Engulfment of gram-positive bacteria by pancreatic stellate cells in pancreatic fibrosis

Pancreas

Volumn 39, Issue 7, 2010, Pages 1002-1007

  Morishita, Keiichi ^a   Shimizu, Kyoko ^a   Haruta, Ikuko ^a   Kawamura, Shunji ^a   Kobayashi, Makio ^a   Shiratori, Keiko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

fibrosis; gram positive bacteria; lipoteichoic acid; pancreatic stellate cell; phagocytosis; toll like receptor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; LIPOTEICHOIC ACID; TOLL LIKE RECEPTOR 2;

ADULT; AGED; ANIMAL CELL; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOPLASM; DISEASE SEVERITY; FEMALE; GRAM POSITIVE BACTERIUM; HISTOLOGY; HUMAN; MALE; NONHUMAN; PANCREATIC STELLATE CELL; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCORING SYSTEM; SEPSIS; SMOOTH MUSCLE; STATISTICAL SIGNIFICANCE; STELLATE CELL;

ANIMALS; CELLS, CULTURED; FIBROSIS; GRAM-POSITIVE BACTERIA; LIPOPOLYSACCHARIDES; MALE; PANCREAS; PANCREATIC STELLATE CELLS; PHAGOCYTOSIS; RATS; RATS, WISTAR; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2;

EID: 77957374561     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181d7ace1     Document Type: Article

References (33)

1. Kengatharan KM, De Kimpe S, Robson C, et al. Mechanism for gram-positive shock: identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure. J Exp Med. 1998;2:305-315.
2. Ginsburg I. Role of lipoteichoic acid in infection and inflammation. Lancet Infect Dis. 2002;2:171-179.
3. Cirera I, Bauer TM, Navasa M, et al. Bacterial translocation of enteric organisms in patients with cirrhosis. J Hepatol. 2001;34:32-37.
4. Chang CS, Chen GH, Lien HC, et al. Small intestine dysmotility and bacterial overgrowth in cirrhotic patients with spontaneous bacterial peritonitis. Hepatology. 1998;28:1187-1190.
5. Guarner C, Runyon BA, Young S, et al. Intestinal bacterial overgrowth and bacterial translocation in cirrhotic rats with ascites. J Hepatol. 1997;26:1372-1378.
6. Riordan SM, Skinner N, Nagree A, et al. Peripheral blood mononuclear cell expression of toll-like receptors and relation to cytokine levels in cirrhosis. Hepatology. 2003;37:979-982.
7. Su GL. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol. 2002;283:G256-G265.
8. Laine VJ, Nyman KM, Peuravuori HJ, et al. Lipopolysaccharide induced apoptosis of rat pancreatic acinar cells. Gut. 1996;38:747-754.
9. Vaccaro MI, Calvo EL, Suburo AM, et al. Lipopolysaccharide directly affects pancreatic acinar cells: implications on acute pancreatitis pathophysiology. Dig Dis Sci. 2000;45:915-926.
10. Fortunato F, Deng X, Gates LK, et al. Pancreatic response to endotoxin after chronic alcohol exposure: switch from apoptosis to necrosis. Am J Physiol Gastrointest Liver Physiol. 2006;290:G232-G241.
11. Isenmann R, Rau B, Beger HG. Bacterial infection and extent of necrosis are determinants of organ failure in patients with acute necrotizing pancreatitis. Br J Surg. 1999;86:1020-1024.
12. Vonlaufen A, Xu Z, Daniel B, et al. Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model. Gastroenterology. 2007;133:1293-1303.
13. Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 1998;43:128-133.
14. Bachem MG, Schneider E, Gross H, et al. Identification, culture and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 1998;115:421-432.
15. Shimizu K. Mechanisms of pancreatic fibrosis and applications to the treatments of chronic pancreatitis. J Gastroenterol. 2008;43: 823-832.
16. Shimizu K, Kobayashi M, Tahara J, et al. Cytokines and peroxisome proliferator-activated receptor F ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology. 2005;128:2105-2118.
17. Tahara J, Shimizu K, Shiratori K. Engulfment of necrotic acinar cells by pancreatic stellate cells inhibits pancreatic fibrogenesis. Pancreas. 2008;37:69-74.
18. Shimizu K. Pancreatic stellate cells: molecular mechanism of pancreatic fibrosis. J Gastroenterol Hepatol. 2008;23(suppl 1):S119-S121.
19. Medzhitov R, Janeway C. Innate immunity. N Engl J Med. 2000;343:338-344.
20. Akira S, Kakeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2:675-680. (Pubitemid 32747155)
21. Akiara S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124:783-801.
22. Aliprantis AO, Yang RB, Mark MR, et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science. 1999;285:736-739.
23. Takeuchi O, Hoshino K, Kawai T, et al. Differential role of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999;11:443-451.
24. Schwandner R, Dziarski R, Wesche H, et al. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem. 1999;274:17406-17409.
25. Paik TH, Lee KS, Lee HJ, et al. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Lab Invest. 2006;86:676-686.
26. Paik YH, Schwabe RF, Bataller R, et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 2003;37:1043-1055.
27. Brun P, Castagliuolo I, Pinzani M, et al. Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2005;289:G570-G578.
28. Masamune A, Kikuta K, Watanabe T, et al. Pancreatic stellate cells express Toll-like receptors. J Gastroenterol. 2008;43:352-362.
29. Suda K, Takase M, Takei K, et al. Histopathological and immunohistochemical studies on the mechanism of interlobular fibrosis of the pancreas. Arch Pathol Lab Med. 2000;124:1302-1305.
30. Ammori BJ. Role of the gut in the course of severe acute pancreatitis. Pancreas. 2003;26:112-119.
31. Runkel NS, Moody FG, Smith GS, et al. The role of the gut in the development of sepsis in acute pancreatitis. J Surg Res. 1991; 51:18-23.
32. Luiten EJ, Hop WC, Lange JF, et al. Differential prognosis of gram-negative versus gram-positive infected and sterile pancreatic necrosis: results of a randomized trial in patients with severe acute pancreatitis treated with adjuvant selective decontamination. Clin Infect Dis. 1997;25:811-816.
33. Schmid-Katsas A, Gross HJ, Menke A, et al. Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and c-fibronectin in cultured pancreatic stellate cells. Am J Pathol. 1999;155:1749-1758.