Transglycosylated stevia and hesperidin as pharmaceutical excipients: Dramatic improvement in drug dissolution and bioavailability

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 76, Issue 2, 2010, Pages 238-244

  Uchiyama, Hiromasa ^a   Tozuka, Yuichi ^a   Imono, Masaaki ^a   Takeuchi, Hirofumi ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

glucosyl hesperidin; glycosyltransferase treated stevia; Absorption enhancement; Dissolution enhancement; Flurbiprofen; Probucol

Indexed keywords

EXCIPIENT; FLURBIPROFEN; GLYCOSYLTRANSFERASE; HESPERIDIN; NATURAL PRODUCT; PROBUCOL; STEVIA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG SOLUBILITY; GLYCOSYLATION; MALE; NONHUMAN; RAT; SPRAY DRYING; STEVIA;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; EXCIPIENTS; FLURBIPROFEN; GLYCOSYLATION; HESPERIDIN; HUMANS; MALE; PLANT EXTRACTS; PROBUCOL; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; STEVIA; TOXICITY TESTS;

EID: 77957286113     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.07.006     Document Type: Article

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