메뉴 건너뛰기




Volumn 104, Issue 3, 2007, Pages 768-778

Vascular endothelial growth factor (VEGF) pathway as a therapeutic target in gynecologic malignancies

Author keywords

Angiogenesis; Gynecologic cancer; Vascular endothelial growth factor (VEGF)

Indexed keywords

6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; ANGIOZYME; ANTIHYPERTENSIVE AGENT; AXITINIB; BEVACIZUMAB; CALCIUM CHANNEL BLOCKING AGENT; CAPECITABINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXORUBICIN; FLUOROURACIL; GEMCITABINE; MONOCLONAL ANTIBODY 2 C3; PACLITAXEL; SORAFENIB; SUNITINIB; TOPOTECAN; UNCLASSIFIED DRUG; VANDETANIB; VASCULAR ENDOTHELIAL GROWTH FACTOR TRAP; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR; VATALANIB; ZD 7474;

EID: 33846933952     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2006.10.062     Document Type: Review
Times cited : (57)

References (81)
  • 1
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent?. J. Natl. Cancer Inst. 82 1 (1990) 4-6
    • (1990) J. Natl. Cancer Inst. , vol.82 , Issue.1 , pp. 4-6
    • Folkman, J.1
  • 2
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G., and Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat. Rev., Cancer 3 6 (2003) 401-410
    • (2003) Nat. Rev., Cancer , vol.3 , Issue.6 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 3
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 386 6626 (1997) 671-674
    • (1997) Nature , vol.386 , Issue.6626 , pp. 671-674
    • Risau, W.1
  • 4
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • Holash J., Wiegand S.J., and Yancopoulos G.D. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 18 38 (1999) 5356-5362
    • (1999) Oncogene , vol.18 , Issue.38 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 5
    • 0038143145 scopus 로고    scopus 로고
    • Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma
    • Hendrix M.J., Seftor E.A., Hess A.R., and Seftor R.E. Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat. Rev., Cancer 3 6 (2003) 411-421
    • (2003) Nat. Rev., Cancer , vol.3 , Issue.6 , pp. 411-421
    • Hendrix, M.J.1    Seftor, E.A.2    Hess, A.R.3    Seftor, R.E.4
  • 7
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger D.R., Galli S.J., Dvorak A.M., Perruzzi C.A., Harvey V.S., and Dvorak H.F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219 4587 (1983) 983-985
    • (1983) Science , vol.219 , Issue.4587 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 8
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., and Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 4935 (1989) 1306-1309
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 9
    • 0030265393 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its receptors
    • Klagsbrun M., and D'Amore P.A. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev. 7 3 (1996) 259-270
    • (1996) Cytokine Growth Factor Rev. , vol.7 , Issue.3 , pp. 259-270
    • Klagsbrun, M.1    D'Amore, P.A.2
  • 10
    • 33746851955 scopus 로고    scopus 로고
    • Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
    • Thaker P.H., Han L.Y., Kamat A.A., Arevalo J.M., Takahashi R., Lu C., et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat. Med. 12 8 (2006) 939-944
    • (2006) Nat. Med. , vol.12 , Issue.8 , pp. 939-944
    • Thaker, P.H.1    Han, L.Y.2    Kamat, A.A.3    Arevalo, J.M.4    Takahashi, R.5    Lu, C.6
  • 11
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat. Med. 9 6 (2003) 669-676
    • (2003) Nat. Med. , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 12
    • 0036899148 scopus 로고    scopus 로고
    • Generation of a syngeneic mouse model to study the effects of vascular endothelial growth factor in ovarian carcinoma
    • Zhang L., Yang N., Garcia J.R., Mohamed A., Benencia F., Rubin S.C., et al. Generation of a syngeneic mouse model to study the effects of vascular endothelial growth factor in ovarian carcinoma. Am. J. Pathol. 161 6 (2002) 2295-2309
    • (2002) Am. J. Pathol. , vol.161 , Issue.6 , pp. 2295-2309
    • Zhang, L.1    Yang, N.2    Garcia, J.R.3    Mohamed, A.4    Benencia, F.5    Rubin, S.C.6
  • 13
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol. 20 21 (2002) 4368-4380
    • (2002) J. Clin. Oncol. , vol.20 , Issue.21 , pp. 4368-4380
    • Dvorak, H.F.1
  • 14
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • Ferrara N. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 9 Suppl. 1 (2004) 2-10
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 1 , pp. 2-10
    • Ferrara, N.1
  • 15
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak H.F., Brown L.F., Detmar M., and Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146 5 (1995) 1029-1039
    • (1995) Am. J. Pathol. , vol.146 , Issue.5 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3    Dvorak, A.M.4
  • 16
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T., Hemo I., Itin A., Pe'er J., Stone J., and Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med. 1 10 (1995) 1024-1028
    • (1995) Nat. Med. , vol.1 , Issue.10 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Pe'er, J.4    Stone, J.5    Keshet, E.6
  • 17
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet P., Moons L., Luttun A., Vincenti V., Compernolle V., De Mol M., et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7 5 (2001) 575-583
    • (2001) Nat. Med. , vol.7 , Issue.5 , pp. 575-583
    • Carmeliet, P.1    Moons, L.2    Luttun, A.3    Vincenti, V.4    Compernolle, V.5    De Mol, M.6
  • 18
    • 9144236286 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    • Karkkainen M.J., Haiko P., Sainio K., Partanen J., Taipale J., Petrova T.V., et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat. Immunol. 5 1 (2004) 74-80
    • (2004) Nat. Immunol. , vol.5 , Issue.1 , pp. 74-80
    • Karkkainen, M.J.1    Haiko, P.2    Sainio, K.3    Partanen, J.4    Taipale, J.5    Petrova, T.V.6
  • 19
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
    • Shibuya M., Yamaguchi S., Yamane A., Ikeda T., Tojo A., Matsushime H., et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5 4 (1990) 519-524
    • (1990) Oncogene , vol.5 , Issue.4 , pp. 519-524
    • Shibuya, M.1    Yamaguchi, S.2    Yamane, A.3    Ikeda, T.4    Tojo, A.5    Matsushime, H.6
  • 20
    • 0025739016 scopus 로고
    • Identification of a new endothelial cell growth factor receptor tyrosine kinase
    • Terman B.I., Carrion M.E., Kovacs E., Rasmussen B.A., Eddy R.L., and Shows T.B. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6 9 (1991) 1677-1683
    • (1991) Oncogene , vol.6 , Issue.9 , pp. 1677-1683
    • Terman, B.I.1    Carrion, M.E.2    Kovacs, E.3    Rasmussen, B.A.4    Eddy, R.L.5    Shows, T.B.6
  • 21
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong G.H., Rossant J., Gertsenstein M., and Breitman M.L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376 6535 (1995) 66-70
    • (1995) Nature , vol.376 , Issue.6535 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 22
    • 0032764427 scopus 로고    scopus 로고
    • Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
    • Fong G.H., Zhang L., Bryce D.M., and Peng J. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development 126 13 (1999) 3015-3025
    • (1999) Development , vol.126 , Issue.13 , pp. 3015-3025
    • Fong, G.H.1    Zhang, L.2    Bryce, D.M.3    Peng, J.4
  • 23
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    • Shalaby F., Rossant J., Yamaguchi T.P., Gertsenstein M., Wu X.F., Breitman M.L., et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376 6535 (1995) 62-66
    • (1995) Nature , vol.376 , Issue.6535 , pp. 62-66
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.P.3    Gertsenstein, M.4    Wu, X.F.5    Breitman, M.L.6
  • 24
    • 0033118228 scopus 로고    scopus 로고
    • VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
    • Takahashi T., Ueno H., and Shibuya M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18 13 (1999) 2221-2230
    • (1999) Oncogene , vol.18 , Issue.13 , pp. 2221-2230
    • Takahashi, T.1    Ueno, H.2    Shibuya, M.3
  • 25
    • 0037182861 scopus 로고    scopus 로고
    • VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism
    • Gerber H.P., Malik A.K., Solar G.P., Sherman D., Liang X.H., Meng G., et al. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417 6892 (2002) 954-958
    • (2002) Nature , vol.417 , Issue.6892 , pp. 954-958
    • Gerber, H.P.1    Malik, A.K.2    Solar, G.P.3    Sherman, D.4    Liang, X.H.5    Meng, G.6
  • 26
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., and Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. 23 5 (2005) 1011-1027
    • (2005) J. Clin. Oncol. , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 27
    • 33644863001 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
    • Wedam S.B., Low J.A., Yang S.X., Chow C.K., Choyke P., Danforth D., et al. Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J. Clin. Oncol. 24 5 (2006) 769-777
    • (2006) J. Clin. Oncol. , vol.24 , Issue.5 , pp. 769-777
    • Wedam, S.B.1    Low, J.A.2    Yang, S.X.3    Chow, C.K.4    Choyke, P.5    Danforth, D.6
  • 28
    • 27644479545 scopus 로고    scopus 로고
    • Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors
    • Thaker P.H., Yazici S., Nilsson M.B., Yokoi K., Tsan R.Z., He J., et al. Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors. Clin. Cancer Res. 11 13 (2005) 4923-4933
    • (2005) Clin. Cancer Res. , vol.11 , Issue.13 , pp. 4923-4933
    • Thaker, P.H.1    Yazici, S.2    Nilsson, M.B.3    Yokoi, K.4    Tsan, R.Z.5    He, J.6
  • 29
    • 1842850792 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients
    • Kassim S.K., El-Salahy E.M., Fayed S.T., Helal S.A., Helal T., Azzam Eel D., et al. Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients. Clin. Biochem. 37 5 (2004) 363-369
    • (2004) Clin. Biochem. , vol.37 , Issue.5 , pp. 363-369
    • Kassim, S.K.1    El-Salahy, E.M.2    Fayed, S.T.3    Helal, S.A.4    Helal, T.5    Azzam Eel, D.6
  • 30
    • 0030923795 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in early stage ovarian carcinoma
    • Paley P.J., Staskus K.A., Gebhard K., Mohanraj D., Twiggs L.B., Carson L.F., et al. Vascular endothelial growth factor expression in early stage ovarian carcinoma. Cancer 80 1 (1997) 98-106
    • (1997) Cancer , vol.80 , Issue.1 , pp. 98-106
    • Paley, P.J.1    Staskus, K.A.2    Gebhard, K.3    Mohanraj, D.4    Twiggs, L.B.5    Carson, L.F.6
  • 31
    • 0036793818 scopus 로고    scopus 로고
    • Preoperative serum vascular endothelial growth factor levels: significance in ovarian cancer
    • Cooper B.C., Ritchie J.M., Broghammer C.L., Coffin J., Sorosky J.I., Buller R.E., et al. Preoperative serum vascular endothelial growth factor levels: significance in ovarian cancer. Clin. Cancer Res. 8 10 (2002) 3193-3197
    • (2002) Clin. Cancer Res. , vol.8 , Issue.10 , pp. 3193-3197
    • Cooper, B.C.1    Ritchie, J.M.2    Broghammer, C.L.3    Coffin, J.4    Sorosky, J.I.5    Buller, R.E.6
  • 32
    • 3242658330 scopus 로고    scopus 로고
    • Correlation of serum VEGF levels with clinical stage, therapy efficacy, tumor metastasis and patient survival in ovarian cancer
    • Li L., Wang L., Zhang W., Tang B., Zhang J., Song H., et al. Correlation of serum VEGF levels with clinical stage, therapy efficacy, tumor metastasis and patient survival in ovarian cancer. Anticancer Res. 24 3b (2004) 1973-1979
    • (2004) Anticancer Res. , vol.24 , Issue.3 b , pp. 1973-1979
    • Li, L.1    Wang, L.2    Zhang, W.3    Tang, B.4    Zhang, J.5    Song, H.6
  • 34
    • 0141841787 scopus 로고    scopus 로고
    • Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer
    • Holland C.M., Day K., Evans A., and Smith S.K. Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer. Br. J. Cancer 89 5 (2003) 891-898
    • (2003) Br. J. Cancer , vol.89 , Issue.5 , pp. 891-898
    • Holland, C.M.1    Day, K.2    Evans, A.3    Smith, S.K.4
  • 35
    • 32544438320 scopus 로고    scopus 로고
    • pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor grade
    • Sanseverino F., Santopietro R., Torricelli M., D'Andrilli G., Russo G., Cevenini G., et al. pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor grade. Cancer Biol. Ther. 5 1 (2006) 84-88
    • (2006) Cancer Biol. Ther. , vol.5 , Issue.1 , pp. 84-88
    • Sanseverino, F.1    Santopietro, R.2    Torricelli, M.3    D'Andrilli, G.4    Russo, G.5    Cevenini, G.6
  • 36
    • 0035136974 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in postmenopausal uterine endometrial carcinoma
    • Hirai M., Nakagawara A., Oosaki T., Hayashi Y., Hirono M., and Yoshihara T. Expression of vascular endothelial growth factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in postmenopausal uterine endometrial carcinoma. Gynecol. Oncol. 80 2 (2001) 181-188
    • (2001) Gynecol. Oncol. , vol.80 , Issue.2 , pp. 181-188
    • Hirai, M.1    Nakagawara, A.2    Oosaki, T.3    Hayashi, Y.4    Hirono, M.5    Yoshihara, T.6
  • 37
    • 0033899157 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix
    • Loncaster J.A., Cooper R.A., Logue J.P., Davidson S.E., Hunter R.D., and West C.M. Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix. Br. J. Cancer 83 5 (2000) 620-625
    • (2000) Br. J. Cancer , vol.83 , Issue.5 , pp. 620-625
    • Loncaster, J.A.1    Cooper, R.A.2    Logue, J.P.3    Davidson, S.E.4    Hunter, R.D.5    West, C.M.6
  • 39
    • 0033790637 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and prognosis of cervical carcinoma
    • Cheng W.F., Chen C.A., Lee C.N., Wei L.H., Hsieh F.J., and Hsieh C.Y. Vascular endothelial growth factor and prognosis of cervical carcinoma. Obstet. Gynecol. 96 5 Pt 1 (2000) 721-726
    • (2000) Obstet. Gynecol. , vol.96 , Issue.5 PART 1 , pp. 721-726
    • Cheng, W.F.1    Chen, C.A.2    Lee, C.N.3    Wei, L.H.4    Hsieh, F.J.5    Hsieh, C.Y.6
  • 40
    • 0033826166 scopus 로고    scopus 로고
    • The association between vascular endothelial growth factor, microvessel density and clinicopathological features in invasive cervical cancer
    • Tjalma W., Weyler J., Weyn B., Van Marck E., Van Daele A., Van Dam P., et al. The association between vascular endothelial growth factor, microvessel density and clinicopathological features in invasive cervical cancer. Eur. J. Obstet. Gynecol. Reprod. Biol. 92 2 (2000) 251-257
    • (2000) Eur. J. Obstet. Gynecol. Reprod. Biol. , vol.92 , Issue.2 , pp. 251-257
    • Tjalma, W.1    Weyler, J.2    Weyn, B.3    Van Marck, E.4    Van Daele, A.5    Van Dam, P.6
  • 41
    • 28544433482 scopus 로고    scopus 로고
    • Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix
    • Gombos Z., Xu X., Chu C.S., Zhang P.J., and Acs G. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin. Cancer Res. 11 23 (2005) 8364-8371
    • (2005) Clin. Cancer Res. , vol.11 , Issue.23 , pp. 8364-8371
    • Gombos, Z.1    Xu, X.2    Chu, C.S.3    Zhang, P.J.4    Acs, G.5
  • 42
    • 0036229358 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor and serum leptin in patients with cervical cancer
    • Lebrecht A., Ludwig E., Huber A., Klein M., Schneeberger C., Tempfer C., et al. Serum vascular endothelial growth factor and serum leptin in patients with cervical cancer. Gynecol. Oncol. 85 1 (2002) 32-35
    • (2002) Gynecol. Oncol. , vol.85 , Issue.1 , pp. 32-35
    • Lebrecht, A.1    Ludwig, E.2    Huber, A.3    Klein, M.4    Schneeberger, C.5    Tempfer, C.6
  • 43
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., Cartwright T., Hainsworth J., Heim W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350 23 (2004) 2335-2342
    • (2004) N. Engl. J. Med. , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 44
    • 0031719516 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization
    • Mesiano S., Ferrara N., and Jaffe R.B. Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization. Am. J. Pathol. 153 4 (1998) 1249-1256
    • (1998) Am. J. Pathol. , vol.153 , Issue.4 , pp. 1249-1256
    • Mesiano, S.1    Ferrara, N.2    Jaffe, R.B.3
  • 45
    • 0036840759 scopus 로고    scopus 로고
    • Vascular endothelial growth factor immunoneutralization plus paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer
    • Hu L., Hofmann J., Zaloudek C., Ferrara N., Hamilton T., and Jaffe R.B. Vascular endothelial growth factor immunoneutralization plus paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer. Am. J. Pathol. 161 5 (2002) 1917-1924
    • (2002) Am. J. Pathol. , vol.161 , Issue.5 , pp. 1917-1924
    • Hu, L.1    Hofmann, J.2    Zaloudek, C.3    Ferrara, N.4    Hamilton, T.5    Jaffe, R.B.6
  • 46
    • 23844485828 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistant or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group study
    • 2005 ASCO Annual Meeting Proceedings
    • Burger R.A., Sill M., Monk B.J., Greer B., and Sorosky J. Phase II trial of bevacizumab in persistant or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group study. 2005 ASCO Annual Meeting Proceedings. J. Clin. Oncol. vol. 23(16S) (2005) 5009
    • (2005) J. Clin. Oncol. , vol.23 16S , pp. 5009
    • Burger, R.A.1    Sill, M.2    Monk, B.J.3    Greer, B.4    Sorosky, J.5
  • 47
    • 33750045710 scopus 로고    scopus 로고
    • Bevacizumab in patients with advanced platinum-resistant ovarian cancer
    • 2006 ASCO Annual Meeting Proceedings
    • Cannistra S.A., Matulonis U., Penson R., Wenham R., Armstrong D., Burger R.A., et al. Bevacizumab in patients with advanced platinum-resistant ovarian cancer. 2006 ASCO Annual Meeting Proceedings. J. Clin. Oncol. 24(18S) (2006) 5006
    • (2006) J. Clin. Oncol. , vol.24 18S , pp. 5006
    • Cannistra, S.A.1    Matulonis, U.2    Penson, R.3    Wenham, R.4    Armstrong, D.5    Burger, R.A.6
  • 48
    • 33748475636 scopus 로고    scopus 로고
    • The use of bevacizumab to palliate symptomatic ascites in patients with refractory ovarian carcinoma
    • Numnum T.M., Rocconi R.P., Whitworth J., and Barnes M.N. The use of bevacizumab to palliate symptomatic ascites in patients with refractory ovarian carcinoma. Gynecol. Oncol. 102 3 (2006) 425-428
    • (2006) Gynecol. Oncol. , vol.102 , Issue.3 , pp. 425-428
    • Numnum, T.M.1    Rocconi, R.P.2    Whitworth, J.3    Barnes, M.N.4
  • 49
    • 33745923690 scopus 로고    scopus 로고
    • Salvage bevacizumab (rhuMAB VEGF)-based therapy after multiple prior cytotoxic regimens in advanced refractory epithelial ovarian cancer
    • Monk B.J., Han E., Josephs-Cowan C.A., Pugmire G., and Burger R.A. Salvage bevacizumab (rhuMAB VEGF)-based therapy after multiple prior cytotoxic regimens in advanced refractory epithelial ovarian cancer. Gynecol. Oncol. 102 2 (2006) 140-144
    • (2006) Gynecol. Oncol. , vol.102 , Issue.2 , pp. 140-144
    • Monk, B.J.1    Han, E.2    Josephs-Cowan, C.A.3    Pugmire, G.4    Burger, R.A.5
  • 50
    • 33744911102 scopus 로고    scopus 로고
    • Sustained response to bevacizumab in refractory well-differentiated ovarian neoplasms
    • Bidus M.A., Webb J.C., Seidman J.D., Rose G.S., Boice C.R., and Elkas J.C. Sustained response to bevacizumab in refractory well-differentiated ovarian neoplasms. Gynecol. Oncol. 102 1 (2006) 5-7
    • (2006) Gynecol. Oncol. , vol.102 , Issue.1 , pp. 5-7
    • Bidus, M.A.1    Webb, J.C.2    Seidman, J.D.3    Rose, G.S.4    Boice, C.R.5    Elkas, J.C.6
  • 51
    • 0028305809 scopus 로고
    • Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents
    • Teicher B.A., Holden S.A., Ara G., Sotomayor E.A., Huang Z.D., Chen Y.N., et al. Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int. J. Cancer 57 6 (1994) 920-925
    • (1994) Int. J. Cancer , vol.57 , Issue.6 , pp. 920-925
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3    Sotomayor, E.A.4    Huang, Z.D.5    Chen, Y.N.6
  • 52
    • 26444484355 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model
    • Hu L., Hofmann J., Holash J., Yancopoulos G.D., Sood A.K., and Jaffe R.B. Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model. Clin. Cancer Res. 11 19 Pt 1 (2005) 6966-6971
    • (2005) Clin. Cancer Res. , vol.11 , Issue.19 PART 1 , pp. 6966-6971
    • Hu, L.1    Hofmann, J.2    Holash, J.3    Yancopoulos, G.D.4    Sood, A.K.5    Jaffe, R.B.6
  • 53
  • 54
    • 33748364149 scopus 로고    scopus 로고
    • Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy
    • Halder J., Kamat A.A., Landen Jr. C.N., Han L.Y., Lutgendorf S.K., Lin Y.G., et al. Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy. Clin. Cancer Res. 12 16 (2006) 4916-4924
    • (2006) Clin. Cancer Res. , vol.12 , Issue.16 , pp. 4916-4924
    • Halder, J.1    Kamat, A.A.2    Landen Jr., C.N.3    Han, L.Y.4    Lutgendorf, S.K.5    Lin, Y.G.6
  • 55
    • 33749003219 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma
    • Han L.Y., Landen C.N., Trevino J.G., Halder J., Lin Y.G., Kamat A.A., et al. Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma. Cancer Res. 66 17 (2006) 8633-8639
    • (2006) Cancer Res. , vol.66 , Issue.17 , pp. 8633-8639
    • Han, L.Y.1    Landen, C.N.2    Trevino, J.G.3    Halder, J.4    Lin, Y.G.5    Kamat, A.A.6
  • 56
    • 29444432612 scopus 로고    scopus 로고
    • Interim report of a phase II clinical trial of bevacizumab and low dose metronomic oral cyclophosphamide in recurrent ovarian and primary peritoneal cancer: a California Cancer Consortium Trial
    • Garcia A.A., Oza A.M., Hirte H., Fleming G., Tsao-Wei D., Roman L., et al. Interim report of a phase II clinical trial of bevacizumab and low dose metronomic oral cyclophosphamide in recurrent ovarian and primary peritoneal cancer: a California Cancer Consortium Trial. J Clin Oncol, 2005 ASCO Annual Meeting Proceedings 23 16S (2005) 5000
    • (2005) J Clin Oncol, 2005 ASCO Annual Meeting Proceedings , vol.23 , Issue.16 S , pp. 5000
    • Garcia, A.A.1    Oza, A.M.2    Hirte, H.3    Fleming, G.4    Tsao-Wei, D.5    Roman, L.6
  • 57
    • 33745875210 scopus 로고    scopus 로고
    • Bevacizumab and weekly taxane chemotherapy demonstrates activity in refractory ovarian cancer
    • Cohn D.E., Valmadre S., Resnick K.E., Eaton L.A., Copeland L.J., and Fowler J.M. Bevacizumab and weekly taxane chemotherapy demonstrates activity in refractory ovarian cancer. Gynecol. Oncol. 102 2 (2006) 134-139
    • (2006) Gynecol. Oncol. , vol.102 , Issue.2 , pp. 134-139
    • Cohn, D.E.1    Valmadre, S.2    Resnick, K.E.3    Eaton, L.A.4    Copeland, L.J.5    Fowler, J.M.6
  • 58
    • 33745308428 scopus 로고    scopus 로고
    • Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: a retrospective analysis
    • Wright J.D., Hagemann A., Rader J.S., Viviano D., Gibb R.K., Norris L., et al. Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: a retrospective analysis. Cancer 107 1 (2006) 83-89
    • (2006) Cancer , vol.107 , Issue.1 , pp. 83-89
    • Wright, J.D.1    Hagemann, A.2    Rader, J.S.3    Viviano, D.4    Gibb, R.K.5    Norris, L.6
  • 62
    • 0345060442 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
    • Byrne A.T., Ross L., Holash J., Nakanishi M., Hu L., Hofmann J.I., et al. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin. Cancer Res. 9 15 (2003) 5721-5728
    • (2003) Clin. Cancer Res. , vol.9 , Issue.15 , pp. 5721-5728
    • Byrne, A.T.1    Ross, L.2    Holash, J.3    Nakanishi, M.4    Hu, L.5    Hofmann, J.I.6
  • 63
    • 4344601239 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the novel oral cell-cycle inhibitor Ro 31-7453 in patients with advanced solid tumors
    • Dupont J., Bienvenu B., Aghajanian C., Pezzulli S., Sabbatini P., Vongphrachanh P., et al. Phase I and pharmacokinetic study of the novel oral cell-cycle inhibitor Ro 31-7453 in patients with advanced solid tumors. J. Clin. Oncol. 22 16 (2004) 3366-3374
    • (2004) J. Clin. Oncol. , vol.22 , Issue.16 , pp. 3366-3374
    • Dupont, J.1    Bienvenu, B.2    Aghajanian, C.3    Pezzulli, S.4    Sabbatini, P.5    Vongphrachanh, P.6
  • 64
    • 0034145605 scopus 로고    scopus 로고
    • Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases
    • Xu L., Yoneda J., Herrera C., Wood J., Killion J.J., and Fidler I.J. Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Int. J. Oncol. 16 3 (2000) 445-454
    • (2000) Int. J. Oncol. , vol.16 , Issue.3 , pp. 445-454
    • Xu, L.1    Yoneda, J.2    Herrera, C.3    Wood, J.4    Killion, J.J.5    Fidler, I.J.6
  • 65
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results
    • Rugo H.S., Herbst R.S., Liu G., Park J.W., Kies M.S., Steinfeldt H.M., et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J. Clin. Oncol. 23 24 (2005) 5474-5483
    • (2005) J. Clin. Oncol. , vol.23 , Issue.24 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3    Park, J.W.4    Kies, M.S.5    Steinfeldt, H.M.6
  • 66
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel D.B., Laird A.D., Xin X., Louie S.G., Christensen J.G., Li G., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. 9 1 (2003) 327-337
    • (2003) Clin. Cancer Res. , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3    Louie, S.G.4    Christensen, J.G.5    Li, G.6
  • 67
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge S.R., Ogilvie D.J., Dukes M., Kendrew J., Chester R., Jackson J.A., et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 62 16 (2002) 4645-4655
    • (2002) Cancer Res. , vol.62 , Issue.16 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3    Kendrew, J.4    Chester, R.5    Jackson, J.A.6
  • 68
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., Wilkie D., McNabola A., Rong H., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64 19 (2004) 7099-7109
    • (2004) Cancer Res. , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3    Wilkie, D.4    McNabola, A.5    Rong, H.6
  • 69
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain M.J., Eisen T., Stadler W.M., Flaherty K.T., Kaye S.B., Rosner G.L., et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24 16 (2006) 2505-2512
    • (2006) J. Clin. Oncol. , vol.24 , Issue.16 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3    Flaherty, K.T.4    Kaye, S.B.5    Rosner, G.L.6
  • 70
    • 31544460436 scopus 로고    scopus 로고
    • Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer
    • Siu L.L., Awada A., Takimoto C.H., Piccart M., Schwartz B., Giannaris T., et al. Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin. Cancer Res. 12 1 (2006) 144-151
    • (2006) Clin. Cancer Res. , vol.12 , Issue.1 , pp. 144-151
    • Siu, L.L.1    Awada, A.2    Takimoto, C.H.3    Piccart, M.4    Schwartz, B.5    Giannaris, T.6
  • 71
    • 0036941125 scopus 로고    scopus 로고
    • A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model
    • Zhang W., Ran S., Sambade M., Huang X., and Thorpe P.E. A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model. Angiogenesis 5 1-2 (2002) 35-44
    • (2002) Angiogenesis , vol.5 , Issue.1-2 , pp. 35-44
    • Zhang, W.1    Ran, S.2    Sambade, M.3    Huang, X.4    Thorpe, P.E.5
  • 72
    • 0037087585 scopus 로고    scopus 로고
    • Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors
    • Kuenen B.C., Rosen L., Smit E.F., Parson M.R., Levi M., Ruijter R., et al. Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. J. Clin. Oncol. 20 6 (2002) 1657-1667
    • (2002) J. Clin. Oncol. , vol.20 , Issue.6 , pp. 1657-1667
    • Kuenen, B.C.1    Rosen, L.2    Smit, E.F.3    Parson, M.R.4    Levi, M.5    Ruijter, R.6
  • 73
    • 33846913979 scopus 로고    scopus 로고
    • F.D. Administration, Important Drug Warning-Bevacizumab. In; 2004.
  • 74
    • 27944456516 scopus 로고    scopus 로고
    • Managing patients treated with bevacizumab combination therapy
    • Gordon M.S., and Cunningham D. Managing patients treated with bevacizumab combination therapy. Oncology 69 Suppl. 3 (2005) 25-33
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 25-33
    • Gordon, M.S.1    Cunningham, D.2
  • 75
    • 0031943236 scopus 로고    scopus 로고
    • VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
    • Hood J.D., Meininger C.J., Ziche M., and Granger H.J. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am. J. Physiol. 274 3 Pt 2 (1998) H1054-H1058
    • (1998) Am. J. Physiol. , vol.274 , Issue.3 PART 2
    • Hood, J.D.1    Meininger, C.J.2    Ziche, M.3    Granger, H.J.4
  • 76
    • 24344442899 scopus 로고    scopus 로고
    • Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab
    • Scappaticci F.A., Fehrenbacher L., Cartwright T., Hainsworth J.D., Heim W., Berlin J., et al. Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab. J. Surg. Oncol. 91 3 (2005) 173-180
    • (2005) J. Surg. Oncol. , vol.91 , Issue.3 , pp. 173-180
    • Scappaticci, F.A.1    Fehrenbacher, L.2    Cartwright, T.3    Hainsworth, J.D.4    Heim, W.5    Berlin, J.6
  • 77
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307 5706 (2005) 58-62
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 78
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain R.K., Duda D.G., Clark J.W., and Loeffler J.S. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Natl. Clin. Pract. Oncol. 3 1 (2006) 24-40
    • (2006) Natl. Clin. Pract. Oncol. , vol.3 , Issue.1 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 79
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F., Hurwitz H.I., Fehrenbacher L., Meropol N.J., Novotny W.F., Lieberman G., et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. 21 1 (2003) 60-65
    • (2003) J. Clin. Oncol. , vol.21 , Issue.1 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3    Meropol, N.J.4    Novotny, W.F.5    Lieberman, G.6
  • 80
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett C.G., Boucher Y., Tomaso diE., Duda D.G., Munn L.L., Tong R.T., et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat. Med. 10 2 (2004) 145-147
    • (2004) Nat. Med. , vol.10 , Issue.2 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    Tomaso, diE.3    Duda, D.G.4    Munn, L.L.5    Tong, R.T.6
  • 81
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., Bergsland E., and Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 111 9 (2003) 1287-1295
    • (2003) J. Clin. Invest. , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.