Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase

Biochemical Pharmacology

Volumn 73, Issue 2, 2007, Pages 198-205

  Gedda, Karin ^a   Briving, Carin ^a   Svensson, Karin ^a   Maxvall, Ingela ^a   Andersson, Kjell ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Fast onset; Gastric drug effects; H+,K+ ATPase antagonists and inhibitors; Mechanism of action; Parietal cell; Selectivity

Indexed keywords

8 [(2,6 DIMETHYLBENZYL)AMINO] 6 [[(2 HYDROXYETHYL)AMINO]CARBONYL] 1,2,3 TRIMETHYLIMIDAZO[1,2 A]PYRIDIN 1 IUM; 8 [(2,6 DIMETHYLBENZYL)AMINO] N [2 HYDROXYETHYL]2,3 DIMETHYLIMIDAZO[1,2 A]PYRIDINE 6 CARBOXAMIDE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE INHIBITOR; AR H 044881; AR H 070091; AZD 0865; BUCLADESINE; CATION; DRUG ANALOG; DRUG METABOLITE; HISTAMINE; HYDROGEN; KIDNEY ENZYME; OMEPRAZOLE; POTASSIUM;

ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); DILUTION; DRUG BINDING; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; PROTON TRANSPORT; RABBIT; STOMACH GLAND;

ANIMALS; CATIONS; ENZYME INHIBITORS; H(+)-K(+)-EXCHANGING ATPASE; IMIDAZOLES; KINETICS; PYRIDINES; STOMACH; SWINE;

EID: 33845212191     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.09.020     Document Type: Article

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