17α-estradiol down-regulates lipopolysaccharide-induced MCP-1 production and cell migration in vascular smooth muscle cells

Journal of Molecular Endocrinology

Volumn 45, Issue 2, 2010, Pages 87-97

  Jiang, Ping ^a   Xu, Jinwen ^a   Zheng, Shuhui ^a   Huang, Jinghe ^a   Xiang, Qiuling ^a   Fu, Xiaodong ^a   Wang, Tinghuai ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 14; MONOCYTE CHEMOTACTIC PROTEIN 1; PYRROLIDINE DITHIOCARBAMATE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MIGRATION; CELL NUCLEUS; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; FEMALE; GENE SILENCING; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ANIMAL; CELL MOTION; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CELL MOVEMENT; CHEMOKINE CCL2; DOWN-REGULATION; ESTRADIOL; FEMALE; LIPOPOLYSACCHARIDES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 77957344326     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-09-0166     Document Type: Article

References (65)

1. Abu-Taha M, Rius C, Hermenegildo C, Noguera I, Cerda-Nicolas JM, Issekutz AC, Jose PJ, Cortijo J, Morcillo EJ & Sanz MJ 2009 Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. Journal of Immunology 183 1393-1402.
2. Aiello RJ, Bourassa PA, Lindsey S, Weng W, Natoli E, Rollins BJ & Milos PM 1999 Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology 19 1518-1525.
3. Anand AR, Bradley R & Ganju RK 2009 LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway. Molecular Immunology 46 962-968.
4. Baeza-Raja B & Munoz-Canoves P 2004 p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6. Molecular Biology of the Cell 15 2013-2026.
5. Baker AE, Brautigam VM & Watters JJ 2004 Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor beta. Endocrinology 145 5021-5032.
6. 2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood 104 1404-1410.
7. Boring L, Gosling J, Cleary M & Charo IF 1998 Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394 894-897.
8. Chakrabarti S, Lekontseva O & Davidge ST 2008 Estrogen is a modulator of vascular inflammation. IUBMB Life 60 376-382.
9. Charo IF & Taubman MB 2004 Chemokines in the pathogenesis of vascular disease. Circulation Research 95 858-866.
10. Corbacho AM, Eiserich JP, Zuniga LA, Valacchi G & Villablanca AC 2007 Compromised aortic vasoreactivity in male estrogen receptor-alpha-deficient mice during acute lipopolysaccharide-induced inflammation. Endocrinology 148 1403-1411.
11. Esteban V, Ruperez M, Sanchez-Lopez E, Rodriguez-Vita J, Lorenzo O, Demaegdt H, Vanderheyden P, Egido J & Ruiz-Ortega M 2005 Angiotensin IV activates the nuclear transcription factor-kappaB and related proinflammatory genes in vascular smooth muscle cells. Circulation Research 96 965-973.
12. Fatima S, Khandekar Z, Parmentier JH & Malik KU 2001 Cytosolic phospholipase A2 activation by the p38 kinase inhibitor SB203580 in rabbit aortic smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 298 331-338.
13. Fu XD & Simoncini T 2007 Non-genomic sex steroid actions in the vascular system. Seminars in Reproductive Medicine 25 178-186.
14. Fu XD, Cui YH, Lin GP & Wang TH 2007 Non-genomic effects of 17beta-estradiol in activation of the ERK1/ERK2 pathway induces cell proliferation through upregulation of cyclinD1 expression in bovine artery endothelial cells. Gynecological Endocrinology 23 131-137.
15. Fu XD, Giretti MS, Baldacci C, Garibaldi S, Flamini M, Sanchez AM, Gadducci A, Genazzani AR & Simoncini T 2008 Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton. PLoS ONE 3 e2790.
16. Galkina E & Ley K 2009 Immune and inflammatory mechanisms of atherosclerosis (*). Annual Review of Immunology 27 165-197.
17. Georgiadou P & Sbarouni E 2009 Effect of hormone replacement therapy on inflammatory biomarkers. Advances in Clinical Chemistry 47 59-93.
18. Ghisletti S, Meda C, Maggi A & Vegeto E 2005 17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization. Molecular and Cellular Biology 25 2957-2968.
19. Gorlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, Roth U, Brandes RP, Kietzmann T & Busse R 2001 Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22(phox)-containing NADPH oxidase. Circulation Research 89 47-54.
20. Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P & Rollins BJ 1998 Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Molecular Cell 2 275-281.
21. Harrington JR 2000 The role of MCP-1 in atherosclerosis. Stem Cells 18 65-66.
22. Hayden MS & Ghosh S 2004 Signaling to NF-kappaB. Genes and Development 18 2195-2224.
23. Hettne KM, Weeber M, Laine ML, ten Cate H, Boyer S, Kors JA & Loos BG 2007 Automatic mining of the literature to generate new hypotheses for the possible link between periodontitis and atherosclerosis: lipopolysaccharide as a case study. Journal of Clinical Periodontology 34 1016-1024.
24. den Hollander P & Kumar R 2006 Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells. Cancer Research 66 5941-5949.
25. Hsu SM, Chen YC & Jiang MC 2000 17beta-estradiol inhibits tumor necrosis factor-alpha-induced nuclear factor-kappa B activation by increasing nuclear factor-kappa B p105 level in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications 279 47-52.
26. Jiang X, Zhang Y, Hou D, Zhu L, Xu W, Ding L, Qi X, Sun G, Liu C, Zhang J et al. 2010 17beta-estradiol inhibits oleic acid-induced rat VSMC proliferation and migration by restoring PGC-1alpha expression. Molecular and Cellular Endocrinology 315 74-80.
27. Kaminska B 2005 MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochimica et Biophysica Acta 1754 253-262.
28. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J & Schwartz DA 2002 Toll-like receptor 4 polymorphisms and atherogenesis. New England Journal of Medicine 347 185-192.
29. Kublickiene K, Fu XD, Svedas E, Landgren BM, Genazzani AR & Simoncini T 2008 Effects in postmenopausal women of estradiol and medroxyprogesterone alone and combined on resistance artery function and endothelial morphology and movement. Journal of Clinical Endocrinology and Metabolism 93 1874-1883.
30. Kyriakis JM & Avruch J 2001 Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiological Reviews 81 807-869.
31. Laman JD, Schoneveld AH, Moll FL, van Meurs M & Pasterkamp G 2002 Significance of peptidoglycan, a proinflammatory bacterial antigen in atherosclerotic arteries and its association with vulnerable plaques. American Journal of Cardiology 90 119-123.
32. Lee EY, Chung CH, Khoury CC, Yeo TK, Pyagay PE, Wang A & Chen S 2009 The monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF-beta, increases podocyte motility and albumin permeability. American Journal of Physiology. Renal Physiology 297 F85-F94.
33. Lehr HA, Sagban TA, Ihling C, Zahringer U, Hungerer KD, Blumrich M, Reifenberg K & Bhakdi S 2001 Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet. Circulation 104 914-920.
34. Lianxu C, Hongti J & Changlong Y 2006 NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes. Osteoarthritis and Cartilage 14 367-376.
35. Liao W 1996 Endotoxin: possible roles in initiation and development of atherosclerosis. Journal of Laboratory and Clinical Medicine 128 452-460.
36. Lin SJ, Lee IT, Chen YH, Lin FY, Sheu LM, Ku HH, Shiao MS, Chen JW & Chen YL 2007 Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells. Journal of Cellular Biochemistry 100 372-384.
37. Liu HB, Loo KK, Palaszynski K, Ashouri J, Lubahn DB & Voskuhl RR 2003 Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease. Journal of Immunology 171 6936-6940.
38. Liu R, Moroi M, Yamamoto M, Kubota T, Ono T, Funatsu A, Komatsu H, Tsuji T, Hara H, Hara H et al. 2006 Presence and severity of Chlamydia pneumoniae and cytomegalovirus infection in coronary plaques are associated with acute coronary syndromes. International Heart Journal 47 511-519.
39. Liu HM, Zhao XF, Guo LN, Tan Z &Wang TH2007 Effects of caveolin-1 on the 17beta-estradiol-mediated inhibition of VSMC proliferation induced by vascular injury. Life Sciences 80 800-812.
40. Liu CJ, Lo JF, Kuo CH, Chu CH, Chen LM, Tsai FJ, Tsai CH, Tzang BS, Kuo WW & Huang CY 2009 Akt mediates 17beta-estradiol and/or estrogen receptor alpha inhibition of LPS-induced tumor necrosis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway. Journal of Cellular and Molecular Medicine 13 3655-3667.
41. Loppnow H, Werdan K & Buerke M 2008 Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms. Innate Immunity 14 63-87.
42. Lu ZY, Jensen LE, Huang Y, Kealey C, Blair IA & Whitehead AS 2009 The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway. Atherosclerosis 205 48-54.
43. Ma J, Wang Q, Fei T, Han JD & Chen YG 2007 MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood 109 987-994.
44. Mendelsohn ME & Karas RH 1999 The protective effects of estrogen on the cardiovascular system. New England Journal of Medicine 340 1801-1811.
45. Polanczyk M, Zamora A, Subramanian S, Matejuk A, Hess DL, Blankenhorn EP, Teuscher C, Vandenbark AA & Offner H 2003 The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha. American Journal of Pathology 163 1599-1605.
46. Pozzi S, Benedusi V, Maggi A & Vegeto E 2006 Estrogen action in neuroprotection and brain inflammation. Annals of the New York Academy of Sciences 1089 302-323.
47. Ross R 1999 Atherosclerosis is an inflammatory disease. American Heart Journal 138 S419-S420.
48. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC et al. 2002 Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. Journal of the American Medical Association 288 321-333.
49. Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, Ko M, LaCroix AZ, Margolis KL & Stefanick ML 2007 Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. Journal of the American Medical Association 297 1465-1477.
50. Rovin BH, Dickerson JA, Tan LC & Hebert CA 1995 Activation of nuclear factor-kappa B correlates with MCP-1 expression by human mesangial cells. Kidney International 48 1263-1271.
51. Ryan S, McNicholas WT & Taylor CT 2007A critical role for p38map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation. Biochemical and Biophysical Research Communications 355 728-733.
52. Shrum CK, Defrancisco D & Meffert MK 2009 Stimulated nuclear translocation of NF-kappaB and shuttling differentially depend on dynein and the dynactin complex. PNAS 106 2647-2652.
53. Simoncini T, Scorticati C, Mannella P, Fadiel A, Giretti MS, Fu XD, Baldacci C, Garibaldi S, Caruso A, Fornari L et al. 2006 Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway. Molecular Endocrinology 20 1756-1771.
54. Smith BJ, Lightfoot SA, Lerner MR, Denson KD, Morgan DL, Hanas JS, Bronze MS, Postier RG & Brackett DJ 2009 Induction of cardiovascular pathology in a novel model of low-grade chronic inflammation. Cardiovascular Pathology 18 1-10.
55. Speyer CL, Rancilio NJ, McClintock SD, Crawford JD, Gao H, Sarma JV & Ward PA 2005 Regulatory effects of estrogen on acute lung inflammation in mice. American Journal of Physiology. Cell Physiology 288 C881-C890.
56. Spinetti G, Wang M, Monticone R, Zhang J, Zhao D & Lakatta EG 2004 Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arteriosclerosis, Thrombosis, and Vascular Biology 24 1397-1402.
57. Tiruppathi C, Shimizu J, Miyawaki-Shimizu K, Vogel SM, Bair AM, Minshall RD, Predescu D & Malik AB 2008 Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide. Journal of Biological Chemistry 283 4210-4218.
58. Vegeto E, Belcredito S, Etteri S, Ghisletti S, Brusadelli A, Meda C, Krust A, Dupont S, Ciana P, Chambon P et al. 2003 Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol. PNAS 100 9614-9619.
59. Wang G, Siow YL & Karmin O 2000 Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C. Biochemical Journal 352 817-826.
60. Wiedermann CJ, Kiechl S, Dunzendorfer S, Schratzberger P, Egger G, Oberhollenzer F & Willeit J 1999 Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study. Journal of the American College of Cardiology 34 1975-1981.
61. Wu J, Gong J, Geng J & Song Y 2008 Deoxycholic acid induces the overexpression of intestinal mucin, MUC2, via NF-kB signaling pathway in human esophageal adenocarcinoma cells. BMC Cancer 8 333.
62. Xing D, Feng W, Miller AP, Weathington NM, Chen YF, Novak L, Blalock JE & Oparil S 2007 Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation. American Journal of Physiology. Heart and Circulatory Physiology 292 H2607-H2612.
63. Yang X, Coriolan D, Murthy V, Schultz K, Golenbock DT & Beasley D 2005 Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling. American Journal of Physiology. Heart and Circulatory Physiology 289 H1069-H1076. (Pubitemid 41208948)
64. Yasui T, Saijo A, Uemura H, Matsuzaki T, Tsuchiya N, Yuzurihara M, Kase Y & Irahara M 2009 Effects of oral and transdermal estrogen therapies on circulating cytokines and chemokines in postmenopausal women with hysterectomy. European Journal of Endocrinology 161 267-273.
65. Yuan Y, Shimizu I, Shen M, Aoyagi E, Takenaka H, Itagaki T, Urata M, Sannomiya K, Kohno N, Tamaki K et al. 2008 Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C. World Journal of Gastroenterology 14 2200-2207.