The therapeutic potential of survivin promoter-driven siRNA on suppressing tumor growth and enhancing radiosensitivity of human cervical carcinoma cells via downregulating hTERT gene expression

Cancer Biology and Therapy

Volumn 6, Issue 8, 2007, Pages 1301-1307

  Wang, Rui ^a   Lin, Fang ^a   Wang, Xi ^a   Gao, Ping ^a   Dong, Ke ^a   Wei, San Hua ^a   Cheng, Shi Yin ^a   Zhang, Hui Zhong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Gene therapy; HeLa; hTERT; Inhibitors of apoptosis; Radiosensitivity; RNA interference; Survivin promoter

Indexed keywords

MESSENGER RNA; SMALL INTERFERING RNA; SURVIVIN; TELOMERASE REVERSE TRANSCRIPTASE; BIRC5 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; TELOMERASE; TERT PROTEIN, HUMAN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HTERT GENE; HUMAN; HUMAN CELL; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; RADIOSENSITIVITY; RADIOSENSITIZATION; RNA INTERFERENCE; SOMATIC CELL; TUMOR GROWTH; UTERINE CERVIX CARCINOMA; ANIMAL; CARCINOMA; DRUG ANTAGONISM; DRUG SCREENING; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE VECTOR; GENETICS; HELA CELL; RADIATION DOSE; UTERINE CERVIX TUMOR;

ANIMALS; APOPTOSIS; CARCINOMA; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HELA CELLS; HUMANS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); RADIATION TOLERANCE; RNA INTERFERENCE; RNA, SMALL INTERFERING; TELOMERASE; UTERINE CERVICAL NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 39749173105     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.6.8.4505     Document Type: Article

References (30)