Pancreatic stellate cells: Molecular mechanism of pancreatic fibrosis

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue SUPPL. 1, 2008, Pages

  Shimizu, Kyoko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Acinar cell; Fibrogenesis; Pancreatic stellate cell; Phagocytosis

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CD36 ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; TROGLITAZONE;

ACINAR CELL; ACUTE PANCREATITIS; APOPTOSIS; CELL DEATH; CELL PROLIFERATION; CHRONIC PANCREATITIS; CONFERENCE PAPER; CYSTIC FIBROSIS; EXTRACELLULAR MATRIX; FIBROGENESIS; NEUTROPHIL; OXIDATIVE STRESS; PANCREAS CANCER; PATHOGENESIS; PRIORITY JOURNAL; STELLATE CELL;

EID: 40749088538     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.05296.x     Document Type: Conference Paper

References (14)

1. Apte MV, Haber PS, Applegate TL et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 1998 43 : 128 33.
2. Apte MV, Haber PS, Darby SJ et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implication for pancreatic fibrogenesis. Gut 1999 44 : 534 41.
3. Shek FWT, Benyon RC, Walker FM et al. Expression of transforming growth factor-β1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am. J. Pathol. 2002 160 : 1787 98.
4. Masamune A, Satoh M, Kikuta K, Suzuki N, Satoh K, Shimosegawa T. Ellagic acid blocks activation of pancreatic stellate cells. Biochem. Pharmacol. 2005 70 : 869 78.
5. Kuno A, Yamada T, Masada K et al. Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. Gastroenterology 2003 124 : 1010 9.
6. Shimizu K, Shiratori K, Kobayashi M, Kawamata H. Troglitazone inhibits the progression of chronic pancreatitis and the profibrogenic activity of pancreatic stellate cells via a PPARγ-independent mechanism. Pancreas 2004 29 : 67 74.
7. McCarroll JA, Phillips PA, Satucci N, Pirola RC, Wilson JS, Apte MV. Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis. Gut 2006 55 : 79 89.
8. Shimizu K, Kobayashi M, Tahara J, Shiratori K. Cytokines and peroxisome proliferator-activated receptor γ ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology 2005 128 : 2105 18.
9. Krieser RJ, White K. Engulfment mechanism of apoptotic cells. Curr. Opin. Cell Biol. 2002 14 : 734 9.
10. Savill J, Fadok V. Corpse clearance defines the meaning of cell death. Nature 2000 407 : 784 8.
11. Vermes I, Haanen C, Reutelingsperger CPM. A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin V. J. Immunol. Methods 1995 180 : 39 52.
12. 2, and PAF. J. Clin. Invest. 1998 101 : 890 8.
13. 1 secretion and the resolution of inflammation. J. Clin. Invest. 2002 109 : 41 50.
14. Otsuka M, Tsuchiya S, Aramaki Y. Involvement of ERK, a MAP kinase, in the production of TGF-β by macrophages treated with liposomes composed of phosphatidylserine. Biochem. Biophys. Res. Commun. 2001 281 : 614 20.