The shady side of sunlight: Current understanding of the mechanisms underlying UV-induction of skin cancers

Frontiers in Bioscience - Scholar

Volumn 2 S, Issue 1, 2010, Pages 11-17

  Trappey, Alison ^a   Fernando, Augusta ^a   Gaur, Rajiv ^a   Raj, Madhwa ^a   Ouhtit, Allal ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cell Proliferation; P16; P53; Rb; Review; Skin Cancer; Sunlight Ultraviolet Radiation

Indexed keywords

P16 PROTEIN, HUMAN; PROTEIN P53; TUMOR PROTEIN;

APOPTOSIS; DNA DAMAGE; DRUG EFFECT; HUMAN; MELANOMA; METABOLISM; RADIATION EXPOSURE; RADIATION INDUCED NEOPLASM; REVIEW; SKIN TUMOR; SUNLIGHT; ULTRAVIOLET RADIATION;

APOPTOSIS; DNA DAMAGE; HUMANS; MELANOMA; NEOPLASM PROTEINS; NEOPLASMS, RADIATION-INDUCED; SKIN NEOPLASMS; SUNLIGHT; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 77957322559     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s42     Document Type: Article

References (56)

1. Benjamin CL, Melnikova VO, and Ananthaswamy HN: Models and mechanisms in malignant melanoma. Mol Carcinog 46, 671-678 (2007) (Pubitemid 47255186)
2. Strom S: Epidemiology of basal and squamous cellcarcinomas of the skin. In: Basal and squamous cell skincancers of the head and neck. Williams and Wilkins Baltimore (1996)
3. Kanjilal S and Ananthaswamy HN: Molecular of skin carcinomas. In: Basal and squamous cell cancers of the head and neck. Williams and Wilkins Baltimore (1996)
4. Erb P, Ji J, Wernli M, Kump E, Glaser A and Buchner SA: Role of apoptosis in basal cell and squamous cell carcinoma formation. Immunol Lett 100, 68-72 (2005) (Pubitemid 41262035)
5. Gloster HM Jr, and Brodland DG: The epidemiology of skin cancer. Dermatol Surg 22, 217-226 (1996) (Pubitemid 26088386)
6. Li W, Sanki A, Karim RZ, Thompson JF, Soon Lee C, Zhuang L, McCarthy SW and Scolyer RA: The role of cell cycle regulatory proteins in the pathogenesis of melanoma. Pathology 38, 287-301 (2006) (Pubitemid 44266625)
7. Zigman S, Fowler E and Krause AL: Black light induction of skin tumors in mice. J Invest Dermatol 67, 723-725 (1976) (Pubitemid 8005955)
8. Strickland PT: Photocarcinogenesis by near-ultraviolet (UVA) radiation in Sencar mice. J Invest Dermatol 87, 272-275 (1986) (Pubitemid 16041742)
9. Setlow RB, Woodhead AD and Grist E: Animal model for ultraviolet radiation-induced melanoma: platyfish-swordtail hybrid. Proc Natl Acad Sci U S A 86, 8922-8926 (1989) (Pubitemid 20010337)
10. Setlow RB, Grist E, Thompson K and Woodhead AD: Wavelengths effective in induction of malignant melanoma. Proc Natl Acad Sci U S A 90, 6666-6670 (1993) (Pubitemid 23207274)
11. Soehnge H, Ouhtit A and Ananthaswamy HN: Mechanisms of induction of skin cancer by UV radiation. Front Biosci 2, d538-551 (1997)
12. Ouhtit A and Ananthaswamy HN: A Model for UV-Induction of Skin Cancer. J Biomed Biotechnol 1, 5-6 (2001) (Pubitemid 46842833)
13. Brash DE: UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer. Photochem Photobiol 48, 59-66 (1988)
14. Ford JM and Hanawalt PC: Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts. J Biol Chem 272, 28073-28080 (1997) (Pubitemid 27473616)
15. Ouhtit A, Muller HK, Davis DW, Ullrich SE, McConkey D and Ananthaswamy HN: Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am J Pathol 156, 201-207 (2000) (Pubitemid 30644453)
16. Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T and Brash DE: Sunburn and p53 in the onset of skin cancer. Nature 372, 773-776 (1994)
17. Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, Halperin AJ and Ponten J: A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A 88, 10124-10128 (1991) (Pubitemid 21915787)
18. Erb P, Ji J, Kump E, Miegla A and Wernli M: Apoptosis and pathogenesis of melanoma and nonmelanoma skin cancer. Sunlight, Vitamin D and Skin Cancer. Adv Exp Med Biol 624, 283-295 (2008)
19. Forrest APM, Carter DC and MacLeod IB: Principles and Practice of Surgery. UK: Churchill Livingstone Edinburgh (1995)
20. Welch DR and Goldberg SF: Molecular mechanisms controlling human melanoma progression and metastasis. Pathobiology 65, 311-330 (1997) (Pubitemid 28041158)
21. Bressac-de-Paillerets B, Avril MF, Chompret A and Demenais F: Genetic and environmental factors in cutaneous malignant melanoma. Biochimie 84, 67-74 (2002) (Pubitemid 34477094)
22. Ouhtit A, Ueda M, Nakazawa H, Ichihashi M, Dumaz N, Sarasin A and Yamasaki H: Quantitative detection of ultraviolet-specific p53 mutations in normal skin from Japanese patients. Cancer Epidemiol Biomarkers Prev 6, 433-438 (1997) (Pubitemid 27270548)
23. Ouhtit A, Nakazawa H, Armstrong BK, Kricker A, Tan E, Yamasaki H and English DR: UV-radiation-specific p53 mutation frequency in normal skin as a predictor of risk of basal cell carcinoma. J Natl Cancer Inst 90, 523-531 (1998) (Pubitemid 28182546)
24. Hill LL, Ouhtit A, Loughlin SM, Kripke ML, Ananthaswamy HN and Owen-Schaub LB: Fas ligand: a sensor for DNA damage critical in skin cancer etiology. Science 285, 898-900 (1999) (Pubitemid 29381992)
25. Ananthaswamy HN, Ouhtit A, Evans RL, Gorny A, Khaskina P, Sands AT and Conti CJ: Persistence of p53 mutations and resistance of keratinocytes to apoptosis are associated with the increased susceptibility of mice lacking the XPC gene to UV carcinogenesis. Oncogene 18, 7395-7398 (1999) (Pubitemid 30032122)
26. Ouhtit A, GornyA, Muller HK, Hill LL, Owen-Schaub L and Ananthaswamy HN: Loss of Fas-ligand expression in mouse keratinocytes during UV carcinogenesis. Am J Pathol 157, 1975-1981 (2000)
27. Ouhtit A, Muller HK, Gorny A and Ananthaswamy HN: UVB-induced experimental carcinogenesis: dysregulation of apoptosis and p53 signalling pathway. Redox Rep 5, 128-129 (2000) (Pubitemid 30487985)
28. Jiang W, Ananthaswamy HN, Muller HK, Ouhtit A, Bolshakov S, Ullrich SE, El-Naggar AK and Kripke ML: UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53. Proc Natl Acad Sci U S A 98, 9790-9795 (2001) (Pubitemid 32769382)
29. Gervin CM, McCulla A, Williams M and Ouhtit A: Dysfunction of p53 in photocarcinogenesis. Front Biosci 8, s715-717 (2003)
30. Williams M and Ouhtit A: Towards a Better Understanding of the Molecular Mechanisms Involved in Sunlight-Induced Melanoma. J Biomed Biotechnol 2005, 57-61 (2005) (Pubitemid 41022987)
31. Abd Elmageed ZY, Gaur RL, Williams M, Abdraboh ME, Rao PN, Raj MH, Ismail FM and Ouhtit A: Characterization of coordinated immediate responses by p16INK4A and p53 pathways in UVB-irradiated human skin cells. J Invest Dermatol 129, 175-183 (2009)
32. Harlow E, Williamson NM, Ralston R, Helfman DM and Adams TE: Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. Mol Cell Biol 5, 1601-1610 (1985) (Pubitemid 15061718)
33. Resnick-Silverman L, Manfredi JJ: Gene-specific mechanisms of p53 transcriptional control and prospects for cancer therapy. J Cell Biochem. 99, 679-89 (2006) (Pubitemid 44521988)
34. Hartwell LH and Weinert TA: Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629-634 (1989) (Pubitemid 19283354)
35. Lane DP: Cancer. p53, guardian of the genome. Nature 358, 15-16(1992)
36. Hao M, Lowy AM, Kapoor M, Deffie A, Liu G and G Lozano: Mutation of phosphoserine 389 affects p53 function in vivo. J Biol Chem 271, 29380-29385 (1996) (Pubitemid 26382655)
37. Gu W and Roeder RG: Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606 (1997) (Pubitemid 27357952)
38. Jiang W, Ananthaswamy HN, Muller HK and Kripke ML: p53 protects against skin cancer induction by UV-B radiation. Oncogene 18, 4247-4253 (1999) (Pubitemid 29377855)
39. Naik E, Michalak EM, Villunger A, Adams JM and Strasser A: Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa. J Cell Biol 176, 415-424 (2007)
40. Daya-Grosjean L, Dumaz N and Sarasin A: The specificity of p53 mutation spectra in sunlight induced human cancers. J Photochem Photobiol 28, 115-124 (1995)
41. Zhang W, Remenyik E, Zelterman D, Brash DE and Wikonkal NM: Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations. Proc Natl Acad Sci U S A 98, 13948-13953 (2001) (Pubitemid 33116004)
42. Daya-Grosjean L and Couve-Privat S: Sonic hedgehog signaling in basal cell carcinomas. Cancer Lett 225, 181-192 (2005) (Pubitemid 40835865)
43. Castellano M and Parmiani G: Genes involved in melanoma: an overview of INK4a and other loci. Melanoma Res 9, 421-432 (1999) (Pubitemid 29494107)
44. Gilchrest BA, Eller MS, Geller AC and Yaar M: The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med 340, 1341-1348 (1999) (Pubitemid 29196597)
45. Larsen CJ: p16INK4a: a gene with a dual capacity to encode unrelated proteins that inhibit cell cycle progression. Oncogene 12, 2041-2044 (1996)
46. Quelle DE, Zindy F, Ashmun RA and Sherr CJ: Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83, 993-1000 (1995) (Pubitemid 26006540)
47. Sharpless NE and DePinho RA: The INK4A/ARF locus and its two gene products. Curr Opin Genet Dev 9, 22-30(1999) (Pubitemid 29080383)
48. Noonan FP, Recio JA, Takayama H, Duray P, Anver MR, Rush WL, De Fabo EC and Merlino G: Neonatal sunburn and melanoma in mice. Nature 413, 271-272 (2001) (Pubitemid 32905840)
49. Jhappan C, Noonan FP and Merlino G: Ultraviolet radiation and cutaneous malignant melanoma. Oncogene 22, 3099-3112 (2003) (Pubitemid 36713762)
50. Kannan K, Sharpless NE, Xu J, O'Hagan RC, Bosenberg M and Chin L: Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proc Natl Acad Sci U S A 100, 1221-1225 (2003) (Pubitemid 36183983)
51. Shirodkar S, Ewen M, DeCaprio JA, Morgan J, Livingston DM and Chittenden T: The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 68, 157-166 (1992)
52. Ghiorzo P and Scarra GB: Genetics of melanoma susceptibility. Forum (Genova) 13, 114-22 (2003)
53. Zuo L, Weger J, Yang Q, Goldstein AM, Tucker MA, Walker GJ, Hayward N and Dracopoli NC: Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet 12, 97-99 (1996) (Pubitemid 26013159)
54. Soufir N, Avril MF, Chompret A, Demenais F, Bombled J, Spatz A, Stoppa-Lyonnet D, Benard J and Bressac-de Paillerets B: Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group. Hum Mol Genet 7, 209-216 (1998) (Pubitemid 28048536)
55. Wolfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Meyer zum Buschenfelde KH and Beach D: A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269, 1281-1284 (1995)
56. Honda R and Yasuda H: Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. Embo J 18, 22-27 (1999) (Pubitemid 29005019)