Dysfunction of p53 in photocarcinogenesis

Frontiers in Bioscience

Volumn 8, Issue SUPPL., 2003, Pages

  Gervin, Celine M ^a   McCulla, Andrea ^a   Williams, Mandy ^a   Ouhtit, Allal ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Non melanoma skin caners; p53 mutant Keratinocytes; Review; Sunlight; UV induced p53 mutations

Indexed keywords

PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

ACETYLATION; CANCER INCIDENCE; DNA SYNTHESIS; HUMAN; KERATINOCYTE; MUTAGENESIS; OZONE LAYER; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RADIATION CARCINOGENESIS; SHORT SURVEY; SKIN CARCINOGENESIS; TATA BOX; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION; MELANOMA; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIATION INJURY; REVIEW; SKIN TUMOR;

GENES, P53; HUMANS; MELANOMA; NEOPLASMS, RADIATION-INDUCED; SKIN NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 1542779783     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (23)

1. Gloster H. M. & D. G. Brodland: The epidemiology of skin cancer. Dermatol Sur 22, 217-26 (1996)
2. Armstrong B. K. & A. Kricker: Epidemiology of sun exposure and skin cancer. Cancer Surveys 26, 133-53 (1996)
3. Brash D. E: UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer. Photochem Photobiol 48, 59-66 (1988)
4. Ford J. M. & P. C. Hanawalt: Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts. J Biol Chem 272, 28073-28080 (1997)
5. Ouhtit A, K. Muller, D. Davis, S. E. Ullrich, D. McConkey & H. N. Ananthaswamy: Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am J Pathol 156, 201-207 (2000)
6. Ziegler A, A. S. Jonason, D. J. Leffell, J. A. Simon, HW Sharma, J. Kimmelman, L. Remington, T. Jacks & D. E. Brash: Sunburn and p53 in the onset of skin cancer. Nature 372, 773-6 (1994)
7. Brash DE, J. A. Rudolph, J. A. Simon, A. Lin, G. J. McKenna, H. P. Baden, A. J. Halperin & J. Ponten: A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A 88, 10124-8 (1991)
8. Leffell D. J & D. E. Brash: Sunlight and skin cancer. Sci Am 275, 52-3, 56-9 (1996)
9. Malkin D & S. H. Friend. Correction: a Li-Fraumeni syndrome p53 mutation. Science 259, 878 (1993)
10. Donehower L. A, M. Harvey, B. L. Slagle, M. J. McArthur, C. A. Montgomery Jr, J. S. Butel & A Bradley: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-21 (1992)
11. Harlow E, N. M. Williamson, R. Ralston, D. M. Helfman & T. E. Adams: Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. Mol Cell Biol 5, 1601-10 (1985)
12. Field S & S. J. Jang: Phosphorylation of p53 tumour suppressor gene. Science 249: 1046-1049 (1990)
13. Thut C. J, J. L. Chen, R. Klemm & R. Tjian: p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science 267, 100-4 (1995)
14. Hollstein M, D. Sidransky, B. Vogelstein & C. C. Harris: p53 mutations in human cancers. Science 253, 49-53 (1991)
15. Vogelstein B & K. W. Kinzler. p53 function and dysfunction. Cell 70, 523-6 (1992)
16. Sturzbecher HW, R. Brain, C. Addison, K. Rudge, M. Remm, M. Grimaldi, E. Keenan & J. R. Jenkins: A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization. Oncogene 7, 1513-23 (1992)
17. Hao M, A. M. Lowy, M. Kapoor, A. Deffie, G. Liu & G. Lozano: Mutation of phosphoserine 389 affects p53 function in vivo. J Biol Chem 271, 29380-5 (1996)
18. Gu W & R. G. Roeder. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell. 90, 595-606 (1997)
19. Hoffman W. H, S. Biade, J. T. Zilfou, J. Chen & M. Murphy: Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem 277, 3247-57 (2002)
20. Soehnge H, A. Ouhtit & H. N. Ananthaswamy: Mechanisms of induction of skin cancer by UV radiation. Front Biosci 2, D538-D551 (1997)
21. Daya-Grosjean L, N. Dumaz & A. Sarasin. The specificity of p53 mutation spectra in sunlight induced human cancers. J Photochem Photobiol B. 28, 115-24 (1995)
22. Zhang W, E. Remenyik, D. Zelterman, D. E. Brash & N. M. Wikonkal: Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations. Proc Natl Acad Sci U S A 98, 13948-53 (2001)
23. Ananthaswamy H. N, S. M. Loughlin, P. Cox, R. L. Evans, S. E. Ullrich, M. L. Kripke: Sunlight and skin cancer: inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens. Nat Med 3, 510-4 (1997)