phase II study
    • Papadimitriou CA, Markaki S, Siapkaras J et al.: Hormonal therapy with letrozole for relapsed epithelial ovarian cancer. Long-term results of a Phase II study. Oncology 66(2), 112-117 (2004).
    • (2004) Oncology , vol.66 , Issue.2 , pp. 112-117
    • Papadimitriou, C.A.1    Markaki, S.2    Siapkaras, J.3
  • 112
    • 34250708027 scopus 로고    scopus 로고
    • Antiestrogen therapy is active in selected ovarian cancer cases: The use of letrozole in estrogen receptor-positive patients
    • Smyth JF, Gourley C, Walker G et al.: Antiestrogen therapy is active in selected ovarian cancer cases: the use of letrozole in estrogen receptor-positive patients. Clin. Cancer Res. 13(12), 3617-3622 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.12 , pp. 3617-3622
    • Smyth, J.F.1    Gourley, C.2    Walker, G.3
  • 113
    • 47649127006 scopus 로고    scopus 로고
    • Phase II study of exemestane in refractory ovarian cancer
    • Verma S, Alhayki M, Le T et al.: Phase II study of exemestane in refractory ovarian cancer. J. Clin. Oncol. 24 (Suppl. 18), (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.SUPPL. 18
    • Verma, S.1    Alhayki Le M, T.2
  • 114
    • 64149110213 scopus 로고    scopus 로고
    • A Phase II study of fulvestrant in the treatment of multiply-recurrent epithelial ovarian cancer
    • Argenta PA, Thomas SG, Judson PL et al.: A Phase II study of fulvestrant in the treatment of multiply-recurrent epithelial ovarian cancer. Gynecol. Oncol. 113(2), 205-209 (2009).
    • (2009) Gynecol. Oncol. , vol.113 , Issue.2 , pp. 205-209
    • Argenta, P.A.1    Thomas, S.G.2    Judson, P.L.3
  • 115
    • 0032547564 scopus 로고    scopus 로고
    • Polychemotherapy for early breast cancer: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group
    • Polychemotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet 352(9132), 930-942 (1998).
    • (1998) Lancet , vol.352 , Issue.9132 , pp. 930-942
  • 117
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J et al.: Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1673-1684 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 118
    • 24344459713 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activating mutations in Spanish geftinib-treated non-small-cell lung cancer patients
    • Cortes-Funes H, Gomez C, Rosell R et al.: Epidermal growth factor receptor activating mutations in Spanish geftinib-treated non-small-cell lung cancer patients. Ann. Oncol. 16(7), 1081-1086 (2005).
    • (2005) Ann. Oncol. , vol.16 , Issue.7 , pp. 1081-1086
    • Cortes-Funes, H.1    Gomez, C.2    Rosell, R.3
  • 119
    • 20244389188 scopus 로고    scopus 로고
    • Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with geftinib
    • Han SW, Kim TY, Hwang PG et al.: Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with geftinib. J. Clin. Oncol. 23(11), 2493-2501 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.11 , pp. 2493-2501
    • Han, S.W.1    Kim, T.Y.2    Hwang, P.G.3
  • 120
    • 20244388126 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene predict prolonged survival after geftinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    • Mitsudomi T, Kosaka T, Endoh H et al.: Mutations of the epidermal growth factor receptor gene predict prolonged survival after geftinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J. Clin. Oncol. 23(11), 2513-2520 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.11 , pp. 2513-2520
    • Mitsudomi, T.1    Kosaka, T.2    Endoh, H.3
  • 121
    • 33750109066 scopus 로고    scopus 로고
    • Emerging effcacy endpoints for targeted therapies in advanced renal cell carcinoma
    • Gore ME, Escudier B: Emerging effcacy endpoints for targeted therapies in advanced renal cell carcinoma. Oncology (Williston Park) 20(6 Suppl 5), 19-24 (2006).
    • (2006) Oncology (Williston Park) , vol.20 , Issue.6 SUPPL. 5 , pp. 19-24
    • Gore, M.E.1    Escudier, B.2
  • 122
    • 33746879918 scopus 로고    scopus 로고
    • Drug development in oncology: Classical cytotoxics and molecularly targeted agents
    • DOI 10.1111/j.1365-2125.2006.02713.x
    • Kummar S, Gutierrez M, Doroshow JH, Murgo AJ: Drug development in oncology: classical cytotoxics and molecularly targeted agents. Br. J. Clin. Pharmacol. 62(1), 15-26 (2006). (Pubitemid 44195239)
    • (2006) British Journal of Clinical Pharmacology , vol.62 , Issue.1 , pp. 15-26
    • Kummar, S.1    Gutierrez, M.2    Doroshow, J.H.3    Murgo, A.J.4
  • 123
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V et al.: Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359(4), 378-390 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3


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