Effect of serum starvation on expression and phosphorylation of PKC-α and p53 in V79 cells: Implications for cell death

International Journal of Cancer

Volumn 80, Issue 3, 1999, Pages 400-405

  Hasan, Nael M ^a   Adams, Gerald E ^b   Joiner, Michael C ^b  

^a BIRZEIT UNIVERSITY   (Palestine)

^b MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; DACTINOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN P53; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ADHESION; CELL FRACTIONATION; CHINESE HAMSTER; CONTROLLED STUDY; ENZYME SUBUNIT; LUNG FIBROBLAST; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SERUM; STARVATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CRICETINAE; CRICETULUS; CULTURE MEDIA, SERUM-FREE; CYCLOHEXIMIDE; DACTINOMYCIN; ENZYME INHIBITORS; FIBROBLASTS; ISOENZYMES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; STAUROSPORINE; TETRADECANOYLPHORBOL ACETATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032933179     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990129)80:3<400::AID-IJC11>3.0.CO;2-U     Document Type: Article

References (27)

1. BAUDIER, J., DELPHIN, C., GRUNWALD, D., KHOCHBIN, S. and LAWRENCE, J.J., Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein. Proc. nat. Acad. Sci. (Wash.), 89, 11627-11631 (1992).
2. BLANDINO, G., SCARDIGLI, R., RIZZO, M.G., CRESCENZI, M., SODDU, S. and SACCHI, A., Wild-type p53 modulates apoptosis of normal, IL-3 deprived, hematopoietic cells. Oncogene, 10, 731-737 (1995).
3. BORNER, C., UEFFING, M., JAKEN, S., PARKER, P.J. and WEINSTEIN, I.B., Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms. J. biol. Chem., 270, 78-86 (1995).
4. BUCHNER, K., Protein kinase C in the transduction of signals toward and within the cell nucleus. Europ. J. Biochem., 228, 211-221 (1995).
5. CHOI, P.M., TCHOU WONG, K.M. and WEINSTEIN, I.B., Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression. Mol. cell. Biol., 10, 4650-4657 (1990).
6. CHOU, C.C. and YUNG, B.Y., Antiapoptotic effect of ras in the apoptosis induced by serum deprivation and exposure to actinomycin D. Naunyn Schmiedebergs Arch. Pharmacol., 355, 177-182 (1997).
7. COULDWELL., W.T., HINTON, D.R., HE, S., CHEN, T.C., SEBAT, I., WEISS, M.H. and LAW, R.E., Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. FEBS Lett., 345, 43-46 (1994).
8. COURAGE, C., BUDWORTH, J. and GESCHER, A., Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation. Brit. J. Cancer, 71, 697-704 (1995).
9. GORCZYCA, W., GONG, J., ARDELT, B., TRAGANOS, F. and DARZYNKIEWICZ, Z., The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res., 53, 3186-3192 (1993).
10. GREIF, H., BEN CHAIM, J., SHIMON, T., BECHOR, E., ELDAR, H. and LIVNEH, E., The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus. Mol. cell. Biol., 12, 1304-1311 (1992).
11. HAO, M., LOWY, A.M., KAPOOR, M., DEFFIE, A., LUI, G. and LOZANO, G., Mutation of phosphoserine 389 affects p53 function in vivo. J. biol. Chem., 271, 29380-29385 (1996).
12. HASAN, N.M., PARKER, P.J. and ADAMS, G.E., Induction and phosphorylation of protein kinase C-alpha and mitogen-activated protein kinase by hypoxia and by radiation in Chinese hamster V79 cells. Radiat. Res., 145, 128-133 (1996).
13. HOUSEY, G.M., JOHNSON, M.D., HSIAO, W.L., O'BRIAN, C.A., MURPHY, J.P., KIRSCHMEIER, P. and WEINSTEIN, I.B., Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell, 52, 343-354 (1988).
14. 1/S checkpoint responses in two NIH3T3 subclone cells following treatment with DNA-damaging agents. Oncogene, 13, 625-632 (1996).
15. ITANO, Y., ITO, A., UEHARA, T. and NOMURA, Y., Regulation of Bcl-2 protein expression in human neuroblastoma SH-SY5Y cells: positive and negative effects of protein kinases C and A respectively. J. Neurochem., 67, 131-137 (1996).
16. JOYPAUL, B.V., HOPWOOD, D., NEWMAN, E.L., QURESHI, S., GRANT, A., OGSTON, S.A., LANE, D.P. and CUSCHIERI, A., The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma. Brit. J. Cancer, 69, 943-946 (1994).
17. KIKUCHI, H. and IMAJOH OHMI, S., Antibodies specific for proteolyzed forms of protein kinase C alpha. Biochim. biophys. Acta. 1269, 253-259 (1995).
18. KNOX, K.A., JOHNSON, G.D. and GORDON, J., A study of protein kinase C isozyme distribution in relation to Bcl-2 expression during apoptosis of epithelial cells in vivo. Exp. Cell Res., 207, 68-73 (1993).
19. KOLCH, W., HEIDECKER, G., KOCHS, G., HUMMEL, R., VAHIDI, H., MISCHAK, H., FINKENZELLER, G., MARME, D. and RAPP, U.R., Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature (Lond.), 364, 249-252 (1993).
20. KYPRIANOU, N., TU, H. and JACOBS, S.C., Apoptotic versus proliferative activities in human benign prostatic hyperplasia. Hum. Pathol., 27, 668-675 (1996).
21. LEE, J.Y., HANNUN, Y.A. and OBEID, L.M., Ceramide inactivates cellular protein kinase C alpha. J. biol. Chem., 271, 13169-13174 (1996).
22. LESZCZYNSKI, D., JOENVAARA, S. and FOEGH, M.L., Protein kinase C-alpha regulates proliferation but not apoptosis in rat coronary vascular smooth muscle cells. Life Sci., 58, 599-606 (1996).
23. MARAIS, R.M. and PARKER, P.J., Purification and characterisation of bovine-brain protein kinase C isotypes alpha, beta and gamma. Europ. J. Biochem., 182, 129-137 (1989).
24. MILNE, D.M., MCKENDRICK, L., JARDINE, L.J., DEACON, E., LORD, J.M. and MEEK, D.W., Murine p53 is phosphorylated within the PAh421 epitope by protein kinase C in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate. Oncogene, 13, 205-211 (1996).
25. MITCHELL, F.E., MARAIS, R.M. and PARKER, P.J., The phosphorylation of protein kinase C as a potential measure of activation. Biochem. J., 261, 131-136 (1989).
26. PRICE, B.D. and YOUMELL, M.B., Phosphorylation of the p53 protein regulates its transcriptional activity. Proc. 45th annual meeting of the Radiation Research Society, p. 57, Radiation Research Society, Oak Brook, IL (1997).
27. SHAO, R.G., CAO, C.X. and POMMIER, Y., Activation of PKC alpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells. J. biol. Chem., 272, 31321-31325 (1997).