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Volumn 184, Issue C, 2010, Pages 177-192

Imaging the nigrostriatal system to monitor disease progression and treatment-induced complications

Author keywords

Biomarker; Compensation; Dopamine receptors; Dopamine transporter (DAT); Dopamine turnover; Dyskinesias; Fluctuations; Fluorodopa; Impulse control disorders; Positron emission tomography; Vesicular monoamine transporter type 2 (VMAT2)

Indexed keywords

6 FLUORODOPA F 18; DOPAMINE; LEVODOPA;

EID: 77957227804     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(10)84009-9     Document Type: Chapter
Times cited : (19)

References (129)
  • 1
    • 0037432067 scopus 로고    scopus 로고
    • Slowing Parkinson's disease progression: Recent dopamine agonist trials
    • Ahlskog J.E. Slowing Parkinson's disease progression: Recent dopamine agonist trials. Neurology 2003, 60:381-389.
    • (2003) Neurology , vol.60 , pp. 381-389
    • Ahlskog, J.E.1
  • 2
    • 0037432040 scopus 로고    scopus 로고
    • Initial agonist treatment of Parkinson disease: A critique
    • Albin R.L., Frey K.A. Initial agonist treatment of Parkinson disease: A critique. Neurology 2003, 60:390-394.
    • (2003) Neurology , vol.60 , pp. 390-394
    • Albin, R.L.1    Frey, K.A.2
  • 5
    • 0031031846 scopus 로고    scopus 로고
    • Long-term changes of striatal dopamine D2 receptors in patients with Parkinson's disease: A study with positron emission tomography and [11C]raclopride
    • Antonini A., Schwarz J., Oertel W.H., Pogarell O., Leenders K.L. Long-term changes of striatal dopamine D2 receptors in patients with Parkinson's disease: A study with positron emission tomography and [11C]raclopride. Movement Disorder 1997, 12:33-38.
    • (1997) Movement Disorder , vol.12 , pp. 33-38
    • Antonini, A.1    Schwarz, J.2    Oertel, W.H.3    Pogarell, O.4    Leenders, K.L.5
  • 6
    • 33749468221 scopus 로고    scopus 로고
    • Network modulation in the treatment of Parkinson's disease
    • Asanuma K., Tang C., Ma Y., Dhawan V., Mattis P., Edwards C., et al. Network modulation in the treatment of Parkinson's disease. Brain 2006, 129:2667-2678.
    • (2006) Brain , vol.129 , pp. 2667-2678
    • Asanuma, K.1    Tang, C.2    Ma, Y.3    Dhawan, V.4    Mattis, P.5    Edwards, C.6
  • 7
    • 15544391275 scopus 로고    scopus 로고
    • Parkinson's disease: in vivo assessment of disease progression using positron emission tomography
    • Au W.L., Adams J.R., Troiano A.R., Stoessl A.J. Parkinson's disease: in vivo assessment of disease progression using positron emission tomography. Brain Research Molecular Brain Research 2005, 134:24-33.
    • (2005) Brain Research Molecular Brain Research , vol.134 , pp. 24-33
    • Au, W.L.1    Adams, J.R.2    Troiano, A.R.3    Stoessl, A.J.4
  • 10
    • 0035449393 scopus 로고    scopus 로고
    • Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease
    • Bezard E., Dovero S., Prunier C., Ravenscroft P., Chalon S., Guilloteau D., et al. Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. Journal of Neuroscience 2001, 21:6853-6861.
    • (2001) Journal of Neuroscience , vol.21 , pp. 6853-6861
    • Bezard, E.1    Dovero, S.2    Prunier, C.3    Ravenscroft, P.4    Chalon, S.5    Guilloteau, D.6
  • 11
    • 0038579160 scopus 로고    scopus 로고
    • Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function
    • Bezard E., Ferry S., Mach U., Stark H., Leriche L., Boraud T., et al. Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. Nature Medicine 2003, 9:762-767.
    • (2003) Nature Medicine , vol.9 , pp. 762-767
    • Bezard, E.1    Ferry, S.2    Mach, U.3    Stark, H.4    Leriche, L.5    Boraud, T.6
  • 13
    • 55749099180 scopus 로고    scopus 로고
    • Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    • Boileau I., Rusjan P., Houle S., Wilkins D., Tong J., Selby P., et al. Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?. Journal of Neuroscience 2008, 28:9850-9856.
    • (2008) Journal of Neuroscience , vol.28 , pp. 9850-9856
    • Boileau, I.1    Rusjan, P.2    Houle, S.3    Wilkins, D.4    Tong, J.5    Selby, P.6
  • 17
    • 0242302336 scopus 로고    scopus 로고
    • Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease
    • Brooks D.J., Frey K.A., Marek K.L., Oakes D., Paty D., Prentice R., et al. Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease. Experimental Neurology 2003, 184(Suppl 1):S68-S79.
    • (2003) Experimental Neurology , vol.184 , Issue.SUPPL. 1
    • Brooks, D.J.1    Frey, K.A.2    Marek, K.L.3    Oakes, D.4    Paty, D.5    Prentice, R.6
  • 18
    • 67651177750 scopus 로고    scopus 로고
    • A follow-up study on 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease shows nonlinear progression in the putamen
    • Bruck A., Aalto S., Rauhala E., Bergman J., Marttila R., Rinne J.O. A follow-up study on 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease shows nonlinear progression in the putamen. Movement Disorder 2009, 24:1009-1015.
    • (2009) Movement Disorder , vol.24 , pp. 1009-1015
    • Bruck, A.1    Aalto, S.2    Rauhala, E.3    Bergman, J.4    Marttila, R.5    Rinne, J.O.6
  • 20
    • 0026695663 scopus 로고
    • Criteria for diagnosing Parkinson's disease
    • Calne D.B., Snow B.J., Lee C. Criteria for diagnosing Parkinson's disease. Annals of Neurology 1992, 32(Suppl):S125-S127.
    • (1992) Annals of Neurology , vol.32 , Issue.SUPPL.
    • Calne, D.B.1    Snow, B.J.2    Lee, C.3
  • 21
    • 0025794372 scopus 로고
    • Compensatory mechanisms in degenerative neurologic diseases. Insights from parkinsonism
    • Calne D.B., Zigmond M.J. Compensatory mechanisms in degenerative neurologic diseases. Insights from parkinsonism. Archives of Neurology 1991, 48:361-363.
    • (1991) Archives of Neurology , vol.48 , pp. 361-363
    • Calne, D.B.1    Zigmond, M.J.2
  • 23
    • 0037202792 scopus 로고    scopus 로고
    • Dopamine agonist monotherapy in Parkinson's disease
    • Clarke C.E., Guttman M. Dopamine agonist monotherapy in Parkinson's disease. Lancet 2002, 360:1767-1769.
    • (2002) Lancet , vol.360 , pp. 1767-1769
    • Clarke, C.E.1    Guttman, M.2
  • 24
    • 33847614268 scopus 로고    scopus 로고
    • Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    • Dalley J.W., Fryer T.D., Brichard L., Robinson E.S., Theobald D.E., Laane K., et al. Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 2007, 315:1267-1270.
    • (2007) Science , vol.315 , pp. 1267-1270
    • Dalley, J.W.1    Fryer, T.D.2    Brichard, L.3    Robinson, E.S.4    Theobald, D.E.5    Laane, K.6
  • 25
    • 0037280002 scopus 로고    scopus 로고
    • The discovery of epidepride and its analogs as high-affinity radioligands for imaging extrastriatal dopamine D(2) receptors in human brain
    • de Paulis T. The discovery of epidepride and its analogs as high-affinity radioligands for imaging extrastriatal dopamine D(2) receptors in human brain. Current Pharmaceutical Design 2003, 9:673-696.
    • (2003) Current Pharmaceutical Design , vol.9 , pp. 673-696
    • de Paulis, T.1
  • 26
    • 0034643838 scopus 로고    scopus 로고
    • Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group
    • de Rijk M.C., Launer L.J., Berger K., Breteler M.M., Dartigues J.F., Baldereschi M., et al. Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 2000, 54:S21-S23.
    • (2000) Neurology , vol.54
    • de Rijk, M.C.1    Launer, L.J.2    Berger, K.3    Breteler, M.M.4    Dartigues, J.F.5    Baldereschi, M.6
  • 27
    • 0031595252 scopus 로고    scopus 로고
    • 6-[18F]Fluoro-L-DOPA PET studies of the turnover of dopamine in MPTP-induced parkinsonism in monkeys
    • Doudet D.J., Chan G.L., Holden J.E., McGeer E.G., Aigner T.A., Wyatt R.J., et al. 6-[18F]Fluoro-L-DOPA PET studies of the turnover of dopamine in MPTP-induced parkinsonism in monkeys. Synapse 1998, 29:225-232.
    • (1998) Synapse , vol.29 , pp. 225-232
    • Doudet, D.J.1    Chan, G.L.2    Holden, J.E.3    McGeer, E.G.4    Aigner, T.A.5    Wyatt, R.J.6
  • 28
    • 16344381905 scopus 로고    scopus 로고
    • Neuroimaging and therapeutics in movement disorders
    • Eckert T., Eidelberg D. Neuroimaging and therapeutics in movement disorders. NeuroRx 2005, 2:361-371.
    • (2005) NeuroRx , vol.2 , pp. 361-371
    • Eckert, T.1    Eidelberg, D.2
  • 31
  • 34
    • 0032890731 scopus 로고    scopus 로고
    • Parkinson disease, the effect of levodopa, and the ELLDOPA trial. Earlier vs later L-DOPA
    • Fahn S. Parkinson disease, the effect of levodopa, and the ELLDOPA trial. Earlier vs later L-DOPA. Archives of Neurology 1999, 56:529-535.
    • (1999) Archives of Neurology , vol.56 , pp. 529-535
    • Fahn, S.1
  • 36
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: Substantia nigra regional selectivity
    • Fearnley J.M., Lees A.J. Ageing and Parkinson's disease: Substantia nigra regional selectivity. Brain 1991, 114(Pt 5):2283-2301.
    • (1991) Brain , vol.114 , Issue.PART 5 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 40
    • 0035092779 scopus 로고    scopus 로고
    • Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease: PET evidence of increased dopamine turnover
    • Fuente-Fernandez R., Lu J.Q., Sossi V., Jivan S., Schulzer M., Holden J.E., et al. Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease: PET evidence of increased dopamine turnover. Annals of Neurology 2001, 49:298-303.
    • (2001) Annals of Neurology , vol.49 , pp. 298-303
    • Fuente-Fernandez, R.1    Lu, J.Q.2    Sossi, V.3    Jivan, S.4    Schulzer, M.5    Holden, J.E.6
  • 42
    • 10344236071 scopus 로고    scopus 로고
    • Levodopa-induced changes in synaptic dopamine levels increase with progression of Parkinson's disease: Implications for dyskinesias
    • Fuente-Fernandez R., Sossi V., Huang Z., Furtado S., Lu J.Q., Calne D.B., et al. Levodopa-induced changes in synaptic dopamine levels increase with progression of Parkinson's disease: Implications for dyskinesias. Brain 2004, 127:2747-2754.
    • (2004) Brain , vol.127 , pp. 2747-2754
    • Fuente-Fernandez, R.1    Sossi, V.2    Huang, Z.3    Furtado, S.4    Lu, J.Q.5    Calne, D.B.6
  • 43
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    • Gill S.S., Patel N.K., Hotton G.R., O'Sullivan K., McCarter R., Bunnage M., et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nature Medicine 2003, 9:589-595.
    • (2003) Nature Medicine , vol.9 , pp. 589-595
    • Gill, S.S.1    Patel, N.K.2    Hotton, G.R.3    O'Sullivan, K.4    McCarter, R.5    Bunnage, M.6
  • 44
    • 0025973526 scopus 로고
    • Young-onset Parkinson's disease: A clinical review
    • Golbe L.I. Young-onset Parkinson's disease: A clinical review. Neurology 1991, 41:168-173.
    • (1991) Neurology , vol.41 , pp. 168-173
    • Golbe, L.I.1
  • 45
    • 0033390640 scopus 로고    scopus 로고
    • Risk factors for levodopa-induced dyskinesias in Parkinson's disease
    • Grandas F., Galiano M.L., Tabernero C. Risk factors for levodopa-induced dyskinesias in Parkinson's disease. Journal of Neurology 1999, 246:1127-1133.
    • (1999) Journal of Neurology , vol.246 , pp. 1127-1133
    • Grandas, F.1    Galiano, M.L.2    Tabernero, C.3
  • 47
    • 0030781707 scopus 로고    scopus 로고
    • Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra
    • Hersch S.M., Yi H., Heilman C.J., Edwards R.H., Levey A.I. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. Journal of Comparative Neurology 1997, 388:211-227.
    • (1997) Journal of Comparative Neurology , vol.388 , pp. 211-227
    • Hersch, S.M.1    Yi, H.2    Heilman, C.J.3    Edwards, R.H.4    Levey, A.I.5
  • 49
    • 14844300111 scopus 로고    scopus 로고
    • Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
    • Hilker R., Schweitzer K., Coburger S., Ghaemi M., Weisenbach S., Jacobs A.H., et al. Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity. Archives of Neurology 2005, 62:378-382.
    • (2005) Archives of Neurology , vol.62 , pp. 378-382
    • Hilker, R.1    Schweitzer, K.2    Coburger, S.3    Ghaemi, M.4    Weisenbach, S.5    Jacobs, A.H.6
  • 50
    • 42949086515 scopus 로고    scopus 로고
    • Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease
    • Hirano S., Asanuma K., Ma Y., Tang C., Feigin A., Dhawan V., et al. Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease. Journal of Neuroscience 2008, 28:4201-4209.
    • (2008) Journal of Neuroscience , vol.28 , pp. 4201-4209
    • Hirano, S.1    Asanuma, K.2    Ma, Y.3    Tang, C.4    Feigin, A.5    Dhawan, V.6
  • 51
    • 0031682676 scopus 로고    scopus 로고
    • Biochemical aspects of Parkinson's disease
    • Hornykiewicz O. Biochemical aspects of Parkinson's disease. Neurology 1998, 51:S2-S9.
    • (1998) Neurology , vol.51
    • Hornykiewicz, O.1
  • 52
    • 34447636064 scopus 로고    scopus 로고
    • Changes in network activity with the progression of Parkinson's disease
    • Huang C., Tang C., Feigin A., Lesser M., Ma Y., Pourfar M., et al. Changes in network activity with the progression of Parkinson's disease. Brain 2007, 130:1834-1846.
    • (2007) Brain , vol.130 , pp. 1834-1846
    • Huang, C.1    Tang, C.2    Feigin, A.3    Lesser, M.4    Ma, Y.5    Pourfar, M.6
  • 53
    • 0033957270 scopus 로고    scopus 로고
    • Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: A comparative PET study with [11C] raclopride and [11C]N-methylspiperone
    • Kaasinen V., Ruottinen H.M., Nagren K., Lehikoinen P., Oikonen V., Rinne J.O. Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: A comparative PET study with [11C] raclopride and [11C]N-methylspiperone. Journal of Nuclear Medicine 2000, 41:65-70.
    • (2000) Journal of Nuclear Medicine , vol.41 , pp. 65-70
    • Kaasinen, V.1    Ruottinen, H.M.2    Nagren, K.3    Lehikoinen, P.4    Oikonen, V.5    Rinne, J.O.6
  • 55
    • 33646351299 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
    • Kraytsberg Y., Kudryavtseva E., McKee A.C., Geula C., Kowall N.W., Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nature Genetics 2006, 38:518-520.
    • (2006) Nature Genetics , vol.38 , pp. 518-520
    • Kraytsberg, Y.1    Kudryavtseva, E.2    McKee, A.C.3    Geula, C.4    Kowall, N.W.5    Khrapko, K.6
  • 56
    • 18144423079 scopus 로고    scopus 로고
    • Levodopa-dyskinesia incidence by age of Parkinson's disease onset
    • Kumar N., Van Gerpen J.A., Bower J.H., Ahlskog J.E. Levodopa-dyskinesia incidence by age of Parkinson's disease onset. Movement Disorder 2005, 20:342-344.
    • (2005) Movement Disorder , vol.20 , pp. 342-344
    • Kumar, N.1    Van Gerpen, J.A.2    Bower, J.H.3    Ahlskog, J.E.4
  • 57
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
    • Lang A.E., Gill S., Patel N.K., Lozano A., Nutt J.G., Penn R., et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Annals of Neurology 2006, 59:459-466.
    • (2006) Annals of Neurology , vol.59 , pp. 459-466
    • Lang, A.E.1    Gill, S.2    Patel, N.K.3    Lozano, A.4    Nutt, J.G.5    Penn, R.6
  • 58
    • 2542612292 scopus 로고    scopus 로고
    • Time to move beyond nigrostriatal dopamine deficiency in Parkinson's disease
    • Lang A.E., Obeso J.A. Time to move beyond nigrostriatal dopamine deficiency in Parkinson's disease. Annals of Neurology 2004, 55:761-765.
    • (2004) Annals of Neurology , vol.55 , pp. 761-765
    • Lang, A.E.1    Obeso, J.A.2
  • 59
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston J.W., Forno L.S., Tetrud J., Reeves A.G., Kaplan J.A., Karluk D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Annals of Neurology 1999, 46:598-605.
    • (1999) Annals of Neurology , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 60
    • 18844471416 scopus 로고    scopus 로고
    • In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease
    • Lee C.S., Samii A., Sossi V., Ruth T.J., Schulzer M., Holden J.E., et al. in vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease. Annals of Neurology 2000, 47:493-503.
    • (2000) Annals of Neurology , vol.47 , pp. 493-503
    • Lee, C.S.1    Samii, A.2    Sossi, V.3    Ruth, T.J.4    Schulzer, M.5    Holden, J.E.6
  • 61
    • 0036897933 scopus 로고    scopus 로고
    • Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: A PET/[11C]raclopride study in healthy men
    • Leyton M., Boileau I., Benkelfat C., Diksic M., Baker G., Dagher A. Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: A PET/[11C]raclopride study in healthy men. Neuropsychopharmacology 2002, 27:1027-1035.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 1027-1035
    • Leyton, M.1    Boileau, I.2    Benkelfat, C.3    Diksic, M.4    Baker, G.5    Dagher, A.6
  • 62
    • 1842728438 scopus 로고    scopus 로고
    • Pharmacological and PET studies in patient's with Parkinson's disease and a short duration-motor response: Implications in the pathophysiology of motor complications
    • Linazasoro G., Antonini A., Maguire R.P., Leenders K.L. Pharmacological and PET studies in patient's with Parkinson's disease and a short duration-motor response: Implications in the pathophysiology of motor complications. Journal of Neural Transmission 2004, 111:497-509.
    • (2004) Journal of Neural Transmission , vol.111 , pp. 497-509
    • Linazasoro, G.1    Antonini, A.2    Maguire, R.P.3    Leenders, K.L.4
  • 63
    • 0036830588 scopus 로고    scopus 로고
    • Dyskinesia after fetal cell transplantation for parkinsonism: A PET study
    • Ma Y., Feigin A., Dhawan V., Fukuda M., Shi Q., Greene P., et al. Dyskinesia after fetal cell transplantation for parkinsonism: A PET study. Annals of Neurology 2002, 52:628-634.
    • (2002) Annals of Neurology , vol.52 , pp. 628-634
    • Ma, Y.1    Feigin, A.2    Dhawan, V.3    Fukuda, M.4    Shi, Q.5    Greene, P.6
  • 65
    • 0029664364 scopus 로고    scopus 로고
    • [123I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease
    • Marek K.L., Seibyl J.P., Zoghbi S.S., Zea-Ponce Y., Baldwin R.M., Fussell B., et al. [123I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease. Neurology 1996, 46:231-237.
    • (1996) Neurology , vol.46 , pp. 231-237
    • Marek, K.L.1    Seibyl, J.P.2    Zoghbi, S.S.3    Zea-Ponce, Y.4    Baldwin, R.M.5    Fussell, B.6
  • 66
    • 41949110690 scopus 로고    scopus 로고
    • Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: An open-label, phase I trial
    • Marks W.J., Ostrem J.L., Verhagen L., Starr P.A., Larson P.S., Bakay R.A., et al. Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: An open-label, phase I trial. Lancet Neurology 2008, 7:400-408.
    • (2008) Lancet Neurology , vol.7 , pp. 400-408
    • Marks, W.J.1    Ostrem, J.L.2    Verhagen, L.3    Starr, P.A.4    Larson, P.S.5    Bakay, R.A.6
  • 67
    • 0242384667 scopus 로고    scopus 로고
    • Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration
    • McGeer P.L., Schwab C., Parent A., Doudet D. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Annals of Neurology 2003, 54:599-604.
    • (2003) Annals of Neurology , vol.54 , pp. 599-604
    • McGeer, P.L.1    Schwab, C.2    Parent, A.3    Doudet, D.4
  • 70
    • 0037014426 scopus 로고    scopus 로고
    • Protein misfolding, amyloid formation, and neurodegeneration: A critical role for molecular chaperones?
    • Muchowski P.J. Protein misfolding, amyloid formation, and neurodegeneration: A critical role for molecular chaperones?. Neuron 2002, 35:9-12.
    • (2002) Neuron , vol.35 , pp. 9-12
    • Muchowski, P.J.1
  • 71
    • 0034909937 scopus 로고    scopus 로고
    • Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease
    • Nakamura T., Dhawan V., Chaly T., Fukuda M., Ma Y., Breeze R., et al. Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease. Annals of Neurology 2001, 50:181-187.
    • (2001) Annals of Neurology , vol.50 , pp. 181-187
    • Nakamura, T.1    Dhawan, V.2    Chaly, T.3    Fukuda, M.4    Ma, Y.5    Breeze, R.6
  • 72
    • 70350678559 scopus 로고    scopus 로고
    • Longitudinal progression of sporadic Parkinson's disease: A multi-tracer positron emission tomography study
    • Nandhagopal R., Kuramoto L., Schulzer M., Mak E., Cragg J., Lee C.S., et al. Longitudinal progression of sporadic Parkinson's disease: A multi-tracer positron emission tomography study. Brain 2009, 132:2970-2979.
    • (2009) Brain , vol.132 , pp. 2970-2979
    • Nandhagopal, R.1    Kuramoto, L.2    Schulzer, M.3    Mak, E.4    Cragg, J.5    Lee, C.S.6
  • 73
  • 74
    • 0030031457 scopus 로고    scopus 로고
    • The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons
    • Nirenberg M.J., Vaughan R.A., Uhl G.R., Kuhar M.J., Pickel V.M. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. Journal of Neuroscience 1996, 16:436-447.
    • (1996) Journal of Neuroscience , vol.16 , pp. 436-447
    • Nirenberg, M.J.1    Vaughan, R.A.2    Uhl, G.R.3    Kuhar, M.J.4    Pickel, V.M.5
  • 76
    • 0037409714 scopus 로고    scopus 로고
    • Progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease using [18F]CFT PET
    • Nurmi E., Bergman J., Eskola O., Solin O., Vahlberg T., Sonninen P., et al. Progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease using [18F]CFT PET. Synapse 2003, 48:109-115.
    • (2003) Synapse , vol.48 , pp. 109-115
    • Nurmi, E.1    Bergman, J.2    Eskola, O.3    Solin, O.4    Vahlberg, T.5    Sonninen, P.6
  • 78
    • 0034041228 scopus 로고    scopus 로고
    • Progression in Parkinson's disease: A positron emission tomography study with a dopamine transporter ligand [18F]CFT
    • Nurmi E., Ruottinen H.M., Kaasinen V., Bergman J., Haaparanta M., Solin O., et al. Progression in Parkinson's disease: A positron emission tomography study with a dopamine transporter ligand [18F]CFT. Annals of Neurology 2000, 47:804-808.
    • (2000) Annals of Neurology , vol.47 , pp. 804-808
    • Nurmi, E.1    Ruottinen, H.M.2    Kaasinen, V.3    Bergman, J.4    Haaparanta, M.5    Solin, O.6
  • 80
    • 0042837887 scopus 로고    scopus 로고
    • A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease.
    • Olanow C.W., Goetz C.G., Kordower J.H., Stoessl A.J., Sossi V., Brin M.F., et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Annals of Neurology 2003, 54:403-414.
    • (2003) Annals of Neurology , vol.54 , pp. 403-414
    • Olanow, C.W.1    Goetz, C.G.2    Kordower, J.H.3    Stoessl, A.J.4    Sossi, V.5    Brin, M.F.6
  • 81
    • 0033960907 scopus 로고    scopus 로고
    • A randomized controlled trial comparing pramipexole with levodopa in early Parkinson's disease: Design and methods of the CALM-PD Study. Parkinson Study Group
    • Parkinson study group
    • A randomized controlled trial comparing pramipexole with levodopa in early Parkinson's disease: Design and methods of the CALM-PD Study. Parkinson Study Group. Clinical Neuropharmacology 2000, 23:34-44. Parkinson study group.
    • (2000) Clinical Neuropharmacology , vol.23 , pp. 34-44
  • 82
    • 0037012478 scopus 로고    scopus 로고
    • Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression
    • Parkinson study group
    • Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. Journal of the American Medical Association 2002, 287:1653-1661. Parkinson study group.
    • (2002) Journal of the American Medical Association , vol.287 , pp. 1653-1661
  • 83
  • 85
    • 33750975077 scopus 로고    scopus 로고
    • Clinical correlates of levodopa-induced dopamine release in Parkinson disease: A PET study
    • Pavese N., Evans A.H., Tai Y.F., Hotton G., Brooks D.J., Lees A.J., et al. Clinical correlates of levodopa-induced dopamine release in Parkinson disease: A PET study. Neurology 2006, 67:1612-1617.
    • (2006) Neurology , vol.67 , pp. 1612-1617
    • Pavese, N.1    Evans, A.H.2    Tai, Y.F.3    Hotton, G.4    Brooks, D.J.5    Lees, A.J.6
  • 87
    • 28544441892 scopus 로고    scopus 로고
    • Factors affecting the clinical outcome after neural transplantation in Parkinson's disease
    • Piccini P., Pavese N., Hagell P., Reimer J., Bjorklund A., Oertel W.H., et al. Factors affecting the clinical outcome after neural transplantation in Parkinson's disease. Brain 2005, 128:2977-2986.
    • (2005) Brain , vol.128 , pp. 2977-2986
    • Piccini, P.1    Pavese, N.2    Hagell, P.3    Reimer, J.4    Bjorklund, A.5    Oertel, W.H.6
  • 88
    • 0030727688 scopus 로고    scopus 로고
    • Alterations in opioid receptor binding in Parkinson's disease patients with levodopa-induced dyskinesias
    • Piccini P., Weeks R.A., Brooks D.J. Alterations in opioid receptor binding in Parkinson's disease patients with levodopa-induced dyskinesias. Annals of Neurology 1997, 42:720-726.
    • (1997) Annals of Neurology , vol.42 , pp. 720-726
    • Piccini, P.1    Weeks, R.A.2    Brooks, D.J.3
  • 89
    • 33846817053 scopus 로고    scopus 로고
    • [123I]epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: Implications for the use of cerebellum as a reference region
    • Pinborg L.H., Videbaek C., Ziebell M., Mackeprang T., Friberg L., Rasmussen H., et al. [123I]epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: Implications for the use of cerebellum as a reference region. Neuroimage 2007, 34:1450-1453.
    • (2007) Neuroimage , vol.34 , pp. 1450-1453
    • Pinborg, L.H.1    Videbaek, C.2    Ziebell, M.3    Mackeprang, T.4    Friberg, L.5    Rasmussen, H.6
  • 90
    • 0242382825 scopus 로고    scopus 로고
    • Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?
    • Pirker W. Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?. Movement Disorder 2003, 18(Suppl 7):S43-S51.
    • (2003) Movement Disorder , vol.18 , Issue.SUPPL. 7
    • Pirker, W.1
  • 91
    • 77955617871 scopus 로고    scopus 로고
    • Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants
    • Politis M.M., Wu K., Loane C., Quinn N.P., Brooks D.J., Rehncrona S., et al. Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants. Sci Transl Med 2010, 2:38-46.
    • (2010) Sci Transl Med , vol.2 , pp. 38-46
    • Politis, M.M.1    Wu, K.2    Loane, C.3    Quinn, N.P.4    Brooks, D.J.5    Rehncrona, S.6
  • 94
  • 95
    • 34447628675 scopus 로고    scopus 로고
    • In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias
    • Sanchez-Pernaute R., Jenkins B.G., Choi J.K., Iris Chen Y.C., Isacson O. in vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias. Neurobiology of Disease 2007, 27:220-227.
    • (2007) Neurobiology of Disease , vol.27 , pp. 220-227
    • Sanchez-Pernaute, R.1    Jenkins, B.G.2    Choi, J.K.3    Iris Chen, Y.C.4    Isacson, O.5
  • 97
    • 0033875826 scopus 로고    scopus 로고
    • What contributes to quality of life in patients with Parkinson's disease? Journal of Neurology
    • Schrag A., Jahanshahi M., Quinn N. What contributes to quality of life in patients with Parkinson's disease? Journal of Neurology. Neurosurgery and Psychiatry 2000, 69:308-312.
    • (2000) Neurosurgery and Psychiatry , vol.69 , pp. 308-312
    • Schrag, A.1    Jahanshahi, M.2    Quinn, N.3
  • 98
    • 0034911575 scopus 로고    scopus 로고
    • Reward signaling by dopamine neurons
    • Schultz W. Reward signaling by dopamine neurons. Neuroscientist 2001, 7:293-302.
    • (2001) Neuroscientist , vol.7 , pp. 293-302
    • Schultz, W.1
  • 99
    • 0028308151 scopus 로고
    • A mathematical model of pathogenesis in idiopathic parkinsonism
    • Schulzer M., Lee C.S., Mak E.K., Vingerhoets F.J., Calne D.B. A mathematical model of pathogenesis in idiopathic parkinsonism. Brain 1994, 117(Pt 3):509-516.
    • (1994) Brain , vol.117 , Issue.PART 3 , pp. 509-516
    • Schulzer, M.1    Lee, C.S.2    Mak, E.K.3    Vingerhoets, F.J.4    Calne, D.B.5
  • 100
    • 0024595594 scopus 로고
    • Endogenous dopamine lowers the dopamine D2 receptor density as measured by [3H]raclopride: Implications for positron emission tomography of the human brain
    • Seeman P., Guan H.C., Niznik H.B. Endogenous dopamine lowers the dopamine D2 receptor density as measured by [3H]raclopride: Implications for positron emission tomography of the human brain. Synapse 1989, 3:96-97.
    • (1989) Synapse , vol.3 , pp. 96-97
    • Seeman, P.1    Guan, H.C.2    Niznik, H.B.3
  • 101
    • 0029094141 scopus 로고
    • Decreased single-photon emission computed tomographic [123I]beta-CIT striatal uptake correlates with symptom severity in Parkinson's disease
    • Seibyl J.P., Marek K.L., Quinlan D., Sheff K., Zoghbi S., Zea-Ponce Y., et al. Decreased single-photon emission computed tomographic [123I]beta-CIT striatal uptake correlates with symptom severity in Parkinson's disease. Annals of Neurology 1995, 38:589-598.
    • (1995) Annals of Neurology , vol.38 , pp. 589-598
    • Seibyl, J.P.1    Marek, K.L.2    Quinlan, D.3    Sheff, K.4    Zoghbi, S.5    Zea-Ponce, Y.6
  • 102
    • 0030930258 scopus 로고    scopus 로고
    • Test/retest reproducibility of iodine-123-betaCIT SPECT brain measurement of dopamine transporters in Parkinson's patients
    • Seibyl J.P., Marek K., Sheff K., Baldwin R.M., Zoghbi S., Zea-Ponce Y., et al. Test/retest reproducibility of iodine-123-betaCIT SPECT brain measurement of dopamine transporters in Parkinson's patients. Journal of Nuclear Medicine 1997, 38:1453-1459.
    • (1997) Journal of Nuclear Medicine , vol.38 , pp. 1453-1459
    • Seibyl, J.P.1    Marek, K.2    Sheff, K.3    Baldwin, R.M.4    Zoghbi, S.5    Zea-Ponce, Y.6
  • 103
    • 0027327049 scopus 로고
    • Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels
    • Snow B.J., Tooyama I., McGeer E.G., Yamada T., Calne D.B., Takahashi H., et al. Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels. Annals of Neurology 1993, 34:324-330.
    • (1993) Annals of Neurology , vol.34 , pp. 324-330
    • Snow, B.J.1    Tooyama, I.2    McGeer, E.G.3    Yamada, T.4    Calne, D.B.5    Takahashi, H.6
  • 106
    • 3843057052 scopus 로고    scopus 로고
    • Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: Their relation to disease-compensatory mechanisms
    • Sossi V., Fuente-Fernandez R., Holden J.E., Schulzer M., Ruth T.J., Stoessl J. Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: Their relation to disease-compensatory mechanisms. Journal of Cerebral Blood Flow and Metabolism 2004, 24:869-876.
    • (2004) Journal of Cerebral Blood Flow and Metabolism , vol.24 , pp. 869-876
    • Sossi, V.1    Fuente-Fernandez, R.2    Holden, J.E.3    Schulzer, M.4    Ruth, T.J.5    Stoessl, J.6
  • 107
    • 33645055382 scopus 로고    scopus 로고
    • Age-related differences in levodopa dynamics in Parkinson's: Implications for motor complications
    • Sossi V., Fuente-Fernandez R., Schulzer M., Adams J., Stoessl J. Age-related differences in levodopa dynamics in Parkinson's: Implications for motor complications. Brain 2006, 129:1050-1058.
    • (2006) Brain , vol.129 , pp. 1050-1058
    • Sossi, V.1    Fuente-Fernandez, R.2    Schulzer, M.3    Adams, J.4    Stoessl, J.5
  • 108
    • 37349038248 scopus 로고    scopus 로고
    • Dopamine transporter relation to dopamine turnover in Parkinson's disease: A positron emission tomography study
    • Sossi V., Fuente-Fernandez R., Schulzer M., Troiano A.R., Ruth T.J., Stoessl A.J. Dopamine transporter relation to dopamine turnover in Parkinson's disease: A positron emission tomography study. Annals of Neurology 2007, 62:468-474.
    • (2007) Annals of Neurology , vol.62 , pp. 468-474
    • Sossi, V.1    Fuente-Fernandez, R.2    Schulzer, M.3    Troiano, A.R.4    Ruth, T.J.5    Stoessl, A.J.6
  • 109
    • 66549083459 scopus 로고    scopus 로고
    • Increased striatal dopamine release in Parkinsonian patients with pathological gambling: A [11C] raclopride PET study
    • Steeves T.D., Miyasaki J., Zurowski M., Lang A.E., Pellecchia G., Van Eimeren T., et al. Increased striatal dopamine release in Parkinsonian patients with pathological gambling: A [11C] raclopride PET study. Brain 2009, 132:1376-1385.
    • (2009) Brain , vol.132 , pp. 1376-1385
    • Steeves, T.D.1    Miyasaki, J.2    Zurowski, M.3    Lang, A.E.4    Pellecchia, G.5    Van Eimeren, T.6
  • 110
    • 0042190152 scopus 로고    scopus 로고
    • Agonizing over dopaminergic replacement therapy - lessons from animal models of Parkinson's disease
    • Stoessl A.J. Agonizing over dopaminergic replacement therapy - lessons from animal models of Parkinson's disease. Experimental Neurology 2003, 183:1-3.
    • (2003) Experimental Neurology , vol.183 , pp. 1-3
    • Stoessl, A.J.1
  • 111
    • 0037378897 scopus 로고    scopus 로고
    • Apoptosis in Parkinson's disease: Signals for neuronal degradation
    • Tatton W.G., Chalmers-Redman R., Brown D., Tatton N. Apoptosis in Parkinson's disease: Signals for neuronal degradation. Annals of Neurology 2003, 53(Suppl 3):S61-S70.
    • (2003) Annals of Neurology , vol.53 , Issue.SUPPL. 3
    • Tatton, W.G.1    Chalmers-Redman, R.2    Brown, D.3    Tatton, N.4
  • 112
    • 0029904201 scopus 로고    scopus 로고
    • Levodopa-induced changes in synaptic dopamine in patients with Parkinson's disease as measured by [11C]raclopride displacement and PET
    • Tedroff J., Pedersen M., Aquilonius S.M., Hartvig P., Jacobsson G., Langstrom B. Levodopa-induced changes in synaptic dopamine in patients with Parkinson's disease as measured by [11C]raclopride displacement and PET. Neurology 1996, 46:1430-1436.
    • (1996) Neurology , vol.46 , pp. 1430-1436
    • Tedroff, J.1    Pedersen, M.2    Aquilonius, S.M.3    Hartvig, P.4    Jacobsson, G.5    Langstrom, B.6
  • 113
    • 7744235165 scopus 로고    scopus 로고
    • Role of dopaminergic treatment in dopamine receptor down-regulation in advanced Parkinson disease: A positron emission tomographic study
    • Thobois S., Vingerhoets F., Fraix V., Xie-Brustolin J., Mollion H., Costes N., et al. Role of dopaminergic treatment in dopamine receptor down-regulation in advanced Parkinson disease: A positron emission tomographic study. Archives of Neurology 2004, 61:1705-1709.
    • (2004) Archives of Neurology , vol.61 , pp. 1705-1709
    • Thobois, S.1    Vingerhoets, F.2    Fraix, V.3    Xie-Brustolin, J.4    Mollion, H.5    Costes, N.6
  • 114
    • 33846423838 scopus 로고    scopus 로고
    • Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists
    • Tippmann-Peikert M., Park J.G., Boeve B.F., Shepard J.W., Silber M.H. Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists. Neurology 2007, 68:301-303.
    • (2007) Neurology , vol.68 , pp. 301-303
    • Tippmann-Peikert, M.1    Park, J.G.2    Boeve, B.F.3    Shepard, J.W.4    Silber, M.H.5
  • 115
    • 52249123447 scopus 로고    scopus 로고
    • Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration
    • Tong J., Wilson A.A., Boileau I., Houle S., Kish S.J. Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration. Synapse 2008, 62:873-876.
    • (2008) Synapse , vol.62 , pp. 873-876
    • Tong, J.1    Wilson, A.A.2    Boileau, I.3    Houle, S.4    Kish, S.J.5
  • 116
    • 65249107128 scopus 로고    scopus 로고
    • PET demonstrates reduced dopamine transporter expression in PD with dyskinesias
    • Troiano A.R., Fuente-Fernandez R., Sossi V., Schulzer M., Mak E., Ruth T.J., et al. PET demonstrates reduced dopamine transporter expression in PD with dyskinesias. Neurology 2009, 72:1211-1216.
    • (2009) Neurology , vol.72 , pp. 1211-1216
    • Troiano, A.R.1    Fuente-Fernandez, R.2    Sossi, V.3    Schulzer, M.4    Mak, E.5    Ruth, T.J.6
  • 117
    • 33646590661 scopus 로고    scopus 로고
    • Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease
    • Trost M., Su S., Su P., Yen R.F., Tseng H.M., Barnes A., et al. Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease. Neuroimage 2006, 31:301-307.
    • (2006) Neuroimage , vol.31 , pp. 301-307
    • Trost, M.1    Su, S.2    Su, P.3    Yen, R.F.4    Tseng, H.M.5    Barnes, A.6
  • 118
    • 0030827709 scopus 로고    scopus 로고
    • In vivo studies on striatal dopamine D1 and D2 site binding in L-dopa-treated Parkinson's disease patients with and without dyskinesias
    • Turjanski N., Lees A.J., Brooks D.J. in vivo studies on striatal dopamine D1 and D2 site binding in L-dopa-treated Parkinson's disease patients with and without dyskinesias. Neurology 1997, 49:717-723.
    • (1997) Neurology , vol.49 , pp. 717-723
    • Turjanski, N.1    Lees, A.J.2    Brooks, D.J.3
  • 119
    • 70449380362 scopus 로고    scopus 로고
    • Dopamine agonists diminish value sensitivity of the orbitofrontal cortex: A trigger for pathological gambling in Parkinson's disease?
    • Van Eimeren T., Ballanger B., Pellecchia G., Miyasaki J.M., Lang A.E., Strafella A.P. Dopamine agonists diminish value sensitivity of the orbitofrontal cortex: A trigger for pathological gambling in Parkinson's disease?. Neuropsychopharmacology 2009, 34:2758-2766.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 2758-2766
    • Van Eimeren, T.1    Ballanger, B.2    Pellecchia, G.3    Miyasaki, J.M.4    Lang, A.E.5    Strafella, A.P.6
  • 120
    • 0037439079 scopus 로고    scopus 로고
    • Effects of oligonucleotide antisense to dopamine D3 receptor mRNA in a rodent model of behavioural sensitization to levodopa
    • van Kampen J.M., Stoessl A.J. Effects of oligonucleotide antisense to dopamine D3 receptor mRNA in a rodent model of behavioural sensitization to levodopa. Neuroscience 2003, 116:307-314.
    • (2003) Neuroscience , vol.116 , pp. 307-314
    • van Kampen, J.M.1    Stoessl, A.J.2
  • 121
    • 0028984466 scopus 로고
    • [3H]methoxytetrabenazine: A high specific activity ligand for estimating monoaminergic neuronal integrity
    • Vander Borght T.M., Sima A.A., Kilbourn M.R., Desmond T.J., Kuhl D.E., Frey K.A. [3H]methoxytetrabenazine: A high specific activity ligand for estimating monoaminergic neuronal integrity. Neuroscience 1995, 68:955-962.
    • (1995) Neuroscience , vol.68 , pp. 955-962
    • Vander Borght, T.M.1    Sima, A.A.2    Kilbourn, M.R.3    Desmond, T.J.4    Kuhl, D.E.5    Frey, K.A.6
  • 122
    • 1842290405 scopus 로고    scopus 로고
    • Which clinical sign of Parkinson's disease best reflects the nigrostriatal lesion?
    • Vingerhoets F.J., Schulzer M., Calne D.B., Snow B.J. Which clinical sign of Parkinson's disease best reflects the nigrostriatal lesion?. Annals of Neurology 1997, 41:58-64.
    • (1997) Annals of Neurology , vol.41 , pp. 58-64
    • Vingerhoets, F.J.1    Schulzer, M.2    Calne, D.B.3    Snow, B.J.4
  • 125
    • 72149094883 scopus 로고    scopus 로고
    • Chronic dopaminergic stimulation in Parkinson's disease: From dyskinesias to impulse control disorders
    • Voon V., Fernagut P.O., Wickens J., Baunez C., Rodriguez M., Pavon N., et al. Chronic dopaminergic stimulation in Parkinson's disease: From dyskinesias to impulse control disorders. Lancet Neurology 2009, 8:1140-1149.
    • (2009) Lancet Neurology , vol.8 , pp. 1140-1149
    • Voon, V.1    Fernagut, P.O.2    Wickens, J.3    Baunez, C.4    Rodriguez, M.5    Pavon, N.6
  • 126
    • 33749823140 scopus 로고    scopus 로고
    • Prevalence of repetitive and reward-seeking behaviors in Parkinson disease
    • Voon V., Hassan K., Zurowski M., de Souza M., Thomsen T., Fox S., et al. Prevalence of repetitive and reward-seeking behaviors in Parkinson disease. Neurology 2006, 67:1254-1257.
    • (2006) Neurology , vol.67 , pp. 1254-1257
    • Voon, V.1    Hassan, K.2    Zurowski, M.3    de Souza, M.4    Thomsen, T.5    Fox, S.6
  • 129
    • 0037785449 scopus 로고    scopus 로고
    • Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study
    • Whone A.L., Watts R.L., Stoessl A.J., Davis M., Reske S., Nahmias C., et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Annals of Neurology 2003, 54:93-101.
    • (2003) Annals of Neurology , vol.54 , pp. 93-101
    • Whone, A.L.1    Watts, R.L.2    Stoessl, A.J.3    Davis, M.4    Reske, S.5    Nahmias, C.6


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