IL6 and the human limbal stem cell niche: A mediator of epithelial-stromal interaction

Stem Cell Research

Volumn 5, Issue 3, 2010, Pages 188-200

  Notara, Maria ^a   Shortt, Alex J ^a,b   Galatowicz, Grazyna ^a   Calder, Virginia ^a   Daniels, Julie T ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; INTERLEUKIN 6; PROTEIN P63; STAT3 PROTEIN;

ARTICLE; CELL INTERACTION; COCULTURE; COLONY FORMATION; CONTROLLED STUDY; CORNEA LIMBUS; CYTOKINE PRODUCTION; EPITHELIUM CELL; FIBROBLAST; GOLD STANDARD; HUMAN; HUMAN CELL; LIMBAL STEM CELL TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STROMA CELL;

APOPTOSIS; ATP-BINDING CASSETTE TRANSPORTERS; CELL PROLIFERATION; COCULTURE TECHNIQUES; EPITHELIUM, CORNEAL; HUMANS; INTERLEUKIN-6; LIMBUS CORNEAE; NEOPLASM PROTEINS; STAT3 TRANSCRIPTION FACTOR; STEM CELLS; STROMAL CELLS; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

EID: 77957662326     PISSN: 18735061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.scr.2010.07.002     Document Type: Article

References (42)

1. Arpitha P., et al. High expression of p63α combined with a large N/C ratio defines a subset of human limbal epithelial cells: Implications on epithelial stem cells. Invest. Ophthalmol. Vis. Sci. 2005, 46:3631-3636.
2. Avizienyte E., et al. Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Mol. Biol. Cell 2004, 15:2794-2803.
3. Barrandon Y., Green H. Three clonal types of keratinocyte with different capacities for multiplication. Proc. Natl Acad. Sci. USA 1987, 84:2302-2306.
4. Barreca A., et al. In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth-factors. J. Cell. Physiol. 1992, 151:262-268.
5. Cotsarelis G., Cheng S.Z., Dong G., Sun T.T., Lavker R.M. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 1989, 57:201-209.
6. Coulie P.G., Stevens M., Vansnick J. High-affinity and low-affinity receptors for murine interleukin.6. Distinct distribution on B-cells and T-cells. Eur. J. Immunol. 1989, 19:2107-2114.
7. Daniels J.T., et al. Temporal and spatial expression of matrix metalloproteinases during wound healing of human corneal tissue. Exp. Eye Res. 2003, 77:653-664.
8. Davanger M., Evensen A. Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature 1971, 229:560-561.
9. Decotto E., Spradling A.C. The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals. Dev. Cell 2005, 9:501-510.
10. Deshpande P., et al. Development of a surface-modified contact lens for the transfer of cultured limbal epithelial cells to the cornea for ocular surface diseases. Tissue Eng. A 2009, 15:2889-2902.
11. Detmar M., et al. Culture of hair matrix and follicular keratinocytes. J. Invest. Dermatol. 1993, 101:S130-S134.
12. Di Iorio E., et al. Isoforms of Delta Np63α and the migration of ocular limbal cells in human corneal regeneration. Proc. Natl Acad. Sci. USA 2005, 102:9523-9528.
13. Fuchs E., Tumbar T., Guasch G. Socializing with the neighbors: stem cells and their niche. Cell 2004, 116:769-778.
14. Hasan N.M., Adams G.E., Joiner M.C. Effect of serum starvation on expression and phosphorylation of PKC-alpha and p53 in V79 cells: Implications for cell death. Int. J. Cancer 1999, 80:400-405.
15. Heinrich P.C., et al. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J. 1998, 334:297-314.
16. Hendricks R.L., Janowicz M., Tumpey T.M. Critical role of corneal Langerhans cells in the Cd4-mediated but Not Cd8-mediated immunopathology in herpes-simplex virus-1-infected mouse corneas. J. Immunol. 1992, 148:2522-2529.
17. Hirano T., Ishihara K., Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000, 19:2548-2556.
18. Humphrey R.K., et al. Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells 2004, 22:522-530.
19. Jones S.A. Directing transition from innate to acquired immunity defining a role for IL-6. J. Immunol. 2005, 175:3463-3468.
20. Kennedy M., et al. Ultraviolet irradiation induces the production of multiple cytokines by human corneal cells. Invest. Ophthalmol. Vis. Sci. 1997, 38:2483-2491.
21. Kernacki K.A., Berk R.S. Characterization of the inflammatory response induced by corneal infection with Pseudomonas-aeruginosa. J. Ocul. Pharmacol. 1994, 10:281-288.
22. Kulkarni G.V., McCulloch C.A.G. Serum deprivation induces apoptotic cell-death in a subset of Balb/C 3t3 fibroblasts. J. Cell Sci. 1994, 107:1169-1179.
23. Majo F., et al. Oligopotent stem cells are distributed throughout the mammalian ocular surface. Nature 2008, 456:250-251.
24. Matsuda T., et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J. 1999, 18:4261-4269.
25. Meyer-Blazejewska E.A., et al. Preservation of the limbal stem cell phenotype by appropriate culture techniques. Invest. Ophthalmol. Vis. Sci. 2009.
26. Nishida T., et al. Interleukin 6 promotes epithelial migration by a fibronectin-dependent mechanism. J. Cell. Physiol. 1992, 153:1-5.
27. Nishida T., et al. Interleukin-6 facilitates corneal epithelial wound closure in vivo. Arch. Ophthalmol. 1992, 110:1292-1294.
28. Notara M., et al. Plasma polymer coated surfaces for serum-free culture of limbal epithelium for ocular surface disease. J. Mater. Sci. Mater. Med. 2007, 18:329-338.
29. Notara M., et al. A xenobiotic-free culture system for human limbal epithelial stem cells. Regen. Med. 2007, 2:919-927.
30. Pellegrini G., et al. Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet 1997, 349:990-993.
31. Planck S.R., et al. Trauma and alkali burns induce distinct patterns of cytokine gene expression in the rat cornea. Ocul. Immunol. Inflamm. 1997, 5:95-100.
32. Polisetty N., et al. Mesenchymal cells from limbal stroma of human eye. Mol. Vis. 2008, 14:431-442.
33. Rama P., et al. Reconstruction of the corneal epithelium: preliminary results. Invest. Ophthalmol. Vis. Sci. 2000, 41:S453-S453.
34. Rheinwald J.G., Green H. Serial cultivation of strains of human epidermal keratinocytes-formation of keratinizing colonies from single cells. Cell 1975, 6:331-344.
35. Schlotzer-Schrehardt U., Kruse F.E. Identification and characterization of limbal stem cells. Exp. Eye Res. 2005, 81:247-264.
36. Schrader S., et al. Conjunctival epithelial cells maintain stem cell properties after long-term culture and cryopreservation. Regen. Med. 2009, 4:677-687.
37. Shortt A.J., et al. Characterization of the limbal epithelial stem cell niche: novel imaging techniques permit in vivo observation and targeted biopsy of limbal epithelial stem cells. Stem Cells 2007, 25:1402-1409.
38. Sotozono C., et al. Cytokine expression in the alkali-burned cornea. Curr. Eye Res. 1997, 16:670-676.
39. Sun T., et al. Developments in xenobiotic-free culture of human keratinocytes for clinical use. Wound Repair Regen. 2004, 12:626-634.
40. Taichman R.S. Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood 2005, 105:2631-2639.
41. Tseng S.C.G., et al. Comparison between serum-free and fibroblast-cocultured single-cell clonal culture systems: evidence showing that epithelial anti-apoptotic activity is present in 3T3 fibroblast-conditioned media. Curr. Eye Res. 1996, 15:973-984.
42. Watanabe K., Nishida K., Yamato M., Umemoto T., Sumide T., Yamamoto K., Maeda N., Watanabe H., Okano T., Tano Y. Human limbal epithelium contains side population cells expressing the ATP-binding cassette transporter ABCG2. FEBS Lett. 2004, 565:6-20.