Quantitative investigation on the metabolism of 1,3-butadiene and of its oxidized metabolites in once-through perfused livers of mice and rats

Toxicological Sciences

Volumn 114, Issue 1, 2009, Pages 25-37

  Filser, Johannes G ^a,b   Bhowmik, Swati ^a,c   Faller, Thomas H ^a,c   Hutzler, Christoph ^a,d   Kessler, Winfried ^a   Midpanon, Supatta ^a,e   Pütz, Christian ^a   Schuster, Andreas ^a,f   Semder, Brigitte ^a   Veereshwarayya, Vimal ^a   Csanády, György A ^a,b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

^d FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^e KASETSART UNIVERSITY   (Thailand)

^f Landshut Silicon Foundry GmbH   (Germany)

Author keywords

1,2 epoxy 3 butene; 1,2:3,4 diepoxybutane; 1,3 butadiene; 2 diol; 3,4 epoxy 1,2 butanediol; 3 butene 1; Mouse and rat liver

Indexed keywords

1,2 EPOXY 3 BUTENE; 1,3 BUTADIENE; 3,4 EPOXY 1,2 BUTANEDIOL; BUTADIENE DIEPOXIDE; BUTANEDIOL; CARCINOGEN; ENZYME; INDUSTRIAL CHEMICAL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIRST PASS EFFECT; LIVER CLEARANCE; LIVER PERFUSION; METABOLISM; MOUSE; MOUSE STRAIN; NONHUMAN; QUANTITATIVE STUDY; RAT; RISK ASSESSMENT; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; TOXICOKINETICS;

MUS; RATTUS; RODENTIA;

EID: 77951600722     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp297     Document Type: Article

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