1,3-Butadiene: I. Review of metabolism and the implications to human health risk assessment

Critical Reviews in Toxicology

Volumn 40, Issue SUPPL. 1, 2010, Pages 1-11

  Kirman, Christopher R ^a,b   Albertini, Richard J ^c   Sweeney, Lisa M ^d,f   Gargas, Michael L ^e,f  

^a LLP   (United States)

^b Sapphire Group   (United States)

^c UNIVERSITY OF VERMONT   (United States)

^d Toxicology Excellence for Risk Assessment   (United States)

^e WRIGHT PATTERSON AIR FORCE BASE   (United States)

^f Sapphire Group   (United States)

Author keywords

1,2 dihydroxy 3; 1,3 Butadiene; 1; 2 epoxy 3 butene; 1; 2; 3; 4 diepoxybutane; 4 epoxybutane; Metabolism; Nonlinearity; Species differences

Indexed keywords

1,3 BUTADIENE DERIVATIVE; ELECTROPHILE; GLUTATHIONE; HEMOGLOBIN; STYRENE;

CARCINOGENICITY; DETOXIFICATION; ENZYME INDUCTION; ENZYME INHIBITION; GENOTOXICITY; HEALTH HAZARD; HUMAN; IN VITRO STUDY; LEUKEMIA; METABOLISM; METABOLITE; NONHUMAN; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; RUBBER INDUSTRY; SPECIES DIFFERENCE; TOXICOKINETICS; URINARY EXCRETION;

ANIMALS; BUTADIENES; CARCINOGENICITY TESTS; ELASTOMERS; EPIDEMIOLOGIC STUDIES; EPOXY COMPOUNDS; FEMALE; HUMANS; LEUKEMIA; MALE; MICE; OCCUPATIONAL HEALTH; RATS; RISK ASSESSMENT; STYRENES;

MUS; RATTUS; RODENTIA;

EID: 77957227523     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2010.507181     Document Type: Review

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