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Volumn 56, Issue 5, 1999, Pages 529-535

Parkinson disease, the effect of levodopa, and the ELLDOPA trial

Author keywords

[No Author keywords available]

Indexed keywords

BROMOCRIPTINE; CABERGOLINE; CARBIDOPA; LEVODOPA; PERGOLIDE MESILATE; PRAMIPEXOLE; ROPINIROLE;

EID: 0032890731     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.56.5.529     Document Type: Review
Times cited : (215)

References (108)
  • 1
    • 0014208039 scopus 로고
    • Aromatic amino acids and modification of parkinsonism
    • Cotzias GC, Van Woert MH, Schiffer LM. Aromatic amino acids and modification of parkinsonism. N Engl J Med. 1967;276:374-379.
    • (1967) N Engl J Med , vol.276 , pp. 374-379
    • Cotzias, G.C.1    Van Woert, M.H.2    Schiffer, L.M.3
  • 2
    • 0014673226 scopus 로고
    • Modification of parkinsonism: Chronic treatment with L-dopa
    • Cotzias GC, Papavasiliou PS, Gellene R. Modification of parkinsonism: chronic treatment with L-dopa. N Engl J Med. 1969;280:337-345.
    • (1969) N Engl J Med , vol.280 , pp. 337-345
    • Cotzias, G.C.1    Papavasiliou, P.S.2    Gellene, R.3
  • 3
    • 0002859737 scopus 로고
    • Adverse effects of levodopa
    • Olanow CW, Lieberman AN, eds. Carnforth, England: Parthenon Publishing Group
    • Fahn S. Adverse effects of levodopa. In: Olanow CW, Lieberman AN, eds. The Scientific Basis for the Treatment of Parkinson's Disease. Carnforth, England: Parthenon Publishing Group; 1992:89-112.
    • (1992) The Scientific Basis for the Treatment of Parkinson's Disease , pp. 89-112
    • Fahn, S.1
  • 4
    • 0017834407 scopus 로고
    • Considerations in the management of parkinsonism
    • Fahn S, Calne DB. Considerations in the management of parkinsonism. Neurology. 1978;28:5-7.
    • (1978) Neurology , vol.28 , pp. 5-7
    • Fahn, S.1    Calne, D.B.2
  • 6
    • 0021257761 scopus 로고
    • Should levodopa therapy be started early or late?
    • Muenter MD. Should levodopa therapy be started early or late? Can J Neurol Sci. 1984;11:195-199.
    • (1984) Can J Neurol Sci , vol.11 , pp. 195-199
    • Muenter, M.D.1
  • 7
    • 0021234640 scopus 로고
    • Should levodopa therapy for parkinsonism be started early or late? evidence against early treatment
    • Fahn S, Bressman SB. Should levodopa therapy for parkinsonism be started early or late? evidence against early treatment. Can J Neurol Sci. 1984;11:200-206.
    • (1984) Can J Neurol Sci , vol.11 , pp. 200-206
    • Fahn, S.1    Bressman, S.B.2
  • 8
    • 0028911347 scopus 로고
    • A case for early levodopa treatment of Parkinson's disease
    • Caraceni T. A case for early levodopa treatment of Parkinson's disease. Clin Neuropharmacol. 1994;17(suppl):S38-S42.
    • (1994) Clin Neuropharmacol , vol.17 , Issue.SUPPL.
    • Caraceni, T.1
  • 9
    • 0028965017 scopus 로고
    • A case against early levodopa treatment of Parkinson's disease
    • Quinn NP. A case against early levodopa treatment of Parkinson's disease. Clin Neuropharmacol. 1994;17(suppl):S43-S49.
    • (1994) Clin Neuropharmacol , vol.17 , Issue.SUPPL.
    • Quinn, N.P.1
  • 10
    • 0019519328 scopus 로고
    • Evidence to support early levodopa therapy in Parkinson disease
    • Markham CH, Diamond SG. Evidence to support early levodopa therapy in Parkinson disease. Neurology. 1981;31:125-131.
    • (1981) Neurology , vol.31 , pp. 125-131
    • Markham, C.H.1    Diamond, S.G.2
  • 11
    • 0020989520 scopus 로고
    • Parkinsonism treated with levodopa: Progression and mortality
    • Hoehn MMM. Parkinsonism treated with levodopa: progression and mortality. J Neural Transm Suppl. 1983;19:253-264.
    • (1983) J Neural Transm Suppl , vol.19 , pp. 253-264
    • Hoehn, M.M.M.1
  • 12
    • 0022627693 scopus 로고
    • Initiation of levodopa therapy in parkinsonian patients should be delayed until the advanced stages of the disease
    • Melamed E. Initiation of levodopa therapy in parkinsonian patients should be delayed until the advanced stages of the disease. Arch Neurol. 1986;43:402-405.
    • (1986) Arch Neurol , vol.43 , pp. 402-405
    • Melamed, E.1
  • 13
    • 0022652016 scopus 로고
    • Modification of Parkinson's disease by long-term levodopa treatment
    • Markham CH, Diamond SG. Modification of Parkinson's disease by long-term levodopa treatment. Arch Neurol. 1986;43:405-407.
    • (1986) Arch Neurol , vol.43 , pp. 405-407
    • Markham, C.H.1    Diamond, S.G.2
  • 14
    • 84938465236 scopus 로고
    • Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease
    • Kostic V, Przedborski S, Flaster E, Sternic N. Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease. Neurology. 1991;41:202-205.
    • (1991) Neurology , vol.41 , pp. 202-205
    • Kostic, V.1    Przedborski, S.2    Flaster, E.3    Sternic, N.4
  • 15
    • 0002504869 scopus 로고
    • Early-onset parkinsonism
    • Jankovic J, Tolosa E, eds. Baltimore, Md: Williams & Wilkins;
    • Gershanik OS. Early-onset parkinsonism. In: Jankovic J, Tolosa E, eds. Parkinson's Disease and Movement Disorders. 2nd ed. Baltimore, Md: Williams & Wilkins; 1993:235-252.
    • (1993) Parkinson's Disease and Movement Disorders. 2nd Ed. , pp. 235-252
    • Gershanik, O.S.1
  • 16
    • 0029818869 scopus 로고    scopus 로고
    • Complications of disease and therapy: A comparison of younger and older patients with Parkinson's disease
    • Wagner ML, Fedak MN, Sage JI, Mark MH. Complications of disease and therapy: a comparison of younger and older patients with Parkinson's disease. Ann Clin Lab Sci. 1996;26:389-395.
    • (1996) Ann Clin Lab Sci , vol.26 , pp. 389-395
    • Wagner, M.L.1    Fedak, M.N.2    Sage, J.I.3    Mark, M.H.4
  • 18
    • 0023026069 scopus 로고
    • Low-dose L-dopa therapy in Parkinson's disease: A 6-year follow-up study
    • Poewe WH, Lees AJ, Stern GM. Low-dose L-dopa therapy in Parkinson's disease: a 6-year follow-up study. Neurology. 1986;36:1528-1530.
    • (1986) Neurology , vol.36 , pp. 1528-1530
    • Poewe, W.H.1    Lees, A.J.2    Stern, G.M.3
  • 19
    • 0023261115 scopus 로고
    • Factors that influence the occurrence of response variations in Parkinson's disease
    • de Jong GJ, Meerwaldt JD, Schmitz PIM. Factors that influence the occurrence of response variations in Parkinson's disease. Ann Neurol. 1987;22:4-7.
    • (1987) Ann Neurol , vol.22 , pp. 4-7
    • De Jong, G.J.1    Meerwaldt, J.D.2    Schmitz, P.I.M.3
  • 20
    • 0023802240 scopus 로고
    • Does levodopa aggravate Parkinson's disease?
    • Blin J, Bonnet A-M, Agid Y. Does levodopa aggravate Parkinson's disease? Neurology. 1988;38:1410-1416.
    • (1988) Neurology , vol.38 , pp. 1410-1416
    • Blin, J.1    Bonnet, A.-M.2    Agid, Y.3
  • 21
    • 0025765530 scopus 로고
    • The occurrence of motor fluctuations in parkinsonian patients treated long term with levodopa: Role of early treatment and disease progression
    • Caraceni T, Scigliano G, Musicco M. The occurrence of motor fluctuations in parkinsonian patients treated long term with levodopa: role of early treatment and disease progression. Neurology. 1991;41:380-384.
    • (1991) Neurology , vol.41 , pp. 380-384
    • Caraceni, T.1    Scigliano, G.2    Musicco, M.3
  • 22
    • 0025802827 scopus 로고
    • Early initiation of levodopa treatment does not promote the development of motor response fluctuations, dyskinesias, or dementia in Parkinson's disease
    • Cedarbaum JM, Gandy SE, McDowell FH. Early initiation of levodopa treatment does not promote the development of motor response fluctuations, dyskinesias, or dementia in Parkinson's disease. Neurology. 1991;41:622-629.
    • (1991) Neurology , vol.41 , pp. 622-629
    • Cedarbaum, J.M.1    Gandy, S.E.2    McDowell, F.H.3
  • 23
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science. 1983;219:979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 24
    • 0021239393 scopus 로고
    • Parkinsonism induced by 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine: Implications for treatment and the pathophysiology of Parkinson's disease
    • Langston JW, Ballard PA. Parkinsonism induced by 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine: implications for treatment and the pathophysiology of Parkinson's disease. Can J Neurosci. 1984;11:160-165.
    • (1984) Can J Neurosci , vol.11 , pp. 160-165
    • Langston, J.W.1    Ballard, P.A.2
  • 25
    • 0021829406 scopus 로고
    • Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): Seven cases
    • Ballard PA, Tetrud JW, Langston JW. Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases. Neurology. 1985;35:949-956.
    • (1985) Neurology , vol.35 , pp. 949-956
    • Ballard, P.A.1    Tetrud, J.W.2    Langston, J.W.3
  • 27
    • 0014937960 scopus 로고
    • Side-effects of L-dopa in post-encephalic parkinsonism
    • Sacks OW, Kohl M, Schwartz W, Messeloff C. Side-effects of L-dopa in post-encephalic parkinsonism [letter]. Lancet. 1970;1:1006.
    • (1970) Lancet , vol.1 , pp. 1006
    • Sacks, O.W.1    Kohl, M.2    Schwartz, W.3    Messeloff, C.4
  • 29
    • 0004059246 scopus 로고
    • Garden City, NY: Doubleday & Co
    • Sacks OW. Awakenings. Garden City, NY: Doubleday & Co; 1974.
    • (1974) Awakenings
    • Sacks, O.W.1
  • 30
    • 0023225016 scopus 로고
    • Early combination of bromocriptine and levodopa in the treatment of Parkinson's disease: A 5-year follow-up
    • Rinne UK. Early combination of bromocriptine and levodopa in the treatment of Parkinson's disease: a 5-year follow-up. Neurology. 1987;37:826-828.
    • (1987) Neurology , vol.37 , pp. 826-828
    • Rinne, U.K.1
  • 31
    • 0024549138 scopus 로고
    • Lisuride, a dopamine agonist in the treatment of early Parkinson's disease
    • Rinne UK. Lisuride, a dopamine agonist in the treatment of early Parkinson's disease. Neurology. 1989;39:336-339.
    • (1989) Neurology , vol.39 , pp. 336-339
    • Rinne, U.K.1
  • 32
    • 0024552993 scopus 로고
    • Early dopamine agonist therapy in Parkinson's disease
    • Rinne UK. Early dopamine agonist therapy in Parkinson's disease. Mov Disord. 1989;4(suppl 1):S86-S94.
    • (1989) Mov Disord. , vol.4 , Issue.SUPPL. 1
    • Rinne, U.K.1
  • 33
    • 0027470879 scopus 로고
    • Early combination therapy (bromocriptine and levodopa) does not prevent motor fluctuations in Parkinson's disease
    • Weiner WJ, Factor SA, Sanchez-Ramos JR, et al. Early combination therapy (bromocriptine and levodopa) does not prevent motor fluctuations in Parkinson's disease. Neurology. 1993;43:21-27.
    • (1993) Neurology , vol.43 , pp. 21-27
    • Weiner, W.J.1    Factor, S.A.2    Sanchez-Ramos, J.R.3
  • 34
    • 0028630805 scopus 로고
    • A randomised controlled study comparing bromocriptine to which levodopa was later added, with levodopa alone in previously untreated patients with Parkinson's disease: A five-year follow up
    • Montastruc JL, Rascal O, Senard JM, Rascol A. A randomised controlled study comparing bromocriptine to which levodopa was later added, with levodopa alone in previously untreated patients with Parkinson's disease: a five-year follow up. J Neurol Neurosurg Psychiatry. 1994;57:1034-1038.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 1034-1038
    • Montastruc, J.L.1    Rascal, O.2    Senard, J.M.3    Rascol, A.4
  • 35
    • 0027931399 scopus 로고
    • The sydney multicentre study of parkinson's disease: A randomised, prospective five-year study comparing low-dose bromocriptine with low-dose levodopa-carbidopa
    • Hely MA, Morris JGL, Reid WGJ, et al. The Sydney Multicentre Study of Parkinson's disease: a randomised, prospective five-year study comparing low-dose bromocriptine with low-dose levodopa-carbidopa. J Neurol Neurosurg Psychiatry. 1994;57:903-910.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 903-910
    • Hely, M.A.1    Morris, J.G.L.2    Reid, W.G.J.3
  • 36
    • 10544247317 scopus 로고    scopus 로고
    • Early institution of bromocriptine in Parkinson's disease inhibits the emergence of levodopa-associated motor side effects: Long-term results of the PRADO study
    • Przuntek H, Welzel D, Gerlach M, et al. Early institution of bromocriptine in Parkinson's disease inhibits the emergence of levodopa-associated motor side effects: long-term results of the PRADO Study. J Neural Transm. 1996;103:699-715.
    • (1996) J Neural Transm , vol.103 , pp. 699-715
    • Przuntek, H.1    Welzel, D.2    Gerlach, M.3
  • 37
    • 0343907188 scopus 로고    scopus 로고
    • Early combination of bromocriptine and levodopa in Parkinson's disease: A prospective randomized study of two parallel groups over a total follow-up period of 44 months including an initial 8-month double-blind stage
    • Gimenez-Roldan S, Tolosa E, Burguera JA, Chacon J, Liano H, Forcadell F. Early combination of bromocriptine and levodopa in Parkinson's disease: a prospective randomized study of two parallel groups over a total follow-up period of 44 months including an initial 8-month double-blind stage. Clin Neuropharmacol. 1997;20:67-76.
    • (1997) Clin Neuropharmacol , vol.20 , pp. 67-76
    • Gimenez-Roldan, S.1    Tolosa, E.2    Burguera, J.A.3    Chacon, J.4    Liano, H.5    Forcadell, F.6
  • 38
    • 0031985731 scopus 로고    scopus 로고
    • Early treatment of Parkinson's disease with cabergoline delays the onset of motor complications: Results of a double-blind levodopa controlled trial
    • Rinne UK, Bracco F, Chouza C, et al. Early treatment of Parkinson's disease with cabergoline delays the onset of motor complications: results of a double-blind levodopa controlled trial. Drugs. 1998;55:23-30.
    • (1998) Drugs , vol.55 , pp. 23-30
    • Rinne, U.K.1    Bracco, F.2    Chouza, C.3
  • 39
    • 0029826472 scopus 로고    scopus 로고
    • Combined effects of cabergoline and L-dopa on parkinsonism in MPTP-treated cynomolgus monkeys
    • Arai N, Isaji M, Kojima M, Mizuta E, Kuno S. Combined effects of cabergoline and L-dopa on parkinsonism in MPTP-treated cynomolgus monkeys. J Neural Transm. 1996;103:1307-1316.
    • (1996) J Neural Transm , vol.103 , pp. 1307-1316
    • Arai, N.1    Isaji, M.2    Kojima, M.3    Mizuta, E.4    Kuno, S.5
  • 40
    • 85069130476 scopus 로고    scopus 로고
    • Induction and prevention of dyskinesias by L-dopa and dopamine agonists in primates
    • Jenner P. Induction and prevention of dyskinesias by L-dopa and dopamine agonists in primates. Mov Disord. 1998;13(suppl 2):12.
    • (1998) Mov Disord , vol.13 , Issue.SUPPL. 2 , pp. 12
    • Jenner, P.1
  • 41
    • 0027725064 scopus 로고
    • Motor response complications and the function of striatal efferent systems
    • Chase TN, Mouradian MM, Engber TM. Motor response complications and the function of striatal efferent systems. Neurology. 1993;43(suppl 6):S23-S27.
    • (1993) Neurology , vol.43 , Issue.SUPPL. 6
    • Chase, T.N.1    Mouradian, M.M.2    Engber, T.M.3
  • 42
    • 0031708168 scopus 로고    scopus 로고
    • Neostriatal mechanisms in parkinson's disease
    • Chase TN, Oh JD, Blanchet PJ. Neostriatal mechanisms in Parkinson's disease. Neurology. 1998;51(suppl 2):S30-S35.
    • (1998) Neurology , vol.51 , Issue.SUPPL. 2
    • Chase, T.N.1    Oh, J.D.2    Blanchet, P.J.3
  • 43
    • 0031976069 scopus 로고    scopus 로고
    • The significance of continuous dopaminergic stimulation in the treatment of Parkinson's disease
    • Chase TN. The significance of continuous dopaminergic stimulation in the treatment of Parkinson's disease. Drugs. 1998;55:1-9.
    • (1998) Drugs , vol.55 , pp. 1-9
    • Chase, T.N.1
  • 44
    • 0029665122 scopus 로고    scopus 로고
    • Levodopa-induced dyskinesias improved by a glutamate antagonist in parkinsonian monkeys
    • Papa SM, Chase TN. Levodopa-induced dyskinesias improved by a glutamate antagonist in parkinsonian monkeys. Ann Neurol. 1996;39:574-578.
    • (1996) Ann Neurol , vol.39 , pp. 574-578
    • Papa, S.M.1    Chase, T.N.2
  • 45
    • 0030908103 scopus 로고    scopus 로고
    • Modulation of levodopa-induced motor response complications by NMDA antagonists in Parkinson's disease
    • Blanchet PJ, Papa SM, Metman LV, Mouradian MM, Chase TN. Modulation of levodopa-induced motor response complications by NMDA antagonists in Parkinson's disease. Neurosci Biobehav Rev. 1997;21:447-453.
    • (1997) Neurosci Biobehav Rev , vol.21 , pp. 447-453
    • Blanchet, P.J.1    Papa, S.M.2    Metman, L.V.3    Mouradian, M.M.4    Chase, T.N.5
  • 46
    • 0027200457 scopus 로고
    • Practice parameters: Initial therapy of Parkinson's disease (summary statement) - Report of the quality standards subcommittee of the American Academy of Neurology
    • Paulson G. Practice parameters: initial therapy of Parkinson's disease (summary statement) - report of the quality standards subcommittee of the American Academy of Neurology. Neurology. 1993;43:1296-1297.
    • (1993) Neurology , vol.43 , pp. 1296-1297
    • Paulson, G.1
  • 47
    • 0028858370 scopus 로고
    • The effect of deprenyl and levodopa on the progression of Parkinson's disease
    • Olanow CW, Hauser RA, Gauger L, et al. The effect of deprenyl and levodopa on the progression of Parkinson's disease. Ann Neurol. 1995;38:771-777.
    • (1995) Ann Neurol , vol.38 , pp. 771-777
    • Olanow, C.W.1    Hauser, R.A.2    Gauger, L.3
  • 48
    • 0018148688 scopus 로고
    • Autooxidation versus covalent binding of quinone as the mechanism of toxicity of dopamine, 6-hydroxy-dopamine and related compounds toward C1300 neuroblastoma cells in vitro
    • Graham DG, Tiffamy SM, Bell WR, Gutknecht WF. Autooxidation versus covalent binding of quinone as the mechanism of toxicity of dopamine, 6-hydroxy-dopamine and related compounds toward C1300 neuroblastoma cells in vitro. Mol Phamacol. 1978;14:644-653.
    • (1978) Mol Phamacol , vol.14 , pp. 644-653
    • Graham, D.G.1    Tiffamy, S.M.2    Bell, W.R.3    Gutknecht, W.F.4
  • 49
    • 0021009820 scopus 로고
    • The pathobiology of Parkinson's disease: Biochemical aspects of dopamine neuron senescence
    • Cohen G. The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence. J Neural Transm Suppl. 1983;19:89-103.
    • (1983) J Neural Transm Suppl , vol.19 , pp. 89-103
    • Cohen, G.1
  • 50
    • 0023188570 scopus 로고
    • Monoamine oxidase, hydrogen peroxide, and Parkinson's disease
    • Cohen G. Monoamine oxidase, hydrogen peroxide, and Parkinson's disease. Adv Neurol. 1986;45:119-125.
    • (1986) Adv Neurol , vol.45 , pp. 119-125
    • Cohen, G.1
  • 51
    • 0024948366 scopus 로고
    • The endogenous toxin hypothesis of the etiology of parkinson's disease and a pilot trial of high dosage antioxidants in an attempt to slow the progression of the illness
    • Fahn S. The endogenous toxin hypothesis of the etiology of Parkinson's disease and a pilot trial of high dosage antioxidants in an attempt to slow the progression of the illness. Ann N Y Acad Sci. 1989;570:186-196.
    • (1989) Ann N Y Acad Sci , vol.570 , pp. 186-196
    • Fahn, S.1
  • 52
    • 0025472463 scopus 로고
    • In vivo autoxidation of dopamine in guinea pig striatum increases with age
    • Fornstedt B, Pileblad E, Carlsson A. In vivo autoxidation of dopamine in guinea pig striatum increases with age. J Neurochem. 1990;55:655-659.
    • (1990) J Neurochem , vol.55 , pp. 655-659
    • Fornstedt, B.1    Pileblad, E.2    Carlsson, A.3
  • 53
    • 0025242960 scopus 로고
    • Oxidation reactions in Parkinson's disease
    • Olanow CW. Oxidation reactions in Parkinson's disease. Neurology. 1990;40 (suppl 3):32-37.
    • (1990) Neurology , vol.40 , Issue.SUPPL. 3 , pp. 32-37
    • Olanow, C.W.1
  • 54
    • 0026704066 scopus 로고
    • An introduction to the free radical hypothesis in Parkinson's disease
    • Olanow CW. An introduction to the free radical hypothesis in Parkinson's disease. Ann Neurol. 1992;32:S2-S9.
    • (1992) Ann Neurol , vol.32
    • Olanow, C.W.1
  • 55
    • 0026337175 scopus 로고
    • Oxidative stress as a cause of Parkinson's disease
    • Jenner P. Oxidative stress as a cause of Parkinson's disease. Acta Neurol Scand. 1991;84:6-15.
    • (1991) Acta Neurol Scand , vol.84 , pp. 6-15
    • Jenner, P.1
  • 56
    • 0026635461 scopus 로고
    • Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease
    • Jenner P, Dexter DT, Sian J, Schapira AHV, Marsden CD. Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. Ann Neurol. 1992;32(suppl):S82-S87.
    • (1992) Ann Neurol , vol.32 , Issue.SUPPL.
    • Jenner, P.1    Dexter, D.T.2    Sian, J.3    Schapira, A.H.V.4    Marsden, C.D.5
  • 57
    • 0026740057 scopus 로고
    • New insights into the cause of Parkinson's disease
    • Jenner P, Schapira AHV, Marsden CD. New insights into the cause of Parkinson's disease. Neurology. 1992;42:2241-2250.
    • (1992) Neurology , vol.42 , pp. 2241-2250
    • Jenner, P.1    Schapira, A.H.V.2    Marsden, C.D.3
  • 58
    • 0026484388 scopus 로고
    • The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
    • Fahn S, Cohen G. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann Neurol. 1992;32:804-812.
    • (1992) Ann Neurol , vol.32 , pp. 804-812
    • Fahn, S.1    Cohen, G.2
  • 59
    • 0027283898 scopus 로고
    • Free radicals and their scavengers in Parkinson's disease
    • Yoshikawa T. Free radicals and their scavengers in Parkinson's disease. Eur Neurol. 1993;33:60-68.
    • (1993) Eur Neurol , vol.33 , pp. 60-68
    • Yoshikawa, T.1
  • 60
    • 0027952849 scopus 로고
    • Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: An HPLC and ESR study
    • Dexter DT, Holley AE, Flitter WD, et al. Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Mov Disord. 1994; 9:92-97.
    • (1994) Mov Disord , vol.9 , pp. 92-97
    • Dexter, D.T.1    Holley, A.E.2    Flitter, W.D.3
  • 61
    • 0028075410 scopus 로고
    • Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
    • Sian J, Dexter DT, Lees AJ, et al. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol. 1994;36:348-355.
    • (1994) Ann Neurol , vol.36 , pp. 348-355
    • Sian, J.1    Dexter, D.T.2    Lees, A.J.3
  • 62
    • 0028492775 scopus 로고
    • Biochemistry of Parkinson's disease with special reference to the dopaminergic systems
    • Hirsch EC. Biochemistry of Parkinson's disease with special reference to the dopaminergic systems. Mol Neurobiol. 1994;9:135-142.
    • (1994) Mol Neurobiol , vol.9 , pp. 135-142
    • Hirsch, E.C.1
  • 63
    • 0000232034 scopus 로고
    • A marker of oxyradical-mediated DNA damage (8-hydroxy-2'deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain
    • Sanchez-Ramos JR, Overvik E, Ames BN. A marker of oxyradical-mediated DNA damage (8-hydroxy-2'deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain. Neurodegeneration. 1994;3:197-204.
    • (1994) Neurodegeneration , vol.3 , pp. 197-204
    • Sanchez-Ramos, J.R.1    Overvik, E.2    Ames, B.N.3
  • 64
    • 0028924168 scopus 로고
    • Oxidative stress in Parkinson's disease: Review
    • Schapira AHV. Oxidative stress in Parkinson's disease: review. Neuropathol Appl Neurobiol. 1995;21:3-9.
    • (1995) Neuropathol Appl Neurobiol , vol.21 , pp. 3-9
    • Schapira, A.H.V.1
  • 65
    • 0030007912 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease and other neurodegenerative disorders
    • Jenner P. Oxidative stress in Parkinson's disease and other neurodegenerative disorders. Pathol Biol. 1996;44:57-64.
    • (1996) Pathol Biol , vol.44 , pp. 57-64
    • Jenner, P.1
  • 67
    • 0030597071 scopus 로고    scopus 로고
    • Glycoxidation and oxidative stress in Parkinson disease and diffuse lewy body disease
    • Castellani R, Smith MA, Richey PL, Perry G. Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease. Brain Res. 1996; 737:195-200.
    • (1996) Brain Res , vol.737 , pp. 195-200
    • Castellani, R.1    Smith, M.A.2    Richey, P.L.3    Perry, G.4
  • 68
    • 0031023430 scopus 로고    scopus 로고
    • Levodopa induces apoptosis in cultured neuronal cells: A possible accelerator of nigrostriatal degeneration in Parkinson's disease?
    • Ziv I, Zilkhafalb R, Offen D, Shirvan A, Barzilai A, Melamed E. Levodopa induces apoptosis in cultured neuronal cells: a possible accelerator of nigrostriatal degeneration in Parkinson's disease? Mov Disord. 1997;12:17-23.
    • (1997) Mov Disord , vol.12 , pp. 17-23
    • Ziv, I.1    Zilkhafalb, R.2    Offen, D.3    Shirvan, A.4    Barzilai, A.5    Melamed, E.6
  • 69
    • 0031043805 scopus 로고    scopus 로고
    • A dopaminergic neurotoxin, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2 (N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigrostriatal system of the human brain
    • Maruyama W, Sobue G, Matsubara K, Hashizume Y, Dostert P, Naoi M. A dopaminergic neurotoxin, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2 (N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigrostriatal system of the human brain. Neurosci Lett. 1997;223:61-64.
    • (1997) Neurosci Lett , vol.223 , pp. 61-64
    • Maruyama, W.1    Sobue, G.2    Matsubara, K.3    Hashizume, Y.4    Dostert, P.5    Naoi, M.6
  • 70
    • 0030960225 scopus 로고    scopus 로고
    • Chronic inhibition of the high-affinity dopamine uptake system increases oxidative damage to proteins in the aged rat substantia nigra
    • Romero-Ramos M, Rodriguez-Gomez JA, Venero JL, Cano J, Machado A. Chronic inhibition of the high-affinity dopamine uptake system increases oxidative damage to proteins in the aged rat substantia nigra. Free Radical Biol Med. 1997; 23:1-7.
    • (1997) Free Radical Biol Med , vol.23 , pp. 1-7
    • Romero-Ramos, M.1    Rodriguez-Gomez, J.A.2    Venero, J.L.3    Cano, J.4    Machado, A.5
  • 71
    • 0031010596 scopus 로고    scopus 로고
    • Parkinson disease: A new link between monoamine oxidase and mitochondrial electron flow
    • Cohen G, Farooqui R, Kesler N. Parkinson disease: a new link between monoamine oxidase and mitochondrial electron flow. Proc Natl Acad Sci U S A. 1997; 94:4890-4894.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4890-4894
    • Cohen, G.1    Farooqui, R.2    Kesler, N.3
  • 72
    • 0030878073 scopus 로고    scopus 로고
    • Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra
    • Alam ZI, Jenner A, Daniel SE, et al. Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem. 1997;69:1196-1203.
    • (1997) J Neurochem , vol.69 , pp. 1196-1203
    • Alam, Z.I.1    Jenner, A.2    Daniel, S.E.3
  • 73
    • 0030805622 scopus 로고    scopus 로고
    • A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental lewy body disease
    • Alam ZI, Daniel SE, Lees AJ, Marsden CD, Jenner P, Halliwell B. A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. J Neurochem. 1997;69:1326-1329.
    • (1997) J Neurochem , vol.69 , pp. 1326-1329
    • Alam, Z.I.1    Daniel, S.E.2    Lees, A.J.3    Marsden, C.D.4    Jenner, P.5    Halliwell, B.6
  • 74
    • 0030724621 scopus 로고    scopus 로고
    • Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease
    • Pearce RKB, Owen A, Daniel S, Jenner P, Marsden CD. Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease. J Neural Transm. 1997;104:661-677.
    • (1997) J Neural Transm. , vol.104 , pp. 661-677
    • Pearce, R.K.B.1    Owen, A.2    Daniel, S.3    Jenner, P.4    Marsden, C.D.5
  • 75
    • 0031283221 scopus 로고    scopus 로고
    • Indices of oxidative stress in Parkinson's disease, Alzheimer's disease and dementia with Lewy bodies
    • Owen AD, Schapira AHV, Jenner P, Marsden CD. Indices of oxidative stress in Parkinson's disease, Alzheimer's disease and dementia with Lewy bodies. J Neural Transm Suppl. 1997;51:167-173.
    • (1997) J Neural Transm Suppl , vol.51 , pp. 167-173
    • Owen, A.D.1    Schapira, A.H.V.2    Jenner, P.3    Marsden, C.D.4
  • 76
    • 0031808220 scopus 로고    scopus 로고
    • Tyrosine hydroxylase and Parkinson's disease
    • Haavik J, Toska K. Tyrosine hydroxylase and Parkinson's disease. Mol Neurobiol. 1998;16:285-309.
    • (1998) Mol Neurobiol. , vol.16 , pp. 285-309
    • Haavik, J.1    Toska, K.2
  • 77
    • 0031899172 scopus 로고    scopus 로고
    • Oxidative mechanisms in nigral cell death in Parkinson's disease
    • Jenner P. Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord. 1998;13:24-34.
    • (1998) Mov Disord. , vol.13 , pp. 24-34
    • Jenner, P.1
  • 78
    • 0030462233 scopus 로고    scopus 로고
    • Differential neurotoxicity induced by L-DOPA and dopamine in cultured striatal neurons
    • Cheng NN, Maeda T, Kume T, et al. Differential neurotoxicity induced by L-DOPA and dopamine in cultured striatal neurons. Brain Res. 1996;743:278-283.
    • (1996) Brain Res , vol.743 , pp. 278-283
    • Cheng, N.N.1    Maeda, T.2    Kume, T.3
  • 79
    • 0030605877 scopus 로고    scopus 로고
    • Effects of bromocriptine and/or L-DOPA on neurons in substantia nigra of MPTP-treated C578L/6 mice
    • Fukuda T, Watabe K, Tanaka J. Effects of bromocriptine and/or L-DOPA on neurons in substantia nigra of MPTP-treated C578L/6 mice. Brain Res. 1996;728: 274-276.
    • (1996) Brain Res , vol.728 , pp. 274-276
    • Fukuda, T.1    Watabe, K.2    Tanaka, J.3
  • 80
    • 0030249286 scopus 로고    scopus 로고
    • Prevention of dopamine-induced cell death by thiol antioxidants: Possible implications for treatment of Parkinson's disease
    • Offen D, Ziv I, Sternin H, Melamed E, Hochman A. Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease. Exp Neurol. 1996;141:32-39.
    • (1996) Exp Neurol , vol.141 , pp. 32-39
    • Offen, D.1    Ziv, I.2    Sternin, H.3    Melamed, E.4    Hochman, A.5
  • 81
    • 0031023430 scopus 로고    scopus 로고
    • Levodopa induces apoptosis in cultured neuronal cells: A possible accelerator of nigrostriatal degeneration in Parkinson's disease?
    • Ziv I, Zilkhafalb R, Offen O, Shirvan A, Barzilai A, Melamed E. Levodopa induces apoptosis in cultured neuronal cells: a possible accelerator of nigrostriatal degeneration in Parkinson's disease? Mov Disord. 1997;12:17-23.
    • (1997) Mov Disord , vol.12 , pp. 17-23
    • Ziv, I.1    Zilkhafalb, R.2    Offen, O.3    Shirvan, A.4    Barzilai, A.5    Melamed, E.6
  • 82
    • 0030977070 scopus 로고    scopus 로고
    • Comparison of neurotoxicity following repeated administration of L-dopa, D-dopa, and dopamine to embryonic mesencephalic dopamine neurons in cultures derived from Fisher 344 and Sprague-Dawley donors
    • Alexander T, Sortwell CE, Sladek CD, Roth RH, Steece-Collier K. Comparison of neurotoxicity following repeated administration of L-dopa, D-dopa, and dopamine to embryonic mesencephalic dopamine neurons in cultures derived from Fisher 344 and Sprague-Dawley donors. Cell Transplant. 1997;6:309-315.
    • (1997) Cell Transplant , vol.6 , pp. 309-315
    • Alexander, T.1    Sortwell, C.E.2    Sladek, C.D.3    Roth, R.H.4    Steece-Collier, K.5
  • 84
    • 0031042677 scopus 로고    scopus 로고
    • Dopamine- and L-beta-3,4-dihydroxyphenylalanine hydrochloride (L-DOPA)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells: Effects of oxidative stress and antioxidative factors
    • Lai CT, Yu PH. Dopamine- and L-beta-3,4-dihydroxyphenylalanine hydrochloride (L-DOPA)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells: effects of oxidative stress and antioxidative factors. Biochem Pharmacol. 1997;53:363-372.
    • (1997) Biochem Pharmacol , vol.53 , pp. 363-372
    • Lai, C.T.1    Yu, P.H.2
  • 85
    • 0030965053 scopus 로고    scopus 로고
    • Dopamine-induced apoptosis is inhibited in PC12 cells expressing bcl-2
    • Offen D, Ziv I, Panet H, et al. Dopamine-induced apoptosis is inhibited in PC12 cells expressing bcl-2. Cell Mol Neurobiol. 1997;17:289-304.
    • (1997) Cell Mol Neurobiol , vol.17 , pp. 289-304
    • Offen, D.1    Ziv, I.2    Panet, H.3
  • 86
    • 0030612204 scopus 로고    scopus 로고
    • Loss of dopaminergic neurons in parkinsonism: Possible role of reactive dopamine metabolites
    • Hastings TG, Zigmond MJ. Loss of dopaminergic neurons in parkinsonism: possible role of reactive dopamine metabolites. J Neural Transm Suppl. 1997;49: 103-110.
    • (1997) J Neural Transm Suppl , vol.49 , pp. 103-110
    • Hastings, T.G.1    Zigmond, M.J.2
  • 87
    • 0030880246 scopus 로고    scopus 로고
    • Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms
    • Mena MA, Casarejos MJ, Carazo A, Paino CL, de Yebenes JG. Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms. J Neural Transm. 1997;104:317-328.
    • (1997) J Neural Transm , vol.104 , pp. 317-328
    • Mena, M.A.1    Casarejos, M.J.2    Carazo, A.3    Paino, C.L.4    De Yebenes, J.G.5
  • 88
    • 0031214246 scopus 로고    scopus 로고
    • Formation of DNA adducts and oxidative base damage by copper mediated oxidation of dopamine and 6-hydroxydopamine
    • Levay G, Ye QP, Bodell WJ. Formation of DNA adducts and oxidative base damage by copper mediated oxidation of dopamine and 6-hydroxydopamine. Exp Neurol. 1997;146:570-574.
    • (1997) Exp Neurol , vol.146 , pp. 570-574
    • Levay, G.1    Ye, Q.P.2    Bodell, W.J.3
  • 89
    • 0031589730 scopus 로고    scopus 로고
    • Metabolic inhibition enhances selective toxicity of L-DOPA toward mesencephalic dopamine neurons in vitro
    • Nakao N, Nakai K, Itakura T. Metabolic inhibition enhances selective toxicity of L-DOPA toward mesencephalic dopamine neurons in vitro. Brain Res. 1997; 777:202-209.
    • (1997) Brain Res , vol.777 , pp. 202-209
    • Nakao, N.1    Nakai, K.2    Itakura, T.3
  • 90
    • 0032488992 scopus 로고    scopus 로고
    • Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway
    • Luo YQ, Umegaki H, Wang XT, Abe R, Roth GS. Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway. J Biol Chem. 1998; 273:3756-3764.
    • (1998) J Biol Chem , vol.273 , pp. 3756-3764
    • Luo, Y.Q.1    Umegaki, H.2    Wang, X.T.3    Abe, R.4    Roth, G.S.5
  • 91
    • 0031776914 scopus 로고    scopus 로고
    • Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor
    • McLaughlin BA, Nelson D, Erecinska M, Chesselet MF. Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor. J Neurochem. 1998;70:2406-2415.
    • (1998) J Neurochem , vol.70 , pp. 2406-2415
    • McLaughlin, B.A.1    Nelson, D.2    Erecinska, M.3    Chesselet, M.F.4
  • 92
    • 0031964353 scopus 로고    scopus 로고
    • Pharmacological approaches to counter the toxicity of dopa
    • Von Voigtlander PF, Fici GJ, Althaus JS. Pharmacological approaches to counter the toxicity of dopa. Amino Acids. 1998;14:189-196.
    • (1998) Amino Acids , vol.14 , pp. 189-196
    • Von Voigtlander, P.F.1    Fici, G.J.2    Althaus, J.S.3
  • 93
    • 0030815243 scopus 로고    scopus 로고
    • Levodopa-induced neurotoxicity: Does it represent a problem for the treatment of Parkinson's disease?
    • Fahn S. Levodopa-induced neurotoxicity: does it represent a problem for the treatment of Parkinson's disease? CNS Drugs. 1997;8:376-393.
    • (1997) CNS Drugs , vol.8 , pp. 376-393
    • Fahn, S.1
  • 94
    • 0029915162 scopus 로고    scopus 로고
    • Glia conditioned medium protects fetal rat midbrain neurones in culture from L-DOPA toxicity
    • Mena MA, Casarejos MJ, Carazo A, Paino CL, De Yebenes JG. Glia conditioned medium protects fetal rat midbrain neurones in culture from L-DOPA toxicity. Neuroreport. 1996;7:441-445.
    • (1996) Neuroreport , vol.7 , pp. 441-445
    • Mena, M.A.1    Casarejos, M.J.2    Carazo, A.3    Paino, C.L.4    De Yebenes, J.G.5
  • 95
    • 0030880246 scopus 로고    scopus 로고
    • Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms
    • Mena MA, Casarejos MJ, Carazo A, Paino CL, de Yebenes JG. Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms. J Neural Transm. 1997;104:317-328.
    • (1997) J Neural Transm , vol.104 , pp. 317-328
    • Mena, M.A.1    Casarejos, M.J.2    Carazo, A.3    Paino, C.L.4    De Yebenes, J.G.5
  • 96
    • 0030931665 scopus 로고    scopus 로고
    • Neurotrophic effects of L-DOPA in postnatal midbrain dopamine neuron cortical astrocyte cocultures
    • Mena MA, Davila V, Sulzer D. Neurotrophic effects of L-DOPA in postnatal midbrain dopamine neuron cortical astrocyte cocultures. J Neurochem. 1997;69: 1398-1408.
    • (1997) J Neurochem , vol.69 , pp. 1398-1408
    • Mena, M.A.1    Davila, V.2    Sulzer, D.3
  • 98
    • 0019447228 scopus 로고
    • Long-term administration of levodopa does not damage dopaminergic neurons in the mouse
    • Hefti F, Melamed E, Bhawan J, Wurtman RJ. Long-term administration of levodopa does not damage dopaminergic neurons in the mouse. Neurology. 1981; 31:1194-1195.
    • (1981) Neurology , vol.31 , pp. 1194-1195
    • Hefti, F.1    Melamed, E.2    Bhawan, J.3    Wurtman, R.J.4
  • 99
    • 0020146055 scopus 로고
    • Chronic dopa feeding of mice
    • Reches A, Fahn S. Chronic dopa feeding of mice. Neurology. 1982;32:684-685.
    • (1982) Neurology , vol.32 , pp. 684-685
    • Reches, A.1    Fahn, S.2
  • 100
    • 0021129038 scopus 로고
    • Nigrostriatal dopamine neurons remain undamaged in rats given high doses of L-DOPA and carbidopa chronically
    • Perry TL, Yong VW, Ito M, et al. Nigrostriatal dopamine neurons remain undamaged in rats given high doses of L-DOPA and carbidopa chronically. J Neurochem. 1984;43:990-993.
    • (1984) J Neurochem , vol.43 , pp. 990-993
    • Perry, T.L.1    Yong, V.W.2    Ito, M.3
  • 101
    • 0022946382 scopus 로고
    • Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period
    • Quinn N, Parkes D, Janota I, Marsden CD. Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period. Mov Disord. 1986;1:65-68.
    • (1986) Mov Disord , vol.1 , pp. 65-68
    • Quinn, N.1    Parkes, D.2    Janota, I.3    Marsden, C.D.4
  • 103
    • 0027287928 scopus 로고
    • Suppressive effect of L-DOPA on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6-hydroxydopamine
    • Blunt SB, Jenner P, Marsden CD. Suppressive effect of L-DOPA on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6-hydroxydopamine. Mov Disord. 1993;8:129-133.
    • (1993) Mov Disord , vol.8 , pp. 129-133
    • Blunt, S.B.1    Jenner, P.2    Marsden, C.D.3
  • 104
    • 0030605877 scopus 로고    scopus 로고
    • Effects of bromocriptine and/or L-DOPA on neurons in substantia nigra of MPTP-treated C57BL/6 mice
    • Fukuda T, Watabe K, Tanaka J. Effects of bromocriptine and/or L-DOPA on neurons in substantia nigra of MPTP-treated C57BL/6 mice. Brain Res. 1996;728: 274-276.
    • (1996) Brain Res , vol.728 , pp. 274-276
    • Fukuda, T.1    Watabe, K.2    Tanaka, J.3
  • 105
    • 0031968959 scopus 로고    scopus 로고
    • Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions
    • Murer MG, Dziewczapolski G, Menalled LB, et al. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Ann Neurol. 1998;43:561-575.
    • (1998) Ann Neurol , vol.43 , pp. 561-575
    • Murer, M.G.1    Dziewczapolski, G.2    Menalled, L.B.3
  • 106
    • 0031899713 scopus 로고    scopus 로고
    • Levodopa: Is toxicity a myth?
    • Agid Y. Levodopa: is toxicity a myth? Neurology. 1998;50:858-863.
    • (1998) Neurology , vol.50 , pp. 858-863
    • Agid, Y.1
  • 107
    • 0031969137 scopus 로고    scopus 로고
    • Welcome news about levodopa, but uncertainty remains
    • Fahn S. Welcome news about levodopa, but uncertainty remains. Ann Neurol. 1998;43:551-554.
    • (1998) Ann Neurol , vol.43 , pp. 551-554
    • Fahn, S.1
  • 108
    • 85069136418 scopus 로고    scopus 로고
    • Neurologists' treatment patterns for Parkinson's disease (PD)
    • Fahn S, Rudolph A, Parkinson Study Group. Neurologists' treatment patterns for Parkinson's disease (PD) [abstract]. Mov Disord. 1996;11:595.
    • (1996) Mov Disord , vol.11 , pp. 595
    • Fahn, S.1    Rudolph, A.2


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