Biosynthesis of H 2S is impaired in non-obese diabetic (NOD) mice

British Journal of Pharmacology

Volumn 155, Issue 5, 2008, Pages 673-680

  Brancaleone, V ^a   Roviezzo, F ^a   Vellecco, V ^a   De Gruttola, L ^a   Bucci, M ^a   Cirino, G ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Endothelium; Hydrogen sulphide; L cysteine; NOD mice

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYSTATHIONINE GAMMA LYASE INHIBITOR; CYSTEINE; ENZYME INHIBITOR; HYDROGEN SULFIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SODIUM HYDROSULFIDE; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BIOSYNTHESIS; BLOOD LEVEL; BLOOD VESSEL REACTIVITY; CHEMICAL REACTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; ENDOTHELIAL DYSFUNCTION; FEMALE; GENETIC MODEL; HOMEOSTASIS; ISOLATED ARTERY; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE LEVEL; VASODILATATION; WESTERN BLOTTING; ANIMAL; BLOOD; DRUG EFFECT; GLUCOSE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; BLOOD GLUCOSE; BLOTTING, WESTERN; CYSTEINE; DIABETES MELLITUS, TYPE 1; ENDOTHELIUM, VASCULAR; FEMALE; HYDROGEN SULFIDE; MICE; MICE, INBRED NOD; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 54949108549     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.296     Document Type: Article

References (30)

1. Ali MY, Ping CY, Mok YY, Ling L, Whiteman M, Bhatia M et al. (2006). Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide? Br J Pharmacol 149: 625-634.
2. Bhatia M (2005). Hydrogen sulfide as a vasodilator. IUBMB Life 57: 603-606.
3. 6 in enzymic formation of hydrogen sulfide from L-cysteineteine. Dokl Akad Nauk SSSR 71: 93-96.
4. Bucci M, Roviezzo F, Brancaleone V, Lin MI, Di Lorenzo A, Cicala C et al. (2004). Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Arterioscler Thromb Vasc Biol 24: 721-726.
5. 2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. J Biol Chem 279: 52082-52086.
6. Cheng Y, Ndisang JF, Tang G, Cao K, Wang R (2004). Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. Am J Physiol Heart Circ Physiol 287: H2316-H2323.
7. Doi T, Hattori M, Agodoa LY, Sato T, Yoshida H, Striker LJ et al. (1990). Glomerular lesions in nonobese diabetic mouse: before and after the onset of hyperglycemia. Lab Invest 63: 204-212.
8. Du J, Yan H, Tan C (2003). Endogenous H2S is involved in the development of spontaneous hypertension. Beijing Da Xue Xue Bao 35: 102-109.
9. Hosoki R, Matsuki N, Kimura H (1997). The possible role of hydrogen sulphide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 237: 527-531.
10. Levonen AL, Lapatto R, Saksela M, Raivio KO (2000). Human cystathionine gamma-lyase: developmental and in vitro expression of two isoforms. Biochem J 347: 291-295.
11. Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y (1980). Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 29: 1-13.
12. Meier M, Janosik M, Kery V, Kraus JP, Burkhard P (2001). Structure of human cystathionine beta-synthase: a unique pyridoxal 5′-phosphate- dependent heme protein. EMBO J 20: 3910-3916.
13. Moore PK, Bhatia M, Moochhala S (2003). Hydrogen sulfide: from the smell of the past to the mediator of the future? Trends Pharmacol Sci 24: 609-611.
14. 2S)? Br J Pharmacol 149: 609-610.
15. Pearson RJ, Wilson T, Wang R (2006). Endogenous hydrogen sulfide and the cardiovascular system - what's the smell all about? Clin Invest Med 29: 146-150.
16. Qu K, Chen CP, Halliwell B, Moore PK, Wong PT (2006). Hydrogen sulfide is a mediator of cerebral ischemic damage. Stroke 37: 889-893.
17. Sheng L, Wharton RA (2006). Functional characterization of two S-nitroso-L-cysteineteine transporters, which mediate movement of NO equivalent into vascular cells. Am J Physiol Cell Physiol 292: C1263-C1271.
18. Stipanuk MH (2004). Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 24: 539-577.
19. Stipanuk MH, Beck PW (1982). Characterization of the enzymatic capacity for cysteine desulphydration in liver and kidney of the rat. Biochem J 206: 267-277.
20. van der Molen EF, Hiipakka MJ, van Lith-Zanders H, Boers GH, van den Heuvel LP, Monnens LA et al. (1997). Homocysteine metabolism in endothelial cells of a patient homozygous for cystathionine beta-synthase (CS) deficiency. Thromb Haemost 78: 827-833.
21. Wang J, Dudman NP, Wilcken DE, Lynch JF (1992). Homocysteine catabolism: levels of 3 enzymes in cultured human vascular endothelium and their relevance to vascular disease. Atherosclerosis 97: 97-106.
22. 2S be the third endogenous gaseous transmitter? FASEB J 16: 1792-1798.
23. Yan H, Du J, Tang C (2004). The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Biochem Biophys Res Commun 313: 22-27.
24. Yang G, Sun X, Wang R (2004). Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3. FASEB J 18: 1782-1784.
25. Yap S, Naughten ER, Wilcken B, Wilcken DE, Boers GH (2000). Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy. Semin Thromb Hemost 26: 335-340.
26. Zanardo RC, Brancaleone V, Distrutti E, Fiorucci S, Cirino G, Wallace JL (2006). Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation. FASEB J 20: 2118-2120.
27. Zhang Y, Hogg N (2005). S-nitrosothiols: cellular formation and transport. Free Radic Biol Med 38: 831-838.
28. 2S in rat tissues. Can J Physiol Pharmacol 81: 848-853.
29. 2S as a novel endogenous gaseous K(ATP) channel opener. EMBO J 20: 6008-6016.
30. Zhong G, Chen F, Cheng Y, Tang C, Du J (2003). The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase. J Hypertens 21: 1879-1885.