Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 4, 2010, Pages

  Malo, A ^a   Kruger B ^b   Seyhun, E ^a   Schafer C ^a   Hoffmann, R T ^a   Goke B ^a   Kubisch, C H ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Chemical chaperone; Endoplasmic reticulum stress; Exocrine pancreatic acini; TUDCA

Indexed keywords

CASPASE 3; CATHEPSIN B; CHOLECYSTOKININ; PROTEIN C JUN; TAUROURSODEOXYCHOLIC ACID; TRYPSIN; TRYPSINOGEN ACTIVATION PEPTIDE; X BOX BINDING PROTEIN 1; AMYLASE; CHOLAGOGUE; TAUROCHENODEOXYCHOLIC ACID;

ACINAR CELL; ACUTE PANCREATITIS; AMYLASE RELEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CELL FUNCTION; CELL ISOLATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; INTRACELLULAR MEMBRANE; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRESS; UPREGULATION; ANIMAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ENDOPLASMIC RETICULUM; METABOLISM; PANCREAS; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SECRETION (PROCESS);

AMYLASES; ANIMALS; APOPTOSIS; CALCIUM SIGNALING; CATHEPSIN B; CHOLAGOGUES AND CHOLERETICS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; PANCREAS; RATS; STRESS, PHYSIOLOGICAL; TAUROCHENODEOXYCHOLIC ACID; TRYPSIN;

EID: 77957361067     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00423.2009     Document Type: Article

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